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Protein Condensation
Kinetic Pathways to Crystallization and Disease

$50.00 USD

  • Date Published: January 2008
  • availability: This ISBN is for an eBook version which is distributed on our behalf by a third party.
  • format: Adobe eBook Reader
  • isbn: 9780511340079

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About the Authors
  • The quest to understand the condensation of proteins from solutions is a rapidly evolving field. The purpose of this book is to bring to an interdisciplinary audience the state-of-the-art in current research. The first part of the book deals with issues related to the production of high quality protein crystals from solution. Since protein function is determined by structure, high quality protein crystals must be grown in order to determine their structure by X-ray crystallography. The book also discusses diseases that occur due to undesired protein condensation, an increasingly important subject. Examples include sickle cell anemia, cataracts and Alzheimer's disease. Current experimental and theoretical work on these diseases is discussed, which seeks understanding at a fundamental, molecular level, to prevent the undesired condensation from occurring. The book, containing color plate sections, is suitable for graduate students and academic researchers in physics, chemistry, structural biology, protein crystallography and medicine.

    • An introduction to a rapidly expanding field
    • Reviews current experimental work for several important proteins to provide cutting-edge summary of current experimental knowledge
    • Contains works from many different disciplines
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    Reviews & endorsements

    '… the text covers just about anything a researcher would need to know of the many research areas of protein crystallisation. From statistical tests to theoretical models and mathematics, Gunton et al. appear to include the lot.' Journal of Biological Education

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    Product details

    • Date Published: January 2008
    • format: Adobe eBook Reader
    • isbn: 9780511340079
    • availability: This ISBN is for an eBook version which is distributed on our behalf by a third party.
  • Table of Contents

    Preface
    1. Introduction
    2. Globular protein structure
    3. Experimental methods
    4. Thermodynamics and statistical mechanics
    5. Protein-protein interactions
    6. Theoretical studies of equilibrium
    7. Nucleation theory
    8. Experimental studies of nucleation
    9. Lysozyme
    10. Some other globular proteins
    11. Membrane proteins
    12. Crystallins and cataracts
    13. Sickle hemoglobin and sickle cell anemia
    14, Alzheimer's disease
    Index.

  • Authors

    James D. Gunton, Lehigh University, Pennsylvania
    J. D. Gunton is Joseph A. Waldschmitt Professor of Physics at Lehigh University in Pennsylvania. He is the author of approximately 200 articles in refereed journals on equilibrium and nonequilibrium phase transitions. He is a Rhodes Scholar and a Danforth Fellow, and a Fellow of the American Physical Society.

    Andrey Shiryayev, Lehigh University, Pennsylvania
    A. Shiryayev is a doctoral candidate at Lehigh University. He has already published several refereed articles that deal with the condensation of globular proteins.

    Daniel L. Pagan, Lehigh University, Pennsylvania
    D. L. Pagan received is PhD degree from Lehigh University in 2005. He has authored several refereed articles on the condensation of globular proteins.

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