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Expanded CAG/CTG Repeats in Schizophrenia

A Study of Clinical Correlates

Published online by Cambridge University Press:  02 January 2018

Alastair G. Cardno ,
Kieran C. Murphy ,
Lisa A. Jones ,
Carol A. Guy ,
Philip Asherson ,
Maria H. P. De Azevedo ,
Isabel M. O. Da Cruz Coelho ,
Antonio J. F. De Macedo e Santos ,
Carlos N. Pato  and
Peter McGuffin
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Alastair G. Cardno*
Affiliation:
University of Wales College of Medicine, Cardiff
Kieran C. Murphy
Affiliation:
University of Wales College of Medicine, Cardiff
Lisa A. Jones
Affiliation:
University of Wales College of Medicine, Cardiff
Carol A. Guy
Affiliation:
University of Wales College of Medicine, Cardiff
Philip Asherson
Affiliation:
University of Wales College of Medicine, Cardiff
Maria H. P. De Azevedo
Affiliation:
Universidade de Coimbra, Portugal
Isabel M. O. Da Cruz Coelho
Affiliation:
Universidade de Coimbra, Portugal
Antonio J. F. De Macedo e Santos
Affiliation:
Universidade de Coimbra, Portugal
Carlos N. Pato
Affiliation:
Universidade de Coimbra, Portugal
Peter McGuffin
Affiliation:
University of Wales College of Medicine, Cardiff
Michael J. Owen
Affiliation:
University of Wales College of Medicine, Cardiff
Michael C. O'Donovan
Affiliation:
University of Wales College of Medicine, Cardiff
*
Dr A. Cardno, Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK
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Abstract

Background

Schizophrenia is associated with expanded CAG/CTG trinucleotide repeats. We wished to determine whether the presence of such expansions correlated with specific subsyndromes or other clinical features of schizophrenia.

Method

Seventy patients from England and Wales and 44 patients from Portugal with a DSM–III–R diagnosis of schizophrenia were rated on the opcrit checklist Patients' maximum CAG/CTG repeat length was measured using repeat expansion detection (RED). Significant differences were sought for repeat lengths in subjects categorised according to dimensional and categorical schizophrenia subsyndromes, affective episodes, individual symptoms, and a range of demographic variables.

Results

Maximum CAG/CTG repeat length did not differ significantly for any of the clinical or demographic variables studied.

Conclusion

There are no subsyndromes or other clinical features of schizophrenia associated with CAG/CTG repeat expansion. Therefore, the identification of the gene(s) that contain expanded CAG/CTG repeats and which are associated with schizophrenia is unlikely to be facilitated at present by using any subsyndromes of schizophrenia as phenotypes.

Type
Papers
Information
The British Journal of Psychiatry , Volume 169 , Issue 6 , December 1996 , pp. 766 - 771
Copyright
Copyright © 1996 The Royal College of Psychiatrists 

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References

American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM–III–R). Washington, DC: APA.Google Scholar
Arndt, S., Alliger, R. J. & Andreasen, N. C. (1991) The distinction of positive and negative symptoms: The failure of a two-dimensional model. British Journal of Psychiatry, 158, 317–322.CrossRefGoogle ScholarPubMed
Werstiuk, E. S., Andreasen, N. C., Flaum, M., et al (1995) A longitudinal study of symptom dimensions in schizophrenia: Prediction and patterns of change. Archives of General Psychiatry, 52, 352–360.Google Scholar
Asherson, P., Walsh, C., Williams, J., et al (1994) Imprinting and anticipation – are they relevant to genetic studies of schizophrenia? British Journal of Psychiatry, 164, 619–624.CrossRefGoogle ScholarPubMed
Azevedo, M. H. de, Dourado, A., Valente, J., et al (1993) The Portuguese-Language Version of the Diagnostic Interview for Genetic Studies. Psychiatric Genetics, Special Issue, 3, 188.Google Scholar
Bassett, A. S. & Honer, W. G. (1994) Evidence for anticipation in schizophrenia. American Journal of Human Genetics, 54, 864–870.Google ScholarPubMed
Bilder, R. M., Mukherjee, S., Rieder, R. O., et al (1985) Symptomatic and neuropsychological components of deficit states. Schizophrenia Bulletin, 11, 409–419.CrossRefGoogle Scholar
Buchanan, R. W. & Carpenter, W. T. (1994) Domains of psychopathology: An approach to the reduction of heterogeneity in schizophrenia. Journal of Nervous and Mental Disease, 182, 193–204.CrossRefGoogle Scholar
Cardno, A. G., Holmans, P. A., Harvey, I., et al (1996) Factor-derived subsyndromes of schizophrenia and familial morbid risks. Schizophrenia Research, in press.CrossRefGoogle Scholar
Cattell, R. B. (1966) The scree test for the number of factors. Multivariate Behavioural Research, 1, 245–276.CrossRefGoogle ScholarPubMed
Crow, T. J. (1980) Molecular pathology of schizophrenia: More than one disease process? British Medical Journal, 280, 66–68.CrossRefGoogle ScholarPubMed
Ebmeier, K. P., Blackwood, D. H. R., Murray, C., et al (1993) Single-photon emission computed tomography with 99mTc-Exametazime in unmedicated schizophrenic patients. Biological Psychiatry, 33, 487–495.CrossRefGoogle ScholarPubMed
Farmer, A. E., McGuffin, P. & Spitznagel, E. L. (1983) Heterogeneity in schizophrenia: A cluster-analytic approach. Psychiatry Research, 8, 1–12.CrossRefGoogle ScholarPubMed
Fu, Y. H., Kuhl, D. P. A., Pizzuti, A., et al (1991) Variation of the CGG repeat at the fragile-X site results in genetic instability: Resolution of the Sherman paradox. Cell, 67, 1047–1058.CrossRefGoogle ScholarPubMed
Huntington's Disease Collaborative Research Group (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell, 72, 971–983.CrossRefGoogle Scholar
Kaplan, R. D., Szechtman, H., Franco, S., et al (1993) Three clinical syndromes of schizophrenia in untreated subjects: Relation to brain glucose activity measured by positron emission tomography (PET). Schizophrenia Research, 11, 47–54.CrossRefGoogle ScholarPubMed
Liddle, P. F. (1987) The symptoms of chronic schizophrenia: A re-examination of the postive–negative dichotomy. British Journal of Psychiatry, 151, 145–151.CrossRefGoogle Scholar
Liddle, P. F. & Morris, D. (1991) Schizophrenic syndromes and frontal lobe performance. British Journal of Psychiatry, 158, 340–345.CrossRefGoogle ScholarPubMed
Liddle, P. F., Friston, K. J., Frith, C. D., et al (1992) Patterns of cerebral blood flow in schizophrenia. British Journal of Psychiatry, 160, 179–186.CrossRefGoogle ScholarPubMed
Lindblad, K., Nylander, P.-O., De Bruyn, A., et al (1995) Detection of expanded CAG repeats in bipolar affective disorder using the repeat expansion detection (RED) method. Neurobiology of Disease, 2, 55–62.CrossRefGoogle ScholarPubMed
McGuffin, P., Farmer, A. E. & Harvey, I. (1991) A polydiagnostic application of operational criteria in studies of psychotic illness: Development and reliability of the opcrit system. Archives of General Psychiatry, 48, 764–770.CrossRefGoogle ScholarPubMed
McGuffin, P., Owen, M. J., O'Donovan, M. C., et al (1994) Seminars in Psychiatric Genetics. London: Gaskell.Google Scholar
Morris, A. G., Gaitonde, E., McKenna, P. J., et al (1995) CAG repeat expansions and schizophrenia: Association with disease in females and with early age-at-onset. Human Molecular Genetics, 4, 1957–1961.CrossRefGoogle ScholarPubMed
Murphy, B. M., Burke, J. G., Bray, J. C., et al (1994) An analysis of the clinical features of familial schizophrenia. Acta Psychiatrica Scandinavica, 89, 421–427.CrossRefGoogle ScholarPubMed
O'Donovan, M. C. & Owen, M. J. (1996) Dynamic mutations and psychiatric genetics. Psychological Medicine, 26, 1–6.CrossRefGoogle ScholarPubMed
O'Donovan, M. C., Guy, C., Craddock, N., et al (1995) Expanded CAG repeats in schizophrenia and bipolar disorder. Nature Genetics, 10, 380–381.CrossRefGoogle ScholarPubMed
O'Donovan, M. C., Guy, C., Craddock, N., et al (1996) Confirmation of association between expanded CAG/CTG repeats and both schizophrenia and bipolar disorder. Psychological Medicine, in press.CrossRefGoogle Scholar
Schalling, M., Hudson, T. J., Buetow, K. H., et al (1993) Direct detection of novel expanded trinucleotide repeats in human genome. Nature Genetics, 4, 135–139.CrossRefGoogle ScholarPubMed
Snell, R. G., MacMillan, J. C., Cheadle, J. P., et al (1993) Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease. Nature Genetics, 4, 394–397.CrossRefGoogle ScholarPubMed
Thibaut, F., Martinez, M., Petit, M., et al (1995) Further evidence for anticipation in schizophrenia. Psychiatry Research, 59, 25–33.CrossRefGoogle ScholarPubMed
Tsuang, M. T. & Winokur, G. (1974) Criteria for subtyping schizophrenia. Archives of General Psychiatry, 31, 43–47.CrossRefGoogle ScholarPubMed
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974) Measurement and Classification of Psychiatric Symptoms. Cambridge: Cambridge University Press.Google Scholar
Wing, J. K., Babor, T., Brugha, T., et al (1990) Schedules for clinical assessment in neuropsychiatry. Archives of General Psychiatry, 47, 589–593.CrossRefGoogle ScholarPubMed
Yu, S., Pritchard, M., Kremer, E., et al (1991) Fragile-X genotype characterized by an unstable region of DNA. Science, 252, 1179–1181.CrossRefGoogle ScholarPubMed
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