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Studies with Brugia pahangi. 18. Anthelmintic effects of stibocaptate

Published online by Cambridge University Press:  05 June 2009

D. A. Denham ,
R. R. Suswillo  and
Rosemary Rogers
D. A. Denham
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT
R. R. Suswillo
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT
Rosemary Rogers
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT
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Abstract

Stibocaptate (Astiban, Hoffman - La Roche) killed third stage larvae of Brugia pahangi in vitro at 50 p.p.m. but had no effect on microfilariae at 1 × 104 p.p.m. No larvae developed in infected mosquitoes fed 1% stibocaptate in 10% sucrose. It was neither micro-nor macrofilaricidal in neither jirds or cats but did affect embryogenesis.

Type
Research Note
Information
Journal of Helminthology , Volume 52 , Issue 3 , September 1978 , pp. 227 - 228
Copyright
Copyright © Cambridge University Press 1978

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References

REFERENCES

Rogers, R. and Denham, D. A. (1976) Studies with Brugia pahangi. 12. The activity of levamisole. Journal of Helminthology, 50, 21–28.CrossRefGoogle ScholarPubMed
Rogers, R., Ellis, D. S. and Denham, D. A. (1976) Studies with Brugia pahangi. 14. Intrauterine development of the microfilaria and a comparison with other filarial species. Journal of Helminthology, 50, 251–257.CrossRefGoogle Scholar
Suswillo, R. R. and Denham, D. A. (1977) A new system of testing for filaricidal activity using transplanted adult Brugia in the jird. Journal of Parasitology, 63, 591–592.CrossRefGoogle ScholarPubMed