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Behavioral Genetics of the Mouse

Volume 2. Genetic Mouse Models of Neurobehavioral Disorders

$165.00 (C)

Part of Cambridge Handbooks in Behavioral Genetics

Frans Sluyter, Wim E. Crusio, F. Josef van der Staay, Saskia Arndt, Rebecca E. Nordquist, Odd-Geir Berge, Stewart Thompson, Alisdair R. Philp, Gertjan van Dijk, Martien J. H. Kas, Glenda Lassi, Valter Tucci, Robert Lalonde, Catherine Strazielle, David Gordon, Kevin Talbot, Ortrud K. Steinlein, Aki Takahashi, Stephen C. Maxson, Ashlyn Swift-Gallant, Douglas Ashley Monks, Valerie J. Bolivar, Laura Ricceri, Bianca De Filippis, Giovanni Laviola, Susanna Pietropaolo, E. Subashi, Tatyana D. Sotnikova, Raul R. Gainetdinov, Nancy S. Woehrle, Stephanie C. Dulawa, Sofya Abazyan, Mikhail V. Pletnikov, Mara Dierssen, Emily Y. Smith, James L. Resnick, Lucy R. Osborne, Zhengping Jia, Guy Griebel, Sandra Beeské, Christopher R. Pryce, Federica Klaus, Nirit Kara, Haim Einat, John C. Crabbe, Rebecca C. Steiner, Marina R. Picciotto, Tim Karl, Jonathon C. Arnold, Tamara J. Phillips, Emily C. Eastwood, John H. Harkness, F. Scott Hall, Ichiro Sora, Angelo Contarino, Christopher Janus, David Borchelt, Iddo Magen, Marie-Françoise Chesselet, Yoon H. Cho
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  • Date Published: October 2014
  • availability: In stock
  • format: Hardback
  • isbn: 9781107044456

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About the Authors
  • The second volume of Behavioral Genetics of the Mouse provides a comprehensive overview of the major genetically modified mouse lines used to model human neurobehavioral disorders: from disorders of perception, of autonomous and motor functions to social and cognitive syndromes, drug abuse and dependence as well as neurodegenerative pathologies. Mouse models obtained with different types of genetic manipulations (i.e. transgenic, knockout/in mice) are described in their pathological phenotypes, with a special emphasis on behavioral abnormalities. The major results obtained with many of the existing models are discussed in depth highlighting their strengths and limitations. A lasting reference, the thorough reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.

    • Presents the major genetically modified mouse lines used to model human neurobehavioral disorders
    • Includes the critical review of the validity of many of the existing genetic mouse models of neuropathologies
    • Each chapter reviews current knowledge about one specific type of disorder, pointing the reader towards the most important studies in the extensive literature
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    Product details

    • Date Published: October 2014
    • format: Hardback
    • isbn: 9781107044456
    • length: 530 pages
    • dimensions: 282 x 224 x 25 mm
    • weight: 1.59kg
    • contains: 15 b/w illus. 31 tables
    • availability: In stock
  • Table of Contents

    List of contributors
    Part I. Introduction to Genetic Mouse Models of Neurobehavioral Disorders:
    1. Introduction Frans Sluyter and Wim E. Crusio
    2. Developing mouse models of neurobehavioral disorders: when is a model a good model? F. Josef van der Staay, Saskia Arndt and Rebecca E. Nordquist
    Part II. Perception Disorders:
    3. Pain disorders Odd-Geir Berge
    4. Disorders of the visual system Stewart Thompson and Alisdair R. Philp
    Part III. Autonomous and Motor Disorders:
    5. Obesity and anorexia Gertjan van Dijk and Martien J. H. Kas
    6. Sleep disorders Glenda Lassi and Valter Tucci
    7. Cerebellar disorders Robert Lalonde and Catherine Strazielle
    8. Motor disorders David Gordon and Kevin Talbot
    9. Epilepsy Ortrud K. Steinlein
    Part IV. Social Dysfunction and Mental Retardation:
    10. Pathological aggression Frans Sluyter, Aki Takahashi and Stephen C. Maxson
    11. Disorders of sex Ashlyn Swift-Gallant and Douglas Ashley Monks
    12. Autism Valerie J. Bolivar
    13. Rett syndrome Laura Ricceri, Bianca De Filippis and Giovanni Laviola
    14. Fragile X syndrome Susanna Pietropaolo and E. Subashi
    15. Attention-deficit hyperactivity disorder Tatyana D. Sotnikova and Raul R. Gainetdinov
    16. Obsessive-compulsive disorder and Gilles de la Tourette's syndrome Nancy S. Woehrle and Stephanie C. Dulawa
    17. Schizophrenia Sofya Abazyan and Mikhail V. Pletnikov
    18. Down syndrome Mara Dierssen
    19. Prader–Willi and Angelmann syndromes Emily Y. Smith and James L. Resnick
    20. Williams syndrome Lucy R. Osborne and Zhengping Jia
    Part V. Anxiety and Mood Disorders:
    21. Anxiety disorders Guy Griebel and Sandra Beeské
    22. Depression Christopher R. Pryce and Federica Klaus
    23. Bipolar disorder Nirit Kara and Haim Einat
    Part VI. Substance Dependence and Abuse:
    24. Alcohol use disorders John C. Crabbe
    25. Drug abuse: nicotine Rebecca C. Steiner and Marina R. Picciotto
    26. Cannabis abuse and dependence Tim Karl and Jonathon C. Arnold
    27. Drug abuse: amphetamines Tamara J. Phillips, Emily C. Eastwood and John H. Harkness
    28. Cocaine-related disorders F. Scott Hall and Ichiro Sora
    29. Opioids-related disorders Angelo Contarino
    Part VII. Neurodegenerative Disorders:
    30. Alzheimer's disease Christopher Janus and David Borchelt
    31. Parkinson's disease Iddo Magen and Marie-Françoise Chesselet
    32. Huntington's disease Yoon H. Cho and Susanna Pietropaolo
    Index.

  • Editors

    Susanna Pietropaolo, Centre National de la Recherche Scientifique (CNRS), Paris
    Susanna Pietropaolo is a Researcher at the Centre National de la Recherche Scientifique (CNRS). She is an expert in the behavioral analysis of the laboratory mouse, with a special interest in social behaviors. Her recent research focuses on mouse models of social dysfunction, including autism and Fragile X syndrome.

    Frans Sluyter, University of Portsmouth
    Frans Sluyter is an expert in (wild) house mouse behavior and neurogenetics. His interests range from aggression, addiction, depression and (stress) coping strategies to gene expression profiles and consciousness. He has worked in The Netherlands, France, Japan and England.

    Wim E. Crusio, Centre National de la Recherche Scientifique (CNRS), Paris
    Wim E. Crusio is a Research Director at the Centre National de la Recherche Scientifique (CNRS). With over 35 years' experience in mouse behavioral neurogenetics and the analysis of mouse behavior, his recent interests cover mouse models of depression, autism, and Fragile X syndrome.

    Contributors

    Frans Sluyter, Wim E. Crusio, F. Josef van der Staay, Saskia Arndt, Rebecca E. Nordquist, Odd-Geir Berge, Stewart Thompson, Alisdair R. Philp, Gertjan van Dijk, Martien J. H. Kas, Glenda Lassi, Valter Tucci, Robert Lalonde, Catherine Strazielle, David Gordon, Kevin Talbot, Ortrud K. Steinlein, Aki Takahashi, Stephen C. Maxson, Ashlyn Swift-Gallant, Douglas Ashley Monks, Valerie J. Bolivar, Laura Ricceri, Bianca De Filippis, Giovanni Laviola, Susanna Pietropaolo, E. Subashi, Tatyana D. Sotnikova, Raul R. Gainetdinov, Nancy S. Woehrle, Stephanie C. Dulawa, Sofya Abazyan, Mikhail V. Pletnikov, Mara Dierssen, Emily Y. Smith, James L. Resnick, Lucy R. Osborne, Zhengping Jia, Guy Griebel, Sandra Beeské, Christopher R. Pryce, Federica Klaus, Nirit Kara, Haim Einat, John C. Crabbe, Rebecca C. Steiner, Marina R. Picciotto, Tim Karl, Jonathon C. Arnold, Tamara J. Phillips, Emily C. Eastwood, John H. Harkness, F. Scott Hall, Ichiro Sora, Angelo Contarino, Christopher Janus, David Borchelt, Iddo Magen, Marie-Françoise Chesselet, Yoon H. Cho

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