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Hepatitis B Immunoprophylaxis: Developing a Cost-Effective Program in the Hospital Setting

Published online by Cambridge University Press:  21 June 2016

Bruce P. Lanphear
Bruce P. Lanphear*
Affiliation:
Medical Center Health Services, University of Cincinnati, Cincinnati, Ohio
*
Medical Center Heath Services, Mail Location #705, University of Cincinnati, Cincinnati, OH 45267
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Extract

There are several goals of a hepatitis B immunoprophylaxis program. Prevention of clinical disease and carrier status in healthcare workers (HCW) is the primary goal. In addition, the uncommon incidence of staff transmitting hepatitis B infection (HBV) to patients should not continue with available methods of prevention. The prevention of disease is not only desirable from a public health standpoint, it is also needed to protect health centers from liability that may result from the occurrence of preventable diseases of occupational origin, such as HBV.

Type
Readers' Forum
Information
Infection Control & Hospital Epidemiology , Volume 11 , Issue 1 , January 1990 , pp. 47 - 50
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1990

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References

1. Mulley, AG, Silverstein, MD, Dienstag, JL. Indications for use of hepatitis B vaccine, based on cost-effectiveness analysis. New Engl J Med. 1982;307:644–652.10.1056/NEJM198209093071103CrossRefGoogle ScholarPubMed
2. Welch, J, Webster, M, Tilzey, AJ, Noah, ND, Banatvala, JE. Hepatitis B infections after gynecologic surgery. Lancets. 1989; 205–206.10.1016/S0140-6736(89)91213-0CrossRefGoogle Scholar
3. Lettau, LA, Smith, JD, Williams, D, et al. Transmission of hepatitis B with resultant restriction of surgical practice. JAMA. 1986;255:934–937.10.1001/jama.1986.03370070088032CrossRefGoogle ScholarPubMed
4. Baker, CH, Brennan, JM. Keeping health-care workers healthy: legal aspects of hepatitis B immunization programs. New Engl J Med. 1984;311:684–688.10.1056/NEJM198409063111035CrossRefGoogle ScholarPubMed
5. Centers for Disease Control. Changing patterns of groups at high risk for hepatitis B in the United States. MMWR. 1988;37;429–432.Google Scholar
6. Department of Labor/Department of Health and Human Services. Protection against occupational exposure to hepatitis B virus and the human immunodeficiency virus. Washington, DC: US Government Printing Office; October 1987:1–14.Google Scholar
7. Centers for Disease Control. Update on hepatitis B prevention. MMWR. 1987;36:353–360.Google Scholar
8. Hashimoto, F, Hunt, WC, Brusuelas, H Physician acceptance of the hepatitis B vaccine at a university medical center. Am J Public Health. 1988;78:973–974.10.2105/AJPH.78.8.973CrossRefGoogle Scholar
9. Grady, GF, Lee, VA, Prince, AM, et al. hepatitis B immune globulin for accidental exposures among medical personnel: final report of a multi-center controlled trial. J Infect Dis. 1978;138:625–638.10.1093/infdis/138.5.625CrossRefGoogle Scholar
10. Seeff, LB, Wright, EC, Zimmerman, HJ et al. Type B hepatitis after needle-stick exposure: prevention with hepatitis B immune globulin. Ann Internal Med. 1978;88:285–293.10.7326/0003-4819-88-3-285CrossRefGoogle ScholarPubMed
11. Krugman, S, Gilles, JP, Hammond, J. Viral hepatitis, type B (MS-2 strain: studies on active immunization. JAMA. 1971;217:41–45.10.1001/jama.1971.03190010023005CrossRefGoogle ScholarPubMed
12. Szmuness, W, Stevens, CE, Harley, EJ, et al. hepatitis B vaccine in medical staff of hemodialysis units; efficacy and sub-type cross protection. New Engl J Med. 1982;307:1481–1486.10.1056/NEJM198212093072403CrossRefGoogle Scholar
13. Francis, DP, Hadler, SC, Thompson, SE, et al. The prevention of hepatitis B with vaccine. Ann Intern Med. 1982;97:362–366.10.7326/0003-4819-97-3-362CrossRefGoogle ScholarPubMed
14. Szmuness, W, Stevens, CE, Zang, EA, Harley, EJ Kellner, A. A controlled clinical trial of the efficacy of the Hepatitis B vaccine (Heptavax B); A final report. Hepatology. 1981;1:377–385.10.1002/hep.1840010502CrossRefGoogle ScholarPubMed
15. Centers for Disease Control. Recommendations for protection against viral hepatitis. MMWR. 1985;34: 313–324, 329–335.Google Scholar
16. Linnemann, CC Jr, Hegg, ME, Ramundo, N, Schiff, GN. Screening hospital patients for Hepatitis B surface antigen. Am J Clin Pathol. 1977;67:257–259.10.1093/ajcp/67.3.257CrossRefGoogle ScholarPubMed
17. Centers for Disease Control. Update: universal precautions for prevention of transmission of human immunodeficiency virus, Hepatitis B virus, and other bloodborne pathogens in healthcare settings. MMWR. 1988;37:377–382, 387–388.Google Scholar
18. Hadler, S, Francis, DP, Maynard, JE et al. Long term immunogenicity and efficacy of Hepatitis B vaccine in homosexual men. New Engl J Med. 1986;315:209–214.10.1056/NEJM198607243150401CrossRefGoogle ScholarPubMed
19. Taylor, PE, Stevens, CE. Persistence of antibody to Hepatitis B surface antigen after vaccination with Hepatitis B vaccine. [Abstract]J Med Virol. 1987;21:90–A.Google Scholar
20. Hadler, S. Are booster doses of hepatitis B vaccine necessary? (ed)Ann Intern Med. 1988;108:457–458.10.7326/0003-4819-108-3-457CrossRefGoogle ScholarPubMed
21. Wainwright, RB, McMahon, BJ, Bulkow, LR, et al. Duration of immunogenicity and efficacy of Hepatitis B vaccine in a Yupik eskimo population. JAMA. 1989;261:2362–2366.10.1001/jama.1989.03420160094029CrossRefGoogle Scholar
22. Immunization against hepatitis B. Lancet. 1988; 875–876.Google Scholar
23. Davidson, M, Krugman, S. Recombinant yeast Hepatitis B vaccine compared with plasma-derived vaccine: immunogenicity and effect of a booster dose. J Infect. 1986;13:(suppl A)31–38.10.1016/S0163-4453(86)92653-8CrossRefGoogle ScholarPubMed
24. Hepatitis B panel. Discussion. J Infect. 1986; 13(suppl A):73–78.Google Scholar
25. McLean, AA, Hilleman, MR, McAleer, WJ, Bunyak, EB. Summary of worldwide clinical experience with H-B-Vax. J Infect. 1983;7(suppl):95–104.10.1016/S0163-4453(83)96879-2CrossRefGoogle ScholarPubMed
26. Barnas, GP, Hanacik, LJ. Hepatitis B vaccine: persistence of antibody following immunization. Infect Control Hosp Epidemiol. 1988;9:147–150.10.2307/30145421CrossRefGoogle ScholarPubMed
27. Horowitz, MM, Ershler, WB, McKinney, WP, Battiola, RJ. Duration of immunity after Hepatitis B vaccination: efficacy of low-dose booster vaccine. Ann Intern Med. 1988;108:185–189.10.7326/0003-4819-108-2-185CrossRefGoogle ScholarPubMed
28. Jilg, W, Schmidt, M, Deinhardt, F. Persistence of specific antibodies after Hepatitis B vaccination. J Hepatol. 1988;6:201–207.10.1016/S0168-8278(88)80032-1CrossRefGoogle ScholarPubMed
29. Haas, R, Beidman, ME. Marketing a Hepatitis B vaccine program. Infect Control. 1986;7:339–341.Google ScholarPubMed
30. Zajac, BA, West, DJ, McAleer, WJ. Scolnick, EM. Overview of clinical studies with Hepatitis B vaccine made by recombinant DNA. J Infect. 1986;13(suppl A):39–45.10.1016/S0163-4453(86)92668-XCrossRefGoogle ScholarPubMed
31. Dandalos, E, Roumeliotou-Karayannis, A, Richardson, SC, Papaevangelou, G. Safety and immunogenicity of a recombinant Hepatitis B vaccine. J Med Virol. 1985;17:57–62.10.1002/jmv.1890170109CrossRefGoogle Scholar
32. Tong, MJ, Co, RL, Marci, RD, Michaelson, PM, Ortega, G. A cost comparison analysis for screening and vaccination of hospital personnel with high and low prevalence Hepatitis B virus antibodies in California. Infect Control Hosp Epidemiol. 1988;9(2):66–71.10.1086/645787CrossRefGoogle ScholarPubMed