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In vitro effect of larval stages of Ascaris lumbricoides on human blood clotting

Published online by Cambridge University Press:  05 June 2009

N. Malla ,
B. A. Sofi ,
N. K. Ganguly  and
R. C. Mahajan
N. Malla
Affiliation:
Departments of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh–160012, India
B. A. Sofi
Affiliation:
Departments of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh–160012, India
N. K. Ganguly
Affiliation:
Experimental Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh–160012, India
R. C. Mahajan
Affiliation:
Departments of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh–160012, India
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Abstract

The effects of larval stages of Ascaris lumbricoides on human blood clotting was studied in vitro. Extracts and excretory/secretory products of third-stage larvae (L3) and late third-stage larvae (LL3) cultured from ova obtained from infected patients were analysed for anti-coagulant activity. Prothrombin time (PT) was prolonged by the addition of either whole extract of L3/LL3 or ES products of L3/LL3 as compared to controls. Partial thromboplastin time with kaolin (PTTK) was also prolonged on the addition of either extracts of ES products of L3/LL3. The prolongation of PTTK was significantly higher with extracts/ES products of L3 when compared to the extracts/ES products of LL3 (p<0.005). Thrombin time (TT) was prolonged by extracts of L3/LL3 and their ES products.

Keywords

Ascaris lumbricoideslarvaeanticoagulant
Type
Research Papers
Information
Journal of Helminthology , Volume 65 , Issue 2 , June 1991 , pp. 133 - 140
Copyright
Copyright © Cambridge University Press 1991

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