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Validation of the Thai version of the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E): Screening for major depressive disorder in patients with epilepsy
- S. Kuladee, T. Prachason, T. Buranapichet, P. Rodwanno, A. Boongird
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- Journal:
- European Psychiatry / Volume 66 / Issue S1 / March 2023
- Published online by Cambridge University Press:
- 19 July 2023, pp. S763-S764
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Introduction
Depression has been recognized as a common comorbidity in patient with epilepsy and is associated with low quality of life. Regular screening for depression may aid in early detection and enhance quality of life.
ObjectivesTo validate the Thai version of the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E).
MethodsThe English version of NDDI-E was translated into Thai. Patients with epilepsy were enrolled at the outpatient neurology clinic from May 2019 to September 2019. Demographic data and clinical characteristics were collected. Participants underwent a psychiatric structured interview using the Mini-International Neuropsychiatric Interview (M.I.N.I.) as a gold standard for the diagnosis of major depressive disorder. Then, participants completed the NDDI-E. The internal consistency was measured by Cronbach’s alpha coefficient. The validity of the Thai version of the NDDI-E was assessed using the receiver operating characteristic (ROC) curve analysis. Youden’s index was used to determine the optimal cut-off score of the Thai version of the NDDI-E.
ResultsA total of 115 patients with epilepsy completed the evaluation. Twenty-three patients (20%) had major depressive disorder according to M.I.N.I. criteria. The Cronbach’s alpha coefficient of the Thai version of the NDDI-E was 0.826. The area under the ROC curve was 0.995. A cut-off score greater than 17 provided a sensitivity of 95.65%, a specificity of 97.83%, a positive predictive value of 91.67% ,and a negative predictive value of 98.90%.
Table 1: Demographic and clinical characteristics of the study population.
Non-depressed (N = 92) Major depression (N = 23) P-value Age in years, median (IQR) 31 (22) 28 (30) 0.637 Female, N (%) 50 (54.3) 15 (65.2) 0.347 Comorbid medical illnesses, N (%) 0.009 Present 40 (43.5) 17 (73.9) Absent 52 (56.5) 6 (26.1) Years since onset of seizures, mean (SD) 19.4 (11.9) 16.4 (14.1) 0.297 Seizure free for the last 6 months, N (%) 55 (59.8) 10 (43.5) 0.158 NDDI-E score, median (IQR) 12 (5) 19 (4) <0.001 Table 2: Corrected item-total correlation and Cronbach’s alpha if an item is deleted from the NDDI-E.
Corrected item-total correlation Cronbach’s alpha if item deleted 1. Everything is a struggle 0.554 0.807 2. Nothing I do is right 0.590 0.800 3. Feel guilty 0.573 0.803 4. I’d be better off dead 0.643 0.788 5. Frustrated 0.660 0.784 6. Difficulty finding pleasure 0.548 0.808 ConclusionsThe Thai version of the NDDI-E is a valid screening tool for major depressive disorder in patients with epilepsy.
Disclosure of InterestNone Declared
Differential associations of childhood adversity subtypes and psychopathology in men and women
- T. Prachason, I. Mutlu, L. Fusar-Poli, C. Menne-Lothmann, J. Decoster, R. van Winkel, D. Collip, P. Delespaul, M. De Hert, C. Derom, E. Thiery, N. Jacobs, M. Wichers, J. van Os, B. P. F. Rutten, L.-K. Pries, S. Gülöksüz
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- Journal:
- European Psychiatry / Volume 66 / Issue S1 / March 2023
- Published online by Cambridge University Press:
- 19 July 2023, pp. S80-S81
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- Article
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- You have access Access
- Open access
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Introduction
Prior evidence suggests that men and women might be differentially susceptible to distinct types of childhood adversity (CA), but research on gender-specific associations between CA subtypes and psychiatric symptoms is limited.
ObjectivesTo test the gender-specific associations of CA subtypes and psychiatric symptoms in the general population.
MethodsData from 791 twins and siblings from the TwinssCan project were used. Psychopathology and CA exposure were assessed using the Symptom Checklist-90 Revised (SCL-90) and the Childhood Trauma Questionnaire (CTQ), respectively. The associations between the total CTQ scores and SCL-90 scores (i.e. total SCL-90, psychoticism, paranoid ideation, anxiety, depression, somatization, obsessive-compulsive, interpersonal sensitivity, hostility, and phobic anxiety) were tested in men and women separately. The associations between the five CA subtypes (i.e. physical abuse, emotional abuse, sexual abuse, physical neglect, and emotional neglect) and total SCL-90 were tested in a mutually adjusted model. As exploratory analyses, the associations between all CA subtypes and the nine SCL-90 subdomain scores were similarly tested. The regression coefficients between men and women were compared using Chow’s test. All models were adjusted for age and family structure.
ResultsTotal CTQ was significantly associated with total SCL-90 in men (B = 0.013, SE = 0.003, P < .001) and women (B = 0.011, SE = 0.002, P < .001). The associations with the nine symptom domains were also significant in both genders (P < .001). No significant gender differences in the regression coefficients of total CTQ were detected. The analyses of CA subtypes showed a significant association between emotional abuse and total SCL-90 in women (B = 0.173, SE = 0.030, P < .001) and men (B = 0.080, SE = 0.035, P = .023), but the association was significantly stronger in women (ꭓ2(1) = 4.10, P = .043). The association of sexual abuse and total SCL-90 was only significant in women (B = 0.217, SE = 0.053, P < .001). The associations of emotional neglect (B = 0.061, SE = 0.027, P = .026) and physical neglect (B = 0.167, SE = 0.043, P < .001) with total SCL-90 were only significant in men. The explorative analyses of SCL-90 subdomains revealed significant associations of emotional abuse with all nine symptom domains and of sexual abuse with seven symptom domains in women. Significant associations of physical neglect with six symptom domains and of emotional neglect with depression were also detected in men. No other significant associations between CT subtypes and total SCL-90 or symptom domain scores were observed in men and women.
ConclusionsCA exposure was associated with diverse psychopathology similarly in both genders. However, women are more sensitive to abuse, but men are more sensitive to neglect. Gender-specific influences of CA subtypes on psychopathology should be considered in future studies.
Disclosure of InterestNone Declared