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X-ray powder diffraction data of lapatinib ditosylate monohydrate

Published online by Cambridge University Press:  29 February 2012

Peter Varlashkin
Peter Varlashkin*
Affiliation:
GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, North Carolina 27707, USA
*
a)Electronic mail: peter.g.varlashkin@gsk.com
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Abstract

The room temperature powder pattern of lapatinib ditosylate monohydrate (active ingredient in Tykerb used to treat refractory breast cancer) was indexed and the cell from the single crystal X-ray diffraction structure was refined using the experimental capillary data. Unit-cell parameters for the orthorhombic compound with space group Pbca refined from powder diffraction data are a=9.6850±0.0009 Å, b=29.364±0.003 Å, and c=30.733±0.003 Å, α=β=γ=90°, z=8, V=8740.1 Å3. Values of 2θ, d, I, and Miller indices are reported.

Keywords

lapatiniblapatinib ditosylate monohydrateTykerbpowder diffraction datadrugbreast cancer
Type
New Diffraction Data
Information
Powder Diffraction , Volume 24 , Issue 3 , September 2009 , pp. 250 - 253
Copyright
Copyright © Cambridge University Press 2009

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