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Assessment of health-related quality of life in end-stage chronic obstructive pulmonary disease and non-small-cell lung cancer patients in Serbia

Published online by Cambridge University Press:  02 June 2015

Dragana Maric ,
Dragana Jovanovic ,
Ljudmila Nagorni-Obradovic ,
Mihailo Stjepanovic ,
Darija Kisic-Tepavcevic  and
Tatjana Pekmezovic
Dragana Maric
Affiliation:
Clinic of Pulmonology, Clinical Center of Serbia, Belgrade, Serbia Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Dragana Jovanovic
Affiliation:
Clinic of Pulmonology, Clinical Center of Serbia, Belgrade, Serbia Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Ljudmila Nagorni-Obradovic
Affiliation:
Clinic of Pulmonology, Clinical Center of Serbia, Belgrade, Serbia Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Mihailo Stjepanovic
Affiliation:
Clinic of Pulmonology, Clinical Center of Serbia, Belgrade, Serbia
Darija Kisic-Tepavcevic
Affiliation:
Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Tatjana Pekmezovic*
Affiliation:
Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
*
Address correspondence and reprint requests to: Tatjana D. Pekmezovic, Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Visegradska 26A, Belgrade 11000, Serbia. E-mail: pekmezovic@sezampro.rs
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Abstract

Objective:

Under conditions in which palliative care has not yet become part of clinical practice, the differences in palliative care needs between patients with cancer and other life-limiting diseases can yield knowledge that will be very valuable for future planning. The aim of our investigation was to compare health-related quality of life (HRQoL) for patients with end-stage chronic obstructive pulmonary disease (COPD) and those with non-small-cell lung cancer (NSCLC) in Belgrade, Serbia. We also evaluated the influence of demographic, socioeconomic, and clinical factors on HRQoL for both patient groups.

Method:

This cross-sectional study included 100 NSCLC patients (stages IIIb and IV) and 100 patients with stage IV COPD. Measures included the SF-36 questionnaire, the EORTC QLQ–C30, the St. George's Respiratory Questionnaire, and the Beck Depression Inventory (BDI). Associations of demographic, socioeconomic, and clinical factors with QoL were examined using linear regression analyses.

Results:

The COPD group scored significantly lower compared to NSCLC patients in all SF-36 domains except for bodily pain. Additionally, a significantly higher level of depressive symptoms was observed in COPD patients. A worse physical QoL for COPD patients was independently associated with a longer duration of unemployment, a lack of wage earning, lower Karnofsky Performance Status (KPS) scores, and higher levels of depression. A worse mental QoL for COPD patients was related to a longer duration of disease, poorer KPS scores, and higher BDI scores. The independent variables significantly associated with worse physical and mental QoL of NSCLC patients were lower KPS and higher BDI scores.

Significance of Results:

A worse QoL, a significantly higher level of depressive symptoms, and adverse socioeconomic status in the COPD group imposes the need for development of more intensive psychosocial and community support for COPD patients during implementation of palliative care.

Keywords

Quality of life (QoL)COPDLung cancerSocioeconomic statusDepression
Type
Original Articles
Information
Palliative & Supportive Care , Volume 14 , Issue 1 , February 2016 , pp. 60 - 68
Copyright
Copyright © Cambridge University Press 2015 

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