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The impact of obesity-related single nucleotide polymorphisms on satiety

Published online by Cambridge University Press:  14 October 2011

A. Dougkas ,
A. M. Minihane ,
D. I. Givens ,
C. K. Reynolds  and
P. Yaqoob
A. Dougkas
Affiliation:
Hugh Sinclair Human Nutrition Group, School of Chemistry, Food Biosciences and Pharmacy, Faculty of Life Sciences University of Reading, Reading RG6 6AP, UK School of Agriculture, Policy and Development, Faculty of Life Sciences, University of Reading, Reading RG6 6AR, UK
A. M. Minihane
Affiliation:
Department of Nutrition, Norwich Medical School, University of East Anglia (UEA), Norwich NR4 7TJ, UK
D. I. Givens
Affiliation:
School of Agriculture, Policy and Development, Faculty of Life Sciences, University of Reading, Reading RG6 6AR, UK
C. K. Reynolds
Affiliation:
School of Agriculture, Policy and Development, Faculty of Life Sciences, University of Reading, Reading RG6 6AR, UK
P. Yaqoob
Affiliation:
Hugh Sinclair Human Nutrition Group, School of Chemistry, Food Biosciences and Pharmacy, Faculty of Life Sciences University of Reading, Reading RG6 6AP, UK
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Abstract

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Information
Proceedings of the Nutrition Society , Volume 70 , Issue OCE4: Summer Meeting, 4–6 July 2011, 70th Anniversary: From plough through practice to policy , 2011 , E128
Copyright
Copyright © The Authors 2011

Although behavioural factors are major determinants of obesity risk, genetic variation is also known to significantly impact on body weight regulation(Reference Walley, Asher and Froguel1). A number of studies reported a heritable component for the regulation of appetite and eating behaviour, although the individual polymorphisms and their ‘size effect’ are not fully elucidated(Reference Grimm and Steinle2). The aim of the present study was to examine the relationships between appetite ratings and specific SNP in overweight men.

In a randomised crossover trial, forty overweight men [age: 32 (sd 9) years; BMI (kg/m2): 27 (sd 2)] attended four sessions one week apart and received three isoenergetic and isovolumetric servings of dairy snacks or water (control). Appetite ratings were determined using visual analogue scales (VAS) and energy intake at the ad libitum lunch was assessed 90 min after the snacks. Individuals were genotyped for SNP in the fat mass and obesity-associated (FTO), leptin (LEP), leptin receptor (LEPR) and variant near melanocortin-4 receptor (MC4R) genes.

Fig. 1. LEP*MC4R interaction.

Postprandial response in fullness was 18.2% (P=0.026) lower in TA/AA (dominant) carriers compared with TT carriers in rs9939609 (FTO) and 17.0% (P=0.020) lower in GA/GG (dominant) carriers compared with the AA carriers in rs7799039 (LEP). When interactions among the four genes were examined, a significant interaction for energy intake involving rs7799039 (LEP) and rs17782313 (MC4R) was observed. Under a dominant inheritance model, individuals with the lower energy intake were over represented among AA and TT carriers in rs7799039 (LEP) and rs17782313 (MC4R), respectively, compared with GA/GG and TT carriers in these SNP, respectively (P=0.011), with the rs7799039 (LEP) having the main effect (P=0.041) (Fig. 1).

In conclusion, the FTO and LEP polymorphisms are related to feeling of fullness and may play a role in the regulation of food intake. Further studies are required to confirm the observations and investigate the ‘penetrance’ of these genotypes in additional population subgroups.

References

1.Walley, AJ, Asher, JE & Froguel, P (2009) Nat Rev Genet 10, 431–442.CrossRefGoogle Scholar
2.Grimm, ER & Steinle, NI (2011) Nutr Rev 69(1), 52–60.CrossRefGoogle Scholar
Figure 0

Fig. 1. LEP*MC4R interaction.