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Quantifying parameters in the transmission of Babesia microti by the tick Ixodes trianguliceps amongst voles (Clethrionomys glareolus)

Published online by Cambridge University Press:  06 April 2009

S. E. Randolph
S. E. Randolph
Affiliation:
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS
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Summary

The estimation of two parameters in the transmission of Babesia microti by the tick Ixodes trianguliceps amongst small mammals, (1) the duration of infectivity in natural hosts and (2) the probability of transmission from an infected to a susceptible vole, is described. When B. microti was maintained by direct tick transmission, the probability of a complete cycle of transmission via the larval-nymphal and nymphal-adult transstadial routes was 1·0 and 0·71 respectively, but only if the larvae or nymphs had engorged, as distinct from feeding slowly, while the source parasitaemia exceeded 2 or 0·2% respectively, but had not yet passed the peak level. The duration of this condition for infectivity in voles infected by nymphal bites was only 1–4 days, whilst infections delivered by adult ticks barely reached the threshold level necessary for successful transmission. When syringe passage was introduced into the parasite maintenance schedule (a) the probability of transmission declined markedly and (b) the time-course of the parasitaemia was altered. If these parameter values are put into a simple model, together with field data on tick and host survival rates, it becomes apparent that additional factors, such as the highly aggregated distribution of ticks on their hosts, must account for the maintenance of B. microti at the levels seen in wild small mammal populations.

Keywords

Babesia microtiIxodes triangulicepstickstransmissionnatural systems.
Type
Research Article
Information
Parasitology , Volume 110 , Issue 3 , April 1995 , pp. 287 - 295
Copyright
Copyright © Cambridge University Press 1995

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References

REFERENCES

Clark, I. A. & Howell, M. J. (1990). Protozoan parasites of erythrocytes and macrophages. In Parasites, Immunity and Pathology: the Consequences of Parasitic Infections in Mammals (ed. Behnke, J. M.) pp. 146–67. London: Taylor and Francis.Google Scholar
Clark, I. A., Richmond, J. E., Wills, E. J. & Allison, A. C. (1977). Intra-erythrocytic death of the parasite in mice recovering from infection with Babesia microti. Parasitology 75, 189–96.CrossRefGoogle ScholarPubMed
Cox, F. E. G. & Young, A. S. (1969). Acquired immunity to Babesia microti and Babesia rodhaini in mice. Parasitology 59, 257–68.CrossRefGoogle ScholarPubMed
Fleck, S. L., Butcher, G. A. & Sinden, R. E. (1994). Plasmodium berghei: serum-mediated inhibition of infectivity of infected mice to Anopheles stephensi mosquitoes. Experimental Parasitology 78, 20–7.CrossRefGoogle ScholarPubMed
Hussein, H. S. (1980). Ixodes trianguliceps: seasonal abundance and role in the epidemiology of Babesia microti infection in north-western England. Annals of Tropical Medicine and Parasitology 74, 531–9.CrossRefGoogle ScholarPubMed
Mather, T. N., Telford, S. R., Moore, S. I. & Spielman, A. (1990). Borrelia burgdorferi and Babesia microti: efficiency of transmission from reservoirs to vector ticks (Ixodes dammini). Experimental Parasitology 70, 55–61.CrossRefGoogle ScholarPubMed
Norval, R. A. I., Perry, B. D. & Young, A. S. (1992). The Epidemiology of Theileriosis in Africa. London: Academic Press.Google Scholar
Oliveira, M. R. & Kreier, J. P. (1979). Transmission of Babesia microti using various species of ticks as vectors. Journal of Parasitology 65, 816–17.CrossRefGoogle ScholarPubMed
Piesman, J., Karakashian, S. J., Lewengrub, S., Rudzinska, M. A. & Spielman, A. (1986). Development of Babesia microti sporozoites in adult Ixodes dammini. International Journal for Parasitology 16, 381–5.CrossRefGoogle ScholarPubMed
Randolph, S. E. (1975 a). Seasonal dynamics of a host-parasite system: Ixodes trianguliceps (Acarina; Ixodidae) and its small mammal hosts. Journal of Animal Ecology 44, 425–49.CrossRefGoogle Scholar
Randolph, S. E. (1975 b). Patterns of distribution of the tick Ixodes trianguliceps Birula on its hosts. Journal of Animal Ecology 44, 451–74.CrossRefGoogle Scholar
Randolph, S. E. (1991). The effect of Babesia microti on feeding and survival in its tick vector, Ixodes trianguliceps. Parasitology 102, 9–16.CrossRefGoogle ScholarPubMed
Randolph, S. E. (1994). Density-dependent acquired resistance to ticks in natural hosts, independent of concurrent infection with Babesia microti. Parasitology 108, 413–19.CrossRefGoogle ScholarPubMed
Randolph, S. E. & Nuttall, P. A. (1994). Nearly right or precisely wrong? Natural versus laboratory studies of vector-borne diseases. Parasitology Today 10, 458–62.CrossRefGoogle ScholarPubMed
Rudzinska, M. A., Spielman, A., Riek, R. F., Lewengrub, S. J. & Piesman, J. (1979). Intraerythrocytic ‘gametocytes’ of Babesia microti and their maturation in ticks. Canadian Journal of Zoology 57, 424–34.CrossRefGoogle ScholarPubMed
Telford, S. R. & Spielman, A. (1993). Reservoir competence of white-footed mice for Babesia microti. Journal of Medical Entomology 30, 223–7.CrossRefGoogle ScholarPubMed
Telford, S. R., Urioste, S. S. & Spielman, A. (1992). Clustering of host-seeking nymphal deer ticks (Ixodes dammini) infected by Lyme disease spirochaetes (Borrelia burgdorferi). American Journal of Tropical Medicine and Hygiene 47, 55–60.CrossRefGoogle ScholarPubMed
Turner, C. M. J. (1986). Seasonal and age distributions of Babesia, Hepatozoon, Trypanosoma and Grahamella species in Clethrionomys glareolus and Apodemus sylvaticus populations. Parasitology 93, 279–89.CrossRefGoogle ScholarPubMed
Turner, C. M. J. & Cox, F. E. G. (1985). The stability of Babesia microti infections after prolonged passage, a comparison with a recently isolated strain. Annals of Tropical Medicine and Parasitology 79, 659–61.CrossRefGoogle Scholar
Walter, G. & Weber, G. (1981). Untersuchung zur Ubertragung (transstadial, transovarial) von Babesia microti, Stamm ‘Hannover 1’, in Ixodes ricinus. Tropenmedizin und Parasitologie 32, 228–30.Google Scholar
Young, A. S. (1970). Investigations of the epidemiology of blood parasites of small mammals with special reference to piroplasms. Ph.D. thesis. University of London.Google Scholar
Young, A. S. & Morzaria, S. P. (1986). Biology of Babesia. Parasitology Today 2, 211–18.CrossRefGoogle ScholarPubMed