49 results
Comparison of the Mineralogical and Chemical Composition of 2 Shales from the Western Canada Sedimentary Basin and the United States Gulf Coast
- Patrice de Caritat, John Bloch, Ian Hutcheon, Fred J. Longstaffe, Hugh J. Abercrombie
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- Journal:
- Clays and Clay Minerals / Volume 45 / Issue 3 / June 1997
- Published online by Cambridge University Press:
- 28 February 2024, pp. 327-332
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The mineralogy and geochemistry of shales reflect the composition of the initially deposited precursor mud, subsequently modified by diagenetic processes. To see if significant geochemical differences exist between shales that mainly owe their present-day composition to either deposition or diagenesis, we compare the published mineralogical, bulk and clay-fraction geochemical, and clay-fraction O-isotopic compositions of 2 shales. One shale is from the Western Canada Sedimentary Basin (WCSB), and its composition mainly reflects primary (depositional) chemical and mineralogical variations (smectitic to illitic illite/smectite) within this unit. The other shale is from the United States Gulf Coast (USGC), and its composition mainly reflects mixed-layer illite/smectite (I/S) diagenesis of deposited smectitic clay material. The chemical and mineralogical trends of WCSB and USGC shales, including one of increasing illite content in I/S with depth or maturity, are essentially indistinguishable, in both bulk shale and clay fraction, despite the contrasting genetic interpretations for the origin of the contained I/S. Thus, similar mineralogical and chemical trends with depth or temperature can result either from inherited depositional compositional heterogeneity of the sediment, from burial metamorphism of shale or a combination of both. Interestingly, the O-isotopic compositions of the clay fractions from the WCSB and USGC are significantly different, a fact that reflects original clay formation from source material and water of quite different isotopic compositions. The discrimination between depositional and diagenetic contributions to shale composition continues to pose challenges, but a combination of bentonite, illite polytype, clay isotopic and trace and rare earth elemental analyses together with illite age analysis holds promise for future work.
The need for increased protection of Antarctica's inland waters
- Ian Hawes, Clive Howard-Williams, Neil Gilbert, Kevin A. Hughes, Peter Convey, Antonio Quesada
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- Journal:
- Antarctic Science / Volume 35 / Issue 2 / April 2023
- Published online by Cambridge University Press:
- 18 April 2023, pp. 64-88
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Protection of Antarctica's biodiversity and ecosystem values is enshrined in the Protocol on Environmental Protection to the Antarctic Treaty, which provides for the designation of Antarctic Specially Protected Areas (ASPAs) to areas with outstanding values. Concern has been raised that existing ASPAs fail to prioritize areas to maximize the likelihood of ensuring the long-term conservation of Antarctic ecosystems and biodiversity. The absence of systematic and representative protection is particularly acute for inland aquatic ecosystems, which support a disproportionate amount of inland biodiversity. This paper promotes the case for overt inclusion of inland waters as a critical component of a representative protected area framework for Antarctica, thereby addressing their current underrepresentation. We set out a structured approach to enable the selection of representative freshwater systems for inclusion in the ASPA framework that, with modification, could also be applied across other Antarctic habitats. We acknowledge an overall lack of information on the biogeography of inland aquatic diversity and recommend increased use of remote data collection along with classification tools to mitigate this, as well as the need for the consideration of catchment-scale processes. Changes that accompany contemporary and anticipated climate change make the need for the conservation of representative biodiversity increasingly urgent.
Hallucinations as a risk marker for suicidal behaviour in individuals with a history of sexual assault: a general population study with instant replication
- Kathryn Yates, Ulla Lång, Evyn M. Peters, Johanna T. W. Wigman, David Boyda, Fiona McNicholas, Mary Cannon, Ben Alderson-Day, Michael Bloomfield, Hugh Ramsay, Ian Kelleher
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- Journal:
- Psychological Medicine / Volume 53 / Issue 10 / July 2023
- Published online by Cambridge University Press:
- 14 June 2022, pp. 4627-4633
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Background
Research has shown a strong relationship between hallucinations and suicidal behaviour in general population samples. Whether hallucinations also index suicidal behaviour risk in groups at elevated risk of suicidal behaviour, namely in individuals with a sexual assault history, remains to be seen.
AimsWe assessed whether hallucinations were markers of risk for suicidal behaviour among individuals with a sexual assault history.
MethodsUsing the cross-sectional 2007 (N = 7403) and 2014 (N = 7546) Adult Psychiatric Morbidity Surveys, we assessed for an interaction between sexual assault and hallucinations in terms of the odds of suicide attempt, as well as directly comparing the prevalence of suicide attempt in individuals with a sexual assault history with v. without hallucinations.
ResultsIndividuals with a sexual assault history had increased odds of hallucinations and suicide attempt compared to individuals without a sexual assault history in both samples. There was a significant interaction between sexual assault and hallucinations in terms of the odds of suicide attempt. In total, 14–19% of individuals with a sexual assault history who did not report hallucinations had one or more suicide attempt. This increased to 33–52% of individuals with a sexual assault history who did report hallucinations (2007, aOR = 2.85, 1.71–4.75; 2014, aOR = 4.52, 2.78–7.35).
ConclusionsHallucinations are a risk marker for suicide attempt even among individuals with an elevated risk of suicidal behaviour, specifically individuals with a sexual assault history. This finding highlights the clinical significance of hallucinations with regard to suicidal behaviour risk, even among high-risk populations.
Impact of COVID-19 on mental health research: is this the breaking point?
- Oli Sparasci, Kamaldeep Bhui, Asit Biswas, Samuel Chamberlain, Bernadka Dubicka, Robert Dudas, Saeed Farooq, Tamsin Ford, Nusrat Husain, Ian Jones, Helen Killaspy, William Lee, Anne Lingford-Hughes, Ciaran Mulholland, Judy Rubinsztein, Rohit Shankar, Aditya Sharma, Lindsey Sinclair, James Stone, Allan Young
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- Journal:
- The British Journal of Psychiatry / Volume 220 / Issue 5 / May 2022
- Published online by Cambridge University Press:
- 17 February 2022, pp. 254-256
- Print publication:
- May 2022
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There are many structural problems facing the UK at present, from a weakened National Health Service to deeply ingrained inequality. These challenges extend through society to clinical practice and have an impact on current mental health research, which was in a perilous state even before the coronavirus pandemic hit. In this editorial, a group of psychiatric researchers who currently sit on the Academic Faculty of the Royal College of Psychiatrists and represent the breadth of research in mental health from across the UK discuss the challenges faced in academic mental health research. They reflect on the need for additional investment in the specialty and ask whether this is a turning point for the future of mental health research.
Hallucinations in the general population across the adult lifespan: prevalence and psychopathologic significance
- Kathryn Yates, Ulla Lång, Evyn M. Peters, Johanna T. W. Wigman, Fiona McNicholas, Mary Cannon, Jordan DeVylder, Hugh Ramsay, Hans Oh, Ian Kelleher
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- Journal:
- The British Journal of Psychiatry / Volume 219 / Issue 6 / December 2021
- Published online by Cambridge University Press:
- 12 July 2021, pp. 652-658
- Print publication:
- December 2021
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Background
Community studies have found a relatively high prevalence of hallucinations, which are associated with a range of (psychotic and non-psychotic) mental disorders, as well as with suicidal ideation and behaviour. The literature on hallucinations in the general population has largely focused on adolescents and young adults.
AimsWe aimed to explore the prevalence and psychopathologic significance of hallucinations across the adult lifespan.
MethodUsing the 1993, 2000, 2007 and 2014 cross-sectional Adult Psychiatric Morbidity Survey series (N = 33 637), we calculated the prevalence of past-year hallucinations in the general population ages 16 to ≥90 years. We used logistic regression to examine the relationship between hallucinations and a range of mental disorders, suicidal ideation and suicide attempts.
ResultsThe prevalence of past-year hallucinations varied across the adult lifespan, from a high of 7% in individuals aged 16–19 years, to a low of 3% in individuals aged ≥70 years. In all age groups, hallucinations were associated with increased risk for mental disorders, suicidal ideation and suicide attempts, but there was also evidence of significant age-related variation. In particular, hallucinations in older adults were less likely to be associated with a cooccurring mental disorder, suicidal ideation or suicide attempt compared with early adulthood and middle age.
ConclusionsOur findings highlight important life-course developmental features of hallucinations from early adulthood to old age.
Efficacy of the Zero Suicide framework in reducing recurrent suicide attempts: cross-sectional and time-to-recurrent-event analyses
- Nicolas J. C. Stapelberg, Jerneja Sveticic, Ian Hughes, Alice Almeida-Crasto, Taralina Gaee-Atefi, Neeraj Gill, Diana Grice, Ravikumar Krishnaiah, Luke Lindsay, Carla Patist, Heidy Van Engelen, Sarah Walker, Matthew Welch, Sabine Woerwag-Mehta, Kathryn Turner
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- Journal:
- The British Journal of Psychiatry / Volume 219 / Issue 2 / August 2021
- Published online by Cambridge University Press:
- 12 November 2020, pp. 427-436
- Print publication:
- August 2021
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Background
The Zero Suicide framework is a system-wide approach to prevent suicides in health services. It has been implemented worldwide but has a poor evidence-base of effectiveness.
AimsTo evaluate the effectiveness of the Zero Suicide framework, implemented in a clinical suicide prevention pathway (SPP) by a large public mental health service in Australia, in reducing repeated suicide attempts after an index attempt.
MethodA total of 604 persons with 737 suicide attempt presentations were identified between 1 July and 31 December 2017. Relative risk for a subsequent suicide attempt within various time periods was calculated using cross-sectional analysis. Subsequently, a 10-year suicide attempt history (2009–2018) for the cohort was used in time-to-recurrent-event analyses.
ResultsPlacement on the SPP reduced risk for a repeated suicide attempt within 7 days (RR = 0.29; 95% CI 0.11–0.75), 14 days (RR = 0.38; 95% CI 0.18–0.78), 30 days (RR = 0.55; 95% CI 0.33–0.94) and 90 days (RR = 0.62; 95% CI 0.41–0.95). Time-to-recurrent event analysis showed that SPP placement extended time to re-presentation (HR = 0.65; 95% CI 0.57–0.67). A diagnosis of personality disorder (HR = 2.70; 95% CI 2.03–3.58), previous suicide attempt (HR = 1.78; 95% CI 1.46–2.17) and Indigenous status (HR = 1.46; 95% CI 0.98–2.25) increased the hazard for re-presentation, whereas older age decreased it (HR = 0.92; 95% CI 0.86–0.98). The effect of the SPP was similar across all groups, reducing the risk of re-presentation to about 65% of that seen in those not placed on the SPP.
ConclusionsThis paper demonstrates a reduction in repeated suicide attempts after an index attempt and a longer time to a subsequent attempt for those receiving multilevel care based on the Zero Suicide framework.
342 - The Dementia Early Stage Cognitive Aids New Trial (DESCANT) intervention: Goal Attainment Scaling
- Helen Chester, Rebecca Beresford, Paul Clarkson, Charlotte Entwistle, Vincent Gillan, Jane Hughes, Martin Orrell, Rosa Pitts, Ian Russell, Eileen Symonds, David Challis
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- Journal:
- International Psychogeriatrics / Volume 32 / Issue S1 / October 2020
- Published online by Cambridge University Press:
- 04 November 2020, p. 102
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The DESCANT (Dementia Early Stage Cognitive Aids New Trial) intervention provided a personalised care package to improve the cognitive abilities, function and well -being of people with early-stage dementia and their carers by providing a range of memory aids, with training and support for use. This presentation will explore findings from a goal attainment scaling exercise undertaken within a multi-site pragmatic randomised trial, part of a NIHR-funded research programme ‘Effective Home Support in Dementia Care: Components, Impacts and Costs of Tertiary Prevention.’
The aim was to describe the Goal Attainment Scaling (GAS) approach developed; investigate the types of goals identified by people with dementia and their carers and subsequent attainment; and explore the role of Dementia Support Practitioners (DSPs) in the process. This GAS exercise was designed by researchers, a clinical psychologist, a clinician and a DSP. Goal setting and attainment were conducted with the person with dementia and their carer and recorded by DSPs. Data were obtained from 117 intervention records and semi-structured interviews with five DSPs delivering the intervention across seven NHS Trusts in England and Wales. The GAS exercise was conducted as planned with goals and extent of involvement in the exercise tailored to individual participants and engagement was high. Demographic characteristics from the trial baseline dataset were analysed. Measures were created from intervention records to permit quantification and descriptive analysis. Interviews were professionally transcribed and subject to thematic analysis to identify salient themes.
A total of 293 goals were identified across the 117 participants. From these 17 goal types were distinguished across six domains: self -care; household tasks; daily occupation; orientation; communication; and well-being and safety. A measure of goal attainment appropriate to both the client group and a modest intervention was obtained. On average participants had evidenced some improvement regarding goals set. Qualitative findings suggested overall DSPs were positive about their experience of goal setting. Although several challenges were identified, if these were overcome, measuring goal attainment was generally viewed as straightforward. GAS can be used in the context of a psychosocial intervention for people with early-stage dementia to identify and measure attainment of personalised care goals.
4 - A Long-Standing Evolutionary History between Chlamydia trachomatis and Humans: Visible Ocular and Invisible Genital Variants
- from Part Two - The Biomedical Sciences and the History of the STI Microorganisms
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- By Ian N. Clarke, University of Southampton., Hugh R. Taylor, University of Melbourne.
- Edited by Simon Szreter
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- Book:
- The Hidden Affliction
- Published by:
- Boydell & Brewer
- Published online:
- 25 March 2020
- Print publication:
- 01 October 2019, pp 124-152
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Summary
Chlamydiae
The most frequently asked questions about Chlamydia trachomatis, commonly known as “chlamydia,” are (1) what is it? and (2) where did it come from? The capricious and cryptic nature of genital infections caused by C. trachomatis and the difficulties in isolating the pathogen have led to many misconceptions about its origins and how infection occurs. The first question is now easy to answer. There is no doubt: chlamydiae are not viruses, nor are they protozoan parasites; they are bacteria. However, they are not free-living bacteria and so cannot be cultivated on conventional media such as agar plates. Chlamydiae are highly specialized bacteria, which can be grown only within living cells; thus they are obligate intracellular pathogens.
Chlamydiae also have a complex developmental cycle. The name is derived from Chlamydozoa, which means “cloaked organisms,” because they develop within an inclusion membrane within the cytoplasm of the cell and initially in the infection process are not visible. These gram-negative bacteria have a unique development cycle that includes the repeated division of a replicating stage, called an RB, or reticulate body. RBs increase in number to a point where they can be seen under the microscope as moving specks within a defined membrane structure known as an inclusion in the host cell's cytoplasm. With time the inclusion ruptures out of the cell and releases the smaller nonreplicating infectious forms called “elementary bodies.”
The genus is also known as Chlamydia; it is a proper noun written in italics, with no plural. The genus Chlamydia currently contains nine species and no doubt, more will be added. The species C. trachomatis, the focus of our discussion, is made up of a number of serovars, differentiated by surface antigens that induce specific antibodies. It has four ocular serovars that cause blinding endemic trachoma, A, B, Ba, and C and at least eight serovars, D to K, which typically cause genital tract infections. There are additionally the three L serovars that cause the condition known as lymphogranuloma venerum. Closely related species are C. muridarum, which infects mice and hamsters, and C. suis, which is endemic in pigs.
Associations between childhood maltreatment and inflammatory markers
- Alish B. Palmos, Stuart Watson, Tom Hughes, Andreas Finkelmeyer, R. Hamish McAllister-Williams, Nicol Ferrier, Ian M. Anderson, Rajesh Nair, Allan H. Young, Rebecca Strawbridge, Anthony J. Cleare, Raymond Chung, Souci Frissa, Laura Goodwin, Matthew Hotopf, Stephani L. Hatch, Hong Wang, David A. Collier, Sandrine Thuret, Gerome Breen, Timothy R. Powell
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- Journal:
- BJPsych Open / Volume 5 / Issue 1 / January 2019
- Published online by Cambridge University Press:
- 04 January 2019, e3
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Background
Childhood maltreatment is one of the strongest predictors of adulthood depression and alterations to circulating levels of inflammatory markers is one putative mechanism mediating risk or resilience.
AimsTo determine the effects of childhood maltreatment on circulating levels of 41 inflammatory markers in healthy individuals and those with a major depressive disorder (MDD) diagnosis.
MethodWe investigated the association of childhood maltreatment with levels of 41 inflammatory markers in two groups, 164 patients with MDD and 301 controls, using multiplex electrochemiluminescence methods applied to blood serum.
ResultsChildhood maltreatment was not associated with altered inflammatory markers in either group after multiple testing correction. Body mass index (BMI) exerted strong effects on interleukin-6 and C-reactive protein levels in those with MDD.
ConclusionsChildhood maltreatment did not exert effects on inflammatory marker levels in either the participants with MDD or the control group in our study. Our results instead highlight the more pertinent influence of BMI.
Declaration of interestD.A.C. and H.W. work for Eli Lilly Inc. R.N. has received speaker fees from Sunovion, Jansen and Lundbeck. G.B. has received consultancy fees and funding from Eli Lilly. R.H.M.-W. has received consultancy fees or has a financial relationship with AstraZeneca, Bristol-Myers Squibb, Cyberonics, Eli Lilly, Ferrer, Janssen-Cilag, Lundbeck, MyTomorrows, Otsuka, Pfizer, Pulse, Roche, Servier, SPIMACO and Sunovian. I.M.A. has received consultancy fees or has a financial relationship with Alkermes, Lundbeck, Lundbeck/Otsuka, and Servier. S.W. has sat on an advisory board for Sunovion, Allergan and has received speaker fees from Astra Zeneca. A.H.Y. has received honoraria for speaking from Astra Zeneca, Lundbeck, Eli Lilly, Sunovion; honoraria for consulting from Allergan, Livanova and Lundbeck, Sunovion, Janssen; and research grant support from Janssen. A.J.C. has received honoraria for speaking from Astra Zeneca, honoraria for consulting with Allergan, Livanova and Lundbeck and research grant support from Lundbeck.
The relationship between sticky spots and radar reflectivity beneath an active West Antarctic ice stream
- David W. Ashmore, Robert G. Bingham, Richard C.A. Hindmarsh, Hugh F.J. Corr, Ian R. Joughin
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- Journal:
- Annals of Glaciology / Volume 55 / Issue 67 / 2014
- Published online by Cambridge University Press:
- 26 July 2017, pp. 29-38
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Isolated areas of high basal drag, or ‘sticky spots’, are important and poorly understood features in the force balance and dynamics of West Antarctic ice streams. Characterizing sticky spots formed by thin or drying subglacial till using ice-penetrating radar is theoretically possible, as high radar bed-returned power (BRP) is commonly related to an abundance of free water at the ice/bed interface, provided losses from englacial attenuation can be estimated. In this study we use airborne radar data collected over Evans Ice Stream to extract BRP profiles and test the sensitivity of BRP to the adopted englacial attenuation correction. We analyse 11 ~ 2 0 km profiles in four fast-flow areas where sticky spots have been inferred to exist on the basis of model and surface data inversions. In the majority of profiles we note that the increase in basal drag is accompanied by a decrease in BRP and suggest that this is evidence both for the presence of a sticky spot in those locations and that local variations in subglacial hydrology are responsible for their existence. A comparison is made between empirical and numerical modelling approaches for deriving englacial attenuation, and our findings generally support previous studies that advocate a modelling approach.
Effective Kill of Trifluralin-Susceptible and -Resistant Green Foxtail (Setaria viridis)
- Hugh J. Beckie, Ian N. Morrison
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- Journal:
- Weed Technology / Volume 7 / Issue 1 / March 1993
- Published online by Cambridge University Press:
- 12 June 2017, pp. 15-22
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The response of susceptible (S) and resistant (R) green foxtail biotypes to increasing dosages of trifluralin, applied PPI in rapeseed and preemergence incorporated (PEI) in wheat, was investigated in field experiments in 1989 and 1990. Differences in response between the biotypes to PPI- and PEI-trifluralin were 7- and 12-fold, respectively, based on density and shoot biomass determinations 4 wk after emergence. Nine- and 14-times higher dosages of PPI- and PEI-trifluralin, respectively, were required to reduce R-seed production by 50% than to reduce S-seed production by the same amount. At the recommended trifluralin dosage in rapeseed (1.4 kg ha−1), the density of S-plants 4 wk after emergence was reduced by 84% compared with untreated plots, whereas the density of R-plants was reduced by only 4%. The effective kill (seed yield reduction) was 99% and 42%, respectively. At the recommended dosage in wheat (0.9 kg ha−1), the density of S-plants 4 wk after emergence was reduced by over 99% compared with less than 36% for R-plants. The effective kill was 97% and 14%, respectively. Based on determination of effective kill, the selection pressure of trifluralin on green foxtail is greater when the chemical is applied PPI in rapeseed than when applied PEI in wheat, even though initial density reductions are less in the former than the latter.
Effect of Ethalfluralin and Other Herbicides on Trifluralin-Resistant Green Foxtail (Setaria viridis)
- Hugh J. Beckie, Ian N. Morrison
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- Journal:
- Weed Technology / Volume 7 / Issue 1 / March 1993
- Published online by Cambridge University Press:
- 12 June 2017, pp. 6-14
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The response of trifluralin-susceptible (S) and -resistant (R) green foxtail biotypes to herbicides belonging to several chemical groups was compared to determine the cross-resistance pattern of the R-biotype. Dose-response experiments conducted in the growth chamber indicated that R-green foxtail was resistant to other dinitroanilines and a chemically unrelated mitotic disrupter herbicide, but not to nine other herbicides belonging to seven chemical families. The response of S- and R-green foxtail to increasing dosages of ethalfluralin, applied PPI in rapeseed, was investigated in a field experiment in 1989 and 1990. The R-biotype was 7 times more resistant to ethalfluralin than the S-biotype based on density determinations 4 wk after emergence. Seven times higher dosage was required to reduce R-seed production by 50% than to reduce S-seed production by the same amount. The initial reductions in density of R- and S-plants at the recommended dosage of ethalfluralin in rapeseed (1.4 kg ha−1) was 35% and 95%, respectively. The effective kill (seed yield reduction) of R- and S-biotypes was 55% and 99%, respectively. The results indicate that ethalfluralin will not effectively control R-green foxtail. However, several other herbicides with different mechanisms of action can be used to effectively control R-foxtail, thereby reducing any adverse effects of their interference on crop production.
A Rapid Bioassay to Detect Trifluralin-Resistant Green Foxtail (Setaria viridis)
- Hugh J. Beckie, Lyle F. Friesen, Ken M. Nawolsky, Ian N. Morrison
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- Journal:
- Weed Technology / Volume 4 / Issue 3 / September 1990
- Published online by Cambridge University Press:
- 12 June 2017, pp. 505-508
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In a petri dish assay, radicle growth of trifluralin-resistant (R) green foxtail exposed to trifluralin concentrations of up to 0.4 ppm (w/v) was not inhibited. Radicle growth of trifluralinsusceptible (S) biotypes was completely inhibited. Shoots were more sensitive to trifluralin than roots, with shoot growth being inhibited for both R and S biotypes at trifluralin concentrations of 0.2 ppm or more. Best discrimination between R and S green foxtail biotypes was achieved by measuring radicle length after incubation of pregerminated caryopses at 0.3 ppm trifluralin in the dark for 5 d at 22 C.
Evaluating the effectiveness of different approaches to home support for people in later stage dementia: a protocol for an observational study
- Helen Chester, Paul Clarkson, Jane Hughes, Ian Russell, Joan Beresford, Linda Davies, David Jolley, Julie Peconi, Fiona Poland, Chris Roberts, Caroline Sutcliffe, David Challis, Members of the HoSt-D (Home Support in Dementia) Programme Management Group
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- Journal:
- International Psychogeriatrics / Volume 29 / Issue 7 / July 2017
- Published online by Cambridge University Press:
- 07 March 2017, pp. 1213-1221
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Background:
Dementia is a major health problem with a growing number of people affected by the condition, both directly and indirectly through caring for someone with dementia. Many live at home but little is known about the range and intensity of the support they receive. Previous studies have mainly reported on discrete services within a single geographical area. This paper presents a protocol for study of different services across several sites in England. The aim is to explore the presence, effects, and cost-effectiveness of approaches to home support for people in later stage dementia and their carers.
Methods:This is a prospective observational study employing mixed methods. At least 300 participants (people with dementia and their carers) from geographical areas with demonstrably different ranges of services available for people with dementia will be selected. Within each area, participants will be recruited from a range of services. Participants will be interviewed on two occasions and data will be collected on their characteristics and circumstances, quality of life, carer health and burden, and informal and formal support for the person with dementia. The structured interviews will also collect qualitative data to explore the perceptions of older people and carers.
Conclusions:This national study will explore the components of appropriate and effective home support for people with late stage dementia and their carers. It aims to inform commissioners and service providers across health and social care.
The Ecological implications of a Yakutian mammoth's last meal
- Bas van Geel, André Aptroot, Claudia Baittinger, Hilary H. Birks, Ian D. Bull, Hugh B. Cross, Richard P. Evershed, Barbara Gravendeel, Erwin J.O. Kompanje, Peter Kuperus, Dick Mol, Klaas G.J. Nierop, Jan Peter Pals, Alexei N. Tikhonov, Guido van Reenen, Peter H. van Tienderen
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- Journal:
- Quaternary Research / Volume 69 / Issue 3 / May 2008
- Published online by Cambridge University Press:
- 20 January 2017, pp. 361-376
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Part of a large male woolly mammoth (Mammuthus primigenius) was preserved in permafrost in northern Yakutia. It was radiocarbon dated to ca. 18,50014C yr BP (ca. 22,500 cal yr BP). Dung from the lower intestine was subjected to a multiproxy array of microscopic, chemical, and molecular techniques to reconstruct the diet, the season of death, and the paleoenvironment. Pollen and plant macro-remains showed that grasses and sedges were the main food, with considerable amounts of dwarf willow twigs and a variety of herbs and mosses. Analyses of 110-bp fragments of the plastid rbcL gene amplified from DNA and of organic compounds supplemented the microscopic identifications. Fruit-bodies of dung-inhabiting Ascomycete fungi which develop after at least one week of exposure to air were found inside the intestine. Therefore the mammoth had eaten dung. It was probably mammoth dung as no bile acids were detected among the fecal biomarkers analysed. The plant assemblage and the presence of the first spring vessels of terminal tree-rings of dwarf willows indicated that the animal died in early spring. The mammoth lived in extensive cold treeless grassland vegetation interspersed with wetter, more productive meadows. The study demonstrated the paleoecological potential of several biochemical analytical techniques.
Screening for Herbicide Resistance in Weeds
- Hugh J. Beckie, Ian M. Heap, Reid J. Smeda, Linda M. Hall
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- Journal:
- Weed Technology / Volume 14 / Issue 2 / June 2000
- Published online by Cambridge University Press:
- 20 January 2017, pp. 428-445
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Diagnosing herbicide-resistant weeds as a first step in resistance management and monitoring their nature, distribution, and abundance demands efficient and effective screening tests. This review summarizes and recommends appropriate seed sampling techniques, protocols for screening weeds for resistance to herbicides of different sites of action, interpretation of results, and information given to the grower. Elements common to all screening procedures are reviewed. Choosing appropriate discriminating doses to distinguish between resistant and susceptible weed biotypes is the most important factor in achieving accurate and consistent results. Interpretation of results is also critical because resistant weeds may comprise a small portion of the population in suspected accessions or biotypes.
A process evaluation of a Psychomotor Dance Therapy Intervention (DANCIN) for behavior change in dementia: attitudes and beliefs of participating residents and staff
- Azucena Guzmán, Lisa Robinson, Lynn Rochester, Ian A. James, Julian C. Hughes
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- Journal:
- International Psychogeriatrics / Volume 29 / Issue 2 / February 2017
- Published online by Cambridge University Press:
- 07 November 2016, pp. 313-322
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Background:
In a previous paper, we presented results from a 12-week study of a Psychomotor DANCe Therapy INtervention (DANCIN) based on Danzón Latin Ballroom that involves motor, emotional-affective, and cognitive domains, using a multiple-baseline single-case design in three care homes. This paper reports the results of a complementary process evaluation to elicit the attitudes and beliefs of home care staff, participating residents, and family members with the aim of refining the content of DANCIN in dementia care.
Methods:An external researcher collected bespoke questionnaires from ten participating residents, 32 care home staff, and three participants’ family members who provided impromptu feedback in one of the care homes. The Behavior Change Technique Taxonomy v1 (BCTTv1) provided a methodological tool for identifying active components of the DANCIN approach warranting further exploration, development, and implementation.
Results:Ten residents found DANCIN beneficial in terms of mood and socialization in the care home. Overall, 78% of the staff thought DANCIN led to improvements in residents’ mood; 75% agreed that there were improvements in behavior; 56% reported increased job satisfaction; 78% of staff were enthusiastic about receiving further training. Based on participants’ responses, four BCTTv1 labels–Social support (emotional), Focus on past success and verbal persuasion to boost self-efficacy, Restructuring the social environment and Habit formation–were identified to describe the intervention. Residents and staff recommended including additional musical genres and extending the session length. Discussions of implementing a supervision system to sustain DANCIN regularly regardless of management or staff turnover were suggested.
Conclusions:Care home residents with mild to moderate dementia wanted to continue DANCIN as part of their routine care and staff and family members were largely supportive of this approach. This study argues in favor of further dissemination of DANCIN in care homes. We provide recommendations for the future development of DANCIN based on the views of key stakeholder groups.
Cambrian microfossils from the Tethyan Himalaya
- Ian R. Gilbert, Nigel C. Hughes, Paul M. Myrow
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- Journal:
- Journal of Paleontology / Volume 90 / Issue 1 / January 2016
- Published online by Cambridge University Press:
- 15 June 2016, pp. 10-30
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Cambrian biostratigraphy of the Indian subcontinent is best documented from the Parahio Formation of the Tethyan Himalaya. Recently established trilobite biostratigraphy shows that the formation encompasses the latest part of unnamed Stage 4 and much of unnamed Stage 5. A variety of small shelly fossils have been recovered via acid digestion of carbonate beds and include tetract and pentact hexactinellid sponge spicules, chancelloriid spicules belonging to Chancelloria sp. and a new species, Archiasterella dhiraji, shells of an helcionelloid comparable to Igorella maidipingensis, a meraspid ptychopariid trilobite, the tubular Cupitheca sp., a poorly preserved hyolith, and an assortment of spinose microfossils of uncertain affinity. These newly recovered microfossils are consistent with the trilobite-based lower and middle Cambrian age determination and do not support a late Cambrian age for the top of the Parahio Formation advocated in some recent literature. The microfossils reported herein significantly expand the known diversity of such fossils from Cambrian strata in the Himalayan region, and allow for comparison of this fauna with others from Gondwanaland and elsewhere. Integration with trilobite data indicate that the stratigraphic ranges of many small shelly fossils described in this study are greater than previously recognized.
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- By Mitchell Aboulafia, Frederick Adams, Marilyn McCord Adams, Robert M. Adams, Laird Addis, James W. Allard, David Allison, William P. Alston, Karl Ameriks, C. Anthony Anderson, David Leech Anderson, Lanier Anderson, Roger Ariew, David Armstrong, Denis G. Arnold, E. J. Ashworth, Margaret Atherton, Robin Attfield, Bruce Aune, Edward Wilson Averill, Jody Azzouni, Kent Bach, Andrew Bailey, Lynne Rudder Baker, Thomas R. Baldwin, Jon Barwise, George Bealer, William Bechtel, Lawrence C. Becker, Mark A. Bedau, Ernst Behler, José A. Benardete, Ermanno Bencivenga, Jan Berg, Michael Bergmann, Robert L. Bernasconi, Sven Bernecker, Bernard Berofsky, Rod Bertolet, Charles J. Beyer, Christian Beyer, Joseph Bien, Joseph Bien, Peg Birmingham, Ivan Boh, James Bohman, Daniel Bonevac, Laurence BonJour, William J. Bouwsma, Raymond D. Bradley, Myles Brand, Richard B. Brandt, Michael E. Bratman, Stephen E. Braude, Daniel Breazeale, Angela Breitenbach, Jason Bridges, David O. Brink, Gordon G. Brittan, Justin Broackes, Dan W. Brock, Aaron Bronfman, Jeffrey E. Brower, Bartosz Brozek, Anthony Brueckner, Jeffrey Bub, Lara Buchak, Otavio Bueno, Ann E. Bumpus, Robert W. Burch, John Burgess, Arthur W. Burks, Panayot Butchvarov, Robert E. Butts, Marina Bykova, Patrick Byrne, David Carr, Noël Carroll, Edward S. Casey, Victor Caston, Victor Caston, Albert Casullo, Robert L. Causey, Alan K. L. Chan, Ruth Chang, Deen K. Chatterjee, Andrew Chignell, Roderick M. Chisholm, Kelly J. Clark, E. J. Coffman, Robin Collins, Brian P. Copenhaver, John Corcoran, John Cottingham, Roger Crisp, Frederick J. Crosson, Antonio S. Cua, Phillip D. Cummins, Martin Curd, Adam Cureton, Andrew Cutrofello, Stephen Darwall, Paul Sheldon Davies, Wayne A. Davis, Timothy Joseph Day, Claudio de Almeida, Mario De Caro, Mario De Caro, John Deigh, C. F. Delaney, Daniel C. Dennett, Michael R. DePaul, Michael Detlefsen, Daniel Trent Devereux, Philip E. Devine, John M. Dillon, Martin C. Dillon, Robert DiSalle, Mary Domski, Alan Donagan, Paul Draper, Fred Dretske, Mircea Dumitru, Wilhelm Dupré, Gerald Dworkin, John Earman, Ellery Eells, Catherine Z. Elgin, Berent Enç, Ronald P. Endicott, Edward Erwin, John Etchemendy, C. Stephen Evans, Susan L. Feagin, Solomon Feferman, Richard Feldman, Arthur Fine, Maurice A. Finocchiaro, William FitzPatrick, Richard E. Flathman, Gvozden Flego, Richard Foley, Graeme Forbes, Rainer Forst, Malcolm R. Forster, Daniel Fouke, Patrick Francken, Samuel Freeman, Elizabeth Fricker, Miranda Fricker, Michael Friedman, Michael Fuerstein, Richard A. Fumerton, Alan Gabbey, Pieranna Garavaso, Daniel Garber, Jorge L. A. Garcia, Robert K. Garcia, Don Garrett, Philip Gasper, Gerald Gaus, Berys Gaut, Bernard Gert, Roger F. Gibson, Cody Gilmore, Carl Ginet, Alan H. Goldman, Alvin I. Goldman, Alfonso Gömez-Lobo, Lenn E. Goodman, Robert M. Gordon, Stefan Gosepath, Jorge J. E. Gracia, Daniel W. Graham, George A. Graham, Peter J. Graham, Richard E. Grandy, I. Grattan-Guinness, John Greco, Philip T. Grier, Nicholas Griffin, Nicholas Griffin, David A. Griffiths, Paul J. Griffiths, Stephen R. Grimm, Charles L. Griswold, Charles B. Guignon, Pete A. Y. Gunter, Dimitri Gutas, Gary Gutting, Paul Guyer, Kwame Gyekye, Oscar A. Haac, Raul Hakli, Raul Hakli, Michael Hallett, Edward C. Halper, Jean Hampton, R. James Hankinson, K. R. Hanley, Russell Hardin, Robert M. Harnish, William Harper, David Harrah, Kevin Hart, Ali Hasan, William Hasker, John Haugeland, Roger Hausheer, William Heald, Peter Heath, Richard Heck, John F. Heil, Vincent F. Hendricks, Stephen Hetherington, Francis Heylighen, Kathleen Marie Higgins, Risto Hilpinen, Harold T. Hodes, Joshua Hoffman, Alan Holland, Robert L. Holmes, Richard Holton, Brad W. Hooker, Terence E. Horgan, Tamara Horowitz, Paul Horwich, Vittorio Hösle, Paul Hoβfeld, Daniel Howard-Snyder, Frances Howard-Snyder, Anne Hudson, Deal W. Hudson, Carl A. Huffman, David L. Hull, Patricia Huntington, Thomas Hurka, Paul Hurley, Rosalind Hursthouse, Guillermo Hurtado, Ronald E. Hustwit, Sarah Hutton, Jonathan Jenkins Ichikawa, Harry A. Ide, David Ingram, Philip J. Ivanhoe, Alfred L. Ivry, Frank Jackson, Dale Jacquette, Joseph Jedwab, Richard Jeffrey, David Alan Johnson, Edward Johnson, Mark D. Jordan, Richard Joyce, Hwa Yol Jung, Robert Hillary Kane, Tomis Kapitan, Jacquelyn Ann K. Kegley, James A. Keller, Ralph Kennedy, Sergei Khoruzhii, Jaegwon Kim, Yersu Kim, Nathan L. King, Patricia Kitcher, Peter D. Klein, E. D. Klemke, Virginia Klenk, George L. Kline, Christian Klotz, Simo Knuuttila, Joseph J. Kockelmans, Konstantin Kolenda, Sebastian Tomasz Kołodziejczyk, Isaac Kramnick, Richard Kraut, Fred Kroon, Manfred Kuehn, Steven T. Kuhn, Henry E. Kyburg, John Lachs, Jennifer Lackey, Stephen E. Lahey, Andrea Lavazza, Thomas H. Leahey, Joo Heung Lee, Keith Lehrer, Dorothy Leland, Noah M. Lemos, Ernest LePore, Sarah-Jane Leslie, Isaac Levi, Andrew Levine, Alan E. Lewis, Daniel E. Little, Shu-hsien Liu, Shu-hsien Liu, Alan K. L. Chan, Brian Loar, Lawrence B. Lombard, John Longeway, Dominic McIver Lopes, Michael J. Loux, E. J. Lowe, Steven Luper, Eugene C. Luschei, William G. Lycan, David Lyons, David Macarthur, Danielle Macbeth, Scott MacDonald, Jacob L. Mackey, Louis H. Mackey, Penelope Mackie, Edward H. Madden, Penelope Maddy, G. B. Madison, Bernd Magnus, Pekka Mäkelä, Rudolf A. Makkreel, David Manley, William E. Mann (W.E.M.), Vladimir Marchenkov, Peter Markie, Jean-Pierre Marquis, Ausonio Marras, Mike W. Martin, A. P. Martinich, William L. McBride, David McCabe, Storrs McCall, Hugh J. McCann, Robert N. McCauley, John J. McDermott, Sarah McGrath, Ralph McInerny, Daniel J. McKaughan, Thomas McKay, Michael McKinsey, Brian P. McLaughlin, Ernan McMullin, Anthonie Meijers, Jack W. Meiland, William Jason Melanson, Alfred R. Mele, Joseph R. Mendola, Christopher Menzel, Michael J. Meyer, Christian B. Miller, David W. Miller, Peter Millican, Robert N. Minor, Phillip Mitsis, James A. Montmarquet, Michael S. Moore, Tim Moore, Benjamin Morison, Donald R. Morrison, Stephen J. Morse, Paul K. Moser, Alexander P. D. Mourelatos, Ian Mueller, James Bernard Murphy, Mark C. Murphy, Steven Nadler, Jan Narveson, Alan Nelson, Jerome Neu, Samuel Newlands, Kai Nielsen, Ilkka Niiniluoto, Carlos G. Noreña, Calvin G. Normore, David Fate Norton, Nikolaj Nottelmann, Donald Nute, David S. Oderberg, Steve Odin, Michael O’Rourke, Willard G. Oxtoby, Heinz Paetzold, George S. Pappas, Anthony J. Parel, Lydia Patton, R. P. Peerenboom, Francis Jeffry Pelletier, Adriaan T. Peperzak, Derk Pereboom, Jaroslav Peregrin, Glen Pettigrove, Philip Pettit, Edmund L. Pincoffs, Andrew Pinsent, Robert B. Pippin, Alvin Plantinga, Louis P. Pojman, Richard H. Popkin, John F. Post, Carl J. Posy, William J. Prior, Richard Purtill, Michael Quante, Philip L. Quinn, Philip L. Quinn, Elizabeth S. Radcliffe, Diana Raffman, Gerard Raulet, Stephen L. Read, Andrews Reath, Andrew Reisner, Nicholas Rescher, Henry S. Richardson, Robert C. Richardson, Thomas Ricketts, Wayne D. Riggs, Mark Roberts, Robert C. Roberts, Luke Robinson, Alexander Rosenberg, Gary Rosenkranz, Bernice Glatzer Rosenthal, Adina L. Roskies, William L. Rowe, T. M. Rudavsky, Michael Ruse, Bruce Russell, Lilly-Marlene Russow, Dan Ryder, R. M. Sainsbury, Joseph Salerno, Nathan Salmon, Wesley C. Salmon, Constantine Sandis, David H. Sanford, Marco Santambrogio, David Sapire, Ruth A. Saunders, Geoffrey Sayre-McCord, Charles Sayward, James P. Scanlan, Richard Schacht, Tamar Schapiro, Frederick F. Schmitt, Jerome B. Schneewind, Calvin O. Schrag, Alan D. Schrift, George F. Schumm, Jean-Loup Seban, David N. Sedley, Kenneth Seeskin, Krister Segerberg, Charlene Haddock Seigfried, Dennis M. Senchuk, James F. Sennett, William Lad Sessions, Stewart Shapiro, Tommie Shelby, Donald W. Sherburne, Christopher Shields, Roger A. Shiner, Sydney Shoemaker, Robert K. Shope, Kwong-loi Shun, Wilfried Sieg, A. John Simmons, Robert L. Simon, Marcus G. Singer, Georgette Sinkler, Walter Sinnott-Armstrong, Matti T. Sintonen, Lawrence Sklar, Brian Skyrms, Robert C. Sleigh, Michael Anthony Slote, Hans Sluga, Barry Smith, Michael Smith, Robin Smith, Robert Sokolowski, Robert C. Solomon, Marta Soniewicka, Philip Soper, Ernest Sosa, Nicholas Southwood, Paul Vincent Spade, T. L. S. Sprigge, Eric O. Springsted, George J. Stack, Rebecca Stangl, Jason Stanley, Florian Steinberger, Sören Stenlund, Christopher Stephens, James P. Sterba, Josef Stern, Matthias Steup, M. A. Stewart, Leopold Stubenberg, Edith Dudley Sulla, Frederick Suppe, Jere Paul Surber, David George Sussman, Sigrún Svavarsdóttir, Zeno G. Swijtink, Richard Swinburne, Charles C. Taliaferro, Robert B. Talisse, John Tasioulas, Paul Teller, Larry S. Temkin, Mark Textor, H. S. Thayer, Peter Thielke, Alan Thomas, Amie L. Thomasson, Katherine Thomson-Jones, Joshua C. Thurow, Vzalerie Tiberius, Terrence N. Tice, Paul Tidman, Mark C. Timmons, William Tolhurst, James E. Tomberlin, Rosemarie Tong, Lawrence Torcello, Kelly Trogdon, J. D. Trout, Robert E. Tully, Raimo Tuomela, John Turri, Martin M. Tweedale, Thomas Uebel, Jennifer Uleman, James Van Cleve, Harry van der Linden, Peter van Inwagen, Bryan W. Van Norden, René van Woudenberg, Donald Phillip Verene, Samantha Vice, Thomas Vinci, Donald Wayne Viney, Barbara Von Eckardt, Peter B. M. Vranas, Steven J. Wagner, William J. Wainwright, Paul E. Walker, Robert E. Wall, Craig Walton, Douglas Walton, Eric Watkins, Richard A. Watson, Michael V. Wedin, Rudolph H. Weingartner, Paul Weirich, Paul J. Weithman, Carl Wellman, Howard Wettstein, Samuel C. Wheeler, Stephen A. White, Jennifer Whiting, Edward R. Wierenga, Michael Williams, Fred Wilson, W. Kent Wilson, Kenneth P. Winkler, John F. Wippel, Jan Woleński, Allan B. Wolter, Nicholas P. Wolterstorff, Rega Wood, W. Jay Wood, Paul Woodruff, Alison Wylie, Gideon Yaffe, Takashi Yagisawa, Yutaka Yamamoto, Keith E. Yandell, Xiaomei Yang, Dean Zimmerman, Günter Zoller, Catherine Zuckert, Michael Zuckert, Jack A. Zupko (J.A.Z.)
- Edited by Robert Audi, University of Notre Dame, Indiana
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- Book:
- The Cambridge Dictionary of Philosophy
- Published online:
- 05 August 2015
- Print publication:
- 27 April 2015, pp ix-xxx
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The CNDR: Collaborating to Translate New Therapies for Canadians
- Lawrence Korngut, Craig Campbell, Megan Johnston, Timothy Benstead, Angela Genge, Alex MacKenzie, Anna McCormick, Douglas Biggar, Pierre Bourque, Hannah Briemberg, Colleen O'Connell, Suzan Dojeiji, Joseph Dooley, Ian Grant, Gillian Hogan, Wendy Johnston, Sanjay Kalra, Hans D. Katzberg, Jean K. Mah, Laura McAdam, Hugh J. McMillan, Michel Melanson, Kathryn Selby, Christen Shoesmith, Garth Smith, Shannon L. Venance, Joy Wee,
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- Canadian Journal of Neurological Sciences / Volume 40 / Issue 5 / September 2013
- Published online by Cambridge University Press:
- 23 September 2014, pp. 698-704
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Background:
Patient registries represent an important method of organizing “real world” patient information for clinical and research purposes. Registries can facilitate clinical trial planning and recruitment and are particularly useful in this regard for uncommon and rare diseases. Neuromuscular diseases (NMDs) are individually rare but in aggregate have a significant prevalence. In Canada, information on NMDs is lacking. Barriers to performing Canadian multicentre NMD research exist which can be overcome by a comprehensive and collaborative NMD registry.
Methods:We describe the objectives, design, feasibility and initial recruitment results for the Canadian Neuromuscular Disease Registry (CNDR).
Results:The CNDR is a clinic-based registry which launched nationally in June 2011, incorporates paediatric and adult neuromuscular clinics in British Columbia, Alberta, Ontario, Quebec, New Brunswick and Nova Scotia and, as of December 2012, has recruited 1161 patients from 12 provinces and territories. Complete medical datasets have been captured on 460 “index disease” patients. Another 618 “non-index” patients have been recruited with capture of physician-confirmed diagnosis and contact information. We have demonstrated the feasibility of blended clinic and central office-based recruitment. “Index disease” patients recruited at the time of writing include 253 with Duchenne and Becker muscular dystrophy, 161 with myotonic dystrophy, and 71 with ALS.
Conclusions:The CNDR is a new nationwide registry of patients with NMDs that represents an important advance in Canadian neuromuscular disease research capacity. It provides an innovative platform for organizing patient information to facilitate clinical research and to expedite translation of recent laboratory findings into human studies.