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Determinants of confrontation naming deficits on the Boston Naming Test associated with transactive response DNA-binding protein 43 pathology
- Carling G. Robinson, Austin W. Goodrich, Stephen D. Weigand, Nha Trang Thu Pham, Arenn F. Carlos, Marina Buciuc, Melissa E. Murray, Aivi T. Nguyen, R. Ross Reichard, David S. Knopman, Ronald C. Petersen, Dennis W. Dickson, Rene L. Utianski, Jennifer L. Whitwell, Keith A. Josephs, Mary M. Machulda
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- Journal:
- Journal of the International Neuropsychological Society , First View
- Published online by Cambridge University Press:
- 25 March 2024, pp. 1-9
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Objective:
To determine whether poorer performance on the Boston Naming Test (BNT) in individuals with transactive response DNA-binding protein 43 pathology (TDP-43+) is due to greater loss of word knowledge compared to retrieval-based deficits.
Methods:Retrospective clinical-pathologic study of 282 participants with Alzheimer’s disease neuropathologic changes (ADNC) and known TDP-43 status. We evaluated item-level performance on the 60-item BNT for first and last available assessment. We fit cross-sectional negative binomial count models that assessed total number of incorrect items, number correct of responses with phonemic cue (reflecting retrieval difficulties), and number of “I don’t know” (IDK) responses (suggestive of loss of word knowledge) at both assessments. Models included TDP-43 status and adjusted for sex, age, education, years from test to death, and ADNC severity. Models that evaluated the last assessment adjusted for number of prior BNT exposures.
Results:43% were TDP-43+. The TDP-43+ group had worse performance on BNT total score at first (p = .01) and last assessments (p = .01). At first assessment, TDP-43+ individuals had an estimated 29% (CI: 7%–56%) higher mean number of incorrect items after adjusting for covariates, and a 51% (CI: 15%–98%) higher number of IDK responses compared to TDP-43−. At last assessment, compared to TDP-43−, the TDP-43+ group on average missed 31% (CI: 6%–62%; p = .01) more items and had 33% more IDK responses (CI: 1% fewer to 78% more; p = .06).
Conclusions:An important component of poorer performance on the BNT in participants who are TDP-43+ is having loss of word knowledge versus retrieval difficulties.
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- By Mitchell Aboulafia, Frederick Adams, Marilyn McCord Adams, Robert M. Adams, Laird Addis, James W. Allard, David Allison, William P. Alston, Karl Ameriks, C. Anthony Anderson, David Leech Anderson, Lanier Anderson, Roger Ariew, David Armstrong, Denis G. Arnold, E. J. Ashworth, Margaret Atherton, Robin Attfield, Bruce Aune, Edward Wilson Averill, Jody Azzouni, Kent Bach, Andrew Bailey, Lynne Rudder Baker, Thomas R. Baldwin, Jon Barwise, George Bealer, William Bechtel, Lawrence C. Becker, Mark A. Bedau, Ernst Behler, José A. Benardete, Ermanno Bencivenga, Jan Berg, Michael Bergmann, Robert L. Bernasconi, Sven Bernecker, Bernard Berofsky, Rod Bertolet, Charles J. Beyer, Christian Beyer, Joseph Bien, Joseph Bien, Peg Birmingham, Ivan Boh, James Bohman, Daniel Bonevac, Laurence BonJour, William J. Bouwsma, Raymond D. Bradley, Myles Brand, Richard B. Brandt, Michael E. Bratman, Stephen E. Braude, Daniel Breazeale, Angela Breitenbach, Jason Bridges, David O. Brink, Gordon G. 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- By Vanessa Agnew, Gregory Barz, Michael Beckerman, Stephen Blum, Philip V. Bohlman, Salwa El-Shawan Castelo-Branco, Martin Clayton, Nicholas Cook, Timothy J. Cooley, Ruth F. Davis, Beverley Diamond, Aaron A. Fox, Keith Howard, Bernardo Illari, Travis A. Jackson, Jaime Jones, Margaret Kartomi, Sebastian Klotz, Lars-Christian Koch, Peter Manuel, Wayne Marshall, Kaley Mason, Richard Middleton, Bruno Nettl, Regula Burckhardt Qureshi, Ronald Radano, Suzel Ana Reily, Timothy Rommen, Kay Kaufman Shelemay, W. Anthony Sheppard, Jonathan P. J. Stock, Martin Stokes, Timothy D. Taylor, Bonnie C. Wade, Bennett Zon
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2 - The prevalence and correlates of adult ADHD
- from Section 1 - The development of adult ADHD as an epidemiological concept
- Edited by Jan K. Buitelaar, Cornelis C. Kan, Philip Asherson, Institute of Psychiatry, London
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Summary
The aim of the meta-analysis was to develop a mathematical model of the extent to which attention-deficit hyperactivity disorder (ADHD) prevalence decreases with age. In DSM-III, the category of residual attention-deficit disorder was defined to include adults who met full criteria for the disorder as children and have a partial syndrome as adults, but this category was removed from DSM-III-R. The strongest socio-demographic correlate of adult ADHD in the NCS-R was race-ethnicity, with non-Hispanic Blacks having significantly lower odds of the disorder than non-Hispanic Whites. Statistically significant comorbodities were found in the NCS-R between adult ADHD and a wide range of other DSM-IV/CIDI anxiety, mood, impulse-control, and substance use disorders. The NCS-R analysis also examined associations of adult ADHD with work performance. An analysis of work performance based on the WHO Health and Work Performance Questionnaire showed that ADHD was associated with an enormous amount of work role impairment.
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- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. Chapman, James H. Charlesworth, Kenneth R. Chase, Chen Zemin, Luciano Chianeque, Philip Chia Phin Yin, Francisca H. Chimhanda, Daniel Chiquete, John T. Chirban, Soobin Choi, Robert Choquette, Mita Choudhury, Gerald Christianson, John Chryssavgis, Sejong Chun, Esther Chung-Kim, Charles M. A. Clark, Elizabeth A. Clark, Sathianathan Clarke, Fred Cloud, John B. Cobb, W. Owen Cole, John A Coleman, John J. Collins, Sylvia Collins-Mayo, Paul K. Conkin, Beth A. Conklin, Sean Connolly, Demetrios J. Constantelos, Michael A. Conway, Paula M. Cooey, Austin Cooper, Michael L. Cooper-White, Pamela Cooper-White, L. William Countryman, Sérgio Coutinho, Pamela Couture, Shannon Craigo-Snell, James L. Crenshaw, David Crowner, Humberto Horacio Cucchetti, Lawrence S. Cunningham, Elizabeth Mason Currier, Emmanuel Cutrone, Mary L. Daniel, David D. Daniels, Robert Darden, Rolf Darge, Isaiah Dau, Jeffry C. Davis, Jane Dawson, Valentin Dedji, John W. de Gruchy, Paul DeHart, Wendy J. 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Jacob, Arthur James, Maria Jansdotter-Samuelsson, David Jasper, Werner G. Jeanrond, Renée Jeffery, David Lyle Jeffrey, Theodore W. Jennings, David H. Jensen, Robin Margaret Jensen, David Jobling, Dale A. Johnson, Elizabeth A. Johnson, Maxwell E. Johnson, Sarah Johnson, Mark D. Johnston, F. Stanley Jones, James William Jones, John R. Jones, Alissa Jones Nelson, Inge Jonsson, Jan Joosten, Elizabeth Judd, Mulambya Peggy Kabonde, Robert Kaggwa, Sylvester Kahakwa, Isaac Kalimi, Ogbu U. Kalu, Eunice Kamaara, Wayne C. Kannaday, Musimbi Kanyoro, Veli-Matti Kärkkäinen, Frank Kaufmann, Léon Nguapitshi Kayongo, Richard Kearney, Alice A. Keefe, Ralph Keen, Catherine Keller, Anthony J. Kelly, Karen Kennelly, Kathi Lynn Kern, Fergus Kerr, Edward Kessler, George Kilcourse, Heup Young Kim, Kim Sung-Hae, Kim Yong-Bock, Kim Yung Suk, Richard King, Thomas M. King, Robert M. Kingdon, Ross Kinsler, Hans G. Kippenberg, Cheryl A. 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Lotz, Andrew Louth, Robin W. Lovin, William Luis, Frank D. Macchia, Diarmaid N. J. MacCulloch, Kirk R. MacGregor, Marjory A. MacLean, Donald MacLeod, Tomas S. Maddela, Inge Mager, Laurenti Magesa, David G. Maillu, Fortunato Mallimaci, Philip Mamalakis, Kä Mana, Ukachukwu Chris Manus, Herbert Robinson Marbury, Reuel Norman Marigza, Jacqueline Mariña, Antti Marjanen, Luiz C. L. Marques, Madipoane Masenya (ngwan'a Mphahlele), Caleb J. D. Maskell, Steve Mason, Thomas Massaro, Fernando Matamoros Ponce, András Máté-Tóth, Odair Pedroso Mateus, Dinis Matsolo, Fumitaka Matsuoka, John D'Arcy May, Yelena Mazour-Matusevich, Theodore Mbazumutima, John S. McClure, Christian McConnell, Lee Martin McDonald, Gary B. McGee, Thomas McGowan, Alister E. McGrath, Richard J. McGregor, John A. McGuckin, Maud Burnett McInerney, Elsie Anne McKee, Mary B. McKinley, James F. McMillan, Ernan McMullin, Kathleen E. McVey, M. Douglas Meeks, Monica Jyotsna Melanchthon, Ilie Melniciuc-Puica, Everett Mendoza, Raymond A. Mentzer, William W. Menzies, Ina Merdjanova, Franziska Metzger, Constant J. Mews, Marvin Meyer, Carol Meyers, Vasile Mihoc, Gunner Bjerg Mikkelsen, Maria Inêz de Castro Millen, Clyde Lee Miller, Bonnie J. Miller-McLemore, Alexander Mirkovic, Paul Misner, Nozomu Miyahira, R. W. L. Moberly, Gerald Moede, Aloo Osotsi Mojola, Sunanda Mongia, Rebeca Montemayor, James Moore, Roger E. Moore, Craig E. Morrison O.Carm, Jeffry H. Morrison, Keith Morrison, Wilson J. Moses, Tefetso Henry Mothibe, Mokgethi Motlhabi, Fulata Moyo, Henry Mugabe, Jesse Ndwiga Kanyua Mugambi, Peggy Mulambya-Kabonde, Robert Bruce Mullin, Pamela Mullins Reaves, Saskia Murk Jansen, Heleen L. Murre-Van den Berg, Augustine Musopole, Isaac M. T. Mwase, Philomena Mwaura, Cecilia Nahnfeldt, Anne Nasimiyu Wasike, Carmiña Navia Velasco, Thulani Ndlazi, Alexander Negrov, James B. Nelson, David G. Newcombe, Carol Newsom, Helen J. Nicholson, George W. E. Nickelsburg, Tatyana Nikolskaya, Damayanthi M. A. Niles, Bertil Nilsson, Nyambura Njoroge, Fidelis Nkomazana, Mary Beth Norton, Christian Nottmeier, Sonene Nyawo, Anthère Nzabatsinda, Edward T. Oakes, Gerald O'Collins, Daniel O'Connell, David W. Odell-Scott, Mercy Amba Oduyoye, Kathleen O'Grady, Oyeronke Olajubu, Thomas O'Loughlin, Dennis T. Olson, J. Steven O'Malley, Cephas N. Omenyo, Muriel Orevillo-Montenegro, César Augusto Ornellas Ramos, Agbonkhianmeghe E. Orobator, Kenan B. Osborne, Carolyn Osiek, Javier Otaola Montagne, Douglas F. Ottati, Anna May Say Pa, Irina Paert, Jerry G. Pankhurst, Aristotle Papanikolaou, Samuele F. Pardini, Stefano Parenti, Peter Paris, Sung Bae Park, Cristián G. Parker, Raquel Pastor, Joseph Pathrapankal, Daniel Patte, W. Brown Patterson, Clive Pearson, Keith F. Pecklers, Nancy Cardoso Pereira, David Horace Perkins, Pheme Perkins, Edward N. Peters, Rebecca Todd Peters, Bishop Yeznik Petrossian, Raymond Pfister, Peter C. Phan, Isabel Apawo Phiri, William S. F. Pickering, Derrick G. Pitard, William Elvis Plata, Zlatko Plese, John Plummer, James Newton Poling, Ronald Popivchak, Andrew Porter, Ute Possekel, James M. Powell, Enos Das Pradhan, Devadasan Premnath, Jaime Adrían Prieto Valladares, Anne Primavesi, Randall Prior, María Alicia Puente Lutteroth, Eduardo Guzmão Quadros, Albert Rabil, Laurent William Ramambason, Apolonio M. Ranche, Vololona Randriamanantena Andriamitandrina, Lawrence R. Rast, Paul L. Redditt, Adele Reinhartz, Rolf Rendtorff, Pål Repstad, James N. Rhodes, John K. Riches, Joerg Rieger, Sharon H. Ringe, Sandra Rios, Tyler Roberts, David M. Robinson, James M. Robinson, Joanne Maguire Robinson, Richard A. H. Robinson, Roy R. Robson, Jack B. Rogers, Maria Roginska, Sidney Rooy, Rev. Garnett Roper, Maria José Fontelas Rosado-Nunes, Andrew C. Ross, Stefan Rossbach, François Rossier, John D. Roth, John K. Roth, Phillip Rothwell, Richard E. Rubenstein, Rosemary Radford Ruether, Markku Ruotsila, John E. Rybolt, Risto Saarinen, John Saillant, Juan Sanchez, Wagner Lopes Sanchez, Hugo N. Santos, Gerhard Sauter, Gloria L. Schaab, Sandra M. Schneiders, Quentin J. Schultze, Fernando F. Segovia, Turid Karlsen Seim, Carsten Selch Jensen, Alan P. F. Sell, Frank C. Senn, Kent Davis Sensenig, Damían Setton, Bal Krishna Sharma, Carolyn J. Sharp, Thomas Sheehan, N. Gerald Shenk, Christian Sheppard, Charles Sherlock, Tabona Shoko, Walter B. Shurden, Marguerite Shuster, B. Mark Sietsema, Batara Sihombing, Neil Silberman, Clodomiro Siller, Samuel Silva-Gotay, Heikki Silvet, John K. Simmons, Hagith Sivan, James C. Skedros, Abraham Smith, Ashley A. Smith, Ted A. Smith, Daud Soesilo, Pia Søltoft, Choan-Seng (C. S.) Song, Kathryn Spink, Bryan Spinks, Eric O. Springsted, Nicolas Standaert, Brian Stanley, Glen H. Stassen, Karel Steenbrink, Stephen J. Stein, Andrea Sterk, Gregory E. Sterling, Columba Stewart, Jacques Stewart, Robert B. Stewart, Cynthia Stokes Brown, Ken Stone, Anne Stott, Elizabeth Stuart, Monya Stubbs, Marjorie Hewitt Suchocki, David Kwang-sun Suh, Scott W. Sunquist, Keith Suter, Douglas Sweeney, Charles H. Talbert, Shawqi N. Talia, Elsa Tamez, Joseph B. Tamney, Jonathan Y. Tan, Yak-Hwee Tan, Kathryn Tanner, Feiya Tao, Elizabeth S. Tapia, Aquiline Tarimo, Claire Taylor, Mark Lewis Taylor, Bishop Abba Samuel Wolde Tekestebirhan, Eugene TeSelle, M. Thomas Thangaraj, David R. Thomas, Andrew Thornley, Scott Thumma, Marcelo Timotheo da Costa, George E. “Tink” Tinker, Ola Tjørhom, Karen Jo Torjesen, Iain R. Torrance, Fernando Torres-Londoño, Archbishop Demetrios [Trakatellis], Marit Trelstad, Christine Trevett, Phyllis Trible, Johannes Tromp, Paul Turner, Robert G. Tuttle, Archbishop Desmond Tutu, Peter Tyler, Anders Tyrberg, Justin Ukpong, Javier Ulloa, Camillus Umoh, Kristi Upson-Saia, Martina Urban, Monica Uribe, Elochukwu Eugene Uzukwu, Richard Vaggione, Gabriel Vahanian, Paul Valliere, T. J. 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Yee, Viktor Yelensky, Yeo Khiok-Khng, Gustav K. K. Yeung, Angela Yiu, Amos Yong, Yong Ting Jin, You Bin, Youhanna Nessim Youssef, Eliana Yunes, Robert Michael Zaller, Valarie H. Ziegler, Barbara Brown Zikmund, Joyce Ann Zimmerman, Aurora Zlotnik, Zhuo Xinping
- Edited by Daniel Patte, Vanderbilt University, Tennessee
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- The Cambridge Dictionary of Christianity
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- 05 August 2012
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- 20 September 2010, pp xi-xliv
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Contributors
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- By Robert S. Albert, John Baer, Ronald A. Beghetto, Adam S. Bristol, John F. Cabra, Bonnie Cramond, Arthur Cropley, David Cropley, Gregory J. Feist, Julie A. Fiorelli, Liane Gabora, Elena L. Grigorenko, Kyung Hee Kim, Beth A. Hennessey, Allison B. Kaufman, James C. Kaufman, Scott Barry Kaufman, Yuliya Kolomyts, Sergey A. Kornilov, Aaron Kozbelt, Paul J. Locher, Todd Lubart, Matthew C. Makel, Seana Moran, Jonathan A. Plucker, Gerard J. Puccio, Ruth Richards, Mark A. Runco, Sandra W. Russ, R. Keith Sawyer, Paul J. Silvia, Dean Keith Simonton, Jeffrey K. Smith, Lisa F. Smith, Robert J. Sternberg, Mei Tan, Joyce VanTassel-Baska, Thomas B. Ward
- Edited by James C. Kaufman, California State University, San Bernardino, Robert J. Sternberg, Tufts University, Massachusetts
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- The Cambridge Handbook of Creativity
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- 05 June 2012
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- 23 August 2010, pp xi-xii
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- By Kateri Berasi, Carol A. Boyer, Diane R. Brown, Robyn Lewis Brown, Tony N. Brown, Padraic J. Burns, Cleopatra Howard Caldwell, Daniel L. Carlson, Cheryl Corcoran, Manuela Costa, Stephen Crystal, Gary S. Cuddeback, William W. Eaton, Adrianne Frech, Virginia Aldigé Hiday, Stevan E. Hobfoll, Allan V. Horwitz, Robert J. Johnson, Verna M. Keith, Ronald C. Kessler, Corey L. M. Keyes, Jacinta P. Leavell, Harriet P. Lefley, Mary Clare Lennon, Laura Limonic, Bruce G. Link, Athena McLean, David Mechanic, Elizabeth G. Menaghan, Barret Michalec, John Mirowsky, Shirin Montazer, Joseph P. Morrissey, Carles Muntaner, Bernice A. Pescosolido, Christopher Peterson, Jo C. Phelan, Michael Polgar, Sarah Rosenfield, Catherine E. Ross, Ebony Sandusky, Jaime C. Sapag, Teresa L. Scheid, Mark F. Schmitz, Sharon Schwartz, Dena Smith, David T. Takeuchi, Peggy A. Thoits, R. Jay Turner, Edwina S. Uehara, Jerome C. Wakefield, James Walkup, Emily Walton, Blair Wheaton, David R. Williams, Kristi Williams
- Edited by Teresa L. Scheid, University of North Carolina, Charlotte, Tony N. Brown, Vanderbilt University, Tennessee
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- A Handbook for the Study of Mental Health
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- 05 June 2012
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The Chinese Army After MaoEllis Joffe Cambridge: Harvard University Press, 1987, pp. ix, 210
- Ronald C. Keith
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- Canadian Journal of Political Science/Revue canadienne de science politique / Volume 21 / Issue 4 / December 1988
- Published online by Cambridge University Press:
- 10 November 2009, pp. 855-856
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China Under Threat: The Politics of Strategy and DiplomacyMelvin Gurtov and Byong-Moo Hwang Baltimore: Johns Hopkins University Press, 1980, pp. xi, 336
- Ronald C. Keith
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- Canadian Journal of Political Science/Revue canadienne de science politique / Volume 14 / Issue 4 / December 1981
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- 10 November 2009, pp. 870-872
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Socialist Legality and Proletarian Democracy in the People's Republic of China
- Ronald C. Keith
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- Canadian Journal of Political Science/Revue canadienne de science politique / Volume 13 / Issue 3 / September 1980
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- 10 November 2009, pp. 565-582
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Political Participation in BeijingTianjian Shi Cambridge: Harvard University Press, 1997, pp. xv, 334
- Ronald C. Keith
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- Canadian Journal of Political Science/Revue canadienne de science politique / Volume 31 / Issue 3 / September 1998
- Published online by Cambridge University Press:
- 10 November 2009, pp. 611-612
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East Asian Dynamism: Growth, Order and Security in the Pacific RegionSteve Chan Boulder: Westview Press, 1990, pp. xi, 134
- Ronald C. Keith
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- Canadian Journal of Political Science/Revue canadienne de science politique / Volume 24 / Issue 3 / September 1991
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- 10 November 2009, pp. 679-680
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27 - Mild cognitive impairment
- from Part IV - Alzheimer's disease
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- By Keith A. Josephs, Department of Neurology, Mayo Clinic, Rochester, MN, USA, David F. Tang-Wai, Division of Neurology, University Health Network, Toronto Western Hospital, ON, Canada, Ronald C. Petersen, Department of Neurology, Mayo Clinic, Rochester, MN, USA
- M. Flint Beal, Cornell University, New York, Anthony E. Lang, University of Toronto, Albert C. Ludolph, Universität Ulm, Germany
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- Neurodegenerative Diseases
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- 04 August 2010
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- 02 June 2005, pp 409-415
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Summary
Overview
As research in aging and dementia moves toward an earlier identification of individuals with a cognitive impairment, the concept of mild cognitive impairment (MCI) has received considerable attention. Mild cognitive impairment refers to an intermediate stage between the cognitive changes that are felt to be part of normal aging and those that represent the very earliest features of a dementia such as Alzheimer's disease. This stage of intermediate impairment is believed to be important, since several studies have indicated that these subjects are likely to progress to AD at an accelerated rate over the general population (Petersen et al., 1999). The initial literature on the concept of MCI pertained to individuals with memory impairment beyond what would be expected for normal aging (Petersen, 1995). These subjects may have a mild impairment in other cognitive domains but performance is felt to be within the range of normal. Similarly, they may have slight difficulties with activities of daily living, but these are generally felt not to be significant. More recently, the construct of MCI has been broadened to include other presentations of persons with transitional cognitive impairment and these will be discussed below. Implicit in the discussion of MCI is an understanding of the concept of normal cognitive function. While we are learning a great deal about aging and cognitive function, this still remains an area of uncertainty.
28 - Alzheimer's disease: overview
- from Part IV - Alzheimer's disease
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- By David F. Tang-Wai, Division of Neurology, University Health Network, Toronto Western Hospital, Canada, Keith A. Josephs, Division of Neurology, University Health Network, Toronto Western Hospital, Canada, Ronald C. Petersen, Division of Neurology, University Health Network, Toronto Western Hospital, Canada
- M. Flint Beal, Cornell University, New York, Anthony E. Lang, University of Toronto, Albert C. Ludolph, Universität Ulm, Germany
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- Neurodegenerative Diseases
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- 04 August 2010
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- 02 June 2005, pp 416-432
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Summary
Dementia
Dementia, itself, neither implies a specific disease nor implies a specific underlying pathology. It refers to a change in cognitive function that is severe enough to compromise an individual's daily function. The Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) defines dementia as an acquired impairment of cognitive function that includes a decline in memory beyond what would be expected for age and at least one other cognitive function, such as attention, visuospatial skills or language, or a decline in executive functioning such as planning, organization, sequencing, or abstracting. The decline cannot only affect emotional abilities, but must also interfere with work or social activities. The deficits should not be accompanied by an impairment of arousal (delirium) or be accounted for by another psychiatric condition, such as depression or schizophrenia. Dementia can further be defined by a possible, probable, or definite etiologic diagnosis. A degenerative dementia implies disease progression over time.
While the DSM-IV criteria are generally useful, one problem with the criteria is that memory impairment is an essential feature. While this is common in most dementias, other dementias may present with impairment in a non-memory cognitive domain. If the initial presentation is a change in personality or behavior, rather than memory, a frontotemporal dementia may be the diagnosis. In subjects with parkinsonism, hallucinations and fluctuations in behavior, dementia with Lewy bodies may be more likely than AD.
The “Falun Gong Problem”: Politics and the Struggle for the Rule of Law in China
- Ronald C. Keith, Zhiqiu Lin
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- Journal:
- The China Quarterly / Volume 175 / September 2003
- Published online by Cambridge University Press:
- 24 October 2003, pp. 623-642
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- September 2003
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This article examines the CCP's “falun gong problem” with reference to PRC law and policy on “heretical cults,” paying particular attention to the implications of this problem for the ongoing struggle to establish human rights under the rule of law. Official PRC commentary contends that the falun gong not only committed criminal acts but also wilfully sought to undermine the rule of law itself. Human rights critics and agencies, such as the US Commission on International Religious Freedom, have, on the other hand, attacked the PRC for a “repressive legal framework” that threatens human rights. The “falun gong problem” is an important chapter in the struggle for the rule of law in China, and it appears that the law has not been able to transcend the conceptual bias of past criminal law on counter-revolution. The related politicization of the law through a revived principle of “flexibility” challenges the internal process of criminal justice reform and the recent reform focus on the balance of human rights protection and public order.
Legislating Women's and Children's Rights and Interests in the PRCa*
- Ronald C. Keith
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- Journal:
- The China Quarterly / Volume 149 / March 1997
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- 12 February 2009, pp. 29-55
- Print publication:
- March 1997
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Rights and interests, quanyi, are superseding class as the conceptual axis of Chinese law and jurisprudence. Recent legislation highlighting this new social and legal theory has stipulated new law on womens and childrens rights and interests. It has also endorsed an updated conception of the relation between state and society, by which the state is formally required both to provide for newly stipulated civil law protection of rights and interests and to perfect a system of social protection, shehui baozhang zhidu. The latter is to serve as a self–conscious guarantee of the practical enjoyment of rights and interests through broadly based education and social activism. If the leadership of the Peoples Republic of China (PRC) has formally committed itself to the development and protection of such rights, it remains to be seen how this commitment can be squared with the regimes refurbished mass line focus on comprehensive social control.1
Chinese Politics and the New Theory of “Rule of Law”*
- Ronald C. Keith
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- The China Quarterly / Volume 125 / March 1991
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- 12 February 2009, pp. 109-118
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- March 1991
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In light of widespread western condemnation of the Tiananmen Square event, it may seem somewhat capricious to raise the issue of the “rule of law” as it is understood in China; however, prior to 4 June the Chinese Communist Party sanctioned a provocative theoretical debate which featured the “rule of law” as opposed to the “rule of man.” Even though the Chinese rule of law derived self-consciously from Chinese ideology and history, it seemed to parallel loosely the substantive concern in the western theoretical notion of “government of laws, not men.”
Transcript of Discussions With Wu Daying and Zhang Zhonglin Concerning Legal Change and Civil Rights
- Ronald C. Keith
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- Journal:
- The China Quarterly / Volume 81 / March 1980
- Published online by Cambridge University Press:
- 17 February 2009, pp. 111-121
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- March 1980
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The following is an abridged transcript of an afternoon discussion of 9 May 1979 at the central building of the People's Association for Friendship with Foreign Countries in Beijing. Wu Daying is presently deputy director of the Institute of Law, Academy of Social Sciences, while Zhang Zhonglin, also a member of the Institute, is a prominent legal theorist, who has had a high profile in his dealings with western jurists. Miss Gao Jian and Mrs Lu Wanru acted as interpreters. The Chinese principals answered the questions of various members of the Prairie Canada-China Friendship Associations, who are, herein, referred to by their surnames.