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Knowledge Accumulation and Industry Evolution
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  • Page extent: 466 pages
  • Size: 228 x 152 mm
  • Weight: 0.85 kg
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 (ISBN-13: 9780521858229 | ISBN-10: 0521858224)

DOI: 10.2277/0521858224

Manufactured on demand: supplied direct from the printer

 (Stock level updated: 09:07 GMT, 03 October 2015)


Written by internationally acclaimed experts in the economics of innovation, this volume examines how the biotechnology and pharmaceutical sector is affected by the dynamics of innovation, institutions, and public policy. It contributes both theoretically and empirically to the increasingly influential Schumpetarian framework in industrial economics, which places innovation at the centre of the analysis of competition. Both quantitative and qualitative studies are included, and this varied perspective adds to the richness of the volume's insights. The contributors explore different ideas regarding the historical evolution of technology in the sector, and how firms and industry structure have co-evolved with innovation dynamics. Important policy questions are considered regarding the future of innovation in this sector and its impact on the economy.

• Brings together leading US and European scholars from a variety of research traditions • Historical analysis of the biotechnology and pharmaceutical sector • Examines highly topical subjects, such as GM foods and testing for breast cancer


Figures; Tables; Contributors; 1. Introduction: innovation, growth and industry evolution Giovanni Dosi and Mariana Mazzucato; Part I. Innovation and Industry Evolution: 2. Pharmaceutical innovation as a process of creative destruction Frank Lichtenberg; 3. The evolution of pharmaceutical innovation Paul Nightingale and Surya Mahdi; 4. Firm and regional determinants in innovation models: evidence from biotechnology and traditional chemicals Myriam Mariani; 5. Comments on Part I Lou Galambos; Part II. Firm Growth and Market Structure: 6. Growth and diversification patterns of the worldwide pharmaceutical industry Giulio Bottazzi, Fabio Paolli and Angelo Secchi; 7. Heterogeneity in the firms' growth process: the case of the pharmaceutical industry Elena Cefis, Matteo Ciccarelli and Luigi Orsenigo; 8. Entry, market structure and innovation in a history-friendly model of the evolution of the pharmaceutical industry Christian Garavaglia, Franco Malerba and Luigi Orsenigo; 9. Comments on Part II Boyan Jovanovic; Part III. Policy Implications: 10. Effects of research tool patents and licensing on biomedical innovation John P. Walsh, Ashish Arora and Wesley Cohen; 11. Upstream patents and public health: the case for generic testing of breast cancer Fabienne Orsi, Christine Sevilla and Benjamin Coriat; 12. Competition, regulation and intellectual property management in GM foods: preliminary evidence from survey data Pierre Regibeau and Katherine Rockett; 13. Governance, policy and industry strategies: agro-biotechnology and pharmaceuticals Joanna Chataway, Joyce Tait and David Wield; 14. The dynamics of knowledge accumulation, regulation, and appropriability in the pharma-biotech sector: policy issues Luigi Orsenigo, Giovanni Dosi and Mariana Mazzucato.


Review of the hardback: 'The pharmaceuticals industry presents a fascinating set of paradoxes. Dramatic advances in fundamental science have been associated with a wave of mergers among the leading pharmaceutical firms, the entry of small drug-discovery specialist firms, large increases in industry R&D spending and an apparent slowdown in the rate of innovation. This collection examines these paradoxes and derives important implications for our understanding of this science-based industry and for our understanding of industrial dynamics more generally. This volume will be of great interest to students of evolutionary economics, economic theorists and empirical researchers.' David C. Mowery, University of California - Berkeley

Review of the hardback: 'This volume is remarkable and exciting for several reasons - a topic of first-order social importance, outstanding authors, excellent research. Above all, it has the high energy that comes from engaging topical controversies in key areas of scholarship and public policy.' Sidney G. Winter, University of Pennsylvania

Review of the hardback: 'An enriching intellectual tour through the complex and dynamic landscape of the pharmaceutical industry. The rigorous analyses contained in the volume explore a variety of the most salient issues in the economics of innovation and industry evolution.' Gary Pisano, Harry E. Figgie, Jr., Harvard Business School


Giovanni Dosi, Mariana Mazzucato, Frank Lichtenberg, Paul Nightingale, Surya Mahdi, Myriam Mariani, Lou Galambos, Giulio Bottazzi, Fabio Paolli, Angelo Secchi, Elena Cefis, Matteo Ciccarelli, Luigi Orsenigo, Christian Garavaglia, Franco Malerba, Boyan Jovanovic, John P. Walsh, Ashish Arora, Wesley Cohen, Fabienne Orsi, Christine Sevilla, Benjamin Coriat, Pierre Regibeau, Katherine Rockett, Joanna Chataway, Joyce Tait, David Wield

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