8 results
Open innovation: the key to advancing brain health
- Harris A. Eyre, Jason Searfoss, Malcolm Hopwood, Michael Berk, Shuo Chen, Jeffrey Cummings, Francois Veron, Vicki Zikopoulou, Agustin Ibanez, Kacie Kelly, Jair C. Soares, Erin Smith, Barnabas J. Gilbert
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- Journal:
- CNS Spectrums / Volume 28 / Issue 4 / August 2023
- Published online by Cambridge University Press:
- 29 July 2022, pp. 392-394
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With the exponential growth in investment attention to brain health—solutions spanning brain wellness to mental health to neurological disorders—tech giants, payers, and biotechnology companies have been making forays into this field to identify technology solutions and pharmaceutical amplifiers. So far, their investments have had mixed results. The concept of open innovation (OI) was first coined by Henry Chesbrough to describe the paradigm by which enterprises allow free flow of ideas, products, and services from the outside to the inside and vice versa in order to remain competitive, particularly in rapidly evolving fields where there is abundant, relevant knowledge outside the traditional walls of the enterprise. In this article, we advocate for further exploration and advancement of OI in brain health.
Psilocybin in neuropsychiatry: a review of its pharmacology, safety, and efficacy
- Seetal Dodd, Trevor R. Norman, Harris A. Eyre, Stephen M. Stahl, Arnie Phillips, André F. Carvalho, Michael Berk
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- Journal:
- CNS Spectrums / Volume 28 / Issue 4 / August 2023
- Published online by Cambridge University Press:
- 11 July 2022, pp. 416-426
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Psilocybin is a tryptamine alkaloid found in some mushrooms, especially those of the genus Psilocybe. Psilocybin has four metabolites including the pharmacologically active primary metabolite psilocin, which readily enters the systemic circulation. The psychoactive effects of psilocin are believed to arise due to the partial agonist effects at the 5HT2A receptor. Psilocin also binds to various other receptor subtypes although the actions of psilocin at other receptors are not fully explored. Psilocybin administered at doses sufficient to cause hallucinogenic experiences has been trialed for addictive disorders, anxiety and depression. This review investigates studies of psilocybin and psilocin and assesses the potential for use of psilocybin and a treatment agent in neuropsychiatry. The potential for harm is also assessed, which may limit the use of psilocybin as a pharmacotherapy. Careful evaluation of the number needed to harm vs the number needed to treat will ultimately justify the potential clinical use of psilocybin. This field needs a responsible pathway forward.
Catatonic features in children and adolescents with N-methyl-d-aspartate receptor antibody encephalitis
- Michael Eyre, Anya Kaushik, Elizabeth Barrett, Mary D. King, Thomas Pollak, Russell C. Dale, Susan Byrne, Ming Lim
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- Journal:
- BJPsych Open / Volume 6 / Issue 4 / July 2020
- Published online by Cambridge University Press:
- 06 July 2020, e71
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Catatonia is a psychomotor dysregulation syndrome of diverse aetiology, increasingly recognised as a prominent feature of N-methyl-d-aspartate receptor antibody encephalitis (NMDARE) in adults. No study to date has systematically assessed the prevalence and symptomatology of catatonia in children with NMDARE. We analysed 57 paediatric patients with NMDARE from the literature using the Bush-Francis Catatonia Rating Scale. Catatonia was common (occurring in 86% of patients), manifesting as complex clusters of positive and negative features within individual patients. It was both underrecognised and undertreated. Immunotherapy was the only effective intervention, highlighting the importance of prompt recognition and treatment of the underlying cause of catatonia.
Contributors
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- By Syed S. Ali, Nathan Allen, John E. Arbo, Elizabeth Arrington, Ani Aydin, Kenneth R. L. Bernard, Amy Caggiula, Nolan Caldwell, Jennifer L. Carey, Jennifer Carnell, Jayaram Chelluri, Michael N. Cocchi, Cristal Cristia, Vishal Demla, Bram Dolcourt, Andrew Eyre, Shawn Fagan, Brandy Ferguson, Sarah Fisher, Jonathan Friedstat, Brian C. Geyer, Brandon Godbout, Jeremy Gonda, Jeremy Goverman, Ashley L. Greiner, Casey Grover, Carla Haack, Abigail Hankin, John W. Hardin, Katrina L. Harper, Gregory Hayward, Stephen Hendriksen, Daniel Herbert-Cohen, Nadine Himelfarb, Calvin E. Hwang, Jacob D. Isserman, Joshua Jauregui, Joshua W. Joseph, Elena Kapilevich, Feras H. Khan, Sarvotham Kini, Karen A. Kinnaman, Ruth Lamm, Calvin Lee, Jarone Lee, Charles Lei, John Lemos, Daniel J. Lepp, Elisabeth Lessenich, Brandon Maughan, Julie Mayglothling, Kevin McConnell, Laura Medford-Davis, Kamal Medlej, Heather Meissen, Payal Modi, Joel Moll, Jolene H. Nakao, Matthew Nicholls, Lindsay Oelze, Carolyn Maher Overman, Viral Patel, Timothy C. Peck, Jeffrey Pepin, Candace Pettigrew, Byron Pitts, Zubaid Rafique, Chanu Rhee, Jonathan C. Roberts, Daniel Rolston, Steven C. Rougas, Benjamin Schnapp, Kathryn A. Seal, Raghu Seethala, Todd A. Seigel, Navdeep Sekhon, Kaushal Shah, Robert L. Sherwin, Kirill Shishlov, Ashley Shreves, Sebastian Siadecki, Jeffrey N. Siegelman, Liza Gonen Smith, Ted Stettner, Marie Carmelle Tabuteau, Joseph E. Tonna, N. Seth Trueger, Chad Van Ginkel, Bina Vasantharam, Graham Walker, Susan Wilcox, Sandra J. Williams, Matthew L. Wong, Nelson Wong, Samantha Wood, John Woodruff, Benjamin Zabar
- Edited by Kaushal Shah, Jarone Lee, Kamal Medlej, American University of Beirut, Scott D. Weingart
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- Book:
- Practical Emergency Resuscitation and Critical Care
- Published online:
- 05 November 2013
- Print publication:
- 24 October 2013, pp xi-xx
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Chapter 10 - Energy End-Use: Buildings
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- By Diana Ürge-Vorsatz, Central European University, Nick Eyre, Oxford University, Peter Graham, University of New South Wales, Danny Harvey, University of Toronto, Edgar Hertwich, Norwegian University of Science and Technology, Yi Jiang, Tsinghua University, Christian Kornevall, World Business Council for Sustainable Development, Mili Majumdar, The Energy and Resources Institute, James E. McMahon, Lawrence Berkeley National Laboratory, Sevastianos Mirasgedis, National Observatory of Athens, Shuzo Murakami, Keio University, Aleksandra Novikova, Climate Policy Initiative and German Institute for Economic Research, Kathryn Janda, Environmental Change Institute, Oxford University, Omar Masera, National Autonomous University, Michael McNeil, Lawrence Berkeley National Laboratory, Ksenia Petrichenko, Central European University, Sergio Tirado Herrero, Central European University, Eberhard Jochem, Fraunhofer Institute for Systems and Innovation Research
- Global Energy Assessment Writing Team
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- Book:
- Global Energy Assessment
- Published online:
- 05 September 2012
- Print publication:
- 27 August 2012, pp 649-760
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Summary
Executive Summary
Buildings are key to a sustainable future because their design, construction, operation, and the activities in buildings are significant contributors to energy-related sustainability challenges – reducing energy demand in buildings can play one of the most important roles in solving these challenges. More specifically:
The buildings sector and people's activities in buildings are responsible for approximately 31% of global final energy demand, approximately one-third of energy-related CO2 emissions, approximately two-thirds of halocarbon, and approximately 25–33% of black carbon emissions.
Several energy-related problems affecting human health and productivity take place in buildings, including mortality and morbidity due to poor indoor air quality or inadequate indoor temperatures. Therefore, improving buildings and their equipment offers one of the entry points to addressing these challenges.
More efficient energy and material use, as well as sustainable energy supply in buildings, are critical to tackling the sustainability-related challenges outlined in the GEA. Recent major advances in building design, know-how, technology, and policy have made it possible for global building energy use to decline significantly. A number of lowenergy and passive buildings, both retrofitted and newly constructed, already exist, demonstrating that low level of building energy performance is achievable. With the application of on-site and community-scale renewable energy sources, several buildings and communities could become zero-net-energy users and zero-greenhouse gas (GHG) emitters, or net energy suppliers.
Recent advances in materials and know-how make new buildings that use 10–40% of the final heating and cooling energy of conventional new buildings cost-effective in all world regions and climate zones.
Chapter 18 - Urban Energy Systems
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- By Arnulf Grubler, International Institute for Applied Systems Analysis, Austria and Yale University, Xuemei Bai, Australian National University, Thomas Buettner, United Nations Department of Economic and Social Affairs, Shobhakar Dhakal, Global Carbon Project and National Institute for Environmental Studies, David J. Fisk, Imperial College London, Toshiaki Ichinose, National Institute for Environmental Studies, James E. Keirstead, Imperial College London, Gerd Sammer, University of Natural Resources and Applied Life Sciences, David Satterthwaite, International Institute for Environment and Development, Niels B. Schulz, International Institute for Applied Systems Analysis, Austria and Imperial College, Nilay Shah, Imperial College London, Julia Steinberger, The Institute of Social Ecology, Austria and University of Leeds, Helga Weisz, Potsdam Institute for Climate Impact Research, Gilbert Ahamer, University of Graz, Timothy Baynes, Commonwealth Scientific and Industrial Research Organisation, Daniel Curtis, Oxford University Centre for the Environment, Michael Doherty, Commonwealth Scientific and Industrial Research Organisation, Nick Eyre, Oxford University Centre for the Environment, Junichi Fujino, National Institute for Environmental Studies, Keisuke Hanaki, University of Tokyo, Mikiko Kainuma, National Institute for Environmental Studies, Shinji Kaneko, Hiroshima University, Manfred Lenzen, University of Sydney, Jacqui Meyers, Commonwealth Scientific and Industrial Research Organisation, Hitomi Nakanishi, University of Canberra, Victoria Novikova, Oxford University Centre for the Environment, Krishnan S. Rajan, International Institute of Information Technology, Seongwon Seo, Commonwealth Scientific and Industrial Research Organisation, Ram M. Shrestha, Asian Institute of Technology, Priyadarshi R. Shukla, Indian Institute of Management, Alice Sverdlik, International Institute for Environment and Development, Jayant Sathaye, Lawrence Berkeley National Laboratory
- Global Energy Assessment Writing Team
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- Book:
- Global Energy Assessment
- Published online:
- 05 September 2012
- Print publication:
- 27 August 2012, pp 1307-1400
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Summary
Executive Summary
More than 50% of the global population already lives in urban settlements and urban areas are projected to absorb almost all the global population growth to 2050, amounting to some additional three billion people. Over the next decades the increase in rural population in many developing countries will be overshadowed by population flows to cities. Rural populations globally are expected to peak at a level of 3.5 billion people by around 2020 and decline thereafter, albeit with heterogeneous regional trends. This adds urgency in addressing rural energy access, but our common future will be predominantly urban. Most of urban growth will continue to occur in small-to medium-sized urban centers. Growth in these smaller cities poses serious policy challenges, especially in the developing world. In small cities, data and information to guide policy are largely absent, local resources to tackle development challenges are limited, and governance and institutional capacities are weak, requiring serious efforts in capacity building, novel applications of remote sensing, information, and decision support techniques, and new institutional partnerships. While ‘megacities’ with more than 10 million inhabitants have distinctive challenges, their contribution to global urban growth will remain comparatively small.
Energy-wise, the world is already predominantly urban. This assessment estimates that between 60–80% of final energy use globally is urban, with a central estimate of 75%. Applying national energy (or GHG inventory) reporting formats to the urban scale and to urban administrative boundaries is often referred to as a ‘production’ accounting approach and underlies the above GEA estimate.
Visual hallucinations in dementia with Lewy bodies: transcranial magnetic stimulation study
- John-Paul Taylor, Michael Firbank, Nicola Barnett, Sarah Pearce, Anthea Livingstone, Urs Mosimann, Janet Eyre, Ian G. McKeith, John T. O'Brien
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- Journal:
- The British Journal of Psychiatry / Volume 199 / Issue 6 / December 2011
- Published online by Cambridge University Press:
- 02 January 2018, pp. 492-500
- Print publication:
- December 2011
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Background
The aetiology of visual hallucinations is poorly understood in dementia with Lewy bodies. Pathological alterations in visual cortical excitability may be one contributory mechanism.
AimsTo determine visual cortical excitability in people with dementia with Lewy bodies compared with aged-matched controls and also the relationship between visual cortical excitability and visual hallucinations in dementia with Lewy bodies.
MethodVisual cortical excitability was determined by using transcranial magnetic stimulation (TMS) applied to the occiput to elicit phosphenes (transient subjective visual responses) in 21 patients with dementia with Lewy bodies and 19 age-matched controls.
ResultsPhosphene parameters were similar between both groups. However, in the patients with dementia with Lewy bodies, TMS measures of visual cortical excitability correlated strongly with the severity of visual hallucinations (P = 0.005). Six patients with dementia with Lewy bodies experienced visual hallucination-like phosphenes (for example, seeing people or figures on stimulation) compared with none of the controls (P = 0.02).
ConclusionsIncreased visual cortical excitability in dementia with Lewy bodies does not appear to explain visual hallucinations but it may be a marker for their severity.
Contributors
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- By Joanne R. Adler, David A. Alexander, Laurence Alison, Catherine C. Ayoub, Peter Banister, Anthony R. Beech, Amanda Biggs, Julian Boon, Adrian Bowers, Neil Brewer, Eric Broekaert, Paula Brough, Jennifer M. Brown, Kevin Browne, Elizabeth A. Campbell, David Canter, Michael Carlin, Shihning Chou, Martin A. Conway, Claire Cooke, David Cooke, Ilse Derluyn, Robert J. Edelmann, Vincent Egan, Tom Ellis, Marie Eyre, David P. Farrington, Seena Fazel, Daniel B. Fishman, Victoria Follette, Katarina Fritzon, Elizabeth Gilchrist, Nathan D. Gillard, Renée Gobeil, Agnieszka Golec de Zavala, Jane Goodman-Delahunty, Lynsey Gozna, Don Grubin, Gisli H. Gudjonsson, Helinä Häkkänen-Nyholm, Guy Hall, Nathan Hall, Roisin Hall, Sean Hammond, Leigh Harkins, Grant T. Harris, Camilla Herbert, Robert D. Hoge, Todd E. Hogue, Clive R. Hollin, Lorraine Hope, Miranda A. H. Horvath, Kevin Howells, Carol A. Ireland, Jane L. Ireland, Mark Kebbell, Michael King, Bruce D. Kirkcaldy, Heidi La Bash, Cara Laney, William R. Lindsay, Elizabeth F. Loftus, L. E. Marshall, W. L. Marshall, James McGuire, Neil McKeganey, T. M. McMillan, Mary McMurran, Joav Merrick, Becky Milne, Joanne M. Nadkarni, Claire Nee, M. D. O’Brien, William O’Donohue, Darragh O’Neill, Jane Palmer, Adria Pearson, Derek Perkins, Devon L. L. Polaschek, Louise E. Porter, Charlotte C. Powell, Graham E. Powell, Martine Powell, Christine Puckering, Ethel Quayle, Vernon L. Quinsey, Marnie E. Rice, Randall Richardson-Vejlgaard, Richard Rogers, Louis B Schlesinger, Carolyn Semmler, G. A. Serran, Ralph C. Serin, John L. Taylor, Max Taylor, Brian Thomas-Peter, Paul A. Tiffin, Graham Towl, Rosie Travers, Arlene Vetere, Graham Wagstaff, Helen Wakeling, Fiona Warren, Brandon C. Welsh, David Wexler, Margaret Wilson, Dan Yarmey, Susan Young
- Edited by Jennifer M. Brown, London School of Economics and Political Science, Elizabeth A. Campbell, University of Glasgow
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- Book:
- The Cambridge Handbook of Forensic Psychology
- Published online:
- 06 July 2010
- Print publication:
- 29 April 2010, pp xix-xxiii
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