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Fertilization and embryonic developmental capacity of epididymal and testicular sperm and immature spermatids and spermatocytes

Published online by Cambridge University Press:  03 June 2009

Orly Lacham-Kaplan  and
Alan Trounson
Orly Lacham-Kaplan*
Affiliation:
Laboratories of Human and Animal Reproductive Biology, Institute for Reproduction and Development, Monash Medical Centre, Australia
Alan Trounson
Affiliation:
Laboratories of Human and Animal Reproductive Biology, Institute for Reproduction and Development, Monash Medical Centre, Australia
*
Laboratories of Human and Animal Reproductive Biology, Institute for Reproduction and Development, Monash Medical Centre, 246 Clayton Rd, Clayton 3168, Australia.
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Extract

Spermatogenesis in mammalian species begins after birth. The gonocytes, arrested at G2 of the cell cycle in the foetus, resume mitotic proliferation after birth. As identified in the mouse, the gonocytes migrate towards the periphery of the seminiferous cords at day 4 to day 6 after birth and are located in close contact with the basal lamina. From this stage the gonocytes are referred to as primitive type A spermatogonia. These cells continue mitotic proliferation and differentiate to form type B spermatogonia. By day 10 after birth, many of the type B spermatogonia have formed preleptotene primary spermatocytes which undergo a final phase of DNA synthesis (leptotene) prior to entering meiotic prophase (zygotene).

Type
Research Article
Information
Reproductive Medicine Review , Volume 6 , Issue 1 , March 1997 , pp. 55 - 68
Copyright
Copyright © Cambridge University Press 1997

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