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Resection of secondary pulmonary malignancies in head and neck cancer patients

Published online by Cambridge University Press:  02 June 2010

T W Geurts ,
H M Klomp ,
S A Burgers ,
H van Tinteren ,
B Y Roukema  and
A J M Balm
T W Geurts
Affiliation:
Department of Head Neck Oncology and Surgery, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, The Netherlands Department of ORL, Deventer Hospital, The Netherlands
H M Klomp
Affiliation:
Department of Thoracic Oncology and Surgery, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, The Netherlands
S A Burgers
Affiliation:
Department of Thoracic Oncology and Surgery, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, The Netherlands
H van Tinteren
Affiliation:
Department of Medical Statistics, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, The Netherlands
B Y Roukema
Affiliation:
Department of Head Neck Oncology and Surgery, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, The Netherlands
A J M Balm*
Affiliation:
Department of Head Neck Oncology and Surgery, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, The Netherlands Department of ORL, Academic Medical Center, Amsterdam, The Netherlands
*
Address for correspondence: Prof. Dr A J M Balm, Department of Head and Oncology and Surgery, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. Fax: +31 20 5122554 E-mail: a.balm@nki.nl
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Abstract

Background:

This study aimed to evaluate a single institute's experience with resection of metachronous pulmonary malignancy in patients treated for squamous cell carcinoma of the head and neck.

Methods:

Sixty-three consecutive patients treated curatively for head and neck squamous cell carcinoma underwent surgical resection of malignant lung lesions. Survival was estimated and potential prognostic factors investigated.

Results:

The median overall survival for the total group was 22.2 months. Fifty-one patients (81 per cent) had one lung lesion, while the remainder had multiple lesions (range, two to seven). In the 63 patients, 35 lobectomies, 4 pneumonectomies and 24 wedge resections were performed. For patients with pulmonary squamous cell carcinoma (n = 52), the three-year survival rate was 35 per cent (95 per cent confidence interval, 22–48); for patients with resected adenocarcinoma (n = 10), it was 50 per cent (95 per cent confidence interval, 18–75). The overall five-year survival rate was 30 per cent (95 per cent confidence interval, 19–42).

Conclusion:

In patients treated curatively for head and neck squamous cell carcinoma, resection of secondary pulmonary cancer is associated with favourable long term overall survival, especially for patients with adenocarcinoma lesions.

Keywords

Head And Neck NeoplasmsTumour MetastasisLungAdenocarcinoma
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 12 , December 2010 , pp. 1278 - 1283
Copyright
Copyright © JLO (1984) Limited 2010

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