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Influence of Coupling Agent on the Morphology of Multifunctional, Degradable Shape-Memory Polymers

Published online by Cambridge University Press:  15 July 2013

Liang Fang ,
Wan Yan ,
Ulrich Nöchel ,
Michael Zierke ,
Marc Behl ,
Karl Kratz  and
Andreas Lendlein
Liang Fang
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, 14513 Teltow, Germany.
Wan Yan
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, 14513 Teltow, Germany.
Ulrich Nöchel
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, 14513 Teltow, Germany.
Michael Zierke
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, 14513 Teltow, Germany.
Marc Behl
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, 14513 Teltow, Germany.
Karl Kratz
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, 14513 Teltow, Germany.
Andreas Lendlein
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, 14513 Teltow, Germany.
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Abstract

Multifunctional polymer-based biomaterials, which combine degradability and shapememory capability, are promising candidate materials for biomedical implants. An example is a degradable multiblock copolymer (PDC), composed of poly(p-dioxanone) (PPDO) as hard and poly(ε-caprolactone) (PCL) as switching segments. PDC exhibits a unique linear mass loss during hydrolytic degradation, which can be tailored by the PPDO to PCL weight ratio, as well as an excellent thermally induced dual-shape effect. PDC can be synthesized by co-condensation of two oligomeric macrodiols (PCL-diol and PPDO-diol) using aliphatic diisocyanates as coupling agent. Here, we investigated whether different morphologies could be obtained for PDCs synthesized from identical oligomeric macrodiols (PCL-diol with Mn = 2000 g·mol-1 and PPDO-diol with Mn = 5300-5500 g·mol-1) with 2, 2(4), 4-trimethyl-hexamethylene diisocyanate (TMDI) and 1, 6-hexamethylene diisocyanate (HDI), respectively. More specifically, atomic force microscopy (AFM) was utilized for an investigation of the surface morphologies in solution casted PDC thin films in the temperature range from 20 °C to 60 °C. The results obtained in differential scanning calorimetry (DSC) and AFM demonstrated that different morphologies were obtained when TMDI (PDC-TMDI) or HDI (PDC-HDI) were used as linker. PCL related crystals in PDC-HDI were more heterogeneous and less ordered than those in PDCTMDI, while HDI resulted in a larger degree of crystallinity than TMDI. This research provides some new suggestions for choosing a suitable coupling agent to tailor the required morphologies and properties of SMPs with crystallizable switching segments.

Keywords

polymerscanning probe microscopy (SPM)crystal growth
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1569: Symposium NN – Advanced Materials for Biological and Biomedical Applications , 2013 , pp. 57 - 64
Copyright
Copyright © Materials Research Society 2013 

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