23 results
Asian-Pacific perspective on the psychological well-being of healthcare workers during the evolution of the COVID-19 pandemic
- Nicholas W. S. Chew, Jinghao Nicholas Ngiam, Benjamin Yong-Qiang Tan, Sai-Meng Tham, Celine Yan-Shan Tan, Mingxue Jing, Renarebecca Sagayanathan, Jin Tao Chen, Lily Y. H. Wong, Aftab Ahmad, Faheem Ahmed Khan, Maznah Marmin, Fadhlina Binte Hassan, Tai Mei-Ling Sharon, Chin Han Lim, Mohamad Iqbal Bin Mohaini, Rivan Danuaji, Thang H. Nguyen, Georgios Tsivgoulis, Sotirios Tsiodras, Paraskevi C. Fragkou, Dimitra Dimopoulou, Arvind K. Sharma, Kenam Shah, Bhargesh Patel, Suktara Sharma, R. N. Komalkumar, R. V. Meenakshi, Shikha Talati, Hock Luen Teoh, Cyrus S. Ho, Roger C. Ho, Vijay K. Sharma
-
- Journal:
- BJPsych Open / Volume 6 / Issue 6 / November 2020
- Published online by Cambridge University Press:
- 08 October 2020, e116
-
- Article
-
- You have access Access
- Open access
- HTML
- Export citation
-
Background
The coronavirus disease 2019 (COVID-19) pandemic has led to significant strain on front-line healthcare workers.
AimsIn this multicentre study, we compared the psychological outcomes during the COVID-19 pandemic in various countries in the Asia-Pacific region and identified factors associated with adverse psychological outcomes.
MethodFrom 29 April to 4 June 2020, the study recruited healthcare workers from major healthcare institutions in five countries in the Asia-Pacific region. A self-administrated survey that collected information on prior medical conditions, presence of symptoms, and scores on the Depression Anxiety Stress Scales and the Impact of Events Scale-Revised were used. The prevalence of depression, anxiety, stress and post-traumatic stress disorder (PTSD) relating to COVID-19 was compared, and multivariable logistic regression identified independent factors associated with adverse psychological outcomes within each country.
ResultsA total of 1146 participants from India, Indonesia, Singapore, Malaysia and Vietnam were studied. Despite having the lowest volume of cases, Vietnam displayed the highest prevalence of PTSD. In contrast, Singapore reported the highest case volume, but had a lower prevalence of depression and anxiety. In the multivariable analysis, we found that non-medically trained personnel, the presence of physical symptoms and presence of prior medical conditions were independent predictors across the participating countries.
ConclusionsThis study highlights that the varied prevalence of psychological adversity among healthcare workers is independent of the burden of COVID-19 cases within each country. Early psychological interventions may be beneficial for the vulnerable groups of healthcare workers with presence of physical symptoms, prior medical conditions and those who are not medically trained.
Undernutrition in childhood resulted in bad dietary behaviors and the increased risk of hypertension in a middle-aged Chinese population
- L. Zhang, J. Sheng, Y. Xuan, P. Xuan, J. Zhou, Y. Fan, X. Zhu, K. Liu, L. Yang, F. Tao, S. Wang
-
- Journal:
- Journal of Developmental Origins of Health and Disease / Volume 9 / Issue 5 / October 2018
- Published online by Cambridge University Press:
- 01 June 2018, pp. 544-551
-
- Article
- Export citation
-
This study was designed to explore the association between undernutrition in the growth period and cardiovascular risk factors in a middle-aged Chinese population. A total of 1756 subjects, aged 45–60 years, were invited to participate in the Hefei Nutrition and Health Study and divided into three groups according to their self-reported animal food intake in the growth period. Group 1, Group 2 and Group 3 were defined as undernutrition, nutritional improvement and the good nutrition group, respectively. In the three groups, the subjects in Groups 1 and 2 had more oil and salt intake (P<0.001), and less eggs and milk intake (P<0.001), when compared with the subjects in Group 3. After adjusting for age, education, smoking status and other confounding factors, it was found that male participants who experienced nutritional improvement before age 18 had higher risk of hypertension [odds ratio (OR)=1.68; 95% confidence intervals (CI): 1.05, 2.69] than those with good nutrition, and female participants with undernutrition (OR=1.52; 95% CI: 1.01, 2.29) and nutritional improvement (OR=1.68; 95% CI: 1.04, 2.69) before age 18 had a higher risk of hypertension than those with good nutrition. For diabetes, obesity, hypercholesterolemia and hypertriglyceridemia, our results did not found difference among the three groups both in male and female. Our findings indicated that nutritional deficiency in childhood was associated with bad dietary behaviors and a significantly increased risk of hypertension in middle age. Therefore, early adequate nutrition is very important for the prevention of non-communicable diseases later.
Follow Up of GW170817 and Its Electromagnetic Counterpart by Australian-Led Observing Programmes
- Part of
- I. Andreoni, K. Ackley, J. Cooke, A. Acharyya, J. R. Allison, G. E. Anderson, M. C. B. Ashley, D. Baade, M. Bailes, K. Bannister, A. Beardsley, M. S. Bessell, F. Bian, P. A. Bland, M. Boer, T. Booler, A. Brandeker, I. S. Brown, D. A. H. Buckley, S.-W. Chang, D. M. Coward, S. Crawford, H. Crisp, B. Crosse, A. Cucchiara, M. Cupák, J. S. de Gois, A. Deller, H. A. R. Devillepoix, D. Dobie, E. Elmer, D. Emrich, W. Farah, T. J. Farrell, T. Franzen, B. M. Gaensler, D. K. Galloway, B. Gendre, T. Giblin, A. Goobar, J. Green, P. J. Hancock, B. A. D. Hartig, E. J. Howell, L. Horsley, A. Hotan, R. M. Howie, L. Hu, Y. Hu, C. W. James, S. Johnston, M. Johnston-Hollitt, D. L. Kaplan, M. Kasliwal, E. F. Keane, D. Kenney, A. Klotz, R. Lau, R. Laugier, E. Lenc, X. Li, E. Liang, C. Lidman, L. C. Luvaul, C. Lynch, B. Ma, D. Macpherson, J. Mao, D. E. McClelland, C. McCully, A. Möller, M. F. Morales, D. Morris, T. Murphy, K. Noysena, C. A. Onken, N. B. Orange, S. Osłowski, D. Pallot, J. Paxman, S. B. Potter, T. Pritchard, W. Raja, R. Ridden-Harper, E. Romero-Colmenero, E. M. Sadler, E. K. Sansom, R. A. Scalzo, B. P. Schmidt, S. M. Scott, N. Seghouani, Z. Shang, R. M. Shannon, L. Shao, M. M. Shara, R. Sharp, M. Sokolowski, J. Sollerman, J. Staff, K. Steele, T. Sun, N. B. Suntzeff, C. Tao, S. Tingay, M. C. Towner, P. Thierry, C. Trott, B. E. Tucker, P. Väisänen, V. Venkatraman Krishnan, M. Walker, L. Wang, X. Wang, R. Wayth, M. Whiting, A. Williams, T. Williams, C. Wolf, C. Wu, X. Wu, J. Yang, X. Yuan, H. Zhang, J. Zhou, H. Zovaro
-
- Journal:
- Publications of the Astronomical Society of Australia / Volume 34 / 2017
- Published online by Cambridge University Press:
- 20 December 2017, e069
-
- Article
-
- You have access Access
- HTML
- Export citation
-
The discovery of the first electromagnetic counterpart to a gravitational wave signal has generated follow-up observations by over 50 facilities world-wide, ushering in the new era of multi-messenger astronomy. In this paper, we present follow-up observations of the gravitational wave event GW170817 and its electromagnetic counterpart SSS17a/DLT17ck (IAU label AT2017gfo) by 14 Australian telescopes and partner observatories as part of Australian-based and Australian-led research programs. We report early- to late-time multi-wavelength observations, including optical imaging and spectroscopy, mid-infrared imaging, radio imaging, and searches for fast radio bursts. Our optical spectra reveal that the transient source emission cooled from approximately 6 400 K to 2 100 K over a 7-d period and produced no significant optical emission lines. The spectral profiles, cooling rate, and photometric light curves are consistent with the expected outburst and subsequent processes of a binary neutron star merger. Star formation in the host galaxy probably ceased at least a Gyr ago, although there is evidence for a galaxy merger. Binary pulsars with short (100 Myr) decay times are therefore unlikely progenitors, but pulsars like PSR B1534+12 with its 2.7 Gyr coalescence time could produce such a merger. The displacement (~2.2 kpc) of the binary star system from the centre of the main galaxy is not unusual for stars in the host galaxy or stars originating in the merging galaxy, and therefore any constraints on the kick velocity imparted to the progenitor are poor.
D-106 Invited—In Situ Neutron Diffraction Studies of Deformation-Induced Phase Transformation in An Ultrafine Grained Trip Steel
- H. Choo, K. Tao, B. Clausen, J. E. Jin, Y. K. Lee
-
- Journal:
- Powder Diffraction / Volume 22 / Issue 2 / June 2007
- Published online by Cambridge University Press:
- 20 May 2016, p. 182
-
- Article
- Export citation
Subtypes of major depression: latent class analysis in depressed Han Chinese women
- Y. Li, S. Aggen, S. Shi, J. Gao, Y. Li, M. Tao, K. Zhang, X. Wang, C. Gao, L. Yang, Y. Liu, K. Li, J. Shi, G. Wang, L. Liu, J. Zhang, B. Du, G. Jiang, J. Shen, Z. Zhang, W. Liang, J. Sun, J. Hu, T. Liu, X. Wang, G. Miao, H. Meng, Y. Li, C. Hu, Y. Li, G. Huang, G. Li, B. Ha, H. Deng, Q. Mei, H. Zhong, S. Gao, H. Sang, Y. Zhang, X. Fang, F. Yu, D. Yang, T. Liu, Y. Chen, X. Hong, W. Wu, G. Chen, M. Cai, Y. Song, J. Pan, J. Dong, R. Pan, W. Zhang, Z. Shen, Z. Liu, D. Gu, X. Wang, X. Liu, Q. Zhang, J. Flint, K. S. Kendler
-
- Journal:
- Psychological Medicine / Volume 44 / Issue 15 / November 2014
- Published online by Cambridge University Press:
- 09 April 2014, pp. 3275-3288
-
- Article
- Export citation
-
Background.
Despite substantial research, uncertainty remains about the clinical and etiological heterogeneity of major depression (MD). Can meaningful and valid subtypes be identified and would they be stable cross-culturally?
Method.Symptoms at their lifetime worst depressive episode were assessed at structured psychiatric interview in 6008 women of Han Chinese descent, age ⩾30 years, with recurrent DSM-IV MD. Latent class analysis (LCA) was performed in Mplus.
Results.Using the nine DSM-IV MD symptomatic A criteria, the 14 disaggregated DSM-IV criteria and all independently assessed depressive symptoms (n = 27), the best LCA model identified respectively three, four and six classes. A severe and non-suicidal class was seen in all solutions, as was a mild/moderate subtype. An atypical class emerged once bidirectional neurovegetative symptoms were included. The non-suicidal class demonstrated low levels of worthlessness/guilt and hopelessness. Patterns of co-morbidity, family history, personality, environmental precipitants, recurrence and body mass index (BMI) differed meaningfully across subtypes, with the atypical class standing out as particularly distinct.
Conclusions.MD is a clinically complex syndrome with several detectable subtypes with distinct clinical and demographic correlates. Three subtypes were most consistently identified in our analyses: severe, atypical and non-suicidal. Severe and atypical MD have been identified in multiple prior studies in samples of European ethnicity. Our non-suicidal subtype, with low levels of guilt and hopelessness, may represent a pathoplastic variant reflecting Chinese cultural influences.
The structure of the symptoms of major depression: exploratory and confirmatory factor analysis in depressed Han Chinese women
- Y. Li, S. Aggen, S. Shi, J. Gao, Y. Li, M. Tao, K. Zhang, X. Wang, C. Gao, L. Yang, Y. Liu, K. Li, J. Shi, G. Wang, L. Liu, J. Zhang, B. Du, G. Jiang, J. Shen, Z. Zhang, W. Liang, J. Sun, J. Hu, T. Liu, X. Wang, G. Miao, H. Meng, Y. Li, C. Hu, Y. Li, G. Huang, G. Li, B. Ha, H. Deng, Q. Mei, H. Zhong, S. Gao, H. Sang, Y. Zhang, X. Fang, F. Yu, D. Yang, T. Liu, Y. Chen, X. Hong, W. Wu, G. Chen, M. Cai, Y. Song, J. Pan, J. Dong, R. Pan, W. Zhang, Z. Shen, Z. Liu, D. Gu, X. Wang, X. Liu, Q. Zhang, J. Flint, K. S. Kendler
-
- Journal:
- Psychological Medicine / Volume 44 / Issue 7 / May 2014
- Published online by Cambridge University Press:
- 07 August 2013, pp. 1391-1401
-
- Article
-
- You have access Access
- Open access
- HTML
- Export citation
-
Background
The symptoms of major depression (MD) are clinically diverse. Do they form coherent factors that might clarify the underlying nature of this important psychiatric syndrome?
MethodSymptoms at lifetime worst depressive episode were assessed at structured psychiatric interview in 6008 women of Han Chinese descent, age ⩾30 years with recurrent DSM-IV MD. Exploratory factor analysis (EFA) and confirmatoryfactor analysis (CFA) were performed in Mplus in random split-half samples.
ResultsThe preliminary EFA results were consistently supported by the findings from CFA. Analyses of the nine DSM-IV MD symptomatic A criteria revealed two factors loading on: (i) general depressive symptoms; and (ii) guilt/suicidal ideation. Examining 14 disaggregated DSM-IV criteria revealed three factors reflecting: (i) weight/appetite disturbance; (ii) general depressive symptoms; and (iii) sleep disturbance. Using all symptoms (n = 27), we identified five factors that reflected: (i) weight/appetite symptoms; (ii) general retarded depressive symptoms; (iii) atypical vegetative symptoms; (iv) suicidality/hopelessness; and (v) symptoms of agitation and anxiety.
ConclusionsMD is a clinically complex syndrome with several underlying correlated symptom dimensions. In addition to a general depressive symptom factor, a complete picture must include factors reflecting typical/atypical vegetative symptoms, cognitive symptoms (hopelessness/suicidal ideation), and an agitated symptom factor characterized by anxiety, guilt, helplessness and irritability. Prior cross-cultural studies, factor analyses of MD in Western populations and empirical findings in this sample showing risk factor profiles similar to those seen in Western populations suggest that our results are likely to be broadly representative of the human depressive syndrome.
Cognitive trio: relationship with major depression and clinical predictors in Han Chinese women
- L. Wang, L. Liu, S. Shi, J. Gao, Y. Liu, Y. Li, Z. Zhang, G. Wang, K. Zhang, M. Tao, C. Gao, K. Li, X. Wang, L. Lv, G. Jiang, X. Wang, H. Jia, J. Zhang, C. Lu, Y. Li, K. Li, C. Hu, Y. Ning, Y. Li, J. Sun, T. Liu, Y. Zhang, B. Ha, H. Tian, H. Meng, J. Hu, Y. Chen, H. Deng, G. Huang, W. Wu, G. Li, X. Fang, J. Pan, X. Hong, S. Gao, X. Li, D. Yang, G. Chen, T. Liu, M. Cai, J. Dong, Q. Mei, Z. Shen, R. Pan, Z. Liu, X. Wang, Y. Tan, J. Flint, K. S. Kendler
-
- Journal:
- Psychological Medicine / Volume 43 / Issue 11 / November 2013
- Published online by Cambridge University Press:
- 21 February 2013, pp. 2265-2275
-
- Article
-
- You have access Access
- Open access
- HTML
- Export citation
-
Background
Previous studies support Beck's cognitive model of vulnerability to depression. However, the relationship between his cognitive triad and other clinical features and risk factors among those with major depression (MD) has rarely been systematically studied.
MethodThe three key cognitive symptoms of worthlessness, hopelessness and helplessness were assessed during their lifetime worst episode in 1970 Han Chinese women with recurrent MD. Diagnostic and other risk factor information was assessed at personal interview. Odds ratios (ORs) were calculated by logistic regression.
ResultsCompared to patients who did not endorse the cognitive trio, those who did had a greater number of DSM-IV A criteria, more individual depressive symptoms, an earlier age at onset, a greater number of episodes, and were more likely to meet diagnostic criteria for melancholia, postnatal depression, dysthymia and anxiety disorders. Hopelessness was highly related to all the suicidal symptomatology, with ORs ranging from 5.92 to 6.51. Neuroticism, stressful life events (SLEs) and a protective parental rearing style were associated with these cognitive symptoms.
ConclusionsDuring the worst episode of MD in Han Chinese women, the endorsement of the cognitive trio was associated with a worse course of depression and an increased risk of suicide. Individuals with high levels of neuroticism, many SLEs and high parental protectiveness were at increased risk for these cognitive depressive symptoms. As in Western populations, symptoms of the cognitive trio appear to play a central role in the psychopathology of MD in Chinese women.
A comparison of the clinical characteristics of women with recurrent major depression with and without suicidal symptomatology
- B. Bi, X. Xiao, H. Zhang, J. Gao, M. Tao, H. Niu, Y. Wang, Q. Wang, C. Chen, N. Sun, K. Li, J. Fu, Z. Gan, W. Sang, G. Zhang, L. Yang, T. Tian, Q. Li, Q. Yang, L. Sun, Ying Li, H. Rong, C. Guan, X. Zhao, D. Ye, Y. Zhang, Z. Ma, H. Li, K. He, J. Chen, Y. Cai, C. Zhou, Y. Luo, S. Wang, S. Gao, J. Liu, L. Guo, J. Guan, Z. Kang, D. Di, Yajuan Li, S. Shi, Yihan Li, Y. Chen, J. Flint, K. Kendler, Y. Liu
-
- Journal:
- Psychological Medicine / Volume 42 / Issue 12 / December 2012
- Published online by Cambridge University Press:
- 23 April 2012, pp. 2591-2598
-
- Article
-
- You have access Access
- Open access
- HTML
- Export citation
-
Background
The relationship between recurrent major depression (MD) in women and suicidality is complex. We investigated the extent to which patients who suffered with various forms of suicidal symptomatology can be distinguished from those subjects without such symptoms.
MethodWe examined the clinical features of the worst episode in 1970 Han Chinese women with recurrent DSM-IV MD between the ages of 30 and 60 years from across China. Student's t tests, and logistic and multiple logistic regression models were used to determine the association between suicidality and other clinical features of MD.
ResultsSuicidal symptomatology is significantly associated with a more severe form of MD, as indexed by both the number of episodes and number of MD symptoms. Patients reporting suicidal thoughts, plans or attempts experienced a significantly greater number of stressful life events. The depressive symptom most strongly associated with lifetime suicide attempt was feelings of worthlessness (odds ratio 4.25, 95% confidence interval 2.9–6.3). Excessive guilt, diminished concentration and impaired decision-making were also significantly associated with a suicide attempt.
ConclusionsThis study contributes to the existing literature on risk factors for suicidal symptomatology in depressed women. Identifying specific depressive symptoms and co-morbid psychiatric disorders may help improve the clinical assessment of suicide risk in depressed patients. These findings could be helpful in identifying those who need more intense treatment strategies in order to prevent suicide.
Prescribing patterns of low doses of antipsychotic medications in older Asian patients with schizophrenia, 2001–2009
- Yu-Tao Xiang, Faith Dickerson, Julie Kreyenbuhl, Gabor S. Ungvari, Chuan-Yue Wang, Tian-Mei Si, Edwin H. M. Lee, Yan-Ling He, Helen F. K. Chiu, Kelly Y. C. Lai, Naotaka Shinfuku, Shu-Yu Yang, Mian-Yoon Chong, Ee-Heok Kua, Senta Fujii, Kang Sim, Michael K. H. Yong, Jitendra K. Trivedi, Eun-Kee Chung, Pichet Udomratn, Kok-Yoon Chee, Norman Sartorius, Chay-Hoon Tan
-
- Journal:
- International Psychogeriatrics / Volume 24 / Issue 6 / June 2012
- Published online by Cambridge University Press:
- 03 February 2012, pp. 1002-1008
-
- Article
- Export citation
-
Background: This study examined the use of low doses of antipsychotic medications (300 mg/day CPZeq or less) in older Asian patients with schizophrenia and its demographic and clinical correlates.
Methods: Information on hospitalized patients with schizophrenia, aged 55 years or older, was extracted from the database of the Research on Asian Psychotropic Prescription Patterns (REAP) study (2001–2009). Data on 1,452 patients in eight Asian countries and territories including China, Hong Kong, Japan, Korea, Singapore, Taiwan, India, and Malaysia were analyzed. Sociodemographic and clinical characteristics and antipsychotic prescriptions were recorded using a standardized protocol and data collection procedure.
Results: The prescription frequency for low doses of antipsychotic medications was 40.9% in the pooled sample. Multiple logistic regression analysis of the whole sample showed that patients on low doses of antipsychotic medications were more likely to be female, have an older age, a shorter length of illness, and less positive symptoms. Of patients in the six countries and territories that participated in all the surveys between 2001 and 2009, those in Japan were less likely to receive low doses of antipsychotics.
Conclusion: Low doses of antipsychotic medications were only applied in less than half of older Asian patients with schizophrenia.
Patterns of co-morbidity with anxiety disorders in Chinese women with recurrent major depression
- Y. Li, S. Shi, F. Yang, J. Gao, Youhui Li, M. Tao, G. Wang, K. Zhang, C. Gao, L. Liu, Kan Li, Keqing Li, Y. Liu, Xumei Wang, J. Zhang, L. Lv, Xueyi Wang, Q. Chen, J. Hu, L. Sun, J. Shi, Y. Chen, D. Xie, J. Flint, K. S. Kendler, Z. Zhang
-
- Journal:
- Psychological Medicine / Volume 42 / Issue 6 / June 2012
- Published online by Cambridge University Press:
- 30 November 2011, pp. 1239-1248
-
- Article
-
- You have access Access
- Open access
- HTML
- Export citation
-
Background
Studies conducted in Europe and the USA have shown that co-morbidity between major depressive disorder (MDD) and anxiety disorders is associated with various MDD-related features, including clinical symptoms, degree of familial aggregation and socio-economic status. However, few studies have investigated whether these patterns of association vary across different co-morbid anxiety disorders. Here, using a large cohort of Chinese women with recurrent MDD, we examine the prevalence and associated clinical features of co-morbid anxiety disorders.
MethodA total of 1970 female Chinese MDD patients with or without seven co-morbid anxiety disorders [including generalized anxiety disorder (GAD), panic disorder, and five phobia subtypes] were ascertained in the CONVERGE study. Generalized linear models were used to model association between co-morbid anxiety disorders and various MDD features.
ResultsThe lifetime prevalence rate for any type of co-morbid anxiety disorder is 60.2%. Panic and social phobia significantly predict an increased family history of MDD. GAD and animal phobia predict an earlier onset of MDD and a higher number of MDD episodes, respectively. Panic and GAD predict a higher number of DSM-IV diagnostic criteria. GAD and blood-injury phobia are both significantly associated with suicidal attempt with opposite effects. All seven co-morbid anxiety disorders predict higher neuroticism.
ConclusionsPatterns of co-morbidity between MDD and anxiety are consistent with findings from the US and European studies; the seven co-morbid anxiety disorders are heterogeneous when tested for association with various MDD features.
Perceived parenting and risk for major depression in Chinese women
- J. Gao, Y. Li, Y. Cai, J. Chen, Y. Shen, S. Ni, Y. Wei, Y. Qiu, X. Zhu, Y. Liu, C. Lu, C. Chen, Q. Niu, C. Tang, Y. Yang, Q. Wang, W. Cui, J. Xia, T. Liu, J. Zhang, B. Zhao, Z. Guo, J. Pan, H. Chen, Y. Luo, L. Sun, X. Xiao, Q. Chen, X. Zhao, F. He, L. Lv, L. Guo, L. Liu, H. Li, S. Shi, J. Flint, K. S. Kendler, M. Tao
-
- Journal:
- Psychological Medicine / Volume 42 / Issue 5 / May 2012
- Published online by Cambridge University Press:
- 27 September 2011, pp. 921-930
-
- Article
-
- You have access Access
- Open access
- HTML
- Export citation
-
Background
In Western countries, a history of major depression (MD) is associated with reports of received parenting that is low in warmth and caring and high in control and authoritarianism. Does a similar pattern exist in women in China?
MethodReceived parenting was assessed by a shortened version of the Parental Bonding Instrument (PBI) in two groups of Han Chinese women: 1970 clinically ascertained cases with recurrent MD and 2597 matched controls. MD was assessed at personal interview.
ResultsFactor analysis of the PBI revealed three factors for both mothers and fathers: warmth, protectiveness, and authoritarianism. Lower warmth and protectiveness and higher authoritarianism from both mother and father were significantly associated with risk for recurrent MD. Parental warmth was positively correlated with parental protectiveness and negatively correlated with parental authoritarianism. When examined together, paternal warmth was more strongly associated with lowered risk for MD than maternal warmth. Furthermore, paternal protectiveness was negatively and maternal protectiveness positively associated with risk for MD.
ConclusionsAlthough the structure of received parenting is very similar in China and Western countries, the association with MD is not. High parental protectiveness is generally pathogenic in Western countries but protective in China, especially when received from the father. Our results suggest that cultural factors impact on patterns of parenting and their association with MD.
Contributors
-
- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. Chapman, James H. Charlesworth, Kenneth R. Chase, Chen Zemin, Luciano Chianeque, Philip Chia Phin Yin, Francisca H. Chimhanda, Daniel Chiquete, John T. Chirban, Soobin Choi, Robert Choquette, Mita Choudhury, Gerald Christianson, John Chryssavgis, Sejong Chun, Esther Chung-Kim, Charles M. A. Clark, Elizabeth A. Clark, Sathianathan Clarke, Fred Cloud, John B. Cobb, W. Owen Cole, John A Coleman, John J. Collins, Sylvia Collins-Mayo, Paul K. Conkin, Beth A. Conklin, Sean Connolly, Demetrios J. Constantelos, Michael A. Conway, Paula M. Cooey, Austin Cooper, Michael L. Cooper-White, Pamela Cooper-White, L. William Countryman, Sérgio Coutinho, Pamela Couture, Shannon Craigo-Snell, James L. Crenshaw, David Crowner, Humberto Horacio Cucchetti, Lawrence S. Cunningham, Elizabeth Mason Currier, Emmanuel Cutrone, Mary L. Daniel, David D. Daniels, Robert Darden, Rolf Darge, Isaiah Dau, Jeffry C. Davis, Jane Dawson, Valentin Dedji, John W. de Gruchy, Paul DeHart, Wendy J. Deichmann Edwards, Miguel A. De La Torre, George E. Demacopoulos, Thomas de Mayo, Leah DeVun, Beatriz de Vasconcellos Dias, Dennis C. Dickerson, John M. Dillon, Luis Miguel Donatello, Igor Dorfmann-Lazarev, Susanna Drake, Jonathan A. Draper, N. Dreher Martin, Otto Dreydoppel, Angelyn Dries, A. J. Droge, Francis X. D'Sa, Marilyn Dunn, Nicole Wilkinson Duran, Rifaat Ebied, Mark J. Edwards, William H. Edwards, Leonard H. Ehrlich, Nancy L. Eiesland, Martin Elbel, J. Harold Ellens, Stephen Ellingson, Marvin M. Ellison, Robert Ellsberg, Jean Bethke Elshtain, Eldon Jay Epp, Peter C. Erb, Tassilo Erhardt, Maria Erling, Noel Leo Erskine, Gillian R. Evans, Virginia Fabella, Michael A. Fahey, Edward Farley, Margaret A. Farley, Wendy Farley, Robert Fastiggi, Seena Fazel, Duncan S. Ferguson, Helwar Figueroa, Paul Corby Finney, Kyriaki Karidoyanes FitzGerald, Thomas E. FitzGerald, John R. Fitzmier, Marie Therese Flanagan, Sabina Flanagan, Claude Flipo, Ronald B. Flowers, Carole Fontaine, David Ford, Mary Ford, Stephanie A. Ford, Jim Forest, William Franke, Robert M. Franklin, Ruth Franzén, Edward H. Friedman, Samuel Frouisou, Lorelei F. Fuchs, Jojo M. Fung, Inger Furseth, Richard R. Gaillardetz, Brandon Gallaher, China Galland, Mark Galli, Ismael García, Tharscisse Gatwa, Jean-Marie Gaudeul, Luis María Gavilanes del Castillo, Pavel L. Gavrilyuk, Volney P. Gay, Metropolitan Athanasios Geevargis, Kondothra M. George, Mary Gerhart, Simon Gikandi, Maurice Gilbert, Michael J. Gillgannon, Verónica Giménez Beliveau, Terryl Givens, Beth Glazier-McDonald, Philip Gleason, Menghun Goh, Brian Golding, Bishop Hilario M. Gomez, Michelle A. Gonzalez, Donald K. Gorrell, Roy Gottfried, Tamara Grdzelidze, Joel B. Green, Niels Henrik Gregersen, Cristina Grenholm, Herbert Griffiths, Eric W. Gritsch, Erich S. Gruen, Christoffer H. Grundmann, Paul H. Gundani, Jon P. Gunnemann, Petre Guran, Vidar L. Haanes, Jeremiah M. Hackett, Getatchew Haile, Douglas John Hall, Nicholas Hammond, Daphne Hampson, Jehu J. Hanciles, Barry Hankins, Jennifer Haraguchi, Stanley S. Harakas, Anthony John Harding, Conrad L. Harkins, J. William Harmless, Marjory Harper, Amir Harrak, Joel F. Harrington, Mark W. Harris, Susan Ashbrook Harvey, Van A. Harvey, R. Chris Hassel, Jione Havea, Daniel Hawk, Diana L. Hayes, Leslie Hayes, Priscilla Hayner, S. Mark Heim, Simo Heininen, Richard P. Heitzenrater, Eila Helander, David Hempton, Scott H. Hendrix, Jan-Olav Henriksen, Gina Hens-Piazza, Carter Heyward, Nicholas J. Higham, David Hilliard, Norman A. Hjelm, Peter C. Hodgson, Arthur Holder, M. Jan Holton, Dwight N. Hopkins, Ronnie Po-chia Hsia, Po-Ho Huang, James Hudnut-Beumler, Jennifer S. Hughes, Leonard M. Hummel, Mary E. Hunt, Laennec Hurbon, Mark Hutchinson, Susan E. Hylen, Mary Beth Ingham, H. Larry Ingle, Dale T. Irvin, Jon Isaak, Paul John Isaak, Ada María Isasi-Díaz, Hans Raun Iversen, Margaret C. Jacob, Arthur James, Maria Jansdotter-Samuelsson, David Jasper, Werner G. Jeanrond, Renée Jeffery, David Lyle Jeffrey, Theodore W. Jennings, David H. Jensen, Robin Margaret Jensen, David Jobling, Dale A. Johnson, Elizabeth A. Johnson, Maxwell E. Johnson, Sarah Johnson, Mark D. Johnston, F. Stanley Jones, James William Jones, John R. Jones, Alissa Jones Nelson, Inge Jonsson, Jan Joosten, Elizabeth Judd, Mulambya Peggy Kabonde, Robert Kaggwa, Sylvester Kahakwa, Isaac Kalimi, Ogbu U. Kalu, Eunice Kamaara, Wayne C. Kannaday, Musimbi Kanyoro, Veli-Matti Kärkkäinen, Frank Kaufmann, Léon Nguapitshi Kayongo, Richard Kearney, Alice A. Keefe, Ralph Keen, Catherine Keller, Anthony J. Kelly, Karen Kennelly, Kathi Lynn Kern, Fergus Kerr, Edward Kessler, George Kilcourse, Heup Young Kim, Kim Sung-Hae, Kim Yong-Bock, Kim Yung Suk, Richard King, Thomas M. King, Robert M. Kingdon, Ross Kinsler, Hans G. Kippenberg, Cheryl A. Kirk-Duggan, Clifton Kirkpatrick, Leonid Kishkovsky, Nadieszda Kizenko, Jeffrey Klaiber, Hans-Josef Klauck, Sidney Knight, Samuel Kobia, Robert Kolb, Karla Ann Koll, Heikki Kotila, Donald Kraybill, Philip D. W. Krey, Yves Krumenacker, Jeffrey Kah-Jin Kuan, Simanga R. Kumalo, Peter Kuzmic, Simon Shui-Man Kwan, Kwok Pui-lan, André LaCocque, Stephen E. Lahey, John Tsz Pang Lai, Emiel Lamberts, Armando Lampe, Craig Lampe, Beverly J. Lanzetta, Eve LaPlante, Lizette Larson-Miller, Ariel Bybee Laughton, Leonard Lawlor, Bentley Layton, Robin A. Leaver, Karen Lebacqz, Archie Chi Chung Lee, Marilyn J. Legge, Hervé LeGrand, D. L. LeMahieu, Raymond Lemieux, Bill J. Leonard, Ellen M. Leonard, Outi Leppä, Jean Lesaulnier, Nantawan Boonprasat Lewis, Henrietta Leyser, Alexei Lidov, Bernard Lightman, Paul Chang-Ha Lim, Carter Lindberg, Mark R. Lindsay, James R. Linville, James C. Livingston, Ann Loades, David Loades, Jean-Claude Loba-Mkole, Lo Lung Kwong, Wati Longchar, Eleazar López, David W. Lotz, Andrew Louth, Robin W. Lovin, William Luis, Frank D. Macchia, Diarmaid N. J. MacCulloch, Kirk R. MacGregor, Marjory A. MacLean, Donald MacLeod, Tomas S. Maddela, Inge Mager, Laurenti Magesa, David G. Maillu, Fortunato Mallimaci, Philip Mamalakis, Kä Mana, Ukachukwu Chris Manus, Herbert Robinson Marbury, Reuel Norman Marigza, Jacqueline Mariña, Antti Marjanen, Luiz C. L. Marques, Madipoane Masenya (ngwan'a Mphahlele), Caleb J. D. Maskell, Steve Mason, Thomas Massaro, Fernando Matamoros Ponce, András Máté-Tóth, Odair Pedroso Mateus, Dinis Matsolo, Fumitaka Matsuoka, John D'Arcy May, Yelena Mazour-Matusevich, Theodore Mbazumutima, John S. McClure, Christian McConnell, Lee Martin McDonald, Gary B. McGee, Thomas McGowan, Alister E. McGrath, Richard J. McGregor, John A. McGuckin, Maud Burnett McInerney, Elsie Anne McKee, Mary B. McKinley, James F. McMillan, Ernan McMullin, Kathleen E. McVey, M. Douglas Meeks, Monica Jyotsna Melanchthon, Ilie Melniciuc-Puica, Everett Mendoza, Raymond A. Mentzer, William W. Menzies, Ina Merdjanova, Franziska Metzger, Constant J. Mews, Marvin Meyer, Carol Meyers, Vasile Mihoc, Gunner Bjerg Mikkelsen, Maria Inêz de Castro Millen, Clyde Lee Miller, Bonnie J. Miller-McLemore, Alexander Mirkovic, Paul Misner, Nozomu Miyahira, R. W. L. Moberly, Gerald Moede, Aloo Osotsi Mojola, Sunanda Mongia, Rebeca Montemayor, James Moore, Roger E. Moore, Craig E. Morrison O.Carm, Jeffry H. Morrison, Keith Morrison, Wilson J. Moses, Tefetso Henry Mothibe, Mokgethi Motlhabi, Fulata Moyo, Henry Mugabe, Jesse Ndwiga Kanyua Mugambi, Peggy Mulambya-Kabonde, Robert Bruce Mullin, Pamela Mullins Reaves, Saskia Murk Jansen, Heleen L. Murre-Van den Berg, Augustine Musopole, Isaac M. T. Mwase, Philomena Mwaura, Cecilia Nahnfeldt, Anne Nasimiyu Wasike, Carmiña Navia Velasco, Thulani Ndlazi, Alexander Negrov, James B. Nelson, David G. Newcombe, Carol Newsom, Helen J. Nicholson, George W. E. Nickelsburg, Tatyana Nikolskaya, Damayanthi M. A. Niles, Bertil Nilsson, Nyambura Njoroge, Fidelis Nkomazana, Mary Beth Norton, Christian Nottmeier, Sonene Nyawo, Anthère Nzabatsinda, Edward T. Oakes, Gerald O'Collins, Daniel O'Connell, David W. Odell-Scott, Mercy Amba Oduyoye, Kathleen O'Grady, Oyeronke Olajubu, Thomas O'Loughlin, Dennis T. Olson, J. Steven O'Malley, Cephas N. Omenyo, Muriel Orevillo-Montenegro, César Augusto Ornellas Ramos, Agbonkhianmeghe E. Orobator, Kenan B. Osborne, Carolyn Osiek, Javier Otaola Montagne, Douglas F. Ottati, Anna May Say Pa, Irina Paert, Jerry G. Pankhurst, Aristotle Papanikolaou, Samuele F. Pardini, Stefano Parenti, Peter Paris, Sung Bae Park, Cristián G. Parker, Raquel Pastor, Joseph Pathrapankal, Daniel Patte, W. Brown Patterson, Clive Pearson, Keith F. Pecklers, Nancy Cardoso Pereira, David Horace Perkins, Pheme Perkins, Edward N. Peters, Rebecca Todd Peters, Bishop Yeznik Petrossian, Raymond Pfister, Peter C. Phan, Isabel Apawo Phiri, William S. F. Pickering, Derrick G. Pitard, William Elvis Plata, Zlatko Plese, John Plummer, James Newton Poling, Ronald Popivchak, Andrew Porter, Ute Possekel, James M. Powell, Enos Das Pradhan, Devadasan Premnath, Jaime Adrían Prieto Valladares, Anne Primavesi, Randall Prior, María Alicia Puente Lutteroth, Eduardo Guzmão Quadros, Albert Rabil, Laurent William Ramambason, Apolonio M. Ranche, Vololona Randriamanantena Andriamitandrina, Lawrence R. Rast, Paul L. Redditt, Adele Reinhartz, Rolf Rendtorff, Pål Repstad, James N. Rhodes, John K. Riches, Joerg Rieger, Sharon H. Ringe, Sandra Rios, Tyler Roberts, David M. Robinson, James M. Robinson, Joanne Maguire Robinson, Richard A. H. Robinson, Roy R. Robson, Jack B. Rogers, Maria Roginska, Sidney Rooy, Rev. Garnett Roper, Maria José Fontelas Rosado-Nunes, Andrew C. Ross, Stefan Rossbach, François Rossier, John D. Roth, John K. Roth, Phillip Rothwell, Richard E. Rubenstein, Rosemary Radford Ruether, Markku Ruotsila, John E. Rybolt, Risto Saarinen, John Saillant, Juan Sanchez, Wagner Lopes Sanchez, Hugo N. Santos, Gerhard Sauter, Gloria L. Schaab, Sandra M. Schneiders, Quentin J. Schultze, Fernando F. Segovia, Turid Karlsen Seim, Carsten Selch Jensen, Alan P. F. Sell, Frank C. Senn, Kent Davis Sensenig, Damían Setton, Bal Krishna Sharma, Carolyn J. Sharp, Thomas Sheehan, N. Gerald Shenk, Christian Sheppard, Charles Sherlock, Tabona Shoko, Walter B. Shurden, Marguerite Shuster, B. Mark Sietsema, Batara Sihombing, Neil Silberman, Clodomiro Siller, Samuel Silva-Gotay, Heikki Silvet, John K. Simmons, Hagith Sivan, James C. Skedros, Abraham Smith, Ashley A. Smith, Ted A. Smith, Daud Soesilo, Pia Søltoft, Choan-Seng (C. S.) Song, Kathryn Spink, Bryan Spinks, Eric O. Springsted, Nicolas Standaert, Brian Stanley, Glen H. Stassen, Karel Steenbrink, Stephen J. Stein, Andrea Sterk, Gregory E. Sterling, Columba Stewart, Jacques Stewart, Robert B. Stewart, Cynthia Stokes Brown, Ken Stone, Anne Stott, Elizabeth Stuart, Monya Stubbs, Marjorie Hewitt Suchocki, David Kwang-sun Suh, Scott W. Sunquist, Keith Suter, Douglas Sweeney, Charles H. Talbert, Shawqi N. Talia, Elsa Tamez, Joseph B. Tamney, Jonathan Y. Tan, Yak-Hwee Tan, Kathryn Tanner, Feiya Tao, Elizabeth S. Tapia, Aquiline Tarimo, Claire Taylor, Mark Lewis Taylor, Bishop Abba Samuel Wolde Tekestebirhan, Eugene TeSelle, M. Thomas Thangaraj, David R. Thomas, Andrew Thornley, Scott Thumma, Marcelo Timotheo da Costa, George E. “Tink” Tinker, Ola Tjørhom, Karen Jo Torjesen, Iain R. Torrance, Fernando Torres-Londoño, Archbishop Demetrios [Trakatellis], Marit Trelstad, Christine Trevett, Phyllis Trible, Johannes Tromp, Paul Turner, Robert G. Tuttle, Archbishop Desmond Tutu, Peter Tyler, Anders Tyrberg, Justin Ukpong, Javier Ulloa, Camillus Umoh, Kristi Upson-Saia, Martina Urban, Monica Uribe, Elochukwu Eugene Uzukwu, Richard Vaggione, Gabriel Vahanian, Paul Valliere, T. J. Van Bavel, Steven Vanderputten, Peter Van der Veer, Huub Van de Sandt, Louis Van Tongeren, Luke A. Veronis, Noel Villalba, Ramón Vinke, Tim Vivian, David Voas, Elena Volkova, Katharina von Kellenbach, Elina Vuola, Timothy Wadkins, Elaine M. Wainwright, Randi Jones Walker, Dewey D. Wallace, Jerry Walls, Michael J. Walsh, Philip Walters, Janet Walton, Jonathan L. Walton, Wang Xiaochao, Patricia A. Ward, David Harrington Watt, Herold D. Weiss, Laurence L. Welborn, Sharon D. Welch, Timothy Wengert, Traci C. West, Merold Westphal, David Wetherell, Barbara Wheeler, Carolinne White, Jean-Paul Wiest, Frans Wijsen, Terry L. Wilder, Felix Wilfred, Rebecca Wilkin, Daniel H. Williams, D. Newell Williams, Michael A. Williams, Vincent L. Wimbush, Gabriele Winkler, Anders Winroth, Lauri Emílio Wirth, James A. Wiseman, Ebba Witt-Brattström, Teofil Wojciechowski, John Wolffe, Kenman L. Wong, Wong Wai Ching, Linda Woodhead, Wendy M. Wright, Rose Wu, Keith E. Yandell, Gale A. Yee, Viktor Yelensky, Yeo Khiok-Khng, Gustav K. K. Yeung, Angela Yiu, Amos Yong, Yong Ting Jin, You Bin, Youhanna Nessim Youssef, Eliana Yunes, Robert Michael Zaller, Valarie H. Ziegler, Barbara Brown Zikmund, Joyce Ann Zimmerman, Aurora Zlotnik, Zhuo Xinping
- Edited by Daniel Patte, Vanderbilt University, Tennessee
-
- Book:
- The Cambridge Dictionary of Christianity
- Published online:
- 05 August 2012
- Print publication:
- 20 September 2010, pp xi-xliv
-
- Chapter
- Export citation
Progress of Dynamical Nanomaterial Imaging Using Ultrashort Electron Pulses
- Z Tao, H Zhang, RK Raman, T-T Han, K Chang, M Berz, C-Y Ruan
-
- Journal:
- Microscopy and Microanalysis / Volume 16 / Issue S2 / July 2010
- Published online by Cambridge University Press:
- 01 August 2010, pp. 498-499
- Print publication:
- July 2010
-
- Article
-
- You have access Access
- Export citation
-
Extended abstract of a paper presented at Microscopy and Microanalysis 2010 in Portland, Oregon, USA, August 1 – August 5, 2010.
Telomerase inhibition alters telomere maintenance mechanisms in laryngeal squamous carcinoma cells
- W Chen, S M Chen, Y Yu, B K Xiao, Z W Huang, Z Z Tao
-
- Journal:
- The Journal of Laryngology & Otology / Volume 124 / Issue 7 / July 2010
- Published online by Cambridge University Press:
- 20 April 2010, pp. 778-783
- Print publication:
- July 2010
-
- Article
- Export citation
-
Background and purpose:
Telomere length must be maintained throughout cancer cell progression and proliferation. In most tumours, telomerase activity maintains telomere length. Therefore, telomerase is a target for cancer treatments. However, some cancer cells maintain telomere length through an alternative mechanism termed ‘alternative lengthening of telomeres’. To determine how telomerase inhibition relates to the initiation of the alternative lengthening of telomeres pathway, we investigated telomerase activity and telomere maintenance in Hep-2 cells with and without reduced telomerase activity.
Materials and methods:We investigated telomerase activity levels in a normal Hep-2 cell line and in residual cells following telomerase inhibition treatment. Additionally, we looked for expression of a marker protein for the alternative lengthening of telomeres mechanism.
Results and conclusions:In the residual cells, telomerase activity was eliminated. However, these cells had higher levels of the alternative lengthening of telomeres biomarker, suggesting an alternative mechanism for telomere maintenance following telomerase inhibition. These results could have a major impact on the design of new cancer treatments.
The Nearby Supernova Factory: First Results
- E. Pécontal, T. Buchert, Ph. Di Stefano, Y. Copin, Y. Copin, G. Aldering, P. Antilogus, C. Aragon, S. Bailey, C. Baltay, S. Bongard, C. Buton, M. Childress, É. Gangler, J. Jerke, S. Loken, P. Nugent, R. Pain, É. Pécontal, R. Pereira, S. Perlmutter, D. Rabinovitz, G. Rigaudier, P. Ripoche, K. Runge, R. Scalzo, G. Smadja, H. Swift, C. Tao, R.C. Thomas, C. Wu
-
- Journal:
- European Astronomical Society Publications Series / Volume 36 / 2009
- Published online by Cambridge University Press:
- 30 May 2009, pp. 11-15
- Print publication:
- 2009
-
- Article
- Export citation
-
The Nearby Supernova Factory aims at discovering and stud- ying a large sample of nearby (0.03 < z < 0.08) thermonuclear supernovae. Potential targets are extracted from the unbiased Palomar-QUEST survey, and follow-up spectro-photometric observations are performed using the dedicated Supernovae Integral-Field Spectrograph. The current sample comprises more than 2700 flux-calibrated optical spectra (320-1000 nm) from 181 supernovæ followed over their full life-time. Specific operation and data-reduction issues are discussed, and first scientific results from this unprecedented dataset are presented.
Fabrication and Surface Modification of Porous Nano-Structured NiTi Orthopedic Scaffolds for Bone Implants
- Shuilin Wu, Xiangmei Liu, Paul K Chu, Tao Hu, Kelvin Wai Kwok Yeung, Jonathan C Y Chung
-
- Journal:
- MRS Online Proceedings Library Archive / Volume 1181 / 2009
- Published online by Cambridge University Press:
- 31 January 2011, 1181-DD08-01
- Print publication:
- 2009
-
- Article
- Export citation
-
Near-equiatomic porous nickel-titanium shape memory alloys (NiTi SMAs) are becoming one of the most promising biomaterials in bone implants because of their unique advantages over currently used biomaterials. For example, they have good mechanical properties and lower Young�s modulus relative to dense NiTi, Ti, and Ti-based alloys. Porous NiTi SMAs are relatively easy to machine compared to porous ceramics such as hydroxyapatite and calcium phosphate that tend to exhibit brittle failure. The porous structure with interconnecting open pores can also allow tissue in-growth and favors bone osseointegration. In addition, porous NiTi alloys remain exhibiting good shape memory effect (SME) and superelasticity (SE) similar to dense NiTi alloys. To optimize porous NiTi SMAs in bone implant applications, the current research focuses on the fabrication methods and surface modification techniques in order to obtain adjustable bone-like structures with good mechanical properties, excellent superelasticity, as well as bioactive passivation on the entire exposed surface areas to block nickel ion leaching and enhance the surface biological activity. This invited paper describes progress in the fabrication of the porous materials and our recent work on surface nanorization of porous NiTi scaffolds in bone grafts applications.
Protective effect of melatonin against gentamicin ototoxicity
- L-F Ye, Z-Z Tao, Q-Q Hua, B-K Xiao, X-H Zhou, J Li, Y-L Yuan
-
- Journal:
- The Journal of Laryngology & Otology / Volume 123 / Issue 6 / June 2009
- Published online by Cambridge University Press:
- 28 October 2008, pp. 598-602
- Print publication:
- June 2009
-
- Article
- Export citation
-
Objective:
To research the protective effect of melatonin against gentamicin ototoxicity.
Methods:Guinea pigs were randomly divided into four groups. The first group received intramuscular gentamicin (120 mg/kg body weight/day) for 17 days. Over the same time period, a second group simultaneously received intramuscular gentamicin (120 mg/kg body weight/day) plus (on the other side) intramuscular melatonin (0.3 ml kg body weight/day). Two groups of controls were treated for 17 days with either intramuscular melatonin or intramuscular saline. After the 17 days, each animal underwent distortion product otoacoustic emission testing (both ears). The guinea pigs were sacrificed by decapitation just after the final injection. Their cochleae were used to produce a tissue section, surface preparation and scanning electron microscope preparation.
Results:Distortion product otoacoustic emission testing indicated gentamicin-induced hearing loss at 3, 4, 6 and 8 kHz in gentamicin-treated animals. Animals receiving melatonin co-therapy had significantly attenuated hearing loss and their cochleae showed lower rates of outer hair cell loss (comparing the same cochlear turns), compared with gentamicin-treated animals (p < 0.01).
Conclusion:These findings confirm the occurrence of outer hair cell loss after gentamicin treatment, and the attenuation of such loss following simultaneous melatonin injection, using the method of morphological evaluation. These results suggest that melatonin protects against gentamicin ototoxicity by interfering with cytotoxic mechanisms.
Prevalence and sociodemographic correlates of depression in an elderly population living with family members in Beijing, China
- X. Ma, Y.-T. Xiang, S.-R. Li, Y.-Q. Xiang, H.-L. Guo, Y.-Z. Hou, Z.-J. Cai, Z.-B. Li, Z.-J. Li, Y.-F. Tao, W.-M. Dang, X.-M. Wu, J. Deng, G. S. Ungvari, H. F. K. Chiu
-
- Journal:
- Psychological Medicine / Volume 38 / Issue 12 / December 2008
- Published online by Cambridge University Press:
- 26 March 2008, pp. 1723-1730
-
- Article
- Export citation
-
Background
To date, there has been no large-scale survey of geriatric depression (GD) involving both rural and urban areas in China using standardized assessment tools and diagnostic criteria. This study aimed to determine the 12-month and lifetime prevalence rates of GD and sociodemographic correlates in urban and rural regions of Beijing, China.
MethodA total of 1601 elderly patients (aged ⩾60 years) were randomly selected and interviewed in Beijing using the Composite International Diagnostic Interview (CIDI 1.0). Basic sociodemographic and clinical data were also collected during the interviews.
ResultsThe overall 12-month prevalence of GD was 4.33%, and the 12-month prevalence rates for men and women were 2.65% and 5.83% respectively. The overall lifetime prevalence of GD was 7.83%, and lifetime prevalence rates for men and women were 4.65% and 10.66% respectively. Female sex, lower educational level, monthly income, rural abode, and the presence of one or more major medical conditions were associated with increased risk of GD. Of the GD subjects interviewed, 25.2% were receiving some type of treatment, with only 4.7% preferring to seek treatment from mental health professionals.
ConclusionsAlthough still relatively low by international standards, there is an increasing trend in the prevalence of GD in China. The low percentage of subjects treated for GD is a major public health concern that should be addressed urgently.
A-Si Amoled Display Backplanes on Flexible Substrates
- A. Nathan, D. Striakhilev, P. Servati, K. Sakariya, A. Sazonov, S. Alexander, S. Tao, C.-H. Lee, A. Kumar, S. Sambandan, S. Jafarabadiashtiani, Y. Vygranenko, I.W. Chan
-
- Journal:
- MRS Online Proceedings Library Archive / Volume 814 / 2004
- Published online by Cambridge University Press:
- 17 March 2011, I3.1
- Print publication:
- 2004
-
- Article
- Export citation
-
In view of its maturity and low-cost, the amorphous silicon (a-Si) technology is an attractive candidate for active matrix organic light emitting diode (AMOLED) display backplanes on flexible substrates. However, the a-Si material comes with significant intrinsic shortcomings related to speed (mobility) and stability of operation, requiring novel threshold-voltage-shift (ΔVT) compensated thin-film transistor (TFT) pixel circuits and architectures to enable stable OLED operation. But given the dramatic progress in efficiency of OLED materials over recent years, the drive current requirement has been significantly lowered, thus relaxing the constraints on a-Si TFTs. For compatibility to plastic substrates, the a-Si TFT process temperature must be reduced from the conventional 300°C to ∼150°C or below, which tends to compromise the integrity of thin- film materials and device performance. Hence, optimizing the TFT process for high device performance with limited thermal budget is a necessary step towards flexible AMOLEDs with a-Si backplanes. This paper reviews the design and process challenges, and specifically examines the performance of TFTs and ΔVT-compensated integrated pixel driver circuits on plastic substrates with respect to current driving ability and long term stability. More importantly, lifetime tests of circuit degradation behaviour over extended time periods demonstrate highly stable drive currents and its ability to meet commercial standards.
Weak Pinning Centers in Proton Irradiated YBCO Single Crystals
- Y. J. Zhao, J. R. Liu, Y. K. Tao, P. H. Hor, W. K. Chu
-
- Journal:
- MRS Online Proceedings Library Archive / Volume 235 / 1991
- Published online by Cambridge University Press:
- 28 February 2011, 677
- Print publication:
- 1991
-
- Article
- Export citation
-
Observed magnetic Jc enhancement in a 3.4 MeV proton-irradiated Y1Ba2Cu3O7-δ (YBCO) single crystal are shown to be intimately linked with a kind of weak pinning centers. Applied magnetic field transforms weak centers into the normal state or pinning centers, which then cause pinning enhancement. Strong pinning anisotropy of the radiation induced weak center can be explained very well by the size anisotropy of a superconducting unit cell and a flux line, or the coherence length.