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Antigens of Plasmodiwn falciparum blood stages with clinical interest cloned and expressed in E. coli

Published online by Cambridge University Press:  23 August 2011

J. Scaife ,
N. Bone ,
M. Goman ,
R. Hall ,
I. A. Hope ,
J. E. Hyde ,
G. Langsley ,
M. Mackay ,
P. Oquendo  and
D. Simmons
J. Scaife
Affiliation:
Department of Molecular Biology, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh EH9 3JR
N. Bone
Affiliation:
Department of Molecular Biology, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh EH9 3JR
M. Goman
Affiliation:
Department of Molecular Biology, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh EH9 3JR
R. Hall
Affiliation:
Department of Molecular Biology, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh EH9 3JR
I. A. Hope
Affiliation:
Department of Molecular Biology, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh EH9 3JR
J. E. Hyde
Affiliation:
Department of Molecular Biology, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh EH9 3JR
G. Langsley
Affiliation:
Department of Molecular Biology, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh EH9 3JR
M. Mackay
Affiliation:
Department of Molecular Biology, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh EH9 3JR
P. Oquendo
Affiliation:
Department of Molecular Biology, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh EH9 3JR
D. Simmons
Affiliation:
Department of Molecular Biology, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh EH9 3JR
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Extract

The human malaria parasite, Plasmodium falciparum, is currently being actively studied by molecular biologists. It is hoped that the use of recombinant DNA techniques in this area will give new insights into the biology of the organism and, at the same time, provide new approaches to diagnosis and vaccine development.

Our own studies employ the blood stages of the parasite and cover three main areas: enzymes of importance in parasite metabolism; antigens of potential use in a subunit vaccine; and repetitive DNA as a probe able to distinguish genetically different isolates of P. falciparum and as a species-specific diagnostic tool in human and mosquito infections.

Type
Research Article
Information
Parasitology , Volume 92 , supplement S1: Symposia of the British Society for Parasitology Volume 23 Parasites and molecular biology: applications of new techniques , January 1986 , pp. S119 - S137
Copyright
Copyright © Cambridge University Press 1986

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