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Use of acetylsalicylic acid as a feed additive in poultry nutrition

Published online by Cambridge University Press:  09 June 2017

M. ALAGAWANY ,
M.R. FARAG ,
M.E. ABD EL-HACK ,
K. DHAMA  and
J. FOWLER
M. ALAGAWANY*
Affiliation:
Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt
M.R. FARAG
Affiliation:
Department of Forensic Medicine and Toxicology, Veterinary Medicine Faculty, Zagazig University, Zagazig, Egypt
M.E. ABD EL-HACK
Affiliation:
Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt
K. DHAMA
Affiliation:
Division of Pathology, Indian Veterinary Research Institute, Izatnagar, Bareilly (Uttar Pradesh)India
J. FOWLER
Affiliation:
Department of Poultry Science, University of Georgia 30602, USA
*
Corresponding author: dr.mahmoud.alagwany@gmail.com
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Abstract

Salicylate plays an important role as a non-steroid, anti-inflammatory drug. In poultry, those used most commonly are sodium salicylate (SS) and acetylsalicylic acid (ASA), due to their immunomodulatory, analgesic, antipyretic, and anti-inflammatory activities. Other effects have been reported such as minimising the effects of heat stress, allostatic load, ascites, leg disorders, reducing respiratory and digestive disorders, as well as enhancing growth performance, feed utilisation, nutrient digestion and absorption, egg production and the quality of meat and eggs. Furthermore, ASA plays a key role in lowering cholesterol and triglycerides in blood, meat and eggs, and improvements in immune functions and antioxidant enzymes have been noted in birds. This paper reviews the different characteristics and beneficial applications of ASA in poultry nutrition for improving immunity, production, and safeguarding health, especially under heat stress conditions.

Keywords

acetylsalicylic acidperformancehealthheat stresspoultry
Type
Reviews
Information
World's Poultry Science Journal , Volume 73 , Issue 3 , September 2017 , pp. 633 - 642
Copyright
Copyright © World's Poultry Science Association 2017 

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References

ABDEL-FATTAH, S.A. (2006) Physiological and immunological adjustments of dietary ascorbic acid and acetyl salicylic acid in heat stressed Japanese quail. Egyptian Poultry Science 26: 1395-1418.Google Scholar
ABOU EL-SOUD, , SABRIEA, B., EBEID, T.A. and EID, Y. Z. (2006) Physiological and antioxidative effects of dietary acetyl salicylic acid in laying Japanese quail (coturnix japonica) under high ambient temperature. Journal of Poultry Science 43: 255-265.Google Scholar
ADAMS, R. and ROGLER, J.C. (1968) The effects of dietary aspirin and humidity on the performance of light and heavy breed chicks. Poultry Science 47: 1348-1368.Google Scholar
AL-MASHHADANI, E.H., PITAN, M.H. and AHMED, K.H. (1988) Effect of dietary aspirin on performance and deposition of abdominal fat in broilers. International Journal of Poultry Science 23: 18-21.Google Scholar
AL-OBAIDI, F.A. and AL-SHADEEDI, S.M. (2010) Effect of dietary aspirin for reducing ascites and enhancing productive performance of broilers reared in high density. Al-Qadisiya Journal of Veterinary Medicine Science 9: 20-25.Google Scholar
ANWAR, B., KHAN, S.A., ASLAM, A., MAQBOOL, A. and KHAN, K.A. (2004) Effects of ascorbic acid and acetylsalicylic acid supplementation on the performance of broiler chicks exposed to heat stress. Pakistan Veterinary Journal 24: 109-112.Google Scholar
BAERT, K.V. and DE BACKER, P. (2003) Comparative pharmacokinetics of three non-steroidal anti-inflammatory drugs in five bird species. Comparative Biochemistry and Physiology C 134: 25-33.Google Scholar
BALOG, J.M. and HESTER, P.Y. (1991) The effect of dietary acetyl salicylic acid on egg shell quality. Poultry Science 70: 624-630.Google Scholar
BRAKE, J., FERKET, P., GRIMES, J., BALNAVE, D., GORMAN, J. and DIBNER, J.J. (1994) Optimum arginine:lysine ratio changes in hot weather. P. 82-104 in Proc. 21st Annual Carolina Poultry Nutrition Conference, Charlotte, NC. USA.Google Scholar
DARGAN, P.I., WALLACE, C.I. and JONES, A.L. (2002) An evidence-based flowchart to guide the management of acute salicylate (aspirin) overdose. Emergency Medicine Journal 19: 206-209.Google Scholar
DE BOEVER, S., NEIRINCKX, E.A., MEYER, E., DE BAERE, S., BEYAERT, R. and DE BACKER, P. (2010) Pharmacodynamics of tepoxalin, sodium-salicylate and ketoprofen in an intravenous lipopolysaccharide inflammation model in broiler chickens. Journal of Veterinary Pharmacology and Therapeutics 33: 564-572.Google Scholar
DEI, H.K. (2014) Egg production response of laying chickens to feather clipping, cool water and aspirin during hot weather conditions. Tropical Animal Health and Production 46: 1523-1526.Google Scholar
DERAKHSHANFAR, A., KHEIRANDISH, R., ALIDADI, S. and BIDADKOSH, A. (2013) Study of long effects of administration of aspirin (acetylsalicylic acid) on bone in broiler chickens. Comparative Clinical Pathology 22: 1201-1204.CrossRefGoogle Scholar
EL-KHOLY, M.S. (2013) Physiological studies on Japanese quail as affected by some nutritional treatments. Ph.D. Thesis, Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.Google Scholar
GILBERT, A.B., MITCHELL, G.G., DAVIDSON, M.F., LAUGHLIN, K.F. and HUGHES, B.O. (1982) Effect of administering two prostaglandin synthetase inhibitors (indomethacin and aspirin) on egg production in the domestic fowl (Gallus domesticus). Research Veterinary Science 33: 216-220.Google Scholar
GLICK, B. (1963) Influence of acetylsalicylic acid on the body temperature of heat-stressed chickens. Nature 200: 603.Google Scholar
HASSAN, S.M., MADY, M.E., CARTWRIGHT, A.L., SABRI, H.M. and MOBARAK, M.S. (2003) Effect of acetyl salicylic acid in drinking water on reproductive performance of Japanese quail (Coturnix coturnix japonica). Poultry Science 82: 1174-1180.CrossRefGoogle ScholarPubMed
HOCKING, P.M., ROBERTSON, G.W. and GENTLE, M.J. (2005) Effects of non-steroidal anti-inflammatory drugs on painrelated behaviour in a model of articular pain in the domestic fowl. Research in Veterinary Science 78: 69-75.CrossRefGoogle Scholar
MAY, J.D. and MCNAUGHTON, J.L. (1980) Effects of dietary ascorbic acid, aspirin, lysine and thiouracil on thyroid activity. Poultry Science 59: 893-899.Google Scholar
MCDANIEL, C.D. and PARKER, H.M. (2004) The effect of acetylsalicylic acid on heat stress infertility of broiler breeder males. International Journal of Poultry Science 9: 570-577.Google Scholar
MCDANIEL, C.D., BALOG, J.M., FREED, M., ELKIN, R.G., WELLENREITER, R.H., KUCZEK, T. and HESTER, P.Y. (1993a) Response of layer breeder to dietary acetyl salicylic acid. 1. Effects on hen performance and eggshell quality. Poultry Science 72: 1084-1092.CrossRefGoogle Scholar
MCDANIEL, C.D., BALOG, J.M., FREED, M., ELKIN, R.G., WELLENREITER, R.H., KUCZEK, T. and HESTER, P.Y. (1993b) Response of layer breeder to dietary acetyl salicylic acid. 3. Effect on fertility and hatchability of embryos exposed to control and alleviated incubation temperatures. Poultry Science 72: 1100-1108.Google Scholar
MCNEAL, W.D., FLETCHER, D.L. and BUHR, R.J. (2003) Effects of stunning and decapitation on broiler activity during bleeding, blood loss, carcass and breast meat quality. Poultry Science 82:163-168.Google Scholar
MOHAMMAD, F.K., MANSOOR, A.S. and AL-ZUBAIDY, M.H.I. (2012) Comparative single intraperitoneal dose pharmacokinetics of aspirin and acetaminophen in chicks. Veterinari Medicina 57: 121-124.Google Scholar
MOHAMMED, A.A. (2010) Effect of acetyl salicylic acid (ASA) in drinking water on productive performance and blood characteristic of layer hens during heat stress. International Journal of Poultry Science 9: 382-385.Google Scholar
NAKAUE, H.S., WEBER, C.W. and REED, B.L. (1967) The influence of acetyl salicylic acid on growth and some respiratory enzymes in broiler chicks. Proceedings of the Society for Experimental Biology and Medicine 125: 663-664.Google Scholar
NASEEM, S., YOUNUS, M., BILAL, A., AAMIR, G., ASIM, A. and AKHTER, S. (2005) Effect of ascorbic acid and acetylsalicylic acid supplementation on performance of broiler chicks exposed to heat stress. International Journal of Poultry Science 4: 900-904.Google Scholar
OLUYEMI, J.A. and ADEBANJO, A. (1979) Measures applied to combat thermal stress in poultry under practical tropical environment. Poultry Science 58: 767-773.Google Scholar
POŹNIAK, B., YUAN, H., YI, J.E., GUO, C.Z., DENG, S.J., ZHU, L., YANG, Y. and S´WITALA, M. (2010) Influence of salicylate administration on weight gain and serum biochemical parameters in broiler chickens. Medycyna Weterynaryjna 66: 675-679.Google Scholar
POŹNIAK, B., GRABOWSKI, T., MOTYKIEWICZ-PERS, K., BOBREK, K., RAK, L. and BOBUSIA, K. (2015) Pharmacokinetics of repeated sodium salicylate administration to laying hens: evidence for time dependent increase in drug elimination from plasma and eggs. PloS One 10: e0123526. doi:10.1371/journal.pone.0123526.Google Scholar
POŹNIAK, B., ŚWITAŁA, M., JAWORSKI, K., OKONIEWSKI, P. and NIEWIŃSKI, P. (2013) Comparative pharmacokinetics of acetylsalicylic acid and sodium salicylate in chickens and turkeys. British Poultry Science 54: 538-544.Google Scholar
POŹNIAK, B., SWITALA, M., BOBREK, K., GRACZYK, S. and DZIMIRA, S. (2012) Adverse effects associated with high-dose acetylsalicylic acid and sodium salicylate treatment in broilers. British Poultry Science 53: 777-783.Google Scholar
REID, B.L., KURNICK, A.A., THOMAS, J.M. and HULETT, B.J. (1964) Effect of acetyl salicylic acid and oxytetracycline on the performance of White Leghorn breeders and broiler chicks. Poultry Science 43: 880-884.Google Scholar
REYNOLDS, E.F. (1982) Aspirin and similar analgesic and anti-inflammatory agents. Martindale: the extra pharmacopoeia (28th ed), pp. 234-82.Google Scholar
RICHARD, L.M. (2007) The 100 most important chemical compounds: a reference guide. ABC-CLIO. p. 10. ISBN 978-0-313-33758-1.Google Scholar
RIDDELL, C. (1975) The development of tibial dyschondroplasia. Avian Diseases 19: 443-462.Google Scholar
ROHLEDER, N. (2008) Preventing acute stress-induced inflammatory disinhibition by aspirin: What does it tell us about the mechanism? Brain, Behavior and Immunity 22: 148-149.CrossRefGoogle ScholarPubMed
ROUSSAN, D.A., KHWALDEH, G.Y., HADDAD, R.R., SHAHEEN, I.A., SALAMEH, G. and AL RIFAI, R. (2008) Effect of ascorbic acid, acetylsalicylic acid, sodium bicarbonate, and potassium chloride supplementation in water on the performance of broiler chickens exposed to heat stress. Journal of Applied and Poultry Research 17: 141-144.Google Scholar
RUBIO-GARCIA, M.E., RUBIO-LOZANO, M.S., PONCE-ALQUICIRA, E., ROSARIO-CORTES, C., NAVA, G.M. and CASTANEDA-SERRANO, M.P. (2015) Improving appearance and microbiologic quality of broiler carcasses with an allostatic modulator. Poultry Science 94: 1957-1963.Google Scholar
SHARMA, M.L. and BHATTI, J.S. (1998) Mechanical and chemical control of heat stress in growing White Leghorn pullets. Indian Journal of Animal Production and Management 14: 102-105.Google Scholar
STILBORN, H.L. (Jr), HARRIS, G.C., BOTTJE, W.G. and WALDROUP, P.W. (1988) Ascorbic acid and acetyl salicylic acid (Aspirin) in the diet of broilers maintained under heat stress conditions. Poultry Science 67: 1183-1187.CrossRefGoogle Scholar
THOMAS, J.M., NAKAUE, H.S. and REID, B.L. (1966) Effect of increasing levels of dietary acetyl salicylic acid on performance and cecal microbial counts of White Leghorn pullets. Poultry Science 45: 1313-1317.Google Scholar
TRAŞ, B., INAL, F., BAŞ, A., ALTUNOK, V.L., ELMAS, M. and YAZAR, E. (2000) Effect of continuous supplementation of ascorbic acid, aspirin, vitamin E and selenium on some haematological parameters and serum superoxide dismutase level in broiler chickens. British Poultry Science 41: 664-666.Google Scholar
TRUONG, A., SAYAGO, M.M., KUTTEH, W.H. and KE, R.W. (2016) Subchorionic hematomas are increased in early pregnancy in women taking low-dose aspirin. Fertility and Sterility 105: 1241-1246.Google Scholar
UHRIKOVA, I., SCHEER, P., HLOZKOVA, J., SUCHY, P. (Jr) and SEPSI, M. (2016) Effects of acetylsalicylic acid on coagulation tests and haptoglobin concentrations in rabbits with permanent transvenous pacing. Veterinarni Medicina 61: 528-532.Google Scholar
VECEREK, V., GRBALOVA, S., VOSLAROVA, E., JANACKOVA, B. and MALENA, M. (2006) Effects of travel distance and the season of the year on death rates of broilers transported to poultry processing plants. Poultry Science 85: 1881-1884.CrossRefGoogle ScholarPubMed
WANG, X., HUANG, L.L., CHEN, D.M., IHSAN, A. and YUAN, Z.H. (2010) Analytical determination and pharmacokinetics of major metabolites of carbasalate calcium in broilers following oral administration. Journal of Veterinary Pharmacology and Therapeutics 34: 410-416.Google Scholar
WEISSMANN, G. (1991) Aspirin. Science American 264: 84-90.Google Scholar
WHITING, T.L., DRAIN, M.E. and RASALI, D.P. (2007) Warm weather transport of broiler chickens in Manitoba. II. Truck management factors associated with death loss in transit to slaughter. Canadian Veterinary Journal 48: 148-154.Google Scholar
WU, D., ZHANG, M., LU, Y., TANG, S., KEMPER, N., HARTUNG, J. and BAO, E. (2016a) Aspirin-induced heat stress resistance in chicken myocardial cells can be suppressed by BAPTA-AM in vitro. Cell Stress Chaperones 21: 817-827.Google Scholar
WU, D., ZHANG, M., XU, J., SONG, E., LV, Y., TANG, S., ZHANG, X., KEMPER, N., HARTUNG, J. and BAO, E. (2016b) In vitro evaluation of aspirin-induced HspB1 against heat stress damage in chicken myocardial cells. Cell Stress Chaperones 21: 405-413.Google Scholar
WU, D., XU, J., SONG, E., TANG, S., ZHANG, X., KEMPER, N., HARTUNG, J. and BAO, E. (2015) Acetyl salicylic acid protected against heat stress damage in chicken myocardial cells and may associate with induced Hsp27 expression. Cell Stress Chaperones 20: 687-696.Google Scholar
ZHANG, X., QIAN, Z., ZHU, H., TANG, S., WU, D., ZHANG, M., KEMPER, N., HARTUNG, J. and BAO, E. (2016) HSP90 gene expression induced by aspirin is associated with damage remission in a chicken myocardial cell culture exposed to heat stress. British Poultry Science 57:462-73.Google Scholar