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Using Identity-by-descent Information in Affected Sib Pairs to Increase the Efficiency of Genetic Association Studies

Published online by Cambridge University Press:  21 February 2012

Jacqueline Wicks ,
Susan A. Treloar  and
Nicholas G. Martin
Jacqueline Wicks*
Affiliation:
Queensland Institute of Medical Research, Brisbane,Australia. jackiW@qimr.edu.au
Susan A. Treloar
Affiliation:
Queensland Institute of Medical Research, Brisbane,Australia.
Nicholas G. Martin
Affiliation:
Queensland Institute of Medical Research, Brisbane,Australia.
*
*Address for correspondence: Jacqueline Wicks, Queensland Institute of Medical Research, Brisbane Qld 4029, Australia.

Abstract

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The aim of this study was to determine whether identity-by-descent (IBD) information for affected sib pairs (ASPs) can be used to select a sample of cases for a genetic case-control study which will provide more power for detecting association with loci in a known linkage region. By modeling the expected frequency of the disease allele in ASPs showing IBD sharing of 0, 1, or 2 alleles, and considering additive, recessive, and dominant disease models, we show that cases selected from IBD 2 families are best for this purpose, followed by those selected from IBD 1 families; least useful are cases selected from IBD 0 families.

Type
Articles
Information
Twin Research and Human Genetics , Volume 7 , Issue 2 , 01 April 2004 , pp. 211 - 216
Copyright
Copyright © Cambridge University Press 2004