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Genomics and Bioinformatics
An Introduction to Programming Tools for Life Scientists

$64.99 (X)

textbook
  • Date Published: July 2012
  • availability: Available
  • format: Paperback
  • isbn: 9781107401242

$ 64.99 (X)
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  • With the arrival of genomics and genome sequencing projects, biology has been transformed into an incredibly data-rich science. The vast amount of information generated has made computational analysis critical and has increased demand for skilled bioinformaticians. Designed for biologists without previous programming experience, this textbook provides a hands-on introduction to Unix, Perl and other tools used in sequence bioinformatics. Relevant biological topics are used throughout the book and are combined with practical bioinformatics examples, leading students through the process from biological problem to computational solution. All of the Perl scripts, sequence and database files used in the book are available for download at the accompanying website, allowing the reader to easily follow each example using their own computer. Programming examples are kept at an introductory level, avoiding complex mathematics that students often find daunting. The book demonstrates that even simple programs can provide powerful solutions to many complex bioinformatics problems.

    • Demonstrates the biological motivation behind bioinformatics, with substantial biological background and interesting topics introduced in every chapter
    • Hands-on guide to performing specific analyses – practical procedures are described and relevant files are available for download at the book's website
    • Caters for students without a background in computer science and mathematics – complex mathematics is avoided and programming examples are kept at an introductory level
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    Reviews & endorsements

    "... Samuelsson has devised a well-structured, step-by-step approach. Each chapter deals with a different use of bioinformatics, ranging from human disease to gene technology, giving the reader up-to-the-minute information in bite-sized chunks. The topics show the interdisciplinary nature of bioinformatics and are introduced in a readable manner, so the novice is not swamped with detail."
    Dr Leighton Dann, The Biologist

    "The book provides a lively and accessible introduction to current research in the life sciences, and it does so in a succinct way by grounding the explanations with simple algorithms expressed in Perl code. As such, the book can be very useful to a general science audience, particularly those with a computer science background, whether established researchers or undergraduate students. The writing is inspiring and engaging, and the inclusion of Perl code makes it easy for readers to apply the knowledge and observe the outcomes." < br />Sara Kalvala, Computing Reviews

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    Product details

    • Date Published: July 2012
    • format: Paperback
    • isbn: 9781107401242
    • length: 358 pages
    • dimensions: 246 x 189 x 19 mm
    • weight: 0.75kg
    • contains: 20 b/w illus. 70 colour illus. 23 tables 60 exercises
    • availability: Available
  • Table of Contents

    Preface
    Acknowledgements
    Design and conventions of this book
    1. Introduction - working with the molecules of life in the computer
    2. Gene technology - cutting DNA
    3. Gene technology - knocking genes down
    4. Gene technology - amplifying DNA
    5. Human disease - when DNA sequences are toxic
    6. Human disease - iron imbalance and the iron responsive element
    7. Human disease - cancer as a result of aberrant proteins
    8. Evolution - what makes us human?
    9. Evolution - resolving a criminal case
    10. Evolution - the sad case of the Tasmanian tiger
    11. A function to every gene - termites, metagenomics and learning about the function of a sequence
    12. A function to every gene - royal blood and order in the sequence universe
    13. A function to every gene - a slimy molecule
    14. Information resources - learning about flu viruses
    15. Finding genes - going ashore at CpG islands
    16. Finding genes - in the world of snurps
    17. Finding genes - hunting for the distant RNA relatives
    18. Personal genomes - the differences between you and me
    19. Personal genomes - what's in my genome?
    20. Personal genomes - details of family genetics
    Appendix I. Brief Unix reference
    Appendix II. A selection of biological sequence analysis software
    Appendix III. Short Perl reference
    Appendix IV. Brief introduction to R
    Index.

  • Resources for

    Genomics and Bioinformatics

    Tore Samuelsson

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  • Instructors have used or reviewed this title for the following courses

    • Advanced Bioinformatics
    • Biotechnology: Molecular Techniques and Bioinformatics
    • Computational Biology Methods and Research
    • Genome Biology
    • Molecular Mechanisms of Disease
  • Author

    Tore Samuelsson, Göteborgs Universitet, Sweden
    Tore Samuelsson is a Professor in Biochemistry and Bioinformatics at the Institute of Biomedicine, University of Gothenburg, Sweden. He has been active in bioinformatics research for more than fifteen years and has over ten years' experience of teaching in the field, including the development of web resources for molecular biology and bioinformatics education.

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