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Frequency-dependent alterations of global signal topography in patients with major depressive disorder

Published online by Cambridge University Press:  16 February 2024

Chengxiao Yang ,
Bharat Biswal ,
Qian Cui ,
Xiujuan Jing ,
Yujia Ao  and
Yifeng Wang
Chengxiao Yang
Affiliation:
Institute of Brain and Psychological Sciences, Sichuan Normal University, Chengdu 610066, China
Bharat Biswal
Affiliation:
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China
Qian Cui
Affiliation:
School of Public Affairs and Administration, University of Electronic Science and Technology of China, Chengdu 611731, China
Xiujuan Jing
Affiliation:
Institute of Brain and Psychological Sciences, Sichuan Normal University, Chengdu 610066, China
Yujia Ao
Affiliation:
Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Yifeng Wang*
Affiliation:
Institute of Brain and Psychological Sciences, Sichuan Normal University, Chengdu 610066, China
*
Corresponding author: Yifeng Wang; Email: wyf@sicnu.edu.cn
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Abstract

Background

Major depressive disorder (MDD) is associated not only with disorders in multiple brain networks but also with frequency-specific brain activities. The abnormality of spatiotemporal networks in patients with MDD remains largely unclear.

Methods

We investigated the alterations of the global spatiotemporal network in MDD patients using a large-sample multicenter resting-state functional magnetic resonance imaging dataset. The spatiotemporal characteristics were measured by the variability of global signal (GS) and its correlation with local signals (GSCORR) at multiple frequency bands. The association between these indicators and clinical scores was further assessed.

Results

The GS fluctuations were reduced in patients with MDD across the full frequency range (0–0.1852 Hz). The GSCORR was also reduced in the MDD group, especially in the relatively higher frequency range (0.0728–0.1852 Hz). Interestingly, these indicators showed positive correlations with depressive scores in the MDD group and relative negative correlations in the control group.

Conclusion

The GS and its spatiotemporal effects on local signals were weakened in patients with MDD, which may impair inter-regional synchronization and related functions. Patients with severe depression may use the compensatory mechanism to make up for the functional impairments.

Keywords

frequency-dependenceglobal signalglobal topographymajor depressive disorderresting-state fMRI
Type
Original Article
Information
Psychological Medicine , First View , pp. 1 - 10
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Copyright
Copyright © The Author(s), 2024. Published by Cambridge University Press

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