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Achieving antimicrobial activity through poly(N-methylvinylimidazolium) iodide brushes on binary-grafted polypropylene suture threads

Published online by Cambridge University Press:  02 November 2017

F. López-Saucedo ,
G.G. Flores-Rojas ,
E. Bucio ,
C. Alvarez-Lorenzo ,
A. Concheiro  and
O. González-Antonio
F. López-Saucedo*
Affiliation:
Department of Radiation Chemistry and Radiochemistry, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, CDMX 04510, México
G.G. Flores-Rojas
Affiliation:
Department of Radiation Chemistry and Radiochemistry, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, CDMX 04510, México
E. Bucio*
Affiliation:
Department of Radiation Chemistry and Radiochemistry, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, CDMX 04510, México
C. Alvarez-Lorenzo
Affiliation:
Department of Pharmacology, Pharmacy, and Pharmaceutical Technology, R+DPharma Group (GI-1645), Facultad de Farmacia, Universidade de Santiago de Compostela, Santiago de Compostela 15782, España
A. Concheiro
Affiliation:
Department of Pharmacology, Pharmacy, and Pharmaceutical Technology, R+DPharma Group (GI-1645), Facultad de Farmacia, Universidade de Santiago de Compostela, Santiago de Compostela 15782, España
O. González-Antonio
Affiliation:
Department of Organic Chemistry, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, CDMX 04510, México
*
Address all correspondence to F. López-Saucedo and E. Bucio at felipelopezsaucedo@gmail.mx; ebucio@nucleares.unam.mx
Address all correspondence to F. López-Saucedo and E. Bucio at felipelopezsaucedo@gmail.mx; ebucio@nucleares.unam.mx
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Abstract

Harnessing the properties of imidazolium species, antimicrobial activity against Gram-negative and Gram-positive bacteria was attained by binary-grafting 2-hydroxyethyl methacrylate (HEMA) or N-isopropylacrylamide, followed by N-vinylimidazole onto polypropylene (PP) monofilaments (sutures) using 60Co γ-rays. Ulterior functionalization with methyl iodide was carried out to endow brushes with antimicrobial activity on the PP surface. The PP-grafted sutures were characterized by means of Fourier-transform infrared spectroscopy attenuated total reflection, scanning electron microscopy, differential scanning calorimetry, and thermogravimetric analysis, and regarding the mechanical properties and the responsiveness to pH and temperature. Tests were performed on Escherichia coli and Staphylococcus aureus achieving large inhibition zones.

Type
Research Letters
Information
MRS Communications , Volume 7 , Issue 4 , December 2017 , pp. 938 - 946
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Copyright
Copyright © Materials Research Society 2017 

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