Hostname: page-component-848d4c4894-4hhp2 Total loading time: 0 Render date: 2024-06-02T14:03:17.051Z Has data issue: false hasContentIssue false
  • English
  • Français

Pregnancy and neonatal outcomes following hyperemesis gravidarum

Published online by Cambridge University Press:  20 January 2011

R. L. Coetzee ,
B. Cormack ,
L. Sadler  and
F. H. Bloomfield
R. L. Coetzee
Affiliation:
Department of Human Nutrition, University of Otago, Dunedin, New Zealand Nutrition Services, Auckland City Hospital, Auckland, New Zealand
B. Cormack
Affiliation:
Nutrition Services, Auckland City Hospital, Auckland, New Zealand
L. Sadler
Affiliation:
Women's Health, Auckland City Hospital, Auckland, New Zealand
F. H. Bloomfield*
Affiliation:
Newborn Services, Auckland City Hospital, Auckland, New Zealand The Liggins Institute, University of Auckland, Auckland, New Zealand
*
*Address for correspondence: F. H. Bloomfield, Liggins Institute, University of Auckland, Private Bag 92019, Victoria Street West, Auckland, 1142, New Zealand. (Email f.bloomfield@auckland.ac.nz)
Get access Rights & Permissions [Opens in a new window]

Abstract

Undernutrition during pregnancy is associated with detrimental pregnancy and neonatal outcomes, which can have long-term implications for the infant. Hyperemesis gravidarum may severely limit nutritional intake. The aim of this study was to investigate the effect of hyperemesis on pregnancy and neonatal outcome, particularly gestation length and infant size at birth. Seventy-five prospectively recruited women admitted to a tertiary level hospital in Auckland, with hyperemesis gravidarum between March 2003 and October 2005, were compared to 142 controls matched for age, parity, ethnicity and expected date of delivery. Data were obtained from electronic records and analysed by Student's t-test, χ2, Wilcoxon, Fisher's exact tests and linear regression. Length of gestation, birth weight and crown-heel length were not different between participants and controls. Infants born to women with hyperemesis gravidarum had smaller head circumferences (Z-score mean (s.d.) 0.02 (0.16) v. 0.43 (0.11), P = 0.04 in all infants and −0.02 (1.24) v. 0.48 (1.29), P = 0.01 in-term infants). This study found hyperemesis gravidarum to be associated with smaller head circumferences in offspring. Given the reported associations between smaller head circumference at birth and lower cognitive ability and higher risk of cardiovascular disease in later life, further study is necessary to confirm these results and to determine whether there are any long-term implications for the offspring.

Keywords

head circumferencehyperemesis gravidarumneonatal outcomepregnancy outcome
Type
Original Articles
Information
Journal of Developmental Origins of Health and Disease , Volume 2 , Issue 2 , April 2011 , pp. 81 - 88
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Barker, DJP. The fetal and infant origins of disease. Eur J Clin Invest. 1995; 25, 457–463.CrossRefGoogle ScholarPubMed
2. Gluckman, PD, Hanson, MA, Cooper, C, Thornburg, KL. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med. 2008; 359, 61–73.CrossRefGoogle ScholarPubMed
3. Painter, RC, de Rooij, SR, Bossuyt, PM, et al. Early onset of coronary artery disease after prenatal exposure to the Dutch famine. Am J Clin Nutr. 2006; 84, 322–327.CrossRefGoogle Scholar
4. Ravelli, ACJ, van der Meulen, JHP, Michels, RPJ, et al. Glucose tolerance in adults after prenatal exposure to famine. The Lancet. 1998; 352, 173–177.CrossRefGoogle Scholar
5. Victoria, CG, Adair, L, Fall, C, et al. Maternal and child undernutrition 2. Maternal and child undernutrition: consequences for adult health and human capital. The Lancet. 2008; 371, 340–357.CrossRefGoogle Scholar
6. Painter, RC, de Rooij, SR, Bossuyt, PM, et al. Early onset of coronary artery disease after prenatal exposure to the Dutch famine. Am J Clin Nutr. 2006; 84, 322–327.CrossRefGoogle Scholar
7. Brandes, JM. First-trimester nausea and vomiting as related to outcome of pregnancy. Am J Obstet Gynecol. 1967; 30, 427–431.Google ScholarPubMed
8. Davis, M. Nausea and vomiting of pregnancy: an evidence-based review. J Perinat Neonatal Nurs. 2004; 18, 312–328.CrossRefGoogle ScholarPubMed
9. Klebanoff, MA, Koslowe, PA, Kaslow, R, Rhoads, GG. Epidemiology of vomiting in early pregnancy. Am J Obstet Gynecol. 1985; 66, 612–616.Google ScholarPubMed
10. Latva-Pukkila, U, Isolauri, E, Laitinen, K. Dietary and clinical impacts of nausea and vomiting during pregnancy. J Hum Nutr Diet. 2010; 23, 69–77.CrossRefGoogle ScholarPubMed
11. Attard, CL, Kohli, MA, Coleman, S, et al. The burden of illness of severe nausea and vomiting of pregnancy in the United States. Am J Obstet Gynecol. 2002; 185, S220–S227.CrossRefGoogle Scholar
12. Poursharif, B, Korst, L, Fejzo, M, et al. The psychosocial burden of hyperemesis gravidarum. J Perinatol. 2008; 28, 176–181.CrossRefGoogle ScholarPubMed
13. Bailit, JL. Hyperemesis gravidarum: epidemiologic findings from a large cohort. Am J Obstet Gynecol. 2005; 193, 811–814.CrossRefGoogle ScholarPubMed
14. Fairweather, DVI. Nausea and vomiting in pregnancy. Am J Obstet Gynecol. 1968; 102, 1136–1175.CrossRefGoogle ScholarPubMed
15. Tsang, IS, Katz, VL, Wellsa, SD. Maternal and fetal outcomes in hyperemesis gravidarum. Int J Gynaecol Obstet. 1996; 55, 231–235.CrossRefGoogle ScholarPubMed
16. Bashiri, A, Neumann, L, Maymon, E, Katz, M. Hyperemesis gravidarum: epidemiologic features, complications and outcome. Eur J Obstet Gynecol Reprod Biol. 1995; 63, 135–138.CrossRefGoogle ScholarPubMed
17. van Stuijvenberg, ME, Sehabort, I, Labadarios, D, Nel, JT. The nutritional status and treatment of patients with hyperemesis gravidarum. Am J Obstet Gynecol. 1995; 172, 1586–1593.CrossRefGoogle ScholarPubMed
18. Chin, RKH, Lao, TT. Low birth weight and hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol. 1988; 28, 179–183.CrossRefGoogle ScholarPubMed
19. Zhang, J, Cai, W-w. Severe vomiting during pregnancy: antenatal correlates and fetal outcomes. Epidemiology. 1991; 2, 454–457.CrossRefGoogle ScholarPubMed
20. Czeizel, AE, Sarkozi, A, Wyszynski, DF. Protective effect of hyperemesis gravidarum for nonsyndromic oral clefts. Am J Obstet Gynecol. 2003; 101, 737–744.Google ScholarPubMed
21. Gadsbey, R, Barnie-Adshead, AM, Jagger, C. A prospective study of nausea and vomiting during pregnancy. Br J Gen Pract. 1993; 43, 245–248.Google Scholar
22. Verberg, MFG, Gillott, DJ, Al-Fardan, N, Grudzinskas, JG. Hyperemesis gravidarum, a literature review. Hum Reprod Update. 2005; 11, 527–539.CrossRefGoogle ScholarPubMed
23. Goodwin, TM. Hyperemesis gravidarum. Obstet Gynecol Clin North Am. 2008; 35, 401–417.CrossRefGoogle ScholarPubMed
24. Fejzo, MS, Poursharif, B, Korst, LM, et al. Symptoms and pregnancy outcomes associated with extreme weight loss among women with hyperemesis gravidarum. J Womens Health. 2009; 18, 1981–1987.CrossRefGoogle ScholarPubMed
25. Bloomfield, FH, Oliver, MH, Hawkins, P, et al. A periconceptional nutritional origin for noninfectious preterm birth. Science. 2003; 300, 606.CrossRefGoogle ScholarPubMed
26. Brown, JE, Murtaugh, MA, Jacobs, DRJ, Margellos, HC. Variation in newborn size according to pregnancy weight change by trimester. Am J Clin Nutr. 2002; 76, 205–209.CrossRefGoogle ScholarPubMed
27. Haas, JD, Balcazar, H, Caulfield, L. Variation in early neonatal mortality for different types of fetal growth retardation. Am J Phys Anthropol. 1987; 73, 467–473.CrossRefGoogle ScholarPubMed
28. Hickey, CA, Cliver, SP, McNeal, SF. Prenatal weight gain patterns and spontaneous preterm birth among nonobese black and white women. Am J Obstet Gynecol. 1995; 85, 909–914.Google ScholarPubMed
29. Hickey, CA, Cliver, SP, McNeal, SF, Hoffman, HJ, Goldenberg, RL. Prenatal weight gain patterns and birth weight among nonobese black and white women. Am J Obstet Gynecol. 1996; 88, 490–496.Google ScholarPubMed
30. Li, R, Haas, JD, Habicht, J. Timing of the influence of maternal nutritional status during pregnancy on fetal growth. Am J Hum Biol. 1998; 10, 523–539.3.0.CO;2-A>CrossRefGoogle ScholarPubMed
31. Susser, M, Stein, Z. Timing in prenatal nutrition: a reprise of the Dutch famine. Nutr Rev. 1994; 52, 84–95.CrossRefGoogle ScholarPubMed
32. Depue, RH, Bernstein, L, Ross, RK, Judd, HL, Henderson, BE. Hyperemesis gravidarum in relation to estradiol levels, pregnancy outcome, and other maternal factors: a seroepidemiologic study. Am J Obstet Gynecol. 1987; 156, 1137–1141.CrossRefGoogle ScholarPubMed
33. Dodds, L, Fell, DB, Joseph, KS, Allen, V, Butler, B. Outcomes of pregnancies complicated by hyperemesis gravidarum. Am J Obstet Gynecol. 2006; 107, 285–292.Google ScholarPubMed
34. Kallen, B. Hyperemesis during pregnancy and delivery outcome: a registry study. Eur J Obstet Gynecol Reprod Biol. 1987; 26, 291–302.CrossRefGoogle ScholarPubMed
35. Paauw, JD, Bierling, S, Cook, CR, Davis, AT. Hyperemesis gravidarum and fetal outcome. J Parenter Enteral Nutr. 2005; 29, 93–96.CrossRefGoogle ScholarPubMed
36. Hallak, M, Tsalamandris, K, Dombrowski, M, et al. Hyperemesis gravidarum. Effects on fetal outcome. J Reprod Med. 1994; 41, 871–874.Google Scholar
37. Matsuo, K, Ushioda, N, Nagamatsu, M, Kimura, T. Hyperemesis gravidarum in Eastern Asian population. Gynecol Obstet Invest. 2007; 64, 213–216.CrossRefGoogle ScholarPubMed
38. Tan, PC, Jacob, R, Quek, KF, Omar, SZ. Pregnancy outcome in hyperemesis gravidarum and the effect of laboratory clinical indicators of hyperemesis severity. J Obstet Gynaecol Res. 2007; 33, 457–464.CrossRefGoogle ScholarPubMed
39. Stotland, NE, Caughey, AB, Lahiff, M, Abrams, B. Weight gain and spontaneous preterm birth – The role of race or ethnicity and previous preterm birth. Am J Obstet Gynecol. 2006; 108, 1448–1455.Google ScholarPubMed
40. Vikanes, A, Grjibovski, AM, Vangen, S, Magnus, P. Variations in prevalence of hyperemesis gravidarum by country of birth: a study of 900,074 pregnancies in Norway, 1967–2005. Scand J Public Health. 2008; 36, 135–142.CrossRefGoogle ScholarPubMed
41. Walker, LO, Kim, M. Psychosocial thriving during late pregnancy: relationship to ethnicity, gestational weight gain, and birth weight. J Obstet Gynecol Neonatal Nurs. 2002; 31, 263–274.CrossRefGoogle ScholarPubMed
42. Stewart, AL. The reliability and validity of self-reported weight and height. J Chronic Dis. 1982; 35, 295–309.CrossRefGoogle ScholarPubMed
43. McAdams, MA, Van Dam, RM, Hu, FB. Comparison of self-reported and measured BMI correlates of disease markers in U.S. Adults. Obesity. 2007; 15, 188–196.CrossRefGoogle Scholar
44. Institute of Medicine. Part 1: Weight gain. Nutrition During Pregnancy, 1990; National Academy Press: Washington.Google Scholar
45. Ministry of Health. Food and Nutrition Guidelines for Healthy Pregnant and Breastfeeding Women: A Background Paper, 2006; pp. 14–25. Ministry of Health: Wellington.Google Scholar
46. Rowlands, S, Royston, P. Estimated date of delivery from last menstrual period and ultrasounds scan: which is more accurate? Br J Gen Pract. 1993; 43, 322–325.Google ScholarPubMed
47. Beeby, PJ, Bhutap, T, Taylor, LK. New South Wales population-based birthweight percentile charts. J Paediatr Child Health. 1996; 32, 512–518.CrossRefGoogle ScholarPubMed
48. UNICEF, WHO. Low Birthweight: Country, Regional and Global Estimates, 2004; UNICEF: New York.Google Scholar
49. Broekman, BFP, Chan, Y-H, Chong, Y-S, et al. The influence of birth size on intelligence in healthy children. Pediatrics. 2009; 123, e1011–e1016.CrossRefGoogle ScholarPubMed
50. Gale, CR, O'Callaghan, FJ, Bredow, M, Martyn, CN. The influence of head growth in fetal life, infancy, and childhood on intelligence at the ages of 4 and 8 years. Pediatrics. 2006; 118, 1486–1492.CrossRefGoogle ScholarPubMed
51. Lundgren, EM, Cnattingius, S, Jonsson, B, Tuvemo, T. Intellectual and psychological performance in males born small for gestational age with and without catch-up growth. Pediatr Res. 2001; 50, 91–96.CrossRefGoogle ScholarPubMed
52. Barker, DJP, Osmond, C, Simmonds, SJ, Wield, GA. The relation of small head circumference and thinness at birth to death from cardiovascular disease in adult life. Br Med J. 1993; 306, 422–426.CrossRefGoogle ScholarPubMed
53. Martin, RP, Wisenbaker, J, Huttunen, MO. Nausea during pregnancy: relation to early childhood temperament and behavior problems at twelve years. J Abnorm Child Psychol. 1999; 27, 323–329.CrossRefGoogle ScholarPubMed
54. Todd, SE, Oliver, MH, Jaquiery, AL, Bloomfield, FH, Harding, JE. Periconceptional undernutrition of ewes impairs glucose tolerance in their adult offspring. Pediatr Res. 2009; 65, 409–413.CrossRefGoogle ScholarPubMed
55. Roseboom, T, Rooij, Sd, Painter, R. The Dutch famine and its long-term consequences for adult health. Early Hum Dev. 2006; 82, 485–491.CrossRefGoogle ScholarPubMed
56. Vilming, B, Nesheim, B-I. Hyperemesis gravidarum in a contemporary population in Oslo. Acta Obstet Gynecol Scand. 2000; 79, 640–643.CrossRefGoogle Scholar
57. Harding, JE, Johnston, BM. Nutrition and fetal growth. Reprod Fertil Dev. 1995; 7, 539–547.CrossRefGoogle ScholarPubMed
58. Jackson, AA, Robinson, SM. Dietary guidelines for pregnancy: a review of current evidence. Public Health Nutr. 2001; 4, 625–630.CrossRefGoogle ScholarPubMed
59. Godsey, RK, Newman, RB. Hyperemesis gravidarum. A comparison of single and multiple admission. J Reprod Med. 1991; 36, 287–290.Google Scholar
60. Gross, S, Librach, C, Cecutti, A. Maternal weight loss associated with hyperemesis gravidarum. A predictor of fetal outcome. Am J Obstet Gynecol. 1989; 160, 906–909.CrossRefGoogle ScholarPubMed
61. Cedergren, M, Brynhildsen, J, Josefsson, A, Sydsjo, A, Sudsjo, G. Hyperemesis gravidarum that requires hospitalization and the use of antiemetic drugs in relation to maternal body composition. Am J Obstet Gynecol. 2008; 198, 412.e1–412.e5.CrossRefGoogle ScholarPubMed
62. Vikanes, A, Grjibovski, A, Vangen, S, et al. Maternal body composition, smoking, and hyperemesis gravidarum. Ann Epidemiol. 2010; 20, 592–598.CrossRefGoogle ScholarPubMed
63. Rochelson, B, Vohra, N, Darvishzadeh, J, Pagano, M. Low prepregnancy ideal weight:height ratio in women with hyperemesis gravidarum. J Reprod Med. 2003; 48, 422–424.Google ScholarPubMed
64. Keirse, MJNC. Epidemiology and aetiology of the growth retarded baby. Clin Obstet Gynaecol. 1984; 11, 414–436.CrossRefGoogle ScholarPubMed
65. Love, EJ, Kinch, RAH. Factors influencing the birth weight in normal pregnancy. Am J Obstet Gynecol. 1964; 91, 342–350.CrossRefGoogle Scholar
66. Henrichs, J, Schenk, J, Roza, S, et al. Maternal psychological distress and fetal growth trajectories: the generation R study. Psychol Med. 2010; 40, 633–643.CrossRefGoogle ScholarPubMed
67. Neufeld, LM, Haas, JD, Grajeda, R, Martorell, R. Changes in maternal weight from the first to second trimester of pregnancy are associated with fetal growth and infant length at birth. Am J Clin Nutr. 2004; 79, 646–652.CrossRefGoogle ScholarPubMed
68. Barker, DJP. Mothers, Babies, and Disease in Later Life, 1994; BMJ Publishing Group: London.Google Scholar