22 results
Impact of primary care triage using the Head and Neck Cancer Risk Calculator version 2 on tertiary head and neck services in the post-coronavirus disease 2019 period
- Jiak-Ying Tan, Christopher John Callaghan, Alexander William Lewthwaite, Claudia Ching Hei Chan, Colette Teng Wee, Emily Yeg Hei To, Isabel Summers, James William Nelson, Mathew Benjamin Smith, Lucy Qian Li, Catriona Morton, Lorna Porteous, Andrew Stewart Evans, Iain James Nixon
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- The Journal of Laryngology & Otology , First View
- Published online by Cambridge University Press:
- 22 January 2024, pp. 1-6
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Objective
This study investigates the impact of primary care utilisation of a symptom-based head and neck cancer risk calculator (Head and Neck Cancer Risk Calculator version 2) in the post-coronavirus disease 2019 period on the number of primary care referrals and cancer diagnoses.
MethodsThe number of referrals from April 2019 to August 2019 and from April 2020 to July 2020 (pre-calculator) was compared with the number from the period January 2021 to August 2022 (post-calculator) using the chi-square test. The patients’ characteristics, referral urgency, triage outcome, Head and Neck Cancer Risk Calculator version 2 score and cancer diagnosis were recorded.
ResultsIn total, 1110 referrals from the pre-calculator period were compared with 1559 from the post-calculator period. Patient characteristics were comparable for both cohorts. More patients were referred on the cancer pathway in the post-calculator cohort (pre-calculator patients 51.1 per cent vs post-calculator 64.0 per cent). The cancer diagnosis rate increased from 2.7 per cent in the pre-calculator cohort to 3.3 per cent in the post-calculator cohort. A lower rate of cancer diagnosis in the non-cancer pathway occurred in the cohort managed using the Head and Neck Cancer Risk Calculator version 2 (10 per cent vs 23 per cent, p = 0.10).
ConclusionHead and Neck Cancer Risk Calculator version 2 demonstrated high sensitivity in cancer diagnosis. Further studies are required to improve the predictive strength of the calculator.
Floods Amidst COVID-19 in Malaysia: Implications on the Pandemic Responses
- Yuki Julius Ng, Alexander Lourdes Samy, Shu Leed Tan, Prishalini Ramesh, Wei Pin Hung, Attaullah Ahmadi, Don Eliseo Lucero-Prisno III
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- Journal:
- Disaster Medicine and Public Health Preparedness / Volume 16 / Issue 6 / December 2022
- Published online by Cambridge University Press:
- 23 December 2021, pp. 2218-2219
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Frontmatter
- Alex M. Lechner, Chee Meng Tan, Angela Tritto, Alexander Horstmann, Hoong Chen Teo, John R. Owen, Ahimsa Campos-Arceiz
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- The Belt and Road Initiative
- Published by:
- ISEAS–Yusof Ishak Institute
- Published online:
- 28 October 2021
- Print publication:
- 01 August 2021, pp i-iv
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Foreword
- Alex M. Lechner, Chee Meng Tan, Angela Tritto, Alexander Horstmann, Hoong Chen Teo, John R. Owen, Ahimsa Campos-Arceiz
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- The Belt and Road Initiative
- Published by:
- ISEAS–Yusof Ishak Institute
- Published online:
- 28 October 2021
- Print publication:
- 01 August 2021, pp v-vi
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Summary
The economic, political, strategic and cultural dynamism in Southeast Asia has gained added relevance in recent years with the spectacular rise of giant economies in East and South Asia. This has drawn greater attention to the region and to the enhanced role it now plays in international relations and global economics.
The sustained effort made by Southeast Asian nations since 1967 towards a peaceful and gradual integration of their economies has had indubitable success, and perhaps as a consequence of this, most of these countries are undergoing deep political and social changes domestically and are constructing innovative solutions to meet new international challenges. Big Power tensions continue to be played out in the neighbourhood despite the tradition of neutrality exercised by the Association of Southeast Asian Nations (ASEAN).
The Trends in Southeast Asia series acts as a platform for serious analyses by selected authors who are experts in their fields. It is aimed at encouraging policymakers and scholars to contemplate the diversity and dynamism of this exciting region.
THE EDITORS
Series Chairman:
Choi Shing Kwok
Series Editor:
Ooi Kee Beng
Editorial Committee:
Su-Ann Oh
Daljit Singh
Francis E. Hutchinson
Benjamin Loh
The Belt and Road Initiative: Environmental Impacts in Southeast Asia
- Alex M. Lechner, Chee Meng Tan, Angela Tritto, Alexander Horstmann, Hoong Chen Teo, John R. Owen, Ahimsa Campos-Arceiz
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- Book:
- The Belt and Road Initiative
- Published by:
- ISEAS–Yusof Ishak Institute
- Published online:
- 28 October 2021
- Print publication:
- 01 August 2021, pp vii-viii
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Summary
EXECUTIVE SUMMARY
• China's Belt and Road Initiative (BRI) is expected to be the largest infrastructure development scheme of the twenty-first century.
• There is escalating concern over BRI's potential environmental impacts in Southeast Asia, a global biodiversity hotspot and a focus area of BRI development.
• Case studies of Indonesia, Myanmar, Lao PDR and Malaysia show that the success of BRI in bringing about sustainable growth and opportunities depends on the Chinese government and financiers, as well as the agencies and governments involved when BRI investments take place.
• The adoption of best environmental practices is critical in ensuring that growth is sustainable and that bad environmental practices are not locked in for decades to come.
The Belt and Road Initiative: Environmental Impacts in Southeast Asia
- Alex M. Lechner, Chee Meng Tan, Angela Tritto, Alexander Horstmann, Hoong Chen Teo, John R. Owen, Ahimsa Campos-Arceiz
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- Book:
- The Belt and Road Initiative
- Published by:
- ISEAS–Yusof Ishak Institute
- Published online:
- 28 October 2021
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- 01 August 2021, pp 1-30
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Summary
INTRODUCTION
China's Belt and Road Initiative (BRI) is expected to be the largest infrastructure development scheme of the twenty-first century. It involves over eighty countries, with overall investments estimated to be between US$1 trillion to US$8.5 trillion.
President Xi Jinping launched the BRI in 2013, describing the initiative as an exercise in “economic cooperation” with a focus on connectivityand trade. The primary goals are to create policy coordination between countries, increase cultural exchange, promote financial integration and cooperation, facilitate international trade, and increase connectivity through infrastructure development.
While the goal of improving the prospects of developing nations is laudable, scholars across the world have raised concerns around the potential environmental and social impacts of the BRI. Of the five goals, perhaps the most visible and worrying is infrastructure development, notably via six terrestrial infrastructure corridors, a marine economic route and a recently announced polar BRI. These routes are expected to connect more than half of the world's population. Infrastructure development will include mega projects to overcome geographic barriers to growth such as those seen in ASEAN members states.
Southeast Asia, with a population of 320 million, which is expected to grow to 526 million by 2050, represents huge opportunities for trade and is a focus of BRI investment. The economic effects of BRI investments could be transformational and could smooth out income inequalities within ASEAN where gross domestic product per capita varies from as little as US$3,645 in Cambodia to US$85,535 in Singapore.
The direct and secondary impacts associated with major infrastructure corridors have been identified as posing threats to biodiversity in an already ecologically vulnerable region. Infrastructure development could negatively affect the atmosphere, hydrosphere, geosphere, and biosphere. Southeast Asia is home to four out of thirty-four of the planet's biodiversity hotspots and to the Coral Triangle, also known as the Amazon of the ocean, which hosts 600 reef-building coral species.
In this review we provide a synoptic overview of the potential environmental impacts in the region. We start with an inventory of BRI projects in Southeast Asia, and then we describe the potential negative impacts of BRI from an environmental perspective.
The Belt and Road Initiative
- Environmental Impacts in Southeast Asia
- Alex M. Lechner, Chee Meng Tan, Angela Tritto, Alexander Horstmann, Hoong Chen Teo, John R. Owen, Ahimsa Campos-Arceiz
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- Published by:
- ISEAS–Yusof Ishak Institute
- Published online:
- 28 October 2021
- Print publication:
- 01 August 2021
-
China's Belt and Road Initiative (BRI) is expected to be the largest infrastructure development scheme of the twenty-first century. There is escalating concern over BRI's potential environmental impacts in Southeast Asia, a global biodiversity hotspot and a focus area of BRI development. Case studies of Indonesia, Myanmar, Lao PDR and Malaysia show that the success of BRI in bringing about sustainable growth and opportunities depends on the Chinese government and financiers, as well as the agencies and governments involved when BRI investments take place. The adoption of best environmental practices is critical in ensuring that growth is sustainable and that bad environmental practices are not locked in for decades to come.
Air Quality Monitoring During High-Level Biocontainment Ground Transport: Observations From Two Operational Exercises
- Audrey Dang, Brent Williams, William D. Warsing, Michael Noone, Alexander P. Isakov, David K. Tan, Stephen Y. Liang
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- Journal:
- Disaster Medicine and Public Health Preparedness / Volume 16 / Issue 4 / August 2022
- Published online by Cambridge University Press:
- 28 June 2021, pp. 1482-1489
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Objective:
Stretcher transport isolators provide mobile, high-level biocontainment outside the hospital for patients with highly infectious diseases, such as Ebola virus disease. Air quality within this confined space may pose human health risks.
Methods:Ambient air temperature, relative humidity, and CO2 concentration were monitored within an isolator during 2 operational exercises with healthy volunteers, including a ground transport exercise of approximately 257 miles. In addition, failure of the blower unit providing ambient air to the isolator was simulated. A simple compartmental model was developed to predict CO2 and H2O concentrations within the isolator.
Results:In both exercises, CO2 and H2O concentrations were elevated inside the isolator, reaching steady-state values of 4434 ± 1013 ppm CO2 and 22 ± 2 mbar H2O in the first exercise and 3038 ± 269 ppm CO2 and 20 ± 1 mbar H2O in the second exercise. When blower failure was simulated, CO2 concentration exceeded 10 000 ppm within 8 minutes. A simple compartmental model predicted CO2 and H2O concentrations by accounting for human emissions and blower air exchange.
Conclusions:Attention to air quality within stretcher transport isolators (including adequate ventilation to prevent accumulation of CO2 and other bioeffluents) is needed to optimize patient safety.
Implementing standard screening for autism spectrum disorder in CHD
- Alexander Tan, Eric S. Semmel, Ian Wolf, Bailee Hammett, Dawn Ilardi
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- Journal:
- Cardiology in the Young / Volume 30 / Issue 8 / August 2020
- Published online by Cambridge University Press:
- 25 June 2020, pp. 1118-1125
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Introduction:
While the overall prevalence of autism is 1.7% in the United States of America, research has demonstrated a two- to five-fold increase in CHD. The Cardiac Neurodevelopmental Outcome Collaborative recommends screening for autism from infancy through adolescence. This study investigated the frequency of autism concerns at a single Cardiac Neurodevelopmental Program and examined current clinical practice as a way to improve quality of care.
Materials and methods:Patients (n = 134; mean age = 9.0 years) included children with high-risk CHD who completed a neurodevelopmental evaluation following a formalised referral to the Cardiac Neurodevelopmental Program between 2018 and 2019. Retrospective chart review included parent report on the Behaviour Assessment System for Children-3 and Adaptive Behaviour Assessment System-3. Descriptive and correlation analyses were completed.
Results:In this sample, 11.2% presented with autism-related concerns at referral, 2 were diagnosed with autism, 9 were referred to an autism specialist (6 confirmed diagnosis; 3 not completed). Thus, at least 5.9% of the sample were diagnosed with autism following thorough clinical evaluation. Analyses showed atypicality, along with deficient adaptability, leisure, social, and communication skills. Frequency of early intervention, school supports, and relation with comorbidities are reported.
Discussion:Prior to assessment recommendations by the Cardiac Neurodevelopmental Outcome Collaborative, autism screening may not be completed systematically in clinical care for CHD. The current sample demonstrates a high frequency of autism in the typically referred clinical sample. Commonly used parent-report measures may reveal concerns but will not help diagnosis. Systematic use of an autism screener is essential.
Equivalency of the diagnostic accuracy of the PHQ-8 and PHQ-9: a systematic review and individual participant data meta-analysis – ERRATUM
- Yin Wu, Brooke Levis, Kira E. Riehm, Nazanin Saadat, Alexander W. Levis, Marleine Azar, Danielle B. Rice, Jill Boruff, Pim Cuijpers, Simon Gilbody, John P.A. Ioannidis, Lorie A. Kloda, Dean McMillan, Scott B. Patten, Ian Shrier, Roy C. Ziegelstein, Dickens H. Akena, Bruce Arroll, Liat Ayalon, Hamid R. Baradaran, Murray Baron, Charles H. Bombardier, Peter Butterworth, Gregory Carter, Marcos H. Chagas, Juliana C. N. Chan, Rushina Cholera, Yeates Conwell, Janneke M. de Manvan Ginkel, Jesse R. Fann, Felix H. Fischer, Daniel Fung, Bizu Gelaye, Felicity Goodyear-Smith, Catherine G. Greeno, Brian J. Hall, Patricia A. Harrison, Martin Härter, Ulrich Hegerl, Leanne Hides, Stevan E. Hobfoll, Marie Hudson, Thomas Hyphantis, Masatoshi Inagaki, Nathalie Jetté, Mohammad E. Khamseh, Kim M. Kiely, Yunxin Kwan, Femke Lamers, Shen-Ing Liu, Manote Lotrakul, Sonia R. Loureiro, Bernd Löwe, Anthony McGuire, Sherina Mohd-Sidik, Tiago N. Munhoz, Kumiko Muramatsu, Flávia L. Osório, Vikram Patel, Brian W. Pence, Philippe Persoons, Angelo Picardi, Katrin Reuter, Alasdair G. Rooney, Iná S. Santos, Juwita Shaaban, Abbey Sidebottom, Adam Simning, Lesley Stafford, Sharon Sung, Pei Lin Lynnette Tan, Alyna Turner, Henk C. van Weert, Jennifer White, Mary A. Whooley, Kirsty Winkley, Mitsuhiko Yamada, Andrea Benedetti, Brett D. Thombs
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- Journal:
- Psychological Medicine / Volume 50 / Issue 16 / December 2020
- Published online by Cambridge University Press:
- 19 August 2019, p. 2816
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Equivalency of the diagnostic accuracy of the PHQ-8 and PHQ-9: a systematic review and individual participant data meta-analysis
- Yin Wu, Brooke Levis, Kira E. Riehm, Nazanin Saadat, Alexander W. Levis, Marleine Azar, Danielle B. Rice, Jill Boruff, Pim Cuijpers, Simon Gilbody, John P.A. Ioannidis, Lorie A. Kloda, Dean McMillan, Scott B. Patten, Ian Shrier, Roy C. Ziegelstein, Dickens H. Akena, Bruce Arroll, Liat Ayalon, Hamid R. Baradaran, Murray Baron, Charles H. Bombardier, Peter Butterworth, Gregory Carter, Marcos H. Chagas, Juliana C. N. Chan, Rushina Cholera, Yeates Conwell, Janneke M. de Man-van Ginkel, Jesse R. Fann, Felix H. Fischer, Daniel Fung, Bizu Gelaye, Felicity Goodyear-Smith, Catherine G. Greeno, Brian J. Hall, Patricia A. Harrison, Martin Härter, Ulrich Hegerl, Leanne Hides, Stevan E. Hobfoll, Marie Hudson, Thomas Hyphantis, Masatoshi Inagaki, Nathalie Jetté, Mohammad E. Khamseh, Kim M. Kiely, Yunxin Kwan, Femke Lamers, Shen-Ing Liu, Manote Lotrakul, Sonia R. Loureiro, Bernd Löwe, Anthony McGuire, Sherina Mohd-Sidik, Tiago N. Munhoz, Kumiko Muramatsu, Flávia L. Osório, Vikram Patel, Brian W. Pence, Philippe Persoons, Angelo Picardi, Katrin Reuter, Alasdair G. Rooney, Iná S. Santos, Juwita Shaaban, Abbey Sidebottom, Adam Simning, Lesley Stafford, Sharon Sung, Pei Lin Lynnette Tan, Alyna Turner, Henk C. van Weert, Jennifer White, Mary A. Whooley, Kirsty Winkley, Mitsuhiko Yamada, Andrea Benedetti, Brett D. Thombs
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- Psychological Medicine / Volume 50 / Issue 8 / June 2020
- Published online by Cambridge University Press:
- 12 July 2019, pp. 1368-1380
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Background
Item 9 of the Patient Health Questionnaire-9 (PHQ-9) queries about thoughts of death and self-harm, but not suicidality. Although it is sometimes used to assess suicide risk, most positive responses are not associated with suicidality. The PHQ-8, which omits Item 9, is thus increasingly used in research. We assessed equivalency of total score correlations and the diagnostic accuracy to detect major depression of the PHQ-8 and PHQ-9.
MethodsWe conducted an individual patient data meta-analysis. We fit bivariate random-effects models to assess diagnostic accuracy.
Results16 742 participants (2097 major depression cases) from 54 studies were included. The correlation between PHQ-8 and PHQ-9 scores was 0.996 (95% confidence interval 0.996 to 0.996). The standard cutoff score of 10 for the PHQ-9 maximized sensitivity + specificity for the PHQ-8 among studies that used a semi-structured diagnostic interview reference standard (N = 27). At cutoff 10, the PHQ-8 was less sensitive by 0.02 (−0.06 to 0.00) and more specific by 0.01 (0.00 to 0.01) among those studies (N = 27), with similar results for studies that used other types of interviews (N = 27). For all 54 primary studies combined, across all cutoffs, the PHQ-8 was less sensitive than the PHQ-9 by 0.00 to 0.05 (0.03 at cutoff 10), and specificity was within 0.01 for all cutoffs (0.00 to 0.01).
ConclusionsPHQ-8 and PHQ-9 total scores were similar. Sensitivity may be minimally reduced with the PHQ-8, but specificity is similar.
Underground nuclear astrophysics experiment JUNA in China
- LIU WeiPing, LI ZhiHong, HE JiangJun, TANG XiaoDong, LIAN Gang, An Zhu, Chang JianJun, Chen LiHua, Chen Han, Chen QingHao, Chen XiongJun, Chen ZhiJun, Cui BaoQun, Du XianChao, Fu ChangBo, Gan Lin, Guo Bing, He GuoZhu, Heger Alexander, Hou SuQing, Huang HanXiong, Huang Ning, Jia BaoLu, Jiang LiYang, Kubono Shigeru, Li JianMin, Li KuoAng, Li Tao, Li YunJu, Lugaro Maria, Luo XiaoBing, Ma HongYi, Ma ShaoBo, Mei DongMing, Qian YongZhong, Qin JiuChang, Ren Jie, Shen YangPing, Su Jun, Sun LiangTing, Tan WanPeng, Tanihata Isao, Wang Shuo, Wang Peng, Wang YouBao, Wu Qi, Xu ShiWei, Yan ShengQuan, Yang LiTao, Yang Yao, Yu XiangQing, Yue Qian, Zeng Sheng, Zhang HuanYu, Zhang Hui, Zhang LiYong, Zhang NingTao, Zhang QiWei, Zhang Tao, Zhang XiaoPeng, Zhang XueZhen, Zhang ZiMing, Zhao Wei, Zhao Zuo, Zhou Chao
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- Journal:
- Proceedings of the International Astronomical Union / Volume 15 / Issue S350 / April 2019
- Published online by Cambridge University Press:
- 12 October 2020, pp. 313-320
- Print publication:
- April 2019
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Underground Nuclear Astrophysics in China (JUNA) will take the advantage of the ultra-low background in Jinping underground lab. High current accelerator with an ECR source and detectors were commissioned. JUNA plans to study directly a number of nuclear reactions important to hydrostatic stellar evolution at their relevant stellar energies. At the first period, JUNA aims at the direct measurements of 25Mg(p,γ)26 Al, 19F(p,α) 16 O, 13C(α, n) 16O and 12C(α,γ) 16O near the Gamow window. The current progress of JUNA will be given.
3393 Biomarkers of Stroke Recovery Study
- Matthew A. Edwardson, Amrita Cheema, Ming Tan, Alexander Dromerick
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- Journal:
- Journal of Clinical and Translational Science / Volume 3 / Issue s1 / March 2019
- Published online by Cambridge University Press:
- 26 March 2019, pp. 35-36
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OBJECTIVES/SPECIFIC AIMS: There are currently no established blood-based biomarkers of recovery and neural repair following stroke in humans. Such biomarkers would be extremely valuable for aiding in stroke prognosis, timing rehabilitation therapies, and designing drugs to augment natural repair mechanisms. Metabolites, including lipids and amino acids, are engaged in many cellular processes and cross the blood-brain barrier more easily than proteins. Recent advances in liquid chromatography / mass spectrometry (LCMS) allow researchers to obtain a biochemical fingerprint of the metabolites in various biofluids. Thus, metabolite biomarkers of neural repair after brain injury are a promising avenue for future research. Objective: Design and conduct a study to identify metabolite changes in the blood associated with good and poor motor recovery following stroke. METHODS/STUDY POPULATION: We launched the Biomarkers of Stroke Recovery (BIOREC) study, which seeks to enroll 70 participants suffering arm motor impairment following stroke and 35 matched controls. BIOREC is a longitudinal observational study. Fasting blood samples are collected at 5, 15, and 30 days post-stroke, processed, and stored in the Georgetown Lombardi biorepository. Outcome measures, including measures of motor impairment, cognition and language, are assessed at 5, 15, 30, and 90 days post-stroke. The primary outcome measure is the upper extremity Fugl-Meyer score. Control participants are matched for age +/− 1 yr, race, gender, cardiovascular comorbities, and statin use through a computer algorithm that screens the entire MedStar electronic health record (EHR). Control participants provide 2 fasting blood samples one month apart. Once all samples are collected and sent for LCMS analysis, logistic regression analysis will identify potential metabolite biomarkers by comparing participants with good recovery to those with poor recovery as well as stroke participants to controls. RESULTS/ANTICIPATED RESULTS: To date, forty stroke participants have enrolled from 4 acute care hospitals in the Washington, DC metro region and completed all study procedures. Twenty stroke participants either dropped out or were withdrawn due to other medical concerns. Stroke patients ended up at a variety of venues following their acute hospitalization including the acute rehabilitation hospital, skilled nursing facilities, and home. We learned to overcome these logistical challenges by traveling to wherever the patients were sent and notifying medical providers of their study participation. In rare cases we have paid to transport patients from skilled nursing facilities to the clinic, which has reduced dropouts. In addition to the stroke participants, we have enrolled 7 healthy control participants using the EHR screening algorithm. DISCUSSION/SIGNIFICANCE OF IMPACT: Performing a longitudinal study in the early recovery phase following stroke is logistically challenging, but feasible. Difficulty in identifying participants with isolated motor impairment requires added effort to eliminate dropouts. Screening the EHR is an effective method to identify matched controls. Future metabolomics analysis of stored blood samples holds promise to identify biomarkers of stroke recovery and neural repair.
Pitt-Hopkins Syndrome: A Unique Case Study
- Alexander Tan, Kimberly Goodspeed, Veronica Bordes Edgar
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- Journal:
- Journal of the International Neuropsychological Society / Volume 24 / Issue 9 / October 2018
- Published online by Cambridge University Press:
- 30 October 2018, pp. 995-1002
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Objectives: Pitt-Hopkins syndrome (PTHS) is a rare genetic disorder caused by insufficient expression of the TCF4 gene. Most cases are characterized by severe intellectual disability, absent speech, motor delays, and autism spectrum disorder. Many have abnormal brain imaging, dysmorphic facial features, and medical comorbidities: myopia, constipation, epilepsy, and apneic spells. The present case study expands existing understanding of this disorder by presenting a unique phenotype with higher cognitive abilities and fewer medical comorbidities. Methods: The present case study reports on a 13-year-old, Caucasian male with a recent diagnosis of PTHS following genetic testing (i.e., whole exome sequencing). He was referred for a neuropsychological evaluation to document his neurocognitive functioning to assist with intervention planning. Results: Evaluation of intellectual, attention/executive, memory, visual-motor/fine-motor, academic, adaptive, and emotional/behavioral functioning revealed global impairment across all areas of functioning. However, he demonstrated abilities beyond what has been detailed in the literature, including use of full sentences, capacity to learn and solve novel problems, basic academic functioning, and independent ambulation. Conclusions: Children with PTHS may demonstrate a spectrum of abilities beyond what has been documented in the literature thus far. Failure to recognize this spectrum can result in late identification of an accurate diagnosis. (JINS, 2018, 24, 995–1002)
Probability of major depression diagnostic classification using semi-structured versus fully structured diagnostic interviews
- Brooke Levis, Andrea Benedetti, Kira E. Riehm, Nazanin Saadat, Alexander W. Levis, Marleine Azar, Danielle B. Rice, Matthew J. Chiovitti, Tatiana A. Sanchez, Pim Cuijpers, Simon Gilbody, John P. A. Ioannidis, Lorie A. Kloda, Dean McMillan, Scott B. Patten, Ian Shrier, Russell J. Steele, Roy C. Ziegelstein, Dickens H. Akena, Bruce Arroll, Liat Ayalon, Hamid R. Baradaran, Murray Baron, Anna Beraldi, Charles H. Bombardier, Peter Butterworth, Gregory Carter, Marcos H. Chagas, Juliana C. N. Chan, Rushina Cholera, Neerja Chowdhary, Kerrie Clover, Yeates Conwell, Janneke M. de Man-van Ginkel, Jaime Delgadillo, Jesse R. Fann, Felix H. Fischer, Benjamin Fischler, Daniel Fung, Bizu Gelaye, Felicity Goodyear-Smith, Catherine G. Greeno, Brian J. Hall, John Hambridge, Patricia A. Harrison, Ulrich Hegerl, Leanne Hides, Stevan E. Hobfoll, Marie Hudson, Thomas Hyphantis, Masatoshi Inagaki, Khalida Ismail, Nathalie Jetté, Mohammad E. Khamseh, Kim M. Kiely, Femke Lamers, Shen-Ing Liu, Manote Lotrakul, Sonia R. Loureiro, Bernd Löwe, Laura Marsh, Anthony McGuire, Sherina Mohd Sidik, Tiago N. Munhoz, Kumiko Muramatsu, Flávia L. Osório, Vikram Patel, Brian W. Pence, Philippe Persoons, Angelo Picardi, Alasdair G. Rooney, Iná S. Santos, Juwita Shaaban, Abbey Sidebottom, Adam Simning, Lesley Stafford, Sharon Sung, Pei Lin Lynnette Tan, Alyna Turner, Christina M. van der Feltz-Cornelis, Henk C. van Weert, Paul A. Vöhringer, Jennifer White, Mary A. Whooley, Kirsty Winkley, Mitsuhiko Yamada, Yuying Zhang, Brett D. Thombs
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- Journal:
- The British Journal of Psychiatry / Volume 212 / Issue 6 / June 2018
- Published online by Cambridge University Press:
- 02 May 2018, pp. 377-385
- Print publication:
- June 2018
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Background
Different diagnostic interviews are used as reference standards for major depression classification in research. Semi-structured interviews involve clinical judgement, whereas fully structured interviews are completely scripted. The Mini International Neuropsychiatric Interview (MINI), a brief fully structured interview, is also sometimes used. It is not known whether interview method is associated with probability of major depression classification.
AimsTo evaluate the association between interview method and odds of major depression classification, controlling for depressive symptom scores and participant characteristics.
MethodData collected for an individual participant data meta-analysis of Patient Health Questionnaire-9 (PHQ-9) diagnostic accuracy were analysed and binomial generalised linear mixed models were fit.
ResultsA total of 17 158 participants (2287 with major depression) from 57 primary studies were analysed. Among fully structured interviews, odds of major depression were higher for the MINI compared with the Composite International Diagnostic Interview (CIDI) (odds ratio (OR) = 2.10; 95% CI = 1.15–3.87). Compared with semi-structured interviews, fully structured interviews (MINI excluded) were non-significantly more likely to classify participants with low-level depressive symptoms (PHQ-9 scores ≤6) as having major depression (OR = 3.13; 95% CI = 0.98–10.00), similarly likely for moderate-level symptoms (PHQ-9 scores 7–15) (OR = 0.96; 95% CI = 0.56–1.66) and significantly less likely for high-level symptoms (PHQ-9 scores ≥16) (OR = 0.50; 95% CI = 0.26–0.97).
ConclusionsThe MINI may identify more people as depressed than the CIDI, and semi-structured and fully structured interviews may not be interchangeable methods, but these results should be replicated.
Declaration of interestDrs Jetté and Patten declare that they received a grant, outside the submitted work, from the Hotchkiss Brain Institute, which was jointly funded by the Institute and Pfizer. Pfizer was the original sponsor of the development of the PHQ-9, which is now in the public domain. Dr Chan is a steering committee member or consultant of Astra Zeneca, Bayer, Lilly, MSD and Pfizer. She has received sponsorships and honorarium for giving lectures and providing consultancy and her affiliated institution has received research grants from these companies. Dr Hegerl declares that within the past 3 years, he was an advisory board member for Lundbeck, Servier and Otsuka Pharma; a consultant for Bayer Pharma; and a speaker for Medice Arzneimittel, Novartis, and Roche Pharma, all outside the submitted work. Dr Inagaki declares that he has received grants from Novartis Pharma, lecture fees from Pfizer, Mochida, Shionogi, Sumitomo Dainippon Pharma, Daiichi-Sankyo, Meiji Seika and Takeda, and royalties from Nippon Hyoron Sha, Nanzando, Seiwa Shoten, Igaku-shoin and Technomics, all outside of the submitted work. Dr Yamada reports personal fees from Meiji Seika Pharma Co., Ltd., MSD K.K., Asahi Kasei Pharma Corporation, Seishin Shobo, Seiwa Shoten Co., Ltd., Igaku-shoin Ltd., Chugai Igakusha and Sentan Igakusha, all outside the submitted work. All other authors declare no competing interests. No funder had any role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review or approval of the manuscript; and decision to submit the manuscript for publication.
Short-term, daily intake of yogurt containing Bifidobacterium animalis ssp. lactis Bf-6 (LMG 24384) does not affect colonic transit time in women
- Daniel J. Merenstein, Frank D'Amico, Caren Palese, Alexander Hahn, Jessy Sparenborg, Tina Tan, Hillary Scott, Kayla Polzin, Lore Kolberg, Robert Roberts
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- Journal:
- British Journal of Nutrition / Volume 111 / Issue 2 / 28 January 2014
- Published online by Cambridge University Press:
- 08 October 2013, pp. 279-286
- Print publication:
- 28 January 2014
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The present study investigated the effect of Bifidobacterium animalis ssp. lactis Bf-6 (LMG 24 384) (Bf-6)-supplemented yogurt on colonic transit time (CTT). A triple-blinded, randomised, placebo-controlled, two-period cross-over trial was conducted with sixty-eight women with a self-reported history of straining during bowel movements or hard or lumpy stools in the past 2 years. As per regulatory requirements for probiotic studies, eligible women were generally healthy and not actively constipated at the time of enrolment. Participants consumed both Bf-6 and placebo yogurts for 14 d each in a randomised order, with a 6-week washout period between the treatments. The primary outcome, CTT, was assessed via Sitz marker X-rays. The average CTT was 42·1 h for the active period and 43·3 h for the control period (mean difference 1·2 h, 95 % CI − 4·9, 7·4). Since the statistical tests for the cross-over study implied that the mean CTT for the active and control periods in period 2 were biased, the standard protocol suggests examining the results of only period 1 as a traditional randomised controlled trial. This showed that the mean CTT was 35·2 h for the active period v. 52·9 h for the control period (P= 0·015). Bootstrapping demonstrated that both the mean and median differences remained significant (P= 0·016 and P= 0·045, respectively). Few adverse events were noted, with no differences among the active and control periods. The paired analysis showed no differences between the active and control periods during the cross-over trial. Further trials should be conducted in populations with underlying problems associated with disordered transit to determine the potential value of probiotic supplementation more accurately.
Positive solutions of the nonlinear Schrödinger equation with the fractional Laplacian
- Patricio Felmer, Alexander Quaas, Jinggang Tan
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- Journal:
- Proceedings of the Royal Society of Edinburgh. Section A: Mathematics / Volume 142 / Issue 6 / December 2012
- Published online by Cambridge University Press:
- 27 November 2012, pp. 1237-1262
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- December 2012
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We study the existence of positive solutions for the nonlinear Schrödinger equation with the fractional Laplacian
Furthermore, we analyse the regularity, decay and symmetry properties of these solutions.
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- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. 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- Edited by Daniel Patte, Vanderbilt University, Tennessee
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- The Cambridge Dictionary of Christianity
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- 05 August 2012
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- 20 September 2010, pp xi-xliv
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Contributors
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- By Sameena T. Ahmed, Douglas Aitchison, Abdalla Banni, Sion Barnard, Stephen Clark, Ian Conacher, Taj Dhallu, Vijay Jeganath, John Jerstice, David Morrice, Tim Murphy, Jayanta Nandi, Alexander Ng, Leena Pardeshi, David Place, Mahesh Prabhu, O. P. Sanjay, Cait P. Searl, David C. Smith, Jonathan Hayden Smith, Christine Tan, Kamen Valchanov, Alain Vuylsteke, Christopher Wigfield
- Edited by Cait P. Searl, Sameena T. Ahmed
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- Core Topics in Thoracic Anesthesia
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- 10 December 2009
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- 02 April 2009, pp x-xi
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Chapter 28 - Pain management after thoracotomy
- from Section 3 - Post-operative management
- Edited by Cait P. Searl, Sameena T. Ahmed
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- Core Topics in Thoracic Anesthesia
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- 10 December 2009
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- 02 April 2009, pp 190-195
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Summary
This chapter deals with anesthesia for surgery to major intrathoracic structures excluding the heart and great vessels in neonates, infants and children. It focuses on thorough pre-operative assessment, intra-operative management including techniques for one-lung ventilation (OLV) and post-operative care including analgesia as well as a brief discussion of several conditions which present specifically in the pediatric patient population. Each phase of the anesthetic management of the pediatric thoracic patient should be carefully planned in advance and anesthetic nursing staff should be fully briefed. Two-lung ventilation is usually a perfectly acceptable and a simpler technique for many surgical procedures. To help reduce the chance of damaging the lung, apnea can be maintained while the thoracic cavity is entered. Providing satisfactory peri-operative management of the pediatric thoracic patient requires the highest standards of pre-operative assessment, technical expertise and communication between team members, but is both challenging and rewarding.