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Can mesenchymal stem cells derived from adipose tissue and their conditioned medium improve ovarian functions? A mini-review

Published online by Cambridge University Press:  22 June 2022

Tayebe Pouryousefi-koodehi ,
Shika Shayegan ,
Soheyla Hashemi ,
Reza Arefnezhad ,
Hossein Roghani-Shahraki ,
Hossein Motedayyen ,
Neda Taghizabet  and
Fatemeh Rezaei-Tazangi Open the ORCID record for Fatemeh Rezaei-Tazangi [Opens in a new window]
Tayebe Pouryousefi-koodehi
Affiliation:
Department of Emergency, Milad Hospital, Tehran, Iran
Shika Shayegan
Affiliation:
Cyprus University of Health and Social Sciences, Faculty of Pharmacy, Kutlu Adali Boulevard, Guzelyurt, Cyprus
Soheyla Hashemi
Affiliation:
Stem Cell and Regenerative Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Reza Arefnezhad*
Affiliation:
Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Hossein Roghani-Shahraki
Affiliation:
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Hossein Motedayyen
Affiliation:
Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran
Neda Taghizabet
Affiliation:
Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Fatemeh Rezaei-Tazangi
Affiliation:
Department of Anatomy, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
*
Author for correspondence: Reza Arefnezhad. Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. E-mail: Arefnezhad@sums.ac.ir
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Summary

Stable ovarian function is a key factor in the performance of the reproductive system. In contrast, some ovarian function-related diseases, such as polycystic ovarian syndrome, premature ovarian failure (POF), and ovarian cancer, are the main cause of infertility and death of women around the world. Despite multiple attempts, there are no effective tools against these conditions; however, mesenchymal stem cell-based therapy, especially using adipose tissue, has attracted much attention in medicine in light of its advantages such as easy isolation and accessibility. Conversely, it has been suggested that MSC-conditioned medium (CM) can restore injured tissues and has high immunocompatibility. So, here, we will summarize the effects of administration of MSCs and CM derived from adipose tissue on ovarian functions and related diseases.

Keywords

Adipose tissue-derived mesenchymal stem cellConditioned mediumOvarian function
Type
Review Article
Information
Zygote , Volume 30 , Issue 5 , October 2022 , pp. 589 - 592
Copyright
© The Author(s), 2022. Published by Cambridge University Press

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