Hostname: page-component-848d4c4894-p2v8j Total loading time: 0.001 Render date: 2024-05-23T04:54:12.251Z Has data issue: false hasContentIssue false
  • English
  • Français

Hospital-acquired bacterial infections in coronavirus disease 2019 (COVID-19) patients in Israel

Published online by Cambridge University Press:  23 December 2022

Mitchell J. Schwaber ,
Elizabeth Temkin ,
Rona Lobl ,
Vered Schechner Open the ORCID record for Vered Schechner [Opens in a new window] ,
Amir Nutman Open the ORCID record for Amir Nutman [Opens in a new window]  and
Yehuda Carmeli
Mitchell J. Schwaber*
Affiliation:
National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Elizabeth Temkin
Affiliation:
National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel
Rona Lobl
Affiliation:
National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel
Vered Schechner
Affiliation:
National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Amir Nutman
Affiliation:
National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Yehuda Carmeli
Affiliation:
National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
*
Author for correspondence: Mitchell J. Schwaber, E-mail: mitchells@tlvmc.gov.il
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

We sought to determine incidence of common hospital-acquired bacteria among coronavirus disease 2019 (COVID-19) patients in Israeli general hospitals during the first year of the pandemic.

Methods:

We analyzed routinely collected incidence data to determine hospital acquisition of the following sentinel bacteria: Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, Pseudomonas aeruginosa, Acinetobacter baumannii, and Clostridioides difficile. We examined 3 acquisition measures: (1) sentinel bacteria, (2) sentinel bacteremia, and (3) antimicrobial-resistant sentinel bacteremia. The study period was March 1, 2020, through January 31, 2021.

Results:

Analysis of pooled data from the 26 hospitals surveyed revealed that rates were higher for all 3 acquisition measures among COVID-19 patients than they were among patients on general medical wards in 2019, but lower than those among patients in intensive care units in 2019. The incidence rate was highest during the first COVID-19 wave, despite a lower proportion of severe COVID-19 cases among total hospitalized during this wave. Wide variation in incidence was evident between hospitals.

Conclusions:

Hospitalized COVID-19 patients experienced nosocomial bacterial infection at rates higher than those of patients on pre-pandemic general medical wards, adding to the complexity of their care. Lower rates of nosocomial infection after the first wave, despite higher proportions of severely ill patients, suggest that healthcare worker practices, rather than patient-related factors, were responsible for most of these infections.

Type
Original Article
Information
Infection Control & Hospital Epidemiology , Volume 44 , Issue 9 , September 2023 , pp. 1437 - 1442
Check for updates
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Israel Ministry of Health website. https://datadashboard.health.gov.il/COVID-19/general. Accessed October 27, 2022.Google Scholar
Polly, M, de Almeida, BL, Lennon, RP, Cortês, MF, Costa, SF, Guimarães, T. Impact of the COVID-19 pandemic on the incidence of multidrug-resistant bacterial infections in an acute care hospital in Brazil. Am J Infect Control 2022;50:238–239.CrossRefGoogle Scholar
Lemenand, O, Coeffic, T, Thibaut, S, et al. Decreasing proportion of extended-spectrum beta-lactamase among E. coli infections during the COVID-19 pandemic in France. J Infect 2021;83:664–670.CrossRefGoogle ScholarPubMed
Tomczyk, S, Taylor, A, Brown, A, et al. Impact of the COVID-19 pandemic on the surveillance, prevention, and control of antimicrobial resistance: a global survey. J Antimicrob Chemother 2021;76:3045–3058.CrossRefGoogle ScholarPubMed
Wee, LEI, Conceicao, EP, Tan, JY, et al. Unintended consequences of infection prevention and control measures during COVID-19 pandemic. Am J Infect Control 2021;49:469–477.CrossRefGoogle ScholarPubMed
Cona, A, Tavelli, A, Renzelli, A, et al. Incidence, risk factors and impact on clinical outcomes of bloodstream infections in patients hospitalized with COVID-19: a prospective cohort study. Antibiotics (Basel) 2021;10:1031.CrossRefGoogle ScholarPubMed
Gerver, SM, Guy, R, Wilson, K, et al. National surveillance of bacterial and fungal coinfection and secondary infection in COVID-19 patients in England: lessons from the first wave. Clin Microbiol Infect 2021;27:1658–1665.CrossRefGoogle ScholarPubMed
O’Toole, RF. The interface between COVID-19 and bacterial healthcare-associated infections. Clin Microbiol Infect 2021;27:1772–1776.10.1016/j.cmi.2021.06.001CrossRefGoogle ScholarPubMed
Granata, G, Bartoloni, A, Codeluppi, M, et al. The burden of Clostridioides difficile infection during the COVID-19 pandemic: a retrospective case–control study in Italian hospitals (CloVid). J Clin Med 2020;9:3855.CrossRefGoogle ScholarPubMed
Kampmeier, S, Tönnies, H, Correa-Martinez, CL, Mellmann, A, Schwierzeck, V. A nosocomial cluster of vancomycin resistant enterococci among COVID-19 patients in an intensive care unit. Antimicrob Resist Infect Control 2020;9:154.10.1186/s13756-020-00820-8CrossRefGoogle Scholar
Hughes, S, Troise, O, Donaldson, H, Mughal, N, Moore, LSP. Bacterial and fungal coinfection among hospitalized patients with COVID-19: a retrospective cohort study in a UK secondary-care setting. Clin Microbiol Infect 2020;26:1395–1399.CrossRefGoogle Scholar
Garcia-Vidal, C, Sanjuan, G, Moreno-García, E, et al. Incidence of coinfections and superinfections in hospitalized patients with COVID-19: a retrospective cohort study. Clin Microbiol Infect 2021;27:83–88.CrossRefGoogle ScholarPubMed
Ullrich, A, Schranz, M, Rexroth, U, et al. Impact of the COVID-19 pandemic and associated non-pharmaceutical interventions on other notifiable infectious diseases in Germany: An analysis of national surveillance data during week 1-2016–week 32-2020. Lancet Reg Health Eur 2021;6:100103.CrossRefGoogle ScholarPubMed
Cole, J, Barnard, E. The impact of the COVID-19 pandemic on healthcare acquired infections with multidrug resistant organisms. Am J Infect Control 2021;49:653–654.10.1016/j.ajic.2020.09.013CrossRefGoogle ScholarPubMed
Weiner-Lastinger, LM, Pattabiraman, V, Konnor, RY, et al. The impact of coronavirus disease 2019 (COVID-19) on healthcare-associated infections in 2020: A summary of data reported to the National Healthcare Safety Network. Infect Control Hosp Epidemiol 2022;43:12–25.CrossRefGoogle Scholar
Baker, MA, Sands, KE, Huang, SS, et al. The impact of COVID-19 on healthcare-associated infections. Clin Infect Dis 2022;74:1748–1754.10.1093/cid/ciab688CrossRefGoogle ScholarPubMed
Zhu, N, Rawson, TM, Mookerjee, S, et al. Changing patterns of bloodstream infections in the community and acute care across two COVID-19 epidemic waves: a retrospective analysis using data linkage. Clin Infect Dis 2021;75:e1082–e1091.10.1093/cid/ciab869CrossRefGoogle Scholar
Gottlieb, L, Fridkin, SK. It’s hard to measure success while caring for surges in COVID-19 hospitalizations. Clin Infect Dis 2022;74:1755–1756.CrossRefGoogle ScholarPubMed
Gottesman, T, Fedorowsky, R, Yerushalmi, R, Lellouche, J, Nutman, A. An outbreak of carbapenem-resistant Acinetobacter baumannii in a COVID-19 dedicated hospital. Infect Prev Pract 2021;3:100113.CrossRefGoogle Scholar
Supplementary material: Image

Schwaber et al. supplementary material

Figure S2

Download Schwaber et al. supplementary material(Image)
Image 224.1 KB
Supplementary material: Image

Schwaber et al. supplementary material

Figure S1

Download Schwaber et al. supplementary material(Image)
Image 84.8 KB