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The control of haemoglobin synthesis: factors controlling the output of α and β chains

Published online by Cambridge University Press:  24 January 2017

R. T. Hunt ,
A. R. Hunter  and
A. J. Munro
R. T. Hunt
Affiliation:
Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge
A. R. Hunter
Affiliation:
Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge
A. J. Munro
Affiliation:
Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge
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Analysis of the effects of amino acid starvation in reticulocytes is comparatively simple compared with similar analysis in other tissues of whole organisms. This is mainly because of the absence of RNA synthesis in reticulocytes, but also because the bulk of the protein being synthesized is haemoglobin, a protein whose structure is completely known. The absence of RNA synthesis eliminates complications that would otherwise arise through RNA-mediated control mechanisms which in turn might mask the effects of amino acid starvation on the protein synthetic machinery in the cells (Munro, 1969). Consequently reticulocytes have been used to study the effect of amino acid starvation on the actual process of protein synthesis and assembly.

Type
Symposium Proceedings
Information
Proceedings of the Nutrition Society , Volume 28 , Issue 2 , September 1969 , pp. 248 - 254
Copyright
Copyright © Proceedings of the Nutrition Society 1969

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