It is well known that totally geodesic Lagrangian submanifolds of a complex-space-form M˜n(4c) of constant holomorphic sectional curvature 4c are real-space-forms of constant sectional curvature c. In this paper we investigate and determine non-totally geodesic Lagrangian isometric immersions of real-space-forms of constant sectional curvature c into a complex-space-form M˜n(4c). In order to do so, associated with each twisted product decomposition of a real-space-form of the form f1I1×… ×fkIk×1Nn−k(c), we introduce a canonical 1-form, called the twistor form of the twisted product decomposition. Roughly speaking, our main result says that if the twistor form of such a twisted product decomposition of a simply-connected real-space-form of constant sectional curvature c is twisted closed, then it admits a ‘unique’ adapted Lagrangian isometric immersion into a complex-space-form M˜n(4c). Conversely, if L: Mn(c)→ M˜n(4c) is a non-totally geodesic Lagrangian isometric immersion of a real-space-form Mn(c) of constant sectional curvature c into a complex-space-form M˜n(4c), then Mn(c) admits an appropriate twisted product decomposition with twisted closed twistor form and, moreover, the Lagrangian immersion L is given by the corresponding adapted Lagrangian isometric immersion of the twisted product. In this paper we also provide explicit constructions of adapted Lagrangian isometric immersions of some natural twisted product decompositions of real-space-forms.