Myelodysplastic Syndromes was first published in 2006, and continues to stand out as the definitive text on the genetics, pathophysiology, and clinical management of this wide range of syndromes. It remains a major reference on all aspects of the clinical classification underlying pathogenetic mechanisms and treatment of the myelodysplastic syndromes. Authored by international experts, the book provides an assessment of the subject's status and a variety of advances in the field. The chapters cover all aspects of the myelodysplastic syndromes, from an in-depth analysis of the multifactorial nature of this disease, including a careful assessment of stromal, immunological and stem cell abnormalities, to a review of recent molecular and cytogenetic discoveries and insights. This book will be a valuable resource to clinicians and researchers who wish to learn more about myelodysplastic syndromes.
• Written by leading international experts providing a comprehensive description of the clinical, biological, molecular and therapeutic advances in the field • Provides an assessment of supportive care and quality of life of patients with MDS • Chapters have been cross-referenced with each other with implications for the future direction of MDS treatment and research
Preface Peter Greenberg; 1. Clinical and prognostic characterization of Myelodysplastic Syndrome Peter Greenberg; 2. Morphologic classifications of Myelodysplastic Syndrome: French-American-British and the World Health Organization Richard Brunning; 3. Pathogenetic mechanisms underlying Myelodysplastic Syndrome Peter Greenberg; 4. Cytogenetic abnormalities in Myelodysplastic Syndrome Harold J. Olney and Michelle M. Le Beau; 5. Molecular mechanisms and gene expression patterns in Myelodysplastic Syndrome Wolf-Karsten Hofmann and Phillip Koeffler; 6. Immunologic mechanisms and treatment of Myelodysplastic Syndrome A. John Barrett, Elaine Sloand and Neal S. Young; 7. Biologically targeted therapies for Myelodysplastic Syndrome Andrew Buresh and Alan List; 8. Supportive care in Myelodysplastic Syndrome: hemopoietic cytokines and iron chelation therapy Jason Gotlib and Peter Greenberg; 9. Hematopoietic cell transplantation options in Myelodysplastic Syndrome Joachim Deeg and Bart Scott; 10. Health-related quality of life in Myelodysplastic Syndrome: conceptualization, measurement and implications Mary Thomas.