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Effects of biomimetic micropattern on titanium deposited with PDA/Cu and nitric oxide release on behaviors of ECs

Published online by Cambridge University Press:  20 May 2019

Wenyong Ma Open the ORCID record for Wenyong Ma [Opens in a new window] ,
Luying Liu ,
Xiao luo ,
Congzhen Han ,
Ping Yang ,
Yuancong Zhao  and
Nan Huang
Wenyong Ma
Affiliation:
Key Laboratory of Advanced Technology of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People’s Republic of China; and Material Technology Insitution, Yibin University, Yibin 644000, People’s Republic of China
Luying Liu
Affiliation:
Key Laboratory of Advanced Technology of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People’s Republic of China
Xiao luo
Affiliation:
Key Laboratory of Advanced Technology of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People’s Republic of China
Congzhen Han
Affiliation:
Key Laboratory of Advanced Technology of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People’s Republic of China
Ping Yang*
Affiliation:
Key Laboratory of Advanced Technology of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People’s Republic of China
Yuancong Zhao*
Affiliation:
Key Laboratory of Advanced Technology of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People’s Republic of China
Nan Huang
Affiliation:
Key Laboratory of Advanced Technology of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People’s Republic of China
*
a)Address all correspondence to these authors. e-mail: yangping8@263.net
b)e-mail: zhaoyc7320@163.com
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Abstract

Surface modification with poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) is an effective method for improving hemocompatibility. Peptide GREDVY immobilized on Ti is of great benefit to endothelialization. Micropattern of PMPC and GREDVY can regulate cells distribution, behaviors, and nitric oxide (NO) release. Copper can be used as catalytic to release NO from a donor in vitro, which can inhibit platelets adhesion, activation, and aggregation. The Ti-PDA(Cu)-M/R(P) micropattern was fabricated with PMMPC-HD {PMMPC [monomer contain MPC and methacrylic acid (MA)] was cross-linked with hexamethylene diamine} and peptide Gly-Arg-Glu-Asp-Val-Tyr (GREDVY) using PDMS stamp, and it was characterized by SEM, FTIR, and XPS. The results demonstrated that the PMPC and peptide GREDVY were immobilized onto polydopamine successfully. Simultaneously, the copper existed in polydopamine was confirmed by XPS. The rate of NO release in vitro catalyzed by copper ions was 1.5–5.3 × 10−10 mol/(cm2 min). It will be beneficial to inhibiting platelets adhesion and proliferation of ECs.

Keywords

nitric oxidemicropatternECMPCGREDVY
Type
Article
Information
Journal of Materials Research , Volume 34 , Issue 12 , 28 June 2019 , pp. 2037 - 2046
Copyright
Copyright © Materials Research Society 2019 

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