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Systems Biology
Properties of Reconstructed Networks

$98.00 (P)

textbook
  • Date Published: January 2006
  • availability: Available
  • format: Hardback
  • isbn: 9780521859035

$ 98.00 (P)
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About the Authors
  • Genome sequences are now available that enable us to determine the biological components that make up a cell or an organism. The new discipline of systems biology examines how these components interact and form networks, and how the networks generate whole cell functions corresponding to observable phenotypes. This textbook describes how to model networks, determine their properties, and relate these to phenotypic functions. Some knowledge of linear algebra and biochemistry is required, since the book reflects the irreversible trend of increasing mathematical content in biology education.

    • The first textbook in the new field of systems biology
    • An associated website provides slides, projects and problems
    • Features an open layout, summary points, guides to literature and lots of illustrations
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    Reviews & endorsements

    "Systems Biology is a very readable introduction to the subject... make[s] it clear that this is an exciting time for biology."
    Nigel Goldenfeld, Physics Today

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    Product details

    • Date Published: January 2006
    • format: Hardback
    • isbn: 9780521859035
    • length: 336 pages
    • dimensions: 261 x 20 x 181 mm
    • weight: 0.8kg
    • availability: Available
  • Table of Contents

    Preface
    1. Introduction
    2. Basic concepts in systems biology
    Part I. Reconstruction of Biochemical Networks:
    3. Metabolic networks
    4. Regulatory networks
    5. Signalling networks
    Part II. Mathematical Representation of Reconstructed Networks:
    6. Basic features of S
    7. Topological properties
    8. Fundamental subspaces
    9. Null space of S
    10. The left null space of S
    11. The row and column spaces of S
    Part III. Capabilities of Reconstructed Networks:
    12. Dual causality
    13. Properties of solution spaces
    14. Sampling properties of solution spaces
    15. Finding functional states
    16. Parametric sensitivity
    17. Epilogue
    Appendix A: nomenclature and abbreviations
    Appendix B: E. coli core metabolic network
    Bibliography
    Index.

  • Author

    Bernhard Ø. Palsson, University of California, San Diego
    Bernhard Ø. Palsson, Professor of Bioengineering and Adjunct Professor of Medicine, University of California, San Diego.

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