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Slow Progression of White-Matter Changes

Published online by Cambridge University Press:  10 January 2005

Reinhold Schmidt ,
Helena Schmidt ,
Peter Kapeller  and
Franz Fazekas
Reinhold Schmidt
Affiliation:
Department of Neurology, Karl-Franzens University, Graz, Austria MR Center, Karl-Franzens University, Graz, Austria
Helena Schmidt
Affiliation:
Institute of Medical Biochemistry and Medical Molecular Biology, Karl-Franzens University, Graz, Austria
Peter Kapeller
Affiliation:
Department of Neurology, Karl-Franzens University, Graz, Austria MR Center, Karl-Franzens University, Graz, Austria
Franz Fazekas
Affiliation:
Department of Neurology, Karl-Franzens University, Graz, Austria MR Center, Karl-Franzens University, Graz, Austria
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Abstract

A three-year follow-up of 273 participants (mean age 60 years) of the Austrian Stroke Prevention Study provides the first information on the rate, clinical predictors, and cognitive consequences of MRI white-matter lesions in elderly individuals without neuropsychiatric disease. Lesion progression was found in 17.9% of individuals over a time period of 3 years. Diastolic blood pressure and early confluent or confluent white-matter hyperintensities at baseline were the only significant predictors of white-matter hyperintensity progression. Lesion progression had no influence on the course of neuropsychologic test performance over the observational period, but the statistical power of this analysis was low.

Keywords

White-matter lesionsrisk factorscerebral small-vessel diseasecognition
Type
SECONDARY PREVENTION (CVD BRAIN AT RISK OF COGNITIVE DECLINE)
Information
International Psychogeriatrics , Volume 15 , Issue S1 , July 2003 , pp. 173 - 176
Copyright
© 2003 International Psychogeriatric Association

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