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The activity of methyl benzoquate and clopidol against Eimeria maxima: synergy and drug resistance

Published online by Cambridge University Press:  06 April 2009

L. P. Joyner  and
C. C. Norton
L. P. Joyner
Affiliation:
Ministry of Agriculture, Fisheries and Food, Central Veterinary Laboratory, New Haw, Weybridge, Surrey, KT15 3NB
C. C. Norton
Affiliation:
Ministry of Agriculture, Fisheries and Food, Central Veterinary Laboratory, New Haw, Weybridge, Surrey, KT15 3NB
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Summary

Synergy between clopidol and methyl benzoquate against Eimeria maxima was shown to be supra-additive. Collateral sensitivity to these drugs could not be demonstrated in resistant lines of this parasite. Resistance to methyl benzoquate and clopidol was not transferred when lines of E. maxima, resistant to the respective drugs, were propagated together. The failure to demonstrate this phenomenon was judged not to be due to synergy between the drugs. Attempts to induce simultaneous resistance to both drugs failed, although resistance to methyl benzoquate was readily acquired by a line of E. maxima resistant to clopidol. Induced resistance to clopidol in a methyl benzoquate-resistant line required numerous passages.

Type
Research Article
Information
Parasitology , Volume 76 , Issue 3 , June 1978 , pp. 369 - 377
Copyright
Copyright © Cambridge University Press 1978

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References

REFERENCES

Challey, J. R. & Jeffers, T. K. (1973). Synergism between 4-hydroxyquinoline and pyridone coccidiostats. Journal of Parasitology 59, 502–4.CrossRefGoogle ScholarPubMed
Greuel, E., Kuil, H. & Robl, R. (1975). Synergism between metichlorpindol and methylbenzoquate against E. acervulina. Zeitschrift für Parasitenkunde 46, 163–5.CrossRefGoogle ScholarPubMed
Jeffers, T. K. & Challey, J. R. (1973). Collateral sensitivity to 4-hydroxyquinolines in Eimeria acervulina strains resistant to meticlorpindol. Journal of Parasitology 59, 624–30.CrossRefGoogle ScholarPubMed
Joyner, L. P. & Norton, C. C. (1971). The recording and analysis of coccidiostatic activity; quinoline and pyridone compounds. Research in Veterinary Science 12, 80–8.CrossRefGoogle ScholarPubMed
Joyner, L. P. & Norton, C. C. (1975). Transferred drug resistance in Eimeria maxima. Parasitology 71, 385–92.CrossRefGoogle ScholarPubMed
Joyner, L. P. & Norton, C. C. (1977). Further observations on the genetic transfer of drug resistance in Eimeria maxima. Parasitology 74, 205–13.CrossRefGoogle Scholar
Kendall, S. B. & Joyner, L. P. (1956). The synergism between pyrimethamine and sulpha-dimethylpyrimidine in the control of Eimeria tenella. Journal of Comparative Pathology and Therapeutics 66, 145–50.CrossRefGoogle ScholarPubMed
Long, P. L. & Rowell, J. G. (1958). Counting oocysts of chicken coccidia. Laboratory Practice 7, 515–19.Google Scholar
Norton, C. C. & Joyner, L. P. (1975). The development of drug-resistant strains of Eimeria maxima in the laboratory. Parasitology 71, 153–65.CrossRefGoogle ScholarPubMed
Ryley, J. F. (1975). Lerbek, a synergistic mixture of methyl benzoquate and clopidol for the prevention of chicken coccidiosis. Parasitology 70, 377–84.CrossRefGoogle ScholarPubMed
Ryley, J. F. & Betts, M. J. (1973). Chemotherapy of chicken coccidiosis. In Advances in Pharmacology and Chemotherapy, vol. 11, pp. 221–93. New York: Academic Press.Google Scholar