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Interspecies study on the effect of perphenazine on milk yield and composition

Published online by Cambridge University Press:  01 June 2009

J. Shani (Mishkinsky) ,
A. T. Cowie  and
W. H. Broster
J. Shani (Mishkinsky)
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading, RG2 9AT
A. T. Cowie
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading, RG2 9AT
W. H. Broster
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading, RG2 9AT
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Summary

The effects on lactation of perphenazine, a tranquillizer which increases the level of prolactin in the blood, have been studied in cows, goats, guinea-pigs and rabbits. The drug caused a significant depression of milk yield in cows, goats and rabbits, but was without effect on the milk yield of guinea-pigs. It seems probable that the inhibitory effects on lactation were due to the actions of the drug on appetite and behaviour. It is concluded that perphenazine, because of its other actions, is not a suitable agent for studying the physiological effects of increased levels of endogenous prolactin.

Type
Research Article
Information
Journal of Dairy Research , Volume 42 , Issue 1 , February 1975 , pp. 1 - 9
Copyright
Copyright © Proprietors of Journal of Dairy Research 1975

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