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Mycotoxin-contaminated diets and an adsorbent affect the performance of Nellore bulls finished in feedlots
- L. Custodio, L. F. Prados, D. N. Figueira, A. Yiannikouris, E. M. Gloria, V. B. Holder, J. E. Pettigrew, E. Santin, F. D. Resende, G. R. Siqueira
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Mycotoxins are present in almost all feedstuffs used in animal nutrition but are often ignored in beef cattle systems, even though they can affect animal performance. The objective of this study was to evaluate the effects of mycotoxins and a mycotoxin adsorbent (ADS) on performance of Nellore cattle finished in a feedlot. One hundred Nellore cattle (430 ± 13 kg) were used in a randomized complete block design with a 2 × 2 factorial arrangement of treatments. The factors consisted of two diets with either natural contamination (NC) or exogenous contamination (EC) and the presence (1 g/kg of DM; ADS) or absence of a mycotoxin adsorbent. The NC and EC diets had the following contaminations, respectively: 0.00 and 10.0 µg/kg aflatoxins, 5114 and 5754 µg/kg fumonisins, 0.00 and 42.1 µg/kg trichothecenes B, 0.00 and 22.1 µg/kg trichothecenes A and 42.9 and 42.9 µg/kg fusaric acid. At the beginning of the experiment, all animals were weighed, and four randomly selected animals were slaughtered to evaluate the initial carcass weight. After 97 days of treatment, all animals were weighed and slaughtered. There was no interaction among factors for the DM intake (DMI; P = 0.92); however, there was a tendency for the EC diets to decrease the DMI by 650 g/day compared to animals fed NC diets (P = 0.09). There was a trend for interaction among factors (P = 0.08) for the average daily gain (ADG), where the greatest ADG was observed for cattle fed the NC diet (1.77 kg), and the lowest was observed for those fed the EC diet (1.51 kg). The NC + ADS and EC + ADS treatments presented intermediate values for ADG. The animals fed the NC diet had a greater final BW (596 kg) than animals fed the EC treatment (582 kg; P = 0.04). There was a tendency for interaction among factors for carcass gain (P = 0.08). Similarly to ADG, the highest carcass gain was observed for animals fed the NC diet (1.20 kg), and the lowest was observed for those fed the EC diet (1.05 kg). The NC + ADS and EC + ADS treatments presented intermediate values. The natural contamination groups had greater carcass gain than that of the EC groups, and the use of the ADS recovered part of the weight gain in animals fed the EC diet. In conclusion, mycotoxins at the levels evaluated affected the performance of beef cattle, and adsorbents may mitigate their impact.
Better diet quality scores are associated with a lower risk of hypertension and non-fatal CVD in middle-aged Australian women over 15 years of follow-up
- Jacklyn K Jackson, Lesley K MacDonald-Wicks, Mark A McEvoy, Peta M Forder, Carl Holder, Christopher Oldmeadow, Julie E Byles, Amanda J Patterson
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- Journal:
- Public Health Nutrition / Volume 23 / Issue 5 / April 2020
- Published online by Cambridge University Press:
- 14 October 2019, pp. 882-893
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Objective:
To explore if better diet quality scores as a measure of adherence to the Australian Dietary Guidelines (ADG) and the Mediterranean diet (MedDiet) are associated with a lower incidence of hypertension and non-fatal CVD.
Design:Prospective analysis of the 1946–1951 cohort of the Australian Longitudinal Study on Women’s Health (ALSWH). The Australian Recommended Foods Score (ARFS) was calculated as an indicator of adherence to the ADG; the Mediterranean Diet Score (MDS) measured adherence to the MedDiet. Outcomes included hypertension and non-fatal CVD. Generalised estimating equations estimated OR and 95 % CI across quartiles of diet quality scores.
Setting:Australia, 2001–2016.
Participants:1946–1951 cohort of the ALSWH (n 5324), without CVD, hypertension and diabetes at baseline (2001), with complete FFQ data.
Results:There were 1342 new cases of hypertension and 629 new cases of non-fatal CVD over 15 years of follow-up. Multivariate analysis indicated that women reporting better adherence to the ARFS (≥38/74) had 15 % (95 % CI 1, 28 %; P = 0·05) lower odds of hypertension and 46 % (95 % CI 6, 66 %; P = 0·1) lower odds of non-fatal CVD. Women reporting better adherence to the MDS (≥8/17) had 27 % (95 % CI 15, 47 %; P = 0·0006) lower odds of hypertension and 30 % (95 % CI 2, 50 %; P = 0·03) lower odds of non-fatal CVD.
Conclusions:Better adherence to diet quality scores is associated with lower risk of hypertension and non-fatal CVD. These results support the need for updated evidenced based on the ADG as well as public health nutrition policies in Australia.
A continuous 4000-year lake-level record of Owens Lake, south-central Sierra Nevada, California, USA
- Steven N. Bacon, Nicholas Lancaster, Scott Stine, Edward J. Rhodes, Grace A. McCarley Holder
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- Journal:
- Quaternary Research / Volume 90 / Issue 2 / September 2018
- Published online by Cambridge University Press:
- 02 July 2018, pp. 276-302
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Reconstruction of lake-level fluctuations from landform and outcrop evidence typically involves characterizing periods with relative high stands. We developed a new approach to provide water-level estimates in the absence of shoreline evidence for Owens Lake in eastern California by integrating landform, outcrop, and existing lake-core data with wind-wave and sediment entrainment modeling of lake-core sedimentology. We also refined the late Holocene lake-level history of Owens Lake by dating four previously undated shoreline features above the water level (1096.4 m) in AD 1872. The new ages coincide with wetter and cooler climate during the Neopluvial (~3.6 ka), Medieval Pluvial (~0.8 ka), and Little Ice Age (~0.35 ka). Dates from stumps below 1096 m also indicate two periods of low stands at ~0.89 and 0.67 ka during the Medieval Climatic Anomaly. The timing of modeled water levels associated with 22 mud and sand units in lake cores agree well with shoreline records of Owens Lake and nearby Mono Lake, as well as with proxy evidence for relatively wet and dry periods from tree-ring and glacial records within the watershed. Our integrated analysis provides a continuous 4000-yr lake-level record showing the timing, duration, and magnitude of hydroclimate variability along the south-central Sierra Nevada.
Critical periods for weed control in dry beans (Phaseolus vulgaris)
- Orvin C. Burnside, Melvin J. Wiens, Bobby J. Holder, Sanford Weisbere, Eric A. Ristau, Michelle M. Johnson, James H. Cameron
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- Journal:
- Weed Science / Volume 46 / Issue 3 / June 1998
- Published online by Cambridge University Press:
- 12 June 2017, pp. 301-306
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Weed removal experiments in dry edible beans were conducted during 1992 and 1993 at Crookston and Staples, MN. Ten manual weed removal treatments were studied to determine when a natural infestation of weeds first reduced dry bean yield, and when weed removal could be discontinued without further loss of seed yield. Major weeds in order of average biomass production on weedy check plots at dry bean harvest over locations and years were wild mustard, foxtail spp., redroot pigweed, common ragweed, wild buckwheat, hairy nightshade, and common lambsquarters. Hairy nightshade also emerged late in the growing season and could negatively affect harvest efficiency and stain navy beans. Weed removal treatments had little effect on dry bean stands or 100-seed weights of harvested dry bean seed. The critical period for weed control in dry beans was 3 to 5 or 6 weeks after planting (WAP). Thus, weed control practices should begin no later than 3 WAP and continue until at least 5 or 6 WAP for maximum dry bean yields.
Efficacy and Economics of Various Mechanical Plus Chemical Weed Control Systems in Dry Beans (Phaseolus vulgaris)
- Orvin C. Burnside, William H. Ahrens, Bobby J. Holder, Melvin J. Wiens, Michelle M. Johnson, Eric A. Ristau
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- Journal:
- Weed Technology / Volume 8 / Issue 2 / June 1994
- Published online by Cambridge University Press:
- 12 June 2017, pp. 238-244
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Various mechanical plus chemical weed control systems for dry bean production were evaluated at Carrington, ND and Crookston and Staples, MN during 1991 and 1992. A dozen tillage plus herbicide weed control systems are available to growers that can provide selective and effective weed control in dry beans without reliance on chloramben—a standard herbicide on dry beans that has been lost. Dry bean yields were similar with low or high level tillage treatments because most of the herbicide treatments with one cultivation gave adequate weed control and any additional tillage did not improve weed control. Kidney bean yields and prices were greater than either pinto or navy beans so the net returns (bean market value minus production costs) were much greater for kidney bean production. Dry bean producers in the North Central part of the U.S. have at their disposal dependable mechanical plus chemical weed control systems, and their market value has been sufficient to make dry bean production very economical in this region.
Plastic Behavior of Predeformed Ice Crystals*
- D. M. Joncich, J. Holder, A. V. Granato
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- Journal:
- Journal of Glaciology / Volume 21 / Issue 85 / 1978
- Published online by Cambridge University Press:
- 30 January 2017, pp. 700-701
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Conventional studies of plastic deformation have been complicated by the simultaneous variation of dislocation velocity and dislocation density during the tests. In the present study this difficulty was avoided by carrying out deformation tests at low stress levels on samples which had been predeformed to relatively higher stresses prior to the measurements. Creep, mechanical after effect, constant strain-rate, and stress relaxation tests were carried out as a function of measurement stress or strain-rate, temperature, and predeformation level. The results were analysed in terms of a linear stress-dependent dislocation velocity in order to determine whether that simple behavior is able to account for the macroscopic deformation behavior of ice crystals. This report is a brief summary of the results; a complete discussion is to be published elsewhere. The principal results of the study are as follows:
1. The observed behavior was particularly simple for predeformed samples. The creep strain showed a nearly linear increase with time, without the large positive curvature characteristic of conventional tests. No stress maxima were observed in the constant strain-rate tests as have been found in previous studies of non-predeformed samples. The (complete) stress relaxation curve was virtually identical in shape to the inverted constant strain-rate curve.
2. The steady-state creep and constant strain-rate behavior could be described to good approximation in terms of the motion of a constant density of dislocations moving with the same linear stress-dependent velocities as have been observed directly by others. The strain-rates were linear in stress and the estimated dislocation densities (4 to 16 × 10 cm-2) varied with the magnitude of the predeformation level in a manner consistent with previous observa-tions. The strain-rates or stress levels are exponential in 1/T with an activation energy of 0.6 eV, which is approximately equal to the activation energy reported for the motion of dislocations and for the mechanical relaxation time in internal friction studies.
3. A small transient creep behavior, and a small but measurable mechanical after-effect with the same (≈ 3 min) time constant were present. These effects, as well as the non-exponential behavior of the constant strain-rate and stress-relaxation stress—strain results, could be accounted for by including a second, anelastic, component in a deformation model corresponding to a restoring force in addition to the linear viscous drag force on dislocations. This leads to a differential equation which is linear in stress and strain, but involves both first-and second-order time derivatives.
4. The solutions of this differential equation describe the observed mechanical response well, and provide a general internal consistency check for the model.
5. A quantitative fit of the experimental test results to the dislocation model gives values of 3-4 for the ratios of total dislocation density to the recoverable component and values of 7-8 dyn/cm2 for the restoring force constant for the recoverable dislocations. The restoring force constants and recoverable dislocation densities were, within experimental error, found to be independent of temperature, measurement stress and strain-rate, and predeformation level. Values found for the parameters for creep and mechanical after-effect tests were equal within experimental error to the values found from constant strain-rate and stress-relaxation tests carried out on the same sample. If the recoverable dislocation component is identified as bowed-out dislocation segments whose ends are fixed, the restoring force could be accounted for by the elastic line tension of dislocation segments of lengths of about 8 × 10-3 cm.
No feature of the experimental results was inconsistent with this dislocation model, and the results of the study are all in agreement with the theory proposed by Weertman in which the dislocation drag force is very large because of the stress-induced ordering of water molecules in the stress field of the moving dislocation.
A Direct Determination of an Upper Limit for the Electrical Charge on Dislocations in Ice*
- D.M. Joncich, J. Holder, A.V. Granato
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- Journal:
- Journal of Glaciology / Volume 20 / Issue 84 / 1978
- Published online by Cambridge University Press:
- 30 January 2017, pp. 543-546
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A direct determination of the upper limit for the electric charge density along dislocations in ice has been carried out by measuring the simultaneous effects of an electric field and a mechanical stress on the movement of a low-angle tilt boundary in an ice single crystal. The determination is independent of the geometry of the dislocations or the distribution of the charge along them. No measurable effects of the electric field on boundary motion were found, requiring that the charge density be less than one unit of charge for every 300 atomic lengths of dislocation. This estimate is less than large previous estimates, but is consistent with smaller proposed values.
Recent Developments in High Speed Research: In the Aerodynamics Division of the National Physical Laboratory
- J. A. Beavan, D. W. Holder
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- The Aeronautical Journal / Volume 54 / Issue 477 / September 1950
- Published online by Cambridge University Press:
- 28 July 2016, pp. 545-586
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Much work has been done on compressible flow since the contribution of the Aerodynamics Division to research in this field was last described to the Society by the late C. N. H. Lock in 1937. At that time he was able to review many of the data which were available from other sources, whereas today such a task would be impossible in a paper of this length. We shall confine ourselves here, therefore, to a description of some of the experimental work that has been done during the past few years in the high-speed laboratory of the Division, and to an account of the lines along which it is intended to continue the work in the future.
Lessons Learned from Twelve Years of Partnered Tobacco Cessation Research in the Dominican Republic
- Deborah J. Ossip, Sergio Díaz, Zahira Quiñones, Scott McIntosh, Ann Dozier, Nancy Chin, Emily Weber, Heather Holderness, Essie Torres, Arisleyda Bautista, Jóse Javier Sánchez, Esteban Avendaño, Timothy De Ver Dye, Paul McDonald, Eduardo Bianco
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- Journal:
- Journal of Smoking Cessation / Volume 11 / Issue 2 / June 2016
- Published online by Cambridge University Press:
- 10 May 2016, pp. 99-107
- Print publication:
- June 2016
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Engaging partners for tobacco control within low and middle income countries (LMICs) at early stages of tobacco control presents both challenges and opportunities in the global effort to avert the one billion premature tobacco caused deaths projected for this century. The Dominican Republic (DR) is one such early stage country. The current paper reports on lessons learned from 12 years of partnered United States (US)-DR tobacco cessation research conducted through two NIH trials (Proyecto Doble T, PDT1 and 2). The projects began with a grassroots approach of working with interested communities to develop and test interventions for cessation and secondhand smoke reduction that could benefit the communities, while concurrently building local capacity and providing resources, data, and models of implementation that could be used to ripple upward to expand partnerships and tobacco intervention efforts nationally. Lessons learned are discussed in four key areas: partnering for research, logistical issues in setting up the research project, disseminating and national networking, and mentoring. Effectively addressing the global tobacco epidemic will require sustained focus on supporting LMIC infrastructures for tobacco control, drawing on lessons learned across partnered trials such as those reported here, to provide feasible and innovative approaches for addressing this modifiable public health crisis.
13 - Melodrama
- from PART II - THEATRE
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- By Heidi J. Holder, University of Massachusetts, Amherst
- Edited by Brad Kent, Université Laval, Québec
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- Book:
- George Bernard Shaw in Context
- Published online:
- 05 October 2015
- Print publication:
- 14 October 2015, pp 102-108
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Summary
In March 1896, Bernard Shaw attended in his capacity as theatre reviewer a performance of a rather undistinguished nautical melodrama: True Blue, by Leonard Outram and Stewart Gordon. He conjured for his readers a notable scene in which the female villain, a lady matador, plots to eliminate her rival, who, as a stowaway, has chosen to hide herself in a ship's boiler:
Becoming acquainted, heaven knows how, with the hiding place of the heroine, she takes the stage alone, and draws a thrilling picture of her rival's impending doom. She describes her in the clammy darkness of the boiler, listening to the wild beats of her own heart. Then the sensation of wet feet, the water rising to her ankles, her knees, her waist, her neck and only by standing on tip toe, with frantic upturned face, can she breathe. One mercy alone seems vouchsafed to her: the water has lost its deadly chill. Nay, it is getting distinctly warm, even hot – hotter – scalding! Immortal powers, it is BOILING; and what was a moment ago a beautiful English girl in the exquisite budding of her beautiful womanhood, is now but a boilerful of soup, and in a moment will be but a condenser full of low-pressure steam. I must congratulate [the actress] on the courage with which she hurled this terrible word-picture at a house half white with its purgation by pity and terror, and half red with voiceless, apoplectic laughter. (OTN II: 81)
Shaw had long experience with such ‘thrilling pictures’ as this. From youthful trips to the Theatre Royal, Dublin, at which he saw the works of mid-century dramatists including Dion Boucicault, Charles Reade, and Tom Taylor, to his work as a theatre critic for the Saturday Review in the 1890s, Shaw had many opportunities to ponder melodramatic effects. So steeped was he in Victorian popular theatre that, as Martin Meisel has argued, his ‘drama of ideas was a legitimate child of that theater’.
His experience from the start was marked by the kind of doubleness noted earlier, a contrast or interplay between being helplessly gripped by theatrical effect and remaining aware of its artificiality, even absurdity.
Tobacco Cessation in Economically Disadvantaged Dominican Republic Communities: Who are the Ex-Users?
- Deborah J. Ossip, Zahíra Quiñones, Sergio Diaz, Kelly Thevenet-Morrison, Susan Fisher, Heather Holderness, Xeuya Cai, Scott McIntosh, Ann Dozier, Nancy Chin, Emily Weber, Jose Javier Sanchez, Arisleyda Bautista, Héctor Almonte
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- Journal:
- Journal of Smoking Cessation / Volume 11 / Issue 4 / December 2016
- Published online by Cambridge University Press:
- 20 February 2015, pp. 239-249
- Print publication:
- December 2016
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Introduction: Tobacco use and its harm continue to increase in low and middle income countries (LMICs) globally. Smoking cessation is the most effective means of reducing morbidity and mortality from tobacco use. Increasing the prevalence of ex-users is an indicator of population cessation.
Aims: This study provides the first examination of factors associated with ex-tobacco use status in the Dominican Republic (DR), a LMIC in the Latin America and Caribbean region.
Methods: Baseline surveillance was conducted for 1,177 randomly selected households in seven economically disadvantaged DR communities (total N = 2,680 adult household members).
Results: Ex-user prevalence was 10.6% (1.0%–18.5% across communities), 14.8% were current users (9.1–20.4), and quit ratios were 41.7% (9.7%–52.7%). Among ever users, females (OR 2.02, 95% CI 1.41, 2.90), older adults (45–64: OR 1.75, 95% CI 1.12, 2.74; 65+: OR 2.09, 95% CI 1.29, 3.39), and those who could read/write (OR 1.64, 95% CI 1.08, 2.50), had health conditions (OR 1.63, 95% CI 1.11, 2.41), and lived with ex-users (OR 1.70, 95% CI 1.12, 2.58) were over 60% to two times as likely to be ex-users. Those from remote communities (OR 0.52, 95% CI 0.36, 0.74), using chewed tobacco (OR 0.14, 95% CI 0.04, 0.48) and living with tobacco users (OR 0.55, 95% CI 0.37, 0.81) were less likely to be ex-users.
Conclusions: Ex-user prevalence and quit ratios were lower than for high income countries. Implementing broad tobacco control measures, combined with clinically targeting vulnerable groups, may increase tobacco cessation to most effectively reduce this public health crisis.
Contributors
- Edited by Larry May, Vanderbilt University, Tennessee, Elizabeth Edenberg, Vanderbilt University, Tennessee
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- Book:
- <I>Jus Post Bellum</I> and Transitional Justice
- Published online:
- 05 October 2013
- Print publication:
- 07 October 2013, pp ix-x
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- By Nozomi Akanuma, Gonzalo Alarcón, R. Arunachalam, Sarah H. Bernard, Frank M. C. Besag, Istvan Bodi, Stephen Brown, Franz Brunnhuber, Antonella Cerquiglini, J. Helen Cross, R. Shane Delamont, Archana Desurkar, Lee Drummond, Rona Eade, Robert D. C. Elwes, Bidi Evans, Peter Fenwick, Colin D. Ferrie, Paul L. Furlong, Laura H. Goldstein, Sally Gomersall, Sushma Goyal, Jane Hanna, Yvonne Hart, Dominic C. Heaney, Graham E. Holder, Mrinalini Honavar, Elaine Hughes, Jozef M. Jarosz, John G. R. Jefferys, Jane Juler, Mathias Koepp, Michalis Koutroumanidis, Maureen Lahiff, Louis Lemieux, David McCormick, Brian Meldrum, John D. C. Mellers, Nicholas Moran, John Moriarty, Robin G. Morris, Nandini Mullatti, Lina Nashef, Jennifer Nightingale, T. J. von Oertzen, Corina O'Neill, Philip N. Patsalos, Stella Pearson, Charles E. Polkey, Ronit Pressler, Edward H. Reynolds, Mark P. Richardson, Leone Ridsdale, Robert Robinson, Greg Rogers, Euan M. Ross, Richard P. Selway, Stefano Seri, Simeran Sharma, Graeme J. Sills, Andrew Simmons, Shiri Spector, Mark Stevenson, Jade N. Thai, Brian Toone, Antonio Valentín, Nuria T. Villagra, Matthew Walker, William Whitehouse
- Edited by Gonzalo Alarcón, King's College London, Antonio Valentín, King's College London
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- Book:
- Introduction to Epilepsy
- Published online:
- 05 July 2012
- Print publication:
- 26 April 2012, pp xii-xv
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- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. Chapman, James H. Charlesworth, Kenneth R. Chase, Chen Zemin, Luciano Chianeque, Philip Chia Phin Yin, Francisca H. Chimhanda, Daniel Chiquete, John T. Chirban, Soobin Choi, Robert Choquette, Mita Choudhury, Gerald Christianson, John Chryssavgis, Sejong Chun, Esther Chung-Kim, Charles M. A. Clark, Elizabeth A. Clark, Sathianathan Clarke, Fred Cloud, John B. Cobb, W. Owen Cole, John A Coleman, John J. Collins, Sylvia Collins-Mayo, Paul K. Conkin, Beth A. Conklin, Sean Connolly, Demetrios J. Constantelos, Michael A. Conway, Paula M. Cooey, Austin Cooper, Michael L. Cooper-White, Pamela Cooper-White, L. William Countryman, Sérgio Coutinho, Pamela Couture, Shannon Craigo-Snell, James L. Crenshaw, David Crowner, Humberto Horacio Cucchetti, Lawrence S. Cunningham, Elizabeth Mason Currier, Emmanuel Cutrone, Mary L. Daniel, David D. Daniels, Robert Darden, Rolf Darge, Isaiah Dau, Jeffry C. Davis, Jane Dawson, Valentin Dedji, John W. de Gruchy, Paul DeHart, Wendy J. Deichmann Edwards, Miguel A. De La Torre, George E. Demacopoulos, Thomas de Mayo, Leah DeVun, Beatriz de Vasconcellos Dias, Dennis C. Dickerson, John M. Dillon, Luis Miguel Donatello, Igor Dorfmann-Lazarev, Susanna Drake, Jonathan A. Draper, N. Dreher Martin, Otto Dreydoppel, Angelyn Dries, A. J. Droge, Francis X. D'Sa, Marilyn Dunn, Nicole Wilkinson Duran, Rifaat Ebied, Mark J. Edwards, William H. Edwards, Leonard H. Ehrlich, Nancy L. Eiesland, Martin Elbel, J. Harold Ellens, Stephen Ellingson, Marvin M. Ellison, Robert Ellsberg, Jean Bethke Elshtain, Eldon Jay Epp, Peter C. Erb, Tassilo Erhardt, Maria Erling, Noel Leo Erskine, Gillian R. Evans, Virginia Fabella, Michael A. Fahey, Edward Farley, Margaret A. Farley, Wendy Farley, Robert Fastiggi, Seena Fazel, Duncan S. Ferguson, Helwar Figueroa, Paul Corby Finney, Kyriaki Karidoyanes FitzGerald, Thomas E. FitzGerald, John R. Fitzmier, Marie Therese Flanagan, Sabina Flanagan, Claude Flipo, Ronald B. Flowers, Carole Fontaine, David Ford, Mary Ford, Stephanie A. Ford, Jim Forest, William Franke, Robert M. Franklin, Ruth Franzén, Edward H. Friedman, Samuel Frouisou, Lorelei F. Fuchs, Jojo M. Fung, Inger Furseth, Richard R. Gaillardetz, Brandon Gallaher, China Galland, Mark Galli, Ismael García, Tharscisse Gatwa, Jean-Marie Gaudeul, Luis María Gavilanes del Castillo, Pavel L. Gavrilyuk, Volney P. Gay, Metropolitan Athanasios Geevargis, Kondothra M. George, Mary Gerhart, Simon Gikandi, Maurice Gilbert, Michael J. Gillgannon, Verónica Giménez Beliveau, Terryl Givens, Beth Glazier-McDonald, Philip Gleason, Menghun Goh, Brian Golding, Bishop Hilario M. Gomez, Michelle A. Gonzalez, Donald K. Gorrell, Roy Gottfried, Tamara Grdzelidze, Joel B. Green, Niels Henrik Gregersen, Cristina Grenholm, Herbert Griffiths, Eric W. Gritsch, Erich S. Gruen, Christoffer H. Grundmann, Paul H. Gundani, Jon P. Gunnemann, Petre Guran, Vidar L. Haanes, Jeremiah M. Hackett, Getatchew Haile, Douglas John Hall, Nicholas Hammond, Daphne Hampson, Jehu J. Hanciles, Barry Hankins, Jennifer Haraguchi, Stanley S. Harakas, Anthony John Harding, Conrad L. Harkins, J. William Harmless, Marjory Harper, Amir Harrak, Joel F. Harrington, Mark W. Harris, Susan Ashbrook Harvey, Van A. Harvey, R. Chris Hassel, Jione Havea, Daniel Hawk, Diana L. Hayes, Leslie Hayes, Priscilla Hayner, S. Mark Heim, Simo Heininen, Richard P. Heitzenrater, Eila Helander, David Hempton, Scott H. Hendrix, Jan-Olav Henriksen, Gina Hens-Piazza, Carter Heyward, Nicholas J. Higham, David Hilliard, Norman A. Hjelm, Peter C. Hodgson, Arthur Holder, M. Jan Holton, Dwight N. Hopkins, Ronnie Po-chia Hsia, Po-Ho Huang, James Hudnut-Beumler, Jennifer S. Hughes, Leonard M. Hummel, Mary E. Hunt, Laennec Hurbon, Mark Hutchinson, Susan E. Hylen, Mary Beth Ingham, H. Larry Ingle, Dale T. Irvin, Jon Isaak, Paul John Isaak, Ada María Isasi-Díaz, Hans Raun Iversen, Margaret C. Jacob, Arthur James, Maria Jansdotter-Samuelsson, David Jasper, Werner G. Jeanrond, Renée Jeffery, David Lyle Jeffrey, Theodore W. Jennings, David H. Jensen, Robin Margaret Jensen, David Jobling, Dale A. Johnson, Elizabeth A. Johnson, Maxwell E. Johnson, Sarah Johnson, Mark D. Johnston, F. Stanley Jones, James William Jones, John R. Jones, Alissa Jones Nelson, Inge Jonsson, Jan Joosten, Elizabeth Judd, Mulambya Peggy Kabonde, Robert Kaggwa, Sylvester Kahakwa, Isaac Kalimi, Ogbu U. Kalu, Eunice Kamaara, Wayne C. Kannaday, Musimbi Kanyoro, Veli-Matti Kärkkäinen, Frank Kaufmann, Léon Nguapitshi Kayongo, Richard Kearney, Alice A. Keefe, Ralph Keen, Catherine Keller, Anthony J. Kelly, Karen Kennelly, Kathi Lynn Kern, Fergus Kerr, Edward Kessler, George Kilcourse, Heup Young Kim, Kim Sung-Hae, Kim Yong-Bock, Kim Yung Suk, Richard King, Thomas M. King, Robert M. Kingdon, Ross Kinsler, Hans G. Kippenberg, Cheryl A. Kirk-Duggan, Clifton Kirkpatrick, Leonid Kishkovsky, Nadieszda Kizenko, Jeffrey Klaiber, Hans-Josef Klauck, Sidney Knight, Samuel Kobia, Robert Kolb, Karla Ann Koll, Heikki Kotila, Donald Kraybill, Philip D. W. Krey, Yves Krumenacker, Jeffrey Kah-Jin Kuan, Simanga R. Kumalo, Peter Kuzmic, Simon Shui-Man Kwan, Kwok Pui-lan, André LaCocque, Stephen E. Lahey, John Tsz Pang Lai, Emiel Lamberts, Armando Lampe, Craig Lampe, Beverly J. Lanzetta, Eve LaPlante, Lizette Larson-Miller, Ariel Bybee Laughton, Leonard Lawlor, Bentley Layton, Robin A. Leaver, Karen Lebacqz, Archie Chi Chung Lee, Marilyn J. Legge, Hervé LeGrand, D. L. LeMahieu, Raymond Lemieux, Bill J. Leonard, Ellen M. Leonard, Outi Leppä, Jean Lesaulnier, Nantawan Boonprasat Lewis, Henrietta Leyser, Alexei Lidov, Bernard Lightman, Paul Chang-Ha Lim, Carter Lindberg, Mark R. Lindsay, James R. Linville, James C. Livingston, Ann Loades, David Loades, Jean-Claude Loba-Mkole, Lo Lung Kwong, Wati Longchar, Eleazar López, David W. Lotz, Andrew Louth, Robin W. Lovin, William Luis, Frank D. Macchia, Diarmaid N. J. MacCulloch, Kirk R. MacGregor, Marjory A. MacLean, Donald MacLeod, Tomas S. Maddela, Inge Mager, Laurenti Magesa, David G. Maillu, Fortunato Mallimaci, Philip Mamalakis, Kä Mana, Ukachukwu Chris Manus, Herbert Robinson Marbury, Reuel Norman Marigza, Jacqueline Mariña, Antti Marjanen, Luiz C. L. Marques, Madipoane Masenya (ngwan'a Mphahlele), Caleb J. D. Maskell, Steve Mason, Thomas Massaro, Fernando Matamoros Ponce, András Máté-Tóth, Odair Pedroso Mateus, Dinis Matsolo, Fumitaka Matsuoka, John D'Arcy May, Yelena Mazour-Matusevich, Theodore Mbazumutima, John S. McClure, Christian McConnell, Lee Martin McDonald, Gary B. McGee, Thomas McGowan, Alister E. McGrath, Richard J. McGregor, John A. McGuckin, Maud Burnett McInerney, Elsie Anne McKee, Mary B. McKinley, James F. McMillan, Ernan McMullin, Kathleen E. McVey, M. 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Phan, Isabel Apawo Phiri, William S. F. Pickering, Derrick G. Pitard, William Elvis Plata, Zlatko Plese, John Plummer, James Newton Poling, Ronald Popivchak, Andrew Porter, Ute Possekel, James M. Powell, Enos Das Pradhan, Devadasan Premnath, Jaime Adrían Prieto Valladares, Anne Primavesi, Randall Prior, María Alicia Puente Lutteroth, Eduardo Guzmão Quadros, Albert Rabil, Laurent William Ramambason, Apolonio M. Ranche, Vololona Randriamanantena Andriamitandrina, Lawrence R. Rast, Paul L. Redditt, Adele Reinhartz, Rolf Rendtorff, Pål Repstad, James N. Rhodes, John K. Riches, Joerg Rieger, Sharon H. Ringe, Sandra Rios, Tyler Roberts, David M. Robinson, James M. Robinson, Joanne Maguire Robinson, Richard A. H. Robinson, Roy R. Robson, Jack B. Rogers, Maria Roginska, Sidney Rooy, Rev. Garnett Roper, Maria José Fontelas Rosado-Nunes, Andrew C. Ross, Stefan Rossbach, François Rossier, John D. Roth, John K. Roth, Phillip Rothwell, Richard E. 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Yee, Viktor Yelensky, Yeo Khiok-Khng, Gustav K. K. Yeung, Angela Yiu, Amos Yong, Yong Ting Jin, You Bin, Youhanna Nessim Youssef, Eliana Yunes, Robert Michael Zaller, Valarie H. Ziegler, Barbara Brown Zikmund, Joyce Ann Zimmerman, Aurora Zlotnik, Zhuo Xinping
- Edited by Daniel Patte, Vanderbilt University, Tennessee
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- The Cambridge Dictionary of Christianity
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- 05 August 2012
- Print publication:
- 20 September 2010, pp xi-xliv
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A hybrid gene to express protein epitopes from both sporozoite and merozoite surface antigens of Plasmodium falciparum
- A. A. Holder, M. J. Lockyer, G. W. Hardy
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- Journal:
- Parasitology / Volume 97 / Issue 3 / December 1988
- Published online by Cambridge University Press:
- 06 April 2009, pp. 373-382
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The DNA coding for parts of the repetitive amino acid sequence of the Plasmodium falciparum circumsporozoite protein has been spliced to a sequence encoding part of the precursor to the major merozoite surface antigens, to produce a hybrid gene. Expression in Escherichia coli produces a protein with antigenic determinants from both malaria proteins. Antibodies raised against the expressed material react with both a peptide derived from the circumsporozoite repeat sequence, and the merozoite surface molecule. Hybrid molecules of this type may be the basis of a malaria vaccine.
Processing of the precursor to the major merozoite surface antigens of Plasmodium falciparum
- A. A. Holder, J. S. Sandhu, Yvonne Hillman, Lynne S. Davey, S. C. Nicholls, Helen Cooper, M. J. Lockyer
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- Parasitology / Volume 94 / Issue 2 / April 1987
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- 06 April 2009, pp. 199-208
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Specific sequences derived from the gene for the precursor to the major merozoite surface antigens (PMMSA) of Plasmodium falciparum have been expressed in Escherichia coli and the products have been used to produce antibodies. These antibodies, together with monoclonal antibodies, have been used to investigate the form of the PMMSA protein associated with merozoites. Polypeptide fragments derived by processing from the PMMSA protein have been detected in extracts of merozoites and assigned to locations within the PMMSA coding sequence.
Observations on the grazing behaviour of lactating dairy cattle in a sub-tropical environment
- J. M. Holder
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- Journal:
- The Journal of Agricultural Science / Volume 55 / Issue 2 / October 1960
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- 27 March 2009, pp. 261-267
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1. Three trials are reported in which the grazing behaviour of separate groups of cows, one receiving supplementary food, either as conserved roughage, concentrate or fodder crop, was observed over 24 hr. periods. A fourth trial, assessing the effect of summer temperatures on unshaded milking cows, is briefly described.
2. In trials 1 and 2 the stall feeding of either conserved roughage or concentrate reduced grazing as compared with unsupplemented cows by approximately 10%.
3. Allowing access to a fresh ‘strip’ of a fodder crop at a set time each day, whilst not altering total grazing time, very markedly altered periodicity of grazing. Cows delayed grazing up to 3 hr. whilst awaiting a fresh ‘strip’.
4. Environmental temperatures up to 87° F. did not alter total grazing time as compared with grazing time when temperature reached a maximum of only 70° F.
5. The value of supplementary feeding of dairy cattle at pasture, at least where the intake of pasture is sufficient for maintenance and a low level of production, appears to be open to question.
Potential of immunization for increasing animal production
- A. T. Holder, R. Aston, D. J. Flint
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- The Journal of Agricultural Science / Volume 116 / Issue 2 / April 1991
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- 27 March 2009, pp. 175-181
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The use of exogenous hormone treatment as a means of increasing the efficiency of animal production has, in general, been rather poorly received by both the public and government agencies. This antipathy towards hormone treatment has tended to direct research effort into finding less contentious ‘hormonefree’ methods of improving animal production. Over the last 10 years, immunological manipulation of the endocrine system has emerged as an attractive possibility in this search. In this review we briefly outline three approaches under current consideration, whereby growth hormone (GH) concentrations or activity are modified. These methods involve immunological manipulation of GH release, use of antibodies as GH mimics and antibody-mediated enhancement of GH action.
Inverse Compton backscattering source driven by the multi-10 TW laser installed at Daresbury
- G. Priebe, D. Laundy, M.A. Macdonald, G.P. Diakun, S.P. Jamison, L.B. Jones, D.J. Holder, S.L. Smith, P.J. Phillips, B.D. Fell, B. Sheehy, N. Naumova, I.V. Sokolov, S. Ter-Avetisyan, K. Spohr, G.A. Krafft, J.B. Rosenzweig, U. Schramm, F. Grüner, G.J. Hirst, J. Collier, S. Chattopadhyay, E.A. Seddon
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- Laser and Particle Beams / Volume 26 / Issue 4 / December 2008
- Published online by Cambridge University Press:
- 20 November 2008, pp. 649-660
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Inverse Compton scattering is a promising method to implement a high brightness, ultra-short, energy tunable X-ray source at accelerator facilities. We have developed an inverse Compton backscattering X-ray source driven by the multi-10 TW laser installed at Daresbury. Hard X-rays, with spectral peaks ranging from 15 to 30 keV, depending on the scattering geometry, will be generated through the interaction of laser pulses with electron bunches delivered by the energy recovery linac machine, initially known as energy recovery linac prototype and subsequently renamed accelerators and lasers in combined experiments. X-ray pulses containing 9 × 107 photons per pulse will be created from head-on collisions, with a pulse duration comparable to the incoming electron bunch length. For transverse collisions 8 × 106 photons per pulse will be generated, where the laser pulse transit time defines the X-ray pulse duration. The peak spectral brightness is predicted to be ~1021 photons/(s mm2 mrad2 0.1% Δλ/λ).
Shock-tube experiments on Richtmyer–Meshkov instability growth using an enlarged double-bump perturbation
- D.A. HOLDER, A.V. SMITH, C. J. BARTON, D.L. YOUNGS
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- Journal:
- Laser and Particle Beams / Volume 21 / Issue 3 / July 2003
- Published online by Cambridge University Press:
- 03 March 2004, pp. 411-418
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This article reports on the latest experiments in the series of Richtmyer–Meshkov instability (RMI) shock-tube experiments. Previous work described a double-bump experiment that evidenced some degree of unrepeatability. The present work features an enlarged perturbation introduced to improve repeatability. In common with the previous work, the experiments were conducted at shock Mach number 1.26 (70 kPa overpressure), using the Atomic Weapons Establishment 200 × 100 mm shock tube with a three-zone test cell arrangement of air/sulphur hexafluoride/air. The sulphur hexafluoride gas (SF6) was chosen for its high density (5.1 relative to air) providing an Atwood number of 0.67. Gas separation was by means of microfilm membranes, supported by fine wire meshes. A double-bump perturbation of two-dimensional geometry was superimposed on the downstream membrane representing a 0.6% addition to the dense gas volume. Visualization of the turbulent gas mixing was by laser sheet illumination of the seeded SF6 gas using a copper vapor laser pulsing at 12.5 kHz. Mie scattered light was recorded using a 35-mm rotating drum camera to capture a sequence of 50 images per experiment. Sample experimental results shown alongside corresponding three-dimensional hydrocode calculations highlight the problems in both analysis and comparison caused by multiple scattering arising from the necessary use of a high seeding concentration. Included is a demonstration of the effectiveness of introducing into the hydrocode a Monte Carlo-based simulation of the multiple scattering process. The results so derived yield greatly improved qualitative agreement with the experimental images. Quantitative analysis took the form of deriving relative intensity data from line-outs through experimental images and their code equivalents. A comparison revealed substantial agreement on major features.