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An emerging nanostructured molybdenum trioxide-based biocompatible sensor platform for breast cancer biomarker detection

Published online by Cambridge University Press:  03 September 2018

Shine Augustine ,
Amish G. Joshi ,
Birendra Kumar Yadav ,
Anurag Mehta ,
Pragati Kumar ,
Venkatesan Renugopalakrishanan  and
Bansi D. Malhotra
Shine Augustine
Affiliation:
Nanobioelectronics Laboratory, Department of Biotechnology, Delhi Technological University, Delhi-110042, India
Amish G. Joshi
Affiliation:
CSIR-National Physical Laboratory, Dr. K.S. Krishnan Road, New Delhi 110012, India
Birendra Kumar Yadav
Affiliation:
Rajiv Gandhi Cancer Institute and Research Centre, Rohini, Delhi 110085, India
Anurag Mehta
Affiliation:
Rajiv Gandhi Cancer Institute and Research Centre, Rohini, Delhi 110085, India
Pragati Kumar
Affiliation:
Department of Electrical Engineering, Delhi Technological University, Delhi 110042, India
Venkatesan Renugopalakrishanan
Affiliation:
Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA
Bansi D. Malhotra*
Affiliation:
Nanobioelectronics Laboratory, Department of Biotechnology, Delhi Technological University, Delhi-110042, India
*
Address all correspondence to Bansi D. Malhotra at bansi.malhotra@gmail.com
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Abstract

We report results of the studies relating to the development of the emerging nanostructured molybdenum trioxide (nMoO3)-based biocompatible label-free biosensing platform for breast cancer detection. The structural and morphological studies of the synthesized nMoO3 nanorods were investigated by XRD, SEM, X-ray photoelectron spectroscopic, and TEM techniques. This biocompatible one-dimensional (1D) nMoO3-based biosensing platform exhibited high sensitivity (0.904 µAmL/ng/cm2), wide linear detection range (2.5–110 ng/mL), and a lower detection limit as 2.47 ng/mL toward human epidermal growth factor receptor-2 detection. The results obtained using this sensor platform on serum samples of breast cancer patients were validated using ELISA.

Type
2D Nanomaterials for Healthcare and Lab-on-a-Chip Devices Research Letters
Information
MRS Communications , Volume 8 , Issue 3 , September 2018 , pp. 668 - 679
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Copyright
Copyright © Materials Research Society 2018 

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