Hostname: page-component-848d4c4894-hfldf Total loading time: 0 Render date: 2024-06-07T07:58:51.775Z Has data issue: false hasContentIssue false
  • English
  • Français

Pamaquin Resistance in a Strain of Plasmodium gallinaceum and its relationship to Other antimalarial Drugs

Published online by Cambridge University Press:  06 April 2009

Ann Bishop  and
Elspeth W. McConnachie
Ann Bishop
Affiliation:
From the Molteno Institute, University of Cambridge
Elspeth W. McConnachie
Affiliation:
From the Molteno Institute, University of Cambridge
Get access Rights & Permissions [Opens in a new window]

Extract

1. A four- to eight-fold increase in resistance to pamaquin has been developed in a strain of Plasmodium gallinaceum in chicks.

2. Pamaquin resistance conferred no resistance to proguanil, sulphadiazine, mepacrine, chloroquine or sontochin, but it conferred some resistance to pentaquine and to quinine.

3. An appreciable loss in resistance to pamaquin was observed in the pamaquin-resistant strain after it had been maintained in the absence of the drug, in a patent state of infection, for a period of 6 months.

4. No synergism was observed between pamaquin and quinine when these drugs were tested, in combined doses, upon active infections of P. gallinaceum.

Type
Research Article
Information
Parasitology , Volume 42 , Issue 1-2 , March 1952 , pp. 57 - 64
Copyright
Copyright © Cambridge University Press 1952

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Alving, A. S. (1948). Pentaquine (SN. 13,276) and iso-pentaquine (SN. 13,274), therapeutic agents effective in reducing relapse rate in vivax malaria. Proc. 4th Int. Congr. Trap. Med. Mal. p. 734.Google Scholar
Alving, A. S., Craige, B., Jones, R., Whorton, C. M., Pullman, T. N. & Eichelberger, L. (1948). Pentaquine (SN. 13,276), a therapeutic agent effective in reducing the relapse rate in vivax malaria. J. Clin. Invest. 27, 25.CrossRefGoogle ScholarPubMed
Berlinner, R. W., Earle, D. P., Taggart, J. V., Welch, W. J., Zubrod, C. G., Knowlton, P., Atchley, J. A. & Shannon, J. A. (1948). Studies on the chemotherapy of the human malarias. VII. The antimalarial activity of pamaquin. J. Clin. Invest. 27, 108.CrossRefGoogle Scholar
Bishop, A. & Birkett, B. (1947). Acquired resistance to paludrine in Plasmodium gallinaceum. Acquired resistance and persistence after passage through the mosquito. Nature, Lond., 159, 884.CrossRefGoogle Scholar
Bishop, A. & Birkett, B. (1948). Drug-resistance in Plasmodium gallinaceum and the persistence of paludrine-resistance after mosquito transmission. Parasitology, 39, 125.CrossRefGoogle ScholarPubMed
Bishop, A. & McConnachie, E. W. (1948). Resistance to sulphadiazine and ‘paludrine’ in the malaria parasite of the fowl (P. gallinaceum). Nature, Lond., 162, 541.CrossRefGoogle ScholarPubMed
Bishop, A. & McConnachie, E. W. (1950 a). Sulpha-diazine-resistance in Plasmodium gallinaceum and its relation to other antimalarial compounds. Parasitology, 40, 163.CrossRefGoogle ScholarPubMed
Bishop, A. & McConnachie, E. W. (1950 b). Cross-resistance between sulphanilamide and paludrine (proguanil) in a strain of Plasmodium gallinaceum. Parasitology, 40, 175.CrossRefGoogle Scholar
Bishop, A. & McConnachie, E. W. (1950 c). Stability of paludrine-resistance in Plasmodium gallinaceum in the absence of the drug. Parasitology, 40, 159.CrossRefGoogle ScholarPubMed
Bishop, A. & McConnachie, E. W. (1952). Failure to produce resistance to chloroquine in Plasmodium gallinaceum in chicks. Parasitology, 42, 52.CrossRefGoogle ScholarPubMed
Black, R. H. (1946). The effect of anti-malarial drugs on Plasmodium falciparum (New Guinea strains) developing in vitro. Trans. R. Soc. trop. Med. Hyg. 40, 163.CrossRefGoogle ScholarPubMed
Blanchard, K. C. (1947). Antimalarial drugs. Ann. Rev. Biochem. 16, 587.CrossRefGoogle ScholarPubMed
Bratton, A. C. (1945). Continuous intravenous chemotherapy of Plasmodium lophurae infection in ducks. J. Pharmacol. 85, 103.Google ScholarPubMed
Fulton, J. D. (1942). Attempts to prepare in fowls a strain of Plasmodium gallinaceum resistant to plasmoquinine. Ann. Trop. Med. Parasit. 36, 75.CrossRefGoogle Scholar
Fulton, J. D. & Yorke, W. (1941). Studies in chemotherapy. XXIX. The development of plasmoquine-resistance in Plasmodium knowlesi. Ann. Trop. Med. Parasit. 35, 233.CrossRefGoogle Scholar
Fulton, J. D. & Yorke, W. (1943). Studies in chemotherapy. XXXII. Further observations on plasmoquine-resistance in Plasmodium knowlesi. Ann. Trop. Med. Parasit. 37, 41.CrossRefGoogle Scholar
Geiman, Q. M. (1948). Cultivation and metabolism of malarial parasites. Proc. 4th Int. Congr. Trop. Med. Mal. p. 618.Google ScholarPubMed
Greenberg, J. (1949 a). Hypersensitivity to sulfadiazine of a chlorguanide-resistant strain of Plasmodium gallinaceum. J. Nat. Malaria Soc. 8, 80.Google ScholarPubMed
Greenberg, J. (1949 b). The potentiation of the antimalarial activity of chlorguanide by p-aminobenzoic acid competitors. J. Pharmacol. 97, 238.Google ScholarPubMed
Greenberg, J., Boyd, B. L. & Josephson, E. S. (1948). Synergistic effect of chlorguanide and sulfadiazine against Plasmodium gallinaceum in the chick. J. Pharmacol. 94, 60.Google ScholarPubMed
Greenberg, J., Josephson, E. S. & Taylor, D. J. (1951). Studies on Plasmodium gallinaceum in vitro. II. The effects of some 8-aminoquinolines against erythrocytic parasites. J. Infect. Dis. 88, 163.CrossRefGoogle ScholarPubMed
Josephson, E. S., Taylor, D. J., Greenberg, J. & Ray, A. P. (1951). A metabolic intermediate of pamaquine from chicks. Proc. Soc. exp. Biol., NY., 76, 700.CrossRefGoogle Scholar
Knoppers, A. T. (1949). Twofold quinine resistance of Plasmodium gallinaceum, induced by regular administration of the drug. Documenta Neerlandica et Indonesica de Morbis Tropicis, 1, 55.Google ScholarPubMed
Koenig, K. (1949). Die curative Wirkung von Plasmochin bei Malaria tertiana. Zeit. Tropenmedizin Parasit. 1, 420.Google Scholar
Loeb, R. F. (1946). Activity of a new antimalarial agent, Pentaquine (SN. 13, 276). J. Amer. Med. Ass. 132, 321.CrossRefGoogle ScholarPubMed
McConnachie, E. W. (1951). Latent infections in avian malaria in relation to the production of drug-resistance. Parasitology, 41, 110.CrossRefGoogle Scholar
Nauck, E. G. (1934). Chemotherapeutische Versuche bei Affenmalaria (Pl. knowlesi). Arch. Schiffs- u. Tropenhyg. 38, 313.Google Scholar
Reilly, J., Chen, G. & Geiling, E. M. K. (1950). The action of drug combinations on Plasmodium lophurae in the chick. J. Infect. Dis. 86, 105.CrossRefGoogle ScholarPubMed
Rollo, I. M., Williamson, J. & Lourie, E. M. (1948). Acquired paludrine-resistance in Plasmodium gallinaceum. Failure to produce resistance by prolonged treatment of latent infections. Ann. Trop. Med. Parasit. 42, 241.CrossRefGoogle ScholarPubMed
Schmidt, L. H., Genther, S. C., Fradkin, R. & Squires, W. (1949). Development of resistance to chlorguanide (paludrine) during treatment of infections with Plasmodium cynomolgi. J. Pharmacol. 95, 382.Google ScholarPubMed
Sinton, J. A. & Bird, W. (1928). Studies in malaria, with special reference to treatment. IX. Plasmoquine in the treatment of malaria. Indian J. Med. Res. 16, 159.Google Scholar
Sinton, J. A., Smith, S. & Pottinger, D. (1930). Studies in malaria, with special reference to treatment. XII. Further researches into the treatment of chronic benign tertian malaria with plasmoquine and quinine. Indian J. Med. Res. 17, 793.Google Scholar
Thompson, P. E. (1948). On the ability of Plasmodium lophurae to acquire resistance to chlorguanide, camoquin and chloroquine. J. Infect. Dis. 83, 250.CrossRefGoogle ScholarPubMed
White, W. C., Cooper, W. C., Coatney, G. R., Culwell, W. B., Lints, H. A. & Young, M. D. (1948). Studies in human malaria. XXI. The cure of St Elizabeth strain vivax malaria by pentaquine-quinine, administered during acute attacks or during latency. J. Nat. Mai. Soc. 7, 316.Google ScholarPubMed
Williamson, J. & Lourie, E. M. (1947). Acquired paludrine-resistance in Plasmodium gallinaceum. I. Development of resistance to paludrine and failure to develop resistance to certain other antimalarials. Ann. Trop. Med. Parasit. 41, 278.CrossRefGoogle ScholarPubMed
Zubrod, C. G., Kennedy, T. J. & Shannon, J. A. (1948). Studies on the chemotherapy of human malarias. VII. The antimalarial activity of pamaquin. J. Clin. Invest. 27, 114.CrossRefGoogle Scholar