Skip to content
Cart

Your Cart

×

You have 0 items in your cart.

Register Sign in Wishlist
Managing Discovery in the Life Sciences

Managing Discovery in the Life Sciences
Harnessing Creativity to Drive Biomedical Innovation

£76.99

Mark V. Pauly, Philip A. Rea, Lawton R. Burns, Kyle Myers, Vicki Chen, Alec Ren, Simon Basseyn, Sourav Bose, Chris Groskaufmanis, Stephen Goldstein, Peter M. Stokes, Connie Lu, Julian Pei, John Q. Trojanowski, Katherine Clark, Anderson Y. Tien, Mark S. Williams, Vivek Nimgaonkar, Alex Rosen, Steven Nichtberger, Osama Ahmed, Amy Le
View all contributors
  • Publication planned for: March 2018
  • availability: Not yet published - available from March 2018
  • format: Hardback
  • isbn: 9781107130906

£ 76.99
Hardback

Pre-order Add to wishlist

Other available formats:
Paperback


Looking for an inspection copy?

This title is not currently available on inspection

Description
Product filter button
Description
Contents
Resources
Courses
About the Authors
  • In this book, distinguished scholars Philip A. Rea, Mark V. Pauly, and Lawton R. Burns explore the science and management behind marketable biomedical innovations. They look at how the science actually played out through the interplay of personalities, the cultures within and between academic and corporate entities, and the significance of serendipity not as a mysterious phenomenon but one intrinsic to the successes and failures of the experimental approach. With newly aggregated data and case studies, they consider the fundamental economic underpinnings of investor-driven discovery management, not as an obstacle or deficiency as its critics would contend or as something beyond reproach as some of its proponents might claim, but as the only means by which scientists and managers can navigate the unknowable to discover new products and decide how to sell them so as to maximize the likelihood of establishing a sustainable pipeline for still more marketable biomedical innovations.

    • Provides a combination of theory-based management and economics - the challenges faced by scientists in the research laboratory and the challenges faced by investors in deciding which lines of research in which to invest
    • Uses non-technical language to present complex material in a clear and accessible way, including graphs and figures which demonstrate the critical biology
    • Debunks some unsupportable or illogical criticisms of the pharmaceutical industry while pursuing the logic of profit-maximizing behavior through the provision of patents to guarantee market exclusivity
    Read more

    Reviews & endorsements

    Advance praise: 'The authors captured the magic of the biomedical industry from the inception of an idea through translational studies that lead to a product that can transform lives. Case studies illustrate the importance of scientific understanding, long periods of experimentation, willingness to take risks. This book is a 'must read' for anyone who wants to better understand drug discovery.' P. Roy Vagelos, Chairman, Regeneron Pharmaceuticals, Inc

    Advance praise: 'This new study by Philip A. Rea, Mark V. Pauly, and Lawton R. Burns provides useful information and insightful analyses of the biomedical innovation process.' Henry Grabowski, Professor Emeritus of Economics, Duke University, North Carolina

    See more reviews

    Customer reviews

    Not yet reviewed

    Be the first to review

    Review was not posted due to profanity

    ×

    , create a review

    (If you're not , sign out)

    Please enter the right captcha value
    Please enter a star rating.
    Your review must be a minimum of 12 words.

    How do you rate this item?

    ×

    Product details

    • Publication planned for: March 2018
    • format: Hardback
    • isbn: 9781107130906
    • dimensions: 228 x 152 mm
    • contains: 5 b/w illus. 39 colour illus. 3 tables
    • availability: Not yet published - available from March 2018
  • Table of Contents

    Preface
    1. Discoveries now and then: shifting incentives and expectations Mark V. Pauly, Philip A. Rea and Lawton R. Burns
    2. Pharma trends: not what they seem Kyle Myers and Mark V. Pauly
    3. Profit maximizing drug firms: models and myths Vicki Chen and Mark V. Pauly
    Transitional note: introduction to the case studies
    4. The Statins: cholesterols 'penicillins' Philip A. Rea
    5. ACE inhibitors: kidney clamps, snake venoms and peptidomimetics Alec Ren and Philip A. Rea
    6. Angioplasty: catheters, guidewires and balloons Simon Basseyn, Sourav Bose, Lawton R. Burns and Chris Groskaufmanis
    7. Hepatitis C: when cures and prices go viral Stephen Goldstein, Peter M. Stokes, Connie Lu and Philip A. Rea
    8. Alzheimer's: America's new most feared disease Julian Pei, John Q. Trojanowski, Peter M. Stokes, Katherine Clark, Mark V. Pauly and Philip A. Rea
    9. Metformin: to the brink and back Anderson Y. Tien and Philip A Rea
    10. Medical genomics: personalized precision Mark S. Williams
    11. Gleevec: from broken chromosomes to precision cancer therapy Vivek Nimgaonkar and Philip A. Rea
    12. Regeneron: agility, resilience and balance Lawton R. Burns, Alex Rosen, Steven Nichtberger and Philip A. Rea
    13. Avastin and Lucentis: both for eyesight in hindsight Osama Ahmed, Mark V. Pauly, Peter M. Stokes and Philip A. Rea
    14. CAR T-cell therapy: cures for ALL and more? Stephen Goldstein, Amy Le and Philip A. Rea
    15. Organizing discovery: wild ducks nested in multilevel ecosystems Lawton R. Burns and Philip A. Rea
    16. Can government help with the creatively unexpected? Mark V. Pauly, Lawton R. Burns and Philip A. Rea
    Appendix: three key elements in the discovery process: historical and philosophical antecedents Mark V. Pauly
    Index.

  • Authors

    Philip A. Rea, University of Pennsylvania
    Philip A. Rea, Professor of Biology and Rebecka and Arie Belldegrun Distinguished Director, co-founded the Roy and Diana Vagelos Program in Life Sciences and Management at the University of Pennsylvania. A Fellow of the American Association for the Advancement of Science, he has received several prestigious prizes and awards for his pioneering research on membrane transporters and his creative science teaching, including the President's Medal of the Society for Experimental Biology and a Lindback Foundation Award for Distinguished Teaching.

    Mark V. Pauly, University of Pennsylvania
    Mark V. Pauly currently holds the position of Bendheim Professor in the Department of Health Care Management at the Wharton School of the University of Pennsylvania. He is also co-founder of the Roy and Diana Vagelos Program in Life Sciences and Management. As one of the nation's leading health economists, he has published widely and made many significant contributions to the fields of medical economics and health insurance. He has served on Institute of Medicine panels on public accountability for health insurers under Medicare and on improving the financing of vaccines.

    Lawton R. Burns, University of Pennsylvania
    Lawton R. Burns is James Joo-Jin Kim Professor in the Health Care Management Department at the Wharton School of the University of Pennsylvania. He is also the co-director of the Roy and Diana Vagelos Program in Life Sciences and Management, and Program Leader for Healthcare Management at the Indian School of Business. He is co-editor of Health Care Management: Organization Design and Behavior (2012), and author of The Business of Healthcare Innovation (2012) and India's Healthcare Industry (Cambridge, 2014).

    Contributors

    Mark V. Pauly, Philip A. Rea, Lawton R. Burns, Kyle Myers, Vicki Chen, Alec Ren, Simon Basseyn, Sourav Bose, Chris Groskaufmanis, Stephen Goldstein, Peter M. Stokes, Connie Lu, Julian Pei, John Q. Trojanowski, Katherine Clark, Anderson Y. Tien, Mark S. Williams, Vivek Nimgaonkar, Alex Rosen, Steven Nichtberger, Osama Ahmed, Amy Le

Sign In

Please sign in to access your account

Cancel

Not already registered? Create an account now. ×

Sorry, this resource is locked

Please register or sign in to request access. If you are having problems accessing these resources please email lecturers@cambridge.org

Register Sign in
Please note that this file is password protected. You will be asked to input your password on the next screen.

» Proceed

You are now leaving the Cambridge University Press website. Your eBook purchase and download will be completed by our partner www.ebooks.com. Please see the permission section of the www.ebooks.com catalogue page for details of the print & copy limits on our eBooks.

Continue ×

Continue ×

Continue ×

Find content that relates to you

This site uses cookies to improve your experience. Read more Close

Are you sure you want to delete your account?

This cannot be undone.

Cancel

Thank you for your feedback which will help us improve our service.

If you requested a response, we will make sure to get back to you shortly.

×
Please fill in the required fields in your feedback submission.
×