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Quality of life, anxiety, depression, and distress in patients with advanced and metastatic lung cancer

Published online by Cambridge University Press:  10 October 2022

Ana Gonzalez-Ling Open the ORCID record for Ana Gonzalez-Ling [Opens in a new window] ,
Oscar Galindo Vázquez ,
Marcos Espinoza Bello ,
Rebeca Robles ,
María Luisa Rascón-Gasca ,
Luis Lara-Mejía ,
David Heredia  and
Oscar Arrieta Open the ORCID record for Oscar Arrieta [Opens in a new window]
Ana Gonzalez-Ling
Affiliation:
Servicio de Psicooncología, Instituto Nacional de Cancerología, Mexico City, Mexico
Oscar Galindo Vázquez
Affiliation:
Unidad para la Investigación y Desarrollo de la Psicooncología, Instituto Nacional de Cancerología, Mexico City, Mexico
Marcos Espinoza Bello
Affiliation:
Servicio de Psicooncología, Instituto Nacional de Cancerología, Mexico City, Mexico
Rebeca Robles
Affiliation:
Centro de Investigación en Salud Mental Global, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico
María Luisa Rascón-Gasca
Affiliation:
Dirección de Investigaciones Epidemiológicas y Psicosociales, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico
Luis Lara-Mejía
Affiliation:
Department of Thoracic Oncology, Thoracic Oncology Unit, Instituto Nacional de Cancerología, Mexico City, Mexico
David Heredia
Affiliation:
Department of Thoracic Oncology, Thoracic Oncology Unit, Instituto Nacional de Cancerología, Mexico City, Mexico
Oscar Arrieta*
Affiliation:
Department of Thoracic Oncology, Thoracic Oncology Unit, Instituto Nacional de Cancerología, Mexico City, Mexico
*
Author for correspondence: Oscar Arrieta, Head of Thoracic Oncology Unit, Instituto Nacional de Cancerología (INCan), Av. San Fernando #22, Sección XVI, Tlalpan. México City, CDMX 14080, Mexico. E-mail: ogar@unam.mx
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Abstract

Objective

Lung cancer (LC) patients have shown a predisposition for developing emotional and physical symptoms, with detrimental effects on the quality of life (QoL). This study evaluates the bidirectional relationship between main psychological disorders and clinical/sociodemographic factors with the QoL.

Methods

In this observational cross-sectional study, patients with a confirmed LC diagnosis from February 2015 to March 2018 were eligible for this study. Each participant completed screening instruments of anxiety, depression, distress, and QoL assessment. Other relevant clinical data were extracted from electronic health records. Then comparisons, correlations, and logistic regression analyses were performed.

Results

Two hundred and four cases were eligible; of them, the median age was 61 (24–84) years, most had clinical stage IV (95%), and most were under first-line therapy (53%). Concerning psychological status, 46% had symptoms of emotional distress, 35% anxiety, and 31% depression. Patients with psychological disorders experienced a worse global QoL than those without psychological impairment (p < 0.001). Increased financial issues and physical symptoms, combined with lower functioning, were also significantly associated with anxiety, depression, and distress. In the multivariate analysis, female sex and emotional distress were positively associated with an increased risk of depression; likewise, female sex, low social functioning, insomnia, and emotional distress were associated with anxiety.

Conclusions

Emotional symptoms and QoL had a significant bidirectional effect on this study; this underscores the necessity to identify and treat anxiety, depression, and distress to improve psychological well-being and the QoL in LC patients.

Keywords

Advanced lung cancerMood disordersNon-small cell lung cancerPsychiatric disordersQuality of life
Type
Original Article
Information
Palliative & Supportive Care , Volume 21 , Issue 4 , August 2023 , pp. 608 - 615
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Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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