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Lipid metabolism in Giardia: a post-genomic perspective

Published online by Cambridge University Press:  30 September 2010

M. YICHOY ,
T. T. DUARTE ,
A. DE CHATTERJEE ,
T. L. MENDEZ ,
K. Y. AGUILERA ,
D. ROY ,
S. ROYCHOWDHURY ,
S. B. ALEY  and
S. DAS
M. YICHOY
Affiliation:
Department of Biological Sciences, University of Texas at El Paso, Texas 79968-0519 Infectious Diseases and Immunology, The Border Biomedical Research Centre, University of Texas at El Paso, Texas 79968-0519, USA
T. T. DUARTE
Affiliation:
Department of Biological Sciences, University of Texas at El Paso, Texas 79968-0519 Infectious Diseases and Immunology, The Border Biomedical Research Centre, University of Texas at El Paso, Texas 79968-0519, USA
A. DE CHATTERJEE
Affiliation:
Department of Biological Sciences, University of Texas at El Paso, Texas 79968-0519 Infectious Diseases and Immunology, The Border Biomedical Research Centre, University of Texas at El Paso, Texas 79968-0519, USA
T. L. MENDEZ
Affiliation:
Department of Biological Sciences, University of Texas at El Paso, Texas 79968-0519 Infectious Diseases and Immunology, The Border Biomedical Research Centre, University of Texas at El Paso, Texas 79968-0519, USA
K. Y. AGUILERA
Affiliation:
Department of Biological Sciences, University of Texas at El Paso, Texas 79968-0519 Infectious Diseases and Immunology, The Border Biomedical Research Centre, University of Texas at El Paso, Texas 79968-0519, USA
D. ROY
Affiliation:
Department of Biological Sciences, University of Texas at El Paso, Texas 79968-0519 Infectious Diseases and Immunology, The Border Biomedical Research Centre, University of Texas at El Paso, Texas 79968-0519, USA
S. ROYCHOWDHURY
Affiliation:
Department of Biological Sciences, University of Texas at El Paso, Texas 79968-0519 Neurosciences and Metabolic Disorder Programs, The Border Biomedical Research Centre, University of Texas at El Paso, Texas 79968-0519, USA
S. B. ALEY
Affiliation:
Department of Biological Sciences, University of Texas at El Paso, Texas 79968-0519 Infectious Diseases and Immunology, The Border Biomedical Research Centre, University of Texas at El Paso, Texas 79968-0519, USA
S. DAS*
Affiliation:
Department of Biological Sciences, University of Texas at El Paso, Texas 79968-0519 Infectious Diseases and Immunology, The Border Biomedical Research Centre, University of Texas at El Paso, Texas 79968-0519, USA
*
*Corresponding author: Department of Biological Sciences and the Border Biomedical Research Centre, University of Texas at El Paso, 500 West University Avenue, El Paso, Texas 79968-0519, USA. Tel: +915 747 6896. Fax: +915 747 5808. E-mail: sdas@utep.edu
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Summary

Giardia lamblia, a protozoan parasite, infects a wide variety of vertebrates, including humans. Studies indicate that this anaerobic protist possesses a limited ability to synthesize lipid molecules de novo and depends on supplies from its environment for growth and differentiation. It has been suggested that most lipids and fatty acids are taken up by endocytic and non-endocytic pathways and are used by Giardia for energy production and membrane/organelle biosynthesis. The purpose of this article is to provide an update on recent progress in the field of lipid research of this parasite and the validation of lipid metabolic pathways through recent genomic information. Based on current cellular, biochemical and genomic data, a comprehensive pathway has been proposed to facilitate our understanding of lipid and fatty acid metabolism/syntheses in this waterborne pathogen. We envision that the current review will be helpful in identifying targets from the pathways that could be used to design novel therapies to control giardiasis and related diseases.

Keywords

Giardialipidmetabolic pathwaysgiardiasisgenome databaseparasite
Type
Review Article
Information
Parasitology , Volume 138 , Issue 3 , March 2011 , pp. 267 - 278
Copyright
Copyright © Cambridge University Press 2010

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