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Outcomes Assessment in Cancer
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  • Page extent: 676 pages
  • Size: 247 x 174 mm
  • Weight: 1.663 kg
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 (ISBN-13: 9780521838900 | ISBN-10: 0521838908)

DOI: 10.2277/0521838908

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 (Stock level updated: 17:00 GMT, 06 October 2015)


Cancer touches the lives of millions worldwide each year. This is reflected not only in well-publicized mortality statistics but also in the profound - though much more difficult to measure - effects of cancer on the health-related quality of life, economic status, and overall well-being of patients and their families. In 2001, the US National Cancer Institute established the Cancer Outcomes Measurement Working Group to evaluate the state of the science in measuring the important and diverse impacts of this disease on individuals and populations. The findings and recommendations of the working group's 35 internationally recognized members are reported in Outcomes Assessment in Cancer, lucidly written and accessible to both researchers and policy makers in academia, government, and industry. Originally published in 2005, this volume provides a penetrating yet practical discussion of alternative approaches for comprehensively measuring the burden of cancer and the effectiveness of preventive and therapeutic interventions.

• Comprehensive review and synthesis of cancer outcome measures and methods. • Provides invaluable practical guidance to the cancer research manager or individual investigator about how to select high-quality measures of health-related quality of life and other patient-reported outcomes • Individual chapters display empirical findings in lucidly presented tables, figures, and charts that facilitate side-by-side comparisons of alternative outcome measures and instruments • Material accessible to a wide range of disciplinary backgrounds


Acknowledgments; 1. Introduction Joseph Lipscomb, Carolyn C. Gotay and Claire Snyder; 2. Definitions and conceptual models of quality of life Carol Estwing Ferrans; 3. Assessing health status and quality of life of cancer patients: the use of general instruments Pennifer Erickson; 4. The roles for preference-based measures in support of cancer research and policy David H. Feeny; 5. Instruments to measure the specific health impact of surgery, radiation and chemotherapy on cancer patients Michael J. Barry and Janet E. Dancey; 6. Quality of life in breast cancer - what have we learned and where do we go from here? Patricia A. Ganz and Pamela J. Goodwin; 7. Measuring quality of life in prostate cancer: progress and challenges Mark S. Litwin and James A. Talcott; 8. The science of quality of life measurement in lung cancer Craig C. Earle and Jane C. Weeks; 9. Treatment for colorectal cancer: impact on health-related quality of life Carol M. Moinpour and Dawn Provenzale; 10. Short-term outcomes of chemoprevention, genetic susceptibility testing and screening interventions: what are they? How are they measured? When should they be measured? Jeanne S. Mandelblatt and Joe V. Selby; 11. Evaluating quality of life in cancer survivors Brad Zebrack and David Cella; 12. Assessing health-related quality of life at end of life Betty R. Ferrell; 13. Patient advocate perspective on health-related quality of life issues with prostate cancer survivors James E. Williams; 14. Measuring the patient's perspective on the interpersonal aspects of cancer care Charles Darby; 15. Needs assessment in cancer David H. Gustafson; 16. Assessing the subjective impact of caregiving on informal caregivers of cancer patients Claire Snyder; 17. Practical considerations in outcomes assessment for clinical trials Diane L. Fairclough; 18. Statistical issues in the application of cancer outcome measures J. A. Sloan; 19. The clinical value and meaning of health-related quality-of-life outcomes in oncology David Osoba; 20. Cross-cultural use of health-related quality of life assessments in clinical oncology Neil K. Aaronson; 21. Item response theory and its applications for cancer outcomes measurement Steven P. Reise; 22. Applications of item response theory to improve health outcomes assessment: developing item banks, linking instruments, and computer-adaptive testing Ronald K. Hambleton; 23. Subscales and summary scales: issues in health-related outcomes Mark Wilson; 24. On the definition and measurement of the economic burden of cancer Mark C. Hornbrook; 25. Cost-effectiveness analysis in cancer: toward an iterative framework for integration of evidence from trials and models Bernie J. O'Brien; 26. Data for cancer outcomes research: identifying and strengthening the empirical base Carolyn C. Gotay and Joseph Lipscomb; 27. Use of health-related quality-of-life measures by industry and regulatory agencies in evaluating oncology therapies Dennis A. Revicki; 28. Reflections on COMWG findings and moving to the next phase Carolyn C. Gotay, Joseph Lipscomb and Claire F. Snyder; Invited Papers: i. The world of outcomes research: yesterday, today, and tomorrow Bert Spilker; ii. The ten D's of health outcomes measurement for the 21st Century Colleen A. McHorney and Karon Cook; iii. The use of cognitive interviewing techniques in quality of life and patient-reported outcomes assessment Gordon Willis, Bryce B. Reeve and Ivan Barofsky; ivD. Industry perspective regarding outcomes research in oncology Kati Copley-Merriman, Joseph Jackson, Gregory Boyer, Joseph C. Cappelleri, Robert DeMarinis, Joseph DiCesare, Haim Erder, Jean Paul Gagnon, Lou Garrison, Kathleen Gondek, Kim A. Heithoff, Tom Hughes, David Miller, Margaret Rothman, Nancy Santanello, Richard Willke and Bruce Wong; Index.


Review of the hardback: 'This is an excellent and comprehensive book. … A strength of the book is the clear referencing to the vast literature reviewed which will provide a useful resource for student and seasoned expert alike …' Palliative Medicine

Review of the hardback: 'COMWG are to be commended for providing readers with a thoughtful and detailed overview of where we are and where we need to go to … strengthen our capacity to measure, evaluate, and improve the outcomes of cancer care.' Journal of the American Medical Association


Joseph Lipscomb, Carolyn C. Gotay, Claire Snyder, Carol Estwing Ferrans, Pennifer Erickson, David H. Feeny, Michael J. Barry, Janet E. Dancey, Patricia A. Ganz, Pamela J. Goodwin, Mark S. Litwin, James A. Talcott, Craig C. Earle, Jane C. Weeks, Carol M. Moinpour, Dawn Provenzale, Jeanne S. Mandelblatt, Joe V. Selby, Brad Zebrack, David Cella, Betty R. Ferrell, James E. Williams, Charles Darby, David H. Gustafson, Diane L. Fairclough, J. A. Sloan, David Osoba, Neil K. Aaronson, Steven P. Reise, Ronald K. Hambleton, Mark Wilson, Mark C. Hornbrook, Bernie J. O'Brien, Dennis A. Revicki, Bert Spilker, Colleen A. McHorney, Karon Cook, Gordon Willis, Bryce B. Reeve, Ivan Barofsky, Kati Copley-Merriman, Joseph Jackson, Gregory Boyer, Joseph C. Cappelleri, Robert DeMarinis, Joseph DiCesare, Haim Erder, Jean Paul Gagnon, Lou Garrison, Kathleen Gondek, Kim A. Heithoff, Tom Hughes, David Miller, Margaret Rothman, Nancy Santanello, Richard Willke, Bruce Wong

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