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P03-60 - Infant Trauma and Psychopathology in Paranoid Schizophrenia
- M. Henry, E. Diaz-Mesa, A.L. Morera-Fumero, A. Garcia-Hernandez, L. Fernandez-Lopez, S. Yelmo, F. Trujillo, J. Monzon, V. Barrau, R. Gracia-Marco
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- Journal:
- European Psychiatry / Volume 25 / Issue S1 / 2010
- Published online by Cambridge University Press:
- 17 April 2020, 25-E1170
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Background
Stress and trauma have been reported as leading contributing factors in schizophrenia. And certainly child abuse (neglect, emotional, physical and sexual abuse among others) has a lasting negative impact, which is well established in literature.
ObjectivesTo consider the presence of infant trauma and its relationship with psychopathology in paranoid schizophrenics.Methods. 37 patients (mean age 29±6.3; years from onset 9.20±4.7), meeting DSM IV paranoid schizophrenia criteria, undergoing treatment in a university hospital are studied. The PANSS is administered in order to rate psychopathology.
Results27 patients had infant trauma (55.8%). Main traumas are: sexual abuse (12.8%), child abuse (7.7%), both sexual and child abuse (5.18%), parental separation (7.7%), extra-rigid parents (2.6%), alcoholic parents (18.2%), child abuse and mother's death in childhood (2.6%). Infant trauma and psychopathology showed a significant relationship concerning Hostility (No 1.75±1.209, Yes 2.26±1.759), Unnatural Movements and Posture (No 1.55±0.945, Yes 1.16±0.545), Depression (No 1.25±0.550, Yes 1.74±1.284) and Preoccupation (No 2.75±1.410, Yes 3.26±1.996).
ConclusionsInfant trauma is common in paranoid schizophrenia and our findings give some evidence to a relationship with psychopathology, especially with dimensions as Hostility, Unnatural Movements and Posture, Depression and Preoccupation. Despite sample size, a high proportion (55.8%) of the patients presented infant trauma and future research is needed in order to open new avenues in this field, particularly studies concerning infant trauma and symptomatology specificity will be greatly appreciated as well as the plausible link to personality traits and personality disorders.
P03-133 - First Episode Psychosis and Multiple Sclerosis
- S. Yelmo, A. Morera-Fumero, E. Díaz-Mesa, V. Barrau, M. Henry, R. Gracia
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- Journal:
- European Psychiatry / Volume 25 / Issue S1 / 2010
- Published online by Cambridge University Press:
- 17 April 2020, 25-E1102
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Objectives
There is a significant incidence of psychiatric symptoms in patients with multiple sclerosis, the most common after receiving the diagnosis. We describe a man who was admitted for a first episode psychosis and a diagnosis of multiple sclerosis was made moreover.
MethodsA 24-year-old man was admitted with a paranoid delusion, auditory hallucinations with emotional response and the believe that their thoughts were being interfered. Blood test and cranial CT were normal. Risperidone was started. He developed ataxia and sensitive disturbances on the right arm. A cranial and spinal cord MRI revealed multiple T2 and FLAIR hyperintense lesions located in supra and infratentorial white matter, lesions in C3, and one lesion in right basal ganglia that enhanced with gadolinium. CSF analysis showed oligoclonals bands. Three years ago the patient had had transient sensitive symtoms. A diagnosis of relapsing-remitting multiple sclerosis was made and was started methyl-prednisolone intravenously. Risperidone was changed for amisulpride 800 mg/day because lack of response. He was discharged after 25 days. Six months later he has attenuated psychotic symptoms without news lesions in MRI. Glatiramer acetate has been started.
Results and conclusionsThe most frequent disorder associated to multiple sclerosis is depression (prevalence of 20%). Psychosis is unusual, transient, sometimes as the onset relapse followed by remission. There's evidence of correlation between psychosis in multiple sclerosis and multiple lesions in temporal periventricular area. We suggest that in our case these two disorders are two separated entities since the enhanced lesion does not correpond with clinical findings.
Hypothyroidism and psychosis: a case report
- M. Salinas, V. Barrau, S. Yelmo, E. Santana, J. Monzón, R. Gracia
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- Journal:
- European Psychiatry / Volume 26 / Issue S2 / March 2011
- Published online by Cambridge University Press:
- 16 April 2020, p. 1753
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Introduction
Hypothyroidism is a medical condition commonly found in a variety of clinical settings. Physical complaints of thyroid hormone deficiency are many, and psychiatric symptoms include cognitive dysfunction, affective disorders and psychosis.
ObjectivesTo study the possible relationship between psychotic symptoms and secondary to treatment with radioiodine hypothyroidism, presenting a case report.
MethodsWe report a 32 year-old woman without known significant past medical history (except Graves Basedow disease with no current treatment) that came to clinical attention due to psychotic symptoms. The patient was admitted to the hospital and laboratory values revealed hypothyroidism secondary to treatment with radioiodine (which was required six months before for a Graves Basedow disease). We considered the possibility that thyroid dysfunction was the cause of the psychiatric symptoms.
ResultsAfter giving neuroleptic treatment with increasing doses of risperidone (up to 9 mg/day), clinical improvement was observed, with a diminishment of psychiatric symptoms. At the same time, supplementary treatment with thyroid hormone was given, which did not manage to normalize the hormone function at the moment of discharge.
ConclusionIn our patient we cannot establish a definite link between psychotic and clinical thyroid dysfunction, because six months after replacement therapy the hormonal function has not yet been completely standardized. The patient was psychopathologically stable (although treatment was maintained with quetiapine 600 mg/day). There is no doubt that thyroid hormone plays a key role in the regulation of mood, cognition and behavior; we must not ignore this, and always check thyroid function in psychiatric patients.
P-941 - Factor Structure of the Mcmi-iii in a Psychiatric Patients Sample
- M. Salinas, E. Santana, J. Chico, V. Barrau, S. Yelmo, N. Gallego, S. Poyo, R. Gracia
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- Journal:
- European Psychiatry / Volume 27 / Issue S1 / 2012
- Published online by Cambridge University Press:
- 15 April 2020, p. 1
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Introduction
The convenience of a dimensional Axis II in the DSM-5 has been discussed, since there is criticism about the current categorical model, such as the high comorbidity or the scarce interrater agreement. Some think that those flaws could be attributed to the lack of an underlying theoretical model. To this respect, there are evidences that show that the personality disorders could be considered as extreme cases of normal personality traits. We try to find out if the factor analysis of a personality disorder scale (MCMI-III) reflects normal personality factors.
MethodParticipants and procedure: we analyzed the MCMI-III (Millon, 1998) profiles of 50 Personality Disorders patients and 50 controls. Principal Components Factor Analyses with varimax rotation were computed globally and separately for each sample.
ResultsA three factor structure (paranoid introversion, self control and insecurity) was found when analyzing both samples together. The separated samples analysis showed the same structure in controls, while in patients we found a three factor structure: neurotic introversion, hostility and self control. Both structures were basically equivalent, and differences among them could be qualified by a test bias (namely, higher averages for patients in the anxious and psychotic-like disorders).
ConclusionsFactor structures did not reflect the DSM-IV cluster division, and neither did it reflect Millon's classification. Conversely, the factors we found were consistent with personality traits previously described by normal personality models (e.g.: Cattell, 1957; Costa y McCrae, 1990; Eysenck, 1981).
Contributors
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- By Mitchell Aboulafia, Frederick Adams, Marilyn McCord Adams, Robert M. Adams, Laird Addis, James W. Allard, David Allison, William P. Alston, Karl Ameriks, C. Anthony Anderson, David Leech Anderson, Lanier Anderson, Roger Ariew, David Armstrong, Denis G. Arnold, E. J. Ashworth, Margaret Atherton, Robin Attfield, Bruce Aune, Edward Wilson Averill, Jody Azzouni, Kent Bach, Andrew Bailey, Lynne Rudder Baker, Thomas R. Baldwin, Jon Barwise, George Bealer, William Bechtel, Lawrence C. Becker, Mark A. Bedau, Ernst Behler, José A. Benardete, Ermanno Bencivenga, Jan Berg, Michael Bergmann, Robert L. Bernasconi, Sven Bernecker, Bernard Berofsky, Rod Bertolet, Charles J. Beyer, Christian Beyer, Joseph Bien, Joseph Bien, Peg Birmingham, Ivan Boh, James Bohman, Daniel Bonevac, Laurence BonJour, William J. Bouwsma, Raymond D. Bradley, Myles Brand, Richard B. Brandt, Michael E. Bratman, Stephen E. Braude, Daniel Breazeale, Angela Breitenbach, Jason Bridges, David O. Brink, Gordon G. Brittan, Justin Broackes, Dan W. Brock, Aaron Bronfman, Jeffrey E. Brower, Bartosz Brozek, Anthony Brueckner, Jeffrey Bub, Lara Buchak, Otavio Bueno, Ann E. Bumpus, Robert W. Burch, John Burgess, Arthur W. Burks, Panayot Butchvarov, Robert E. Butts, Marina Bykova, Patrick Byrne, David Carr, Noël Carroll, Edward S. Casey, Victor Caston, Victor Caston, Albert Casullo, Robert L. Causey, Alan K. L. Chan, Ruth Chang, Deen K. Chatterjee, Andrew Chignell, Roderick M. Chisholm, Kelly J. Clark, E. J. Coffman, Robin Collins, Brian P. Copenhaver, John Corcoran, John Cottingham, Roger Crisp, Frederick J. Crosson, Antonio S. Cua, Phillip D. Cummins, Martin Curd, Adam Cureton, Andrew Cutrofello, Stephen Darwall, Paul Sheldon Davies, Wayne A. Davis, Timothy Joseph Day, Claudio de Almeida, Mario De Caro, Mario De Caro, John Deigh, C. F. Delaney, Daniel C. Dennett, Michael R. DePaul, Michael Detlefsen, Daniel Trent Devereux, Philip E. Devine, John M. Dillon, Martin C. Dillon, Robert DiSalle, Mary Domski, Alan Donagan, Paul Draper, Fred Dretske, Mircea Dumitru, Wilhelm Dupré, Gerald Dworkin, John Earman, Ellery Eells, Catherine Z. Elgin, Berent Enç, Ronald P. Endicott, Edward Erwin, John Etchemendy, C. Stephen Evans, Susan L. Feagin, Solomon Feferman, Richard Feldman, Arthur Fine, Maurice A. Finocchiaro, William FitzPatrick, Richard E. Flathman, Gvozden Flego, Richard Foley, Graeme Forbes, Rainer Forst, Malcolm R. Forster, Daniel Fouke, Patrick Francken, Samuel Freeman, Elizabeth Fricker, Miranda Fricker, Michael Friedman, Michael Fuerstein, Richard A. Fumerton, Alan Gabbey, Pieranna Garavaso, Daniel Garber, Jorge L. A. Garcia, Robert K. Garcia, Don Garrett, Philip Gasper, Gerald Gaus, Berys Gaut, Bernard Gert, Roger F. Gibson, Cody Gilmore, Carl Ginet, Alan H. Goldman, Alvin I. Goldman, Alfonso Gömez-Lobo, Lenn E. Goodman, Robert M. Gordon, Stefan Gosepath, Jorge J. E. Gracia, Daniel W. Graham, George A. Graham, Peter J. Graham, Richard E. Grandy, I. Grattan-Guinness, John Greco, Philip T. Grier, Nicholas Griffin, Nicholas Griffin, David A. Griffiths, Paul J. Griffiths, Stephen R. Grimm, Charles L. Griswold, Charles B. Guignon, Pete A. Y. Gunter, Dimitri Gutas, Gary Gutting, Paul Guyer, Kwame Gyekye, Oscar A. Haac, Raul Hakli, Raul Hakli, Michael Hallett, Edward C. Halper, Jean Hampton, R. James Hankinson, K. R. Hanley, Russell Hardin, Robert M. Harnish, William Harper, David Harrah, Kevin Hart, Ali Hasan, William Hasker, John Haugeland, Roger Hausheer, William Heald, Peter Heath, Richard Heck, John F. Heil, Vincent F. Hendricks, Stephen Hetherington, Francis Heylighen, Kathleen Marie Higgins, Risto Hilpinen, Harold T. Hodes, Joshua Hoffman, Alan Holland, Robert L. Holmes, Richard Holton, Brad W. Hooker, Terence E. Horgan, Tamara Horowitz, Paul Horwich, Vittorio Hösle, Paul Hoβfeld, Daniel Howard-Snyder, Frances Howard-Snyder, Anne Hudson, Deal W. Hudson, Carl A. Huffman, David L. Hull, Patricia Huntington, Thomas Hurka, Paul Hurley, Rosalind Hursthouse, Guillermo Hurtado, Ronald E. Hustwit, Sarah Hutton, Jonathan Jenkins Ichikawa, Harry A. Ide, David Ingram, Philip J. Ivanhoe, Alfred L. Ivry, Frank Jackson, Dale Jacquette, Joseph Jedwab, Richard Jeffrey, David Alan Johnson, Edward Johnson, Mark D. Jordan, Richard Joyce, Hwa Yol Jung, Robert Hillary Kane, Tomis Kapitan, Jacquelyn Ann K. Kegley, James A. Keller, Ralph Kennedy, Sergei Khoruzhii, Jaegwon Kim, Yersu Kim, Nathan L. King, Patricia Kitcher, Peter D. Klein, E. D. Klemke, Virginia Klenk, George L. Kline, Christian Klotz, Simo Knuuttila, Joseph J. Kockelmans, Konstantin Kolenda, Sebastian Tomasz Kołodziejczyk, Isaac Kramnick, Richard Kraut, Fred Kroon, Manfred Kuehn, Steven T. Kuhn, Henry E. Kyburg, John Lachs, Jennifer Lackey, Stephen E. Lahey, Andrea Lavazza, Thomas H. Leahey, Joo Heung Lee, Keith Lehrer, Dorothy Leland, Noah M. Lemos, Ernest LePore, Sarah-Jane Leslie, Isaac Levi, Andrew Levine, Alan E. Lewis, Daniel E. Little, Shu-hsien Liu, Shu-hsien Liu, Alan K. L. Chan, Brian Loar, Lawrence B. Lombard, John Longeway, Dominic McIver Lopes, Michael J. Loux, E. J. Lowe, Steven Luper, Eugene C. Luschei, William G. Lycan, David Lyons, David Macarthur, Danielle Macbeth, Scott MacDonald, Jacob L. Mackey, Louis H. Mackey, Penelope Mackie, Edward H. Madden, Penelope Maddy, G. B. Madison, Bernd Magnus, Pekka Mäkelä, Rudolf A. Makkreel, David Manley, William E. Mann (W.E.M.), Vladimir Marchenkov, Peter Markie, Jean-Pierre Marquis, Ausonio Marras, Mike W. Martin, A. P. Martinich, William L. McBride, David McCabe, Storrs McCall, Hugh J. McCann, Robert N. McCauley, John J. McDermott, Sarah McGrath, Ralph McInerny, Daniel J. McKaughan, Thomas McKay, Michael McKinsey, Brian P. McLaughlin, Ernan McMullin, Anthonie Meijers, Jack W. Meiland, William Jason Melanson, Alfred R. Mele, Joseph R. Mendola, Christopher Menzel, Michael J. Meyer, Christian B. Miller, David W. Miller, Peter Millican, Robert N. Minor, Phillip Mitsis, James A. Montmarquet, Michael S. Moore, Tim Moore, Benjamin Morison, Donald R. Morrison, Stephen J. Morse, Paul K. Moser, Alexander P. D. Mourelatos, Ian Mueller, James Bernard Murphy, Mark C. Murphy, Steven Nadler, Jan Narveson, Alan Nelson, Jerome Neu, Samuel Newlands, Kai Nielsen, Ilkka Niiniluoto, Carlos G. Noreña, Calvin G. Normore, David Fate Norton, Nikolaj Nottelmann, Donald Nute, David S. Oderberg, Steve Odin, Michael O’Rourke, Willard G. Oxtoby, Heinz Paetzold, George S. Pappas, Anthony J. Parel, Lydia Patton, R. P. Peerenboom, Francis Jeffry Pelletier, Adriaan T. Peperzak, Derk Pereboom, Jaroslav Peregrin, Glen Pettigrove, Philip Pettit, Edmund L. Pincoffs, Andrew Pinsent, Robert B. Pippin, Alvin Plantinga, Louis P. Pojman, Richard H. Popkin, John F. Post, Carl J. Posy, William J. Prior, Richard Purtill, Michael Quante, Philip L. Quinn, Philip L. Quinn, Elizabeth S. Radcliffe, Diana Raffman, Gerard Raulet, Stephen L. Read, Andrews Reath, Andrew Reisner, Nicholas Rescher, Henry S. Richardson, Robert C. Richardson, Thomas Ricketts, Wayne D. Riggs, Mark Roberts, Robert C. Roberts, Luke Robinson, Alexander Rosenberg, Gary Rosenkranz, Bernice Glatzer Rosenthal, Adina L. Roskies, William L. Rowe, T. M. Rudavsky, Michael Ruse, Bruce Russell, Lilly-Marlene Russow, Dan Ryder, R. M. Sainsbury, Joseph Salerno, Nathan Salmon, Wesley C. Salmon, Constantine Sandis, David H. Sanford, Marco Santambrogio, David Sapire, Ruth A. Saunders, Geoffrey Sayre-McCord, Charles Sayward, James P. Scanlan, Richard Schacht, Tamar Schapiro, Frederick F. Schmitt, Jerome B. Schneewind, Calvin O. Schrag, Alan D. Schrift, George F. Schumm, Jean-Loup Seban, David N. Sedley, Kenneth Seeskin, Krister Segerberg, Charlene Haddock Seigfried, Dennis M. Senchuk, James F. Sennett, William Lad Sessions, Stewart Shapiro, Tommie Shelby, Donald W. Sherburne, Christopher Shields, Roger A. Shiner, Sydney Shoemaker, Robert K. Shope, Kwong-loi Shun, Wilfried Sieg, A. John Simmons, Robert L. Simon, Marcus G. Singer, Georgette Sinkler, Walter Sinnott-Armstrong, Matti T. Sintonen, Lawrence Sklar, Brian Skyrms, Robert C. Sleigh, Michael Anthony Slote, Hans Sluga, Barry Smith, Michael Smith, Robin Smith, Robert Sokolowski, Robert C. Solomon, Marta Soniewicka, Philip Soper, Ernest Sosa, Nicholas Southwood, Paul Vincent Spade, T. L. S. Sprigge, Eric O. Springsted, George J. Stack, Rebecca Stangl, Jason Stanley, Florian Steinberger, Sören Stenlund, Christopher Stephens, James P. Sterba, Josef Stern, Matthias Steup, M. A. Stewart, Leopold Stubenberg, Edith Dudley Sulla, Frederick Suppe, Jere Paul Surber, David George Sussman, Sigrún Svavarsdóttir, Zeno G. Swijtink, Richard Swinburne, Charles C. Taliaferro, Robert B. Talisse, John Tasioulas, Paul Teller, Larry S. Temkin, Mark Textor, H. S. Thayer, Peter Thielke, Alan Thomas, Amie L. Thomasson, Katherine Thomson-Jones, Joshua C. Thurow, Vzalerie Tiberius, Terrence N. Tice, Paul Tidman, Mark C. Timmons, William Tolhurst, James E. Tomberlin, Rosemarie Tong, Lawrence Torcello, Kelly Trogdon, J. D. Trout, Robert E. Tully, Raimo Tuomela, John Turri, Martin M. Tweedale, Thomas Uebel, Jennifer Uleman, James Van Cleve, Harry van der Linden, Peter van Inwagen, Bryan W. Van Norden, René van Woudenberg, Donald Phillip Verene, Samantha Vice, Thomas Vinci, Donald Wayne Viney, Barbara Von Eckardt, Peter B. M. Vranas, Steven J. Wagner, William J. Wainwright, Paul E. Walker, Robert E. Wall, Craig Walton, Douglas Walton, Eric Watkins, Richard A. Watson, Michael V. Wedin, Rudolph H. Weingartner, Paul Weirich, Paul J. Weithman, Carl Wellman, Howard Wettstein, Samuel C. Wheeler, Stephen A. White, Jennifer Whiting, Edward R. Wierenga, Michael Williams, Fred Wilson, W. Kent Wilson, Kenneth P. Winkler, John F. Wippel, Jan Woleński, Allan B. Wolter, Nicholas P. Wolterstorff, Rega Wood, W. Jay Wood, Paul Woodruff, Alison Wylie, Gideon Yaffe, Takashi Yagisawa, Yutaka Yamamoto, Keith E. Yandell, Xiaomei Yang, Dean Zimmerman, Günter Zoller, Catherine Zuckert, Michael Zuckert, Jack A. Zupko (J.A.Z.)
- Edited by Robert Audi, University of Notre Dame, Indiana
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- The Cambridge Dictionary of Philosophy
- Published online:
- 05 August 2015
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- 27 April 2015, pp ix-xxx
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Changes in bread consumption and 4-year changes in adiposity in Spanish subjects at high cardiovascular risk
- I. Bautista-Castaño, A. Sánchez-Villegas, R. Estruch, M. A. Martínez-González, D. Corella, J. Salas-Salvadó, M. I. Covas, H. Schroder, J. Alvarez-Pérez, J. Quilez, R. M. Lamuela-Raventós, E. Ros, F. Arós, M. Fiol, J. Lapetra, M. A. Muñoz, E. Gómez-Gracia, J. Tur, X. Pintó, V. Ruiz-Gutierrez, M. P. Portillo-Baquedano, L. Serra-Majem
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- Journal:
- British Journal of Nutrition / Volume 110 / Issue 2 / 28 July 2013
- Published online by Cambridge University Press:
- 03 December 2012, pp. 337-346
- Print publication:
- 28 July 2013
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The effects of bread consumption change over time on anthropometric measures have been scarcely studied. We analysed 2213 participants at high risk for CVD from the PREvención con DIeta MEDiterránea (PREDIMED) trial to assess the association between changes in the consumption of bread and weight and waist circumference gain over time. Dietary habits were assessed with validated FFQ at baseline and repeatedly every year during 4 years of follow-up. Using multivariate models to adjust for covariates, long-term weight and waist circumference changes according to quartiles of change in energy-adjusted white and whole-grain bread consumption were calculated. The present results showed that over 4 years, participants in the highest quartile of change in white bread intake gained 0·76 kg more than those in the lowest quartile (P for trend = 0·003) and 1·28 cm more than those in the lowest quartile (P for trend < 0·001). No significant dose–response relationships were observed for change in whole-bread consumption and anthropometric measures. Gaining weight (>2 kg) and gaining waist circumference (>2 cm) during follow-up was not associated with increase in bread consumption, but participants in the highest quartile of changes in white bread intake had a reduction of 33 % in the odds of losing weight (>2 kg) and a reduction of 36 % in the odds of losing waist circumference (>2 cm). The present results suggest that reducing white bread, but not whole-grain bread consumption, within a Mediterranean-style food pattern setting is associated with lower gains in weight and abdominal fat.
The efficacy of the probiotic feed additive Calsporin® (Bacillus subtilis C-3102) in weaned piglets: combined analysis of four different studies
- T. Marubashi, M. I. Gracia, B. Vilà, V. Bontempo, S. K. Kritas, M. Piskoríková
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- Journal:
- Journal of Applied Animal Nutrition / Volume 1 / 2012
- Published online by Cambridge University Press:
- 02 May 2012, e2
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- 2012
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The efficacy of the probiotic feed product, Calsporin® (Bacillus subtilis C-3102) in weaned piglets was evaluated by statistical analysis of the combined results from four different experiments. The body weight, average daily gain, feed intake, feed conversion ratio and mortality data from these four experiments were tested for homogeneity before being pooled and analysed as a whole, with experiment being included as a blocking factor. Piglets fed diets supplemented with Calsporin® were significantly heavier (3.4%) at 43 days (P < 0.05), their feed intakes decreased by 2.1% and feed efficiency (FCR) improved by 3.2% between 15 and 43 days, although these latter differences were not significant. Over the entire study period (day 1 to 43), significant improvements in daily gain (4.8%) and feed efficiency (6.2%) were observed with Calsporin® supplementation (P < 0.05). The results demonstrated that Calsporin® at 30 mg/kg inclusion in commercial-type diets can improve zootechnical performance in weaned piglets.
Star formation and the ISM in infrared bright galaxies - SHINING
- M. Röllig, R. Simon, V. Ossenkopf, J. Stutzki, E. Sturm, A. Poglitsch, A. Contursi, J. Graciá-Carpio, J. Fischer, E. González-Alfonso, R. Genzel, S. Hailey-Dunsheath, D. Lutz, L. Tacconi, J. deJong, A. Sternberg, A. Verma, S. Madden, L. Vigroux, D. Cormier, U. Klaas, M. Nielbock, O. Krause, J. Schreiber, M. Haas
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- European Astronomical Society Publications Series / Volume 52 / 2011
- Published online by Cambridge University Press:
- 25 November 2011, pp. 55-61
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- 2011
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The Herschel Key Project SHINING performs a study of the ISM in star forming and active infrared bright galaxies (starbursts, AGN, (U)LIRGs, interacting and low metallicity galaxies) at local and intermediate redshifts. Here we present some surprising and promising first results from parts of this programme, including spatially resolved PDR diagnostics, line deficit diagnostics, and large scale molecular outflows traced by the OH molecule.
Fabrication and Applications of Three Dimensional Porous Microwells
- Christina L Randall, Yevgeniy V Kalinin, Anum Azam, David Gracias
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- Journal:
- MRS Online Proceedings Library Archive / Volume 1272 / 2010
- Published online by Cambridge University Press:
- 01 February 2011, 1272-KK10-03
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- 2010
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In many biological applications, such as cell therapy and drug delivery, there is a need to enhance diffusion by enabling chemical transport in all three dimensions. We highlight this need by comparing diffusion in a conventional two-dimensional (2D) microwell with diffusion in a three-dimensional (3D) cubic microwell using numerical simulations. We also describe the fabrication of hollow polymeric (and biocompatible) cubic microwells and microwell arrays. We emphasize that since the assembly process is compatible with 2D lithographic patterning, porosity can be precisely patterned in all three dimensions. Hence, this platform provides considerable versatility for a variety of applications.
The effect of post-injury depression on return to pre-injury function: a prospective cohort study
- T. S. Richmond, J. D. Amsterdam, W. Guo, T. Ackerson, V. Gracias, K. M. Robinson, J. E. Hollander
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- Journal:
- Psychological Medicine / Volume 39 / Issue 10 / October 2009
- Published online by Cambridge University Press:
- 02 March 2009, pp. 1709-1720
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Background
Millions of people seek emergency department (ED) care for injuries each year, the majority for minor injuries. Little is known about the effect of psychiatric co-morbid disorders that emerge after minor injury on functional recovery. This study examined the effect of post-injury depression on return to pre-injury levels of function.
MethodThis was a longitudinal cohort study with follow-up at 3, 6 and 12 months post-injury: 275 adults were randomly selected from those presenting to the ED with minor injury; 248 were retained over the post-injury year. Function was measured with the Functional Status Questionnaire (FSQ). Psychiatric disorders were diagnosed using the Structured Clinical Interview for DSM-IV-TR disorders (SCID).
ResultsDuring the post-injury year, 18.1% [95% confidence interval (CI) 13.3–22.9] were diagnosed with depression. Adjusting for clinical and demographic covariates, the depressed group was less likely to return to pre-injury levels of activities of daily living [odds ratio (OR) 8.37, 95% CI 3.78–18.53] and instrumental activities of daily living (OR 3.25, 95% CI 1.44–7.31), less likely to return to pre-injury work status (OR 2.37, 95% CI 1.04–5.38), and more likely to spend days in bed because of health (OR 2.41, 95% CI 1.15–5.07).
ConclusionsDepression was the most frequent psychiatric diagnosis in the year after minor injury requiring emergency care. Individuals with depression did not return to pre-injury levels of function during the post-injury year.
Photoluminescent coupled multiple microcavity structures made of porous silicon
- V. Agarwal, J.A. Soto Urueta, J. Miguel Gracia
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- Journal:
- MRS Online Proceedings Library Archive / Volume 832 / 2004
- Published online by Cambridge University Press:
- 01 February 2011, F1.6
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- 2004
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In this paper we report the fabrication and experimental characterization of photoluminescent coupled multiple microcavity 1-Dimensional photonic bandgap structures for specific photonic applications. These structures have been prepared on silicon substrate as well as free standing. The comparision with theory gave a good fit showing desired structure formation for more than 184 layered structure. These structures can be useful for a large variety of applications such as silicon lasers.