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Hyper-polyploid embryos survive after implantation in mice

Published online by Cambridge University Press:  10 March 2020

Hiroyuki Imai ,
Tokuko Iwamori ,
Ken Takeshi Kusakabe ,
Yasuo Kiso ,
Etsuro Ono  and
Kiyoshi Kano Open the ORCID record for Kiyoshi Kano [Opens in a new window]
Hiroyuki Imai
Affiliation:
Department of Biomedicine, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan Laboratory of Veterinary Developmental Biology, United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi, Japan
Tokuko Iwamori
Affiliation:
Department of Biomedicine, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
Ken Takeshi Kusakabe
Affiliation:
Laboratory of Veterinary Anatomy, United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi, Japan
Yasuo Kiso
Affiliation:
Laboratory of Veterinary Anatomy, United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi, Japan
Etsuro Ono
Affiliation:
Department of Biomedicine, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
Kiyoshi Kano*
Affiliation:
Laboratory of Veterinary Developmental Biology, United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi, Japan
*
Author for correspondence: Kiyoshi Kano, Laboratory of Veterinary Developmental Biology, United Graduate School of Veterinary Science, Yamaguchi University, 1677-1, Yoshida, Yamaguchi City, Yamaguchi Prefecture, Japan. Tel: +81 83 933 5883. E-mail: kanokiyo@yamaguchi-u.ac.jp
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Summary

Polyploids generated by natural whole genome duplication have served as a dynamic force in vertebrate evolution. As evidence for evolution, polyploid organisms exist generally, however there have been no reports of polyploid organisms in mammals. In mice, polyploid embryos under normal culture conditions normally develop to the blastocyst stage. Nevertheless, most tetraploid embryos degenerate after implantation, indicating that whole genome duplication produces harmful effects on normal development in mice. Most previous research on polyploidy has mainly focused on tetraploid embryos. Analysis of various ploidy outcomes is important to comprehend the effects of polyploidization on embryo development. The purpose of this present study was to discover the extent of the polyploidization effect on implantation and development in post-implantation embryos. This paper describes for the first time an octaploid embryo implanted in mice despite hyper-polyploidization, and indicates that these mammalian embryos have the ability to implant, and even develop, despite the harmfulness of extreme whole genome duplication.

Keywords

EmbryoImplantationMouseOctaploidPolyploid
Type
Short Communication
Information
Zygote , Volume 28 , Issue 3 , June 2020 , pp. 247 - 249
Copyright
© Cambridge University Press 2020

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