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Studies on Brugia pahangi. 13. The anthelmintic effect of compounds F151 (Friedheim), HOE 33258 (Hoechst) and their reaction product

Published online by Cambridge University Press:  05 June 2009

D. A. Denham ,
R. R. Suswillo ,
Rosemary Rogers ,
P. B. McGreevy  and
B. J. Andrews
D. A. Denham
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, LondonWC1E 7HT
R. R. Suswillo
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, LondonWC1E 7HT
Rosemary Rogers
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, LondonWC1E 7HT
P. B. McGreevy
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, LondonWC1E 7HT
B. J. Andrews
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, LondonWC1E 7HT
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Abstract

F151 was a potent filaricide against adult Brugia pahangi in cats and jirds.

HOE 33258 did not kill adult worms in cats but had a marginal effect on adult worms in the peritoneal cavity of jirds. It was not immediately microfilaricidal in cats but the microfilarial counts of treated cats fell within a few weeks of treatment.

The reaction product, or mixture, of these two compounds (V5851 = E) was strongly macrofilaricidal m cats and jirds.

Type
Research Article
Information
Journal of Helminthology , Volume 50 , Issue 4 , December 1976 , pp. 243 - 250
Copyright
Copyright © Cambridge University Press 1976

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References

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