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Post-mortem Proton Magnetic Resonance Spectrometric Measures of Brain Regions in Patients with a Pathological Diagnosis of Alzheimer's Disease and Multi-infarct Dementia

Published online by Cambridge University Press:  02 January 2018

John A. O. Besson ,
Philip V. Best  and
E. Roy Skinner
John A. O. Besson*
Affiliation:
Department of Mental Health, University of Aberdeen
Philip V. Best
Affiliation:
Department of Pathology, University of Aberdeen
E. Roy Skinner
Affiliation:
Department of Biochemistry, University of Aberdeen
*
∗Department of Mental Health, Medical Buildings, Foresterhill, Aberdeen AB9 2ZD
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Abstract

In-vitro spectrometric measures were made of spin-lattice (T1) and spin-spin (T2) relaxation times of samples of grey and white matter from the brains of 15 patients with a pathological diagnosis of Alzheimer's disease, 5 with multi-infarct dementia, and 11 non-demented subjects. Relaxation times were significantly greater in the parietal white matter and temporal white matter of patients with Alzheimer's disease compared with that of the other subjects. This was associated with an increase in tissue water content. These findings confirm measures obtained in some imaging studies.

Type
Papers
Information
The British Journal of Psychiatry , Volume 160 , Issue 2 , February 1992 , pp. 187 - 190
Copyright
Copyright © Royal College of Psychiatrists, 1992 

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References

Besson, J. A. O., Corrigan, F. M., Foreman, E. I., et al (1985) Nuclear magnetic resonance imaging in dementia. British Journal of Psychiatry, 146, 31–36.CrossRefGoogle ScholarPubMed
Besson, J. A. O., Ebmeier, K. P., Best, P. V., et al (1988) Can MRI differentiate between dementia of the Alzheimer's type and multi-infarct dementia? Journal of Neurology, Neurosurgery and Psychiatry, 51, 318–319.Google Scholar
Bondareff, W., Raval, J., Coletti, P. M., et al (1988) Quantitative MRI and severity of dementia in Alzheimer's disease. American Journal of Psychiatry, 145, 853–856.Google Scholar
Brun, A. & Englund, E. (1986) A white matter disorder in dementia of the Alzheimer's type. Annals of Neurology, 19, 252–262.CrossRefGoogle Scholar
Christie, J. E., Blackburn, I., Smith, M. A., et al (1988) Magnetic resonance imaging in presenile dementia of Alzheimer's type, multi-infarct dementia and Korsakoff psychosis. Psychological Medicine, 18, 319–329.CrossRefGoogle Scholar
Ebmeier, K. P., Besson, J. A. O., Crawford, J. R., et al (1987) NMR imaging and SPECT with radio labelled compounds in the diagnosis of dementia. Acta Psychiatrica Scandinavica, 75, 549–556.CrossRefGoogle ScholarPubMed
Englund, E., Brun, A. & Alling, C. (1988) White matter changes in dementia of Alzheimer Type. Brain, 111, 1425–1439.CrossRefGoogle Scholar
Fischer, H. W., Haverbeke, Y. V., Rinke, P. A., et al (1989) Effect of ageing and storage conditions on excised tissue as monitored by longitudinal relaxation dispersion profiles. Magnetic Resonance in Medicine, 9, 315–324.Google Scholar
Hollander, E., Mohs, R. C. & Davis, K. L. (1986) Antemortem markers of Alzheimer's disease. Neurobiology of Ageing, 7, 367–387.CrossRefGoogle ScholarPubMed
Medical Research Council (1987) Report from the MRC Alzheimer's Disease Workshop, pp. 24–25.Google Scholar
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