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Does the meiotic spindle really predicts embryo implantation and live birth rates? An update

Published online by Cambridge University Press:  05 December 2018

Sabela García-Oro Open the ORCID record for Sabela García-Oro [Opens in a new window]  and
Diana Valverde
Sabela García-Oro*
Affiliation:
Equipo Ron – Hospital Quironsalud A Coruña, C/Londres 2, 15009 A Coruña, Spain
Diana Valverde
Affiliation:
Department Biochemistry, Genetics and Immunology, Faculty of Biology, University of Vigo, Campus As Lagoas Marcosende S/N, 36310 Vigo, Spain Instituto de Investigación Sanitaria Galicia Sur, Pontevedra, Spain
*
Address for correspondence: Sabela García-Oro. Equipo Ron – Hospital Quironsalud A Coruña, C/Londres 2, 15009 A Coruña, Spain. E-mail: sabela.oro@quironsalud.es
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Summary

The aim of this study was to determine the capacity of the meiotic spindle (MS) to predict embryo implantation and live birth rates. For this purpose, we performed a broad systematic literature search. Of all publications retrieved, only those in which the implantation rates were related to some characteristics of the MS were evaluated. Despite the different methodology used in all the chosen studies, presence of the MS in oocytes was found to be positively associated with embryo implantation. Moreover, high retardance values, as well as strict criteria of normality in the MS structure, are significantly related to higher embryo implantation numbers and live birth rates.

Keywords

Embryo implantationLive birth rateMeiotic spindlePolarized lightRetardance
Type
Review Article
Information
Zygote , Volume 27 , Issue 1 , February 2019 , pp. 1 - 4
Copyright
© Cambridge University Press 2018 

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References

Chamayou, S, Ragolia, C, Alecci, C, Storaci, G, Maglia, E, Russo, E and Guglielmino, A (2006) Meiotic spindle presence and oocyte morphology do not predict clinical ICSI outcomes: a study of 967 transferred embryos. Reprod Biomed Online 13, 661–667.Google Scholar
Cohen, Y, Malcov, M, Schwartz, T, Mey-Raz, N, Carmon, A, Cohen, T, Lessing, JB, Amit, AA and Azem, F (2004) Spindle imaging: a new marker for optimal timing of ICSI? Hum Reprod 19, 649–654.Google Scholar
de Almeida Ferreira Braga, D, de Cássia Sávio Figueira, R, Rodrigues, D, Madaschi, C, Pasqualotto, FF, Iaconelli, A and Borges, E (2008) Prognostic value of meiotic spindle imaging on fertilization rate and embryo development in in vitro-matured human oocytes. Fertil Steril 90, 429–433.Google Scholar
Fang, C, Tang, M, Li, T, Peng, WL, Zhou, CQ, Zhuang, GL and Leong, M (2007) Visualization of meiotic spindle and subsequent embryonic development in in vitro and in vivo matured human oocytes. J Assist Reprod Genet 24, 547–551.Google Scholar
García-Oro, S, Rey, MI, Rodríguez, M, Durán, Á, Devesa, R and Valverde, D (2017) Predictive value of spindle retardance in embryo implantation rate. J Assist Reprod Genet 34, 617–625.Google Scholar
Heindryckx, B, De Gheselle, S, Lierman, S, Gerris, J and De Sutter, P (2011) Efficiency of polarized microscopy as a predictive tool for human oocyte quality. Hum Reprod 26, 535–544.Google Scholar
Hunt, PA and Hassold, TJ (2008) Human female meiosis: what makes a good egg go bad? Trends Genet 24, 86–93.Google Scholar
Kilani, S, Cooke, S, Kan, A and Chapman, M (2009) Are there non-invasive markers in human oocytes that can predict pregnancy outcome? Reprod Biomed Online 18, 674–680.Google Scholar
Kilani, S, Cooke, S, Tilia, L and Chapman, M (2011) Does meiotic spindle normality predict improved blastocyst development, implantation and live birth rates? Fertil Steril 96, 389–393.Google Scholar
Konc, J, Kanyó, K and Cseh, S (2004) Visualization and examination of the meiotic spindle in human oocytes with polscope. J Assist Reprod Genet 21, 349–353.Google Scholar
Korkmaz, C, Sakinci, M, Bayoglu Tekin, Y and Ercan, CM (2014) Do quantitative birefringence characteristics of meiotic spindle and zona pellucida have an impact on implantation in single embryo transfer cycles? Arch Gynecol Obstet 289, 433–438.Google Scholar
Madaschi, C, de Souza Bonetti, TC, de Almeida Ferreira Braga, DP, Pasqualotto, FF, Iaconelli, A and Borges, E (2008) Spindle imaging: a marker for embryo development and implantation. Fertil Steril 90, 194–198.Google Scholar
Magli, CM, Capoti, A, Resta, S, Stanghellini, I, Ferraretti, AP and Gianaroli, L (2011) Prolonged absence of meiotic spindles by birefringence imaging negatively affects normal fertilization and embryo development. Reprod Biomed Online 23, 747–754.Google Scholar
Molinari, E, Evangelista, F, Racca, C, Cagnazzo, C and Revelli, A (2012) Polarized light microscopy-detectable structures of human oocytes and embryos are related to the likelihood of conception in IVF. J Assist Reprod Genet 29, 1117–1122.Google Scholar
Montag, M and van der Ven, H (2008) Symposium: innovative techniques in human embryo viability assessment. Oocyte assessment and embryo viability prediction: birefringence imaging. Reprod Biomed Online 17, 454–460.Google Scholar
Moon, JH, Hyun, CS, Lee, SW, Son, WY, Yoon, SH and Lim, JH (2003) Visualization of the metaphase II meiotic spindle in living human oocytes using the polscope enables the prediction of embryonic developmental competence after ICSI. Hum Reprod 18, 817–820.Google Scholar
Petersen, CG, Oliveira, JB, Mauri, AL, Massaro, FC, Baruffi, RLR, Pontes, A and Franco, JG (2009) Relationship between visualization of meiotic spindle in human oocytes and ICSI outcomes: a meta-analysis. Reprod Biomed Online 18, 235–243.Google Scholar
Rama Raju, GA, Prakash, GJ, Krishna, KM and Madan, K (2007) Meiotic spindle and zona pellucida characteristics as predictors of embryonic development: a preliminary study using PolScope imaging. Reprod Biomed Online 14, 166–174.Google Scholar
de Santis, L, Cino, I, Rabellotti, E, Calzi, F, Persico, P, Borini, A and Coticchio, G (2005) Polar body morphology and spindle imaging as predictors of oocyte quality. Reprod Biomed Online 11, 36–42.Google Scholar
Sharma, RK, Azeem, A and Agarwal, A (2013) Spindle and chromosomal alterations in metaphase II oocytes. Reprod Sci 20, 1293–1301.Google Scholar
Shen, Y, Stalf, T, Mehnert, C, de Santis, L, Cino, I, Tinneberg, H-R and Eichenlaub-Ritter, U (2006) Light retardance by human oocyte spindle is positively related to pronuclear score after ICSI. Reprod Biomed Online 12, 737–751.Google Scholar
Wang, WH, Meng, L, Hackett, RJ and Keefe, DL (2001a) Developmental ability of human oocytes with or without birefringent spindles imaged by Polscope before insemination. Hum Reprod 16, 1464–1468.Google Scholar
Wang, WH, Meng, L, Hackett, RJ, Odenbourg, R and Keefe, DL (2001b) The spindle observation and its relationship with fertilization after intracytoplasmic sperm injection in living human oocytes. Fertil Steril 75, 348–353.Google Scholar