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The effect of the suckling stimulus on the migration of Strongyloides ratti in lactating rats

Published online by Cambridge University Press:  06 April 2009

P. A. G. Wilson
P. A. G. Wilson
Affiliation:
University of Edinburgh, Department of Zoology, West Mains Road, Edinburgh EH9 3JT
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Extract

The number of adult Strongyloides ratti which developed in the guts of lactating rats after subcutaneous injection of 4000 L3 on day 18–20 post partum was taken to be a measure of the relative importance of alternative larval routes. When injection was carried out at different times before and after weaning, larvae were diverted from a route bypassing the gut in nursing mothers to one leading to the gut (‘migration reversal’) in mothers without young in a period of less than 10 h. Migration reversal was mostly completed in lactating females injected at the time of weaning when compared with nulliparous controls. A stimulus-sensitive period shortly after injection, predicted from these dynamics, was demonstrated. Worms injected into lactating females 10 h after removal from their pups showed complete migration reversal. In similarly treated rats, given 1 h suckling 3 h after injection, migration reversal was practically abolished. These inter-relationships, in conjunction with earlier findings, are used to deduce the possible humoral mechanisms involved and to develop a working hypothesis to account for larval orientation based on features of the mammalian pulmonary microvasculature.

Type
Research Article
Information
Parasitology , Volume 75 , Issue 2 , October 1977 , pp. 233 - 239
Copyright
Copyright © Cambridge University Press 1977

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